The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Heterogeneous Differentiation Patterns of Individual CD8 + T Cells
Abstract
Dynamic Protection: During an immune response, CD8 + T cells are recruited to provide protection. Most cells differentiate into short-lived effectors that help to clear the pathogen, whereas others form long-lived memory cells to protect against reinfection. Gerlach et al. (p. 635 , published online 14 March) and Buchholz et al. (p. 630 , published online 14 March) used in vivo fate mapping of mouse T cells with a defined specificity during a bacterial infection to show that the dynamics of the single-cell response are not uniform. The response of a particular T cell population is the average of a small number of clones that expand greatly (“large clones”) and many clones that only proliferate at low amounts (“small clones”). The memory pool arises largely from small clones whereas effectors are primarily made up of large clones.
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Cites
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Simons, B. D., & Clevers, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.033 · Cited by 489
Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection
Obar, J. J., Khanna, K. M., & Lefrançois, L. (2008) · Immunity · doi:10.1016/j.immuni.2008.04.010 · Cited by 449
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De Simone, G., Mazza, E. M. C., Cassotta, A., Davydov, A. N., Kuka, M., Zanon, V., De Paoli, F., Scamardella, E., Metsger, M., Roberto, A., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1901072 · Cited by 49
Asymmetric cell division during T cell development controls downstream fate
Pham, K., Shimoni, R., Charnley, M., Ludford-Menting, M. J., Hawkins, E. D., Ramsbottom, K., Oliaro, J., Izon, D., Ting, S. B., Reynolds, J., et al. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201502053 · Cited by 39
Metadata
- Authors
- Gerlach, C., Rohr, J. C., Perié, L., van Rooij, N., van Heijst, J. W. J., Velds, A., Urbanus, J., Naik, S. H., Jacobs, H., Beltman, J. B., de Boer, R. J., & Schumacher, T. N. M.
- Venue
- Science
- Published
- 2013-05-03
- Volume
- 340
- Issue
- 6132
- Pages
- 635-639
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1994500716
- Cited by
- 365
- References
- 2
- FWCI
- 20.77
- Type
- journal article
- Language
- en
- Open access
- closed
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