Genome-scale CRISPR-Cas9 knockout screening in human cells

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Items 401–500 of 1,041

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3. Conditionally Stabilized dCas9 Activator for Controlling Gene Expression in Human Cell Reprogramming and Differentiation
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10. CRISPR/dCas9 Tools: Epigenetic Mechanism and Application in Gene Transcriptional Regulation
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11. Covalent linkage of the DNA repair template to the CRISPR-Cas9 nuclease enhances homology-directed repair
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13. Large-Scale Analysis of CRISPR/Cas9 Cell-Cycle Knockouts Reveals the Diversity of p53-Dependent Responses to Cell-Cycle Defects
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14. Selective Killing of SMARCA2- and SMARCA4-deficient Small Cell Carcinoma of the Ovary, Hypercalcemic Type Cells by Inhibition of EZH2: In Vitro and In Vivo Preclinical Models
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17. Construction of a Quadruple Auxotrophic Mutant of an Industrial Polyploid Saccharomyces cerevisiae Strain by Using RNA-Guided Cas9 Nuclease
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18. Targeting androgen receptor phase separation to overcome antiandrogen resistance
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19. Combination Therapies with CDK4/6 Inhibitors to Treat <i>KRAS-</i> Mutant Pancreatic Cancer
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24. Zebrafish Genome Engineering Using the CRISPR–Cas9 System
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25. TALEN and CRISPR/Cas9-mediated genome editing in the early-branching metazoan Nematostella vectensis
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26. Multi-functional genome-wide CRISPR system for high throughput genotype–phenotype mapping
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27. Advances in CRISPR-Cas9 genome engineering: lessons learned from RNA interference
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28. Up-regulation of FOXD1 by YAP alleviates senescence and osteoarthritis
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29. KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer
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30. CRISPR-based functional genomics for neurological disease
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31. Efficient genome editing in Fusarium oxysporum based on CRISPR/Cas9 ribonucleoprotein complexes
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32. Small-molecule targeting of brachyury transcription factor addiction in chordoma
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33. CRISPR/Cas9-Mediated Scanning for Regulatory Elements Required for HPRT1 Expression via Thousands of Large, Programmed Genomic Deletions
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34. Massively parallel single-amino-acid mutagenesis
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35. The regulatory network behind MHC class I expression
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36. Patterns of CRISPR/Cas9 activity in plants, animals and microbes
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37. Breast cancer metastasis suppressor OTUD1 deubiquitinates SMAD7
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38. High-throughput 5’ UTR engineering for enhanced protein production in non-viral gene therapies
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39. Molecular techniques to interrogate and edit the Chlamydomonas nuclear genome
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40. LKB1, Salt-Inducible Kinases, and MEF2C are linked dependencies in acute myeloid leukemia
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41. Long noncoding RNA MALAT1 releases epigenetic silencing of HIV-1 replication by displacing the polycomb repressive complex 2 from binding to the LTR promoter
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42. Genome-wide screening for functional long noncoding RNAs in human cells by Cas9 targeting of splice sites
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43. Generation of Genomic Deletions in Mammalian Cell Lines via CRISPR/Cas9
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44. Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus
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45. CRISPR-mediated genome editing in non-conventional yeasts for biotechnological applications
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46. Advances in Engineering the Fly Genome with the CRISPR-Cas System
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47. CRISPR interference-based specific and efficient gene inactivation in the brain
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48. Systematic analysis of CRISPR–Cas9 mismatch tolerance reveals low levels of off-target activity
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49. Dynamics of phosphoinositide conversion in clathrin-mediated endocytic traffic
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50. Unique and Shared Epigenetic Programs of the CREBBP and EP300 Acetyltransferases in Germinal Center B Cells Reveal Targetable Dependencies in Lymphoma
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51. Multilayered VBC score predicts sgRNAs that efficiently generate loss-of-function alleles
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52. Delivery approaches for CRISPR/Cas9 therapeutics in vivo: advances and challenges
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53. Enhancer Architecture and Essential Core Regulatory Circuitry of Chronic Lymphocytic Leukemia
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54. A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models
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55. Generation of a Collection of Mutant Tomato Lines Using Pooled CRISPR Libraries
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56. Cancer drug addiction is relayed by an ERK2-dependent phenotype switch
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57. CRISPR-Cas9 screen reveals a MYCN-amplified neuroblastoma dependency on EZH2
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58. Dual gene activation and knockout screen reveals directional dependencies in genetic networks
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59. A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV
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61. Conditional Knockouts Generated by Engineered CRISPR-Cas9 Endonuclease Reveal the Roles of Coronin in C. elegans Neural Development
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63. Dual sgRNA-directed gene knockout using CRISPR/Cas9 technology in Caenorhabditis elegans
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69. A Compendium of Genetic Modifiers of Mitochondrial Dysfunction Reveals Intra-organelle Buffering
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71. MARCH8 inhibits HIV-1 infection by reducing virion incorporation of envelope glycoproteins
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73. Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements
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90. Stem Cells, Genome Editing, and the Path to Translational Medicine
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94. A Critical Review: Recent Advancements in the Use of CRISPR/Cas9 Technology to Enhance Crops and Alleviate Global Food Crises
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96. Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9
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97. An anti-CRISPR protein disables type V Cas12a by acetylation
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98. A platform for functional assessment of large variant libraries in mammalian cells
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100. Defining essential genes for human pluripotent stem cells by CRISPR–Cas9 screening in haploid cells
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