Genome-scale CRISPR-Cas9 knockout screening in human cells

Shalem, Ophir, Sanjana, Neville E., Hartenian, Ella, Shi, Xi, Scott, David A., Mikkelsen, Tarjei S., Heckl, Dirk, Ebert, Benjamin L. +3 more·2014·Science

Cited by (1,041)

Items 501–600 of 1,041

  1. Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?
    R. Brooks Robey, Judith Weisz, Nancy B. Kuemmerle, Anna C. Salzberg, Arthur S Berg, Dustin G. Brown, Laura L. Maurer, Roberta Palorini, Fahd Al‐Mulla, Rabeah Abbas Al-Temaimi et al. · 2015 · Carcinogenesis
  2. CRISPR-UMI: single-cell lineage tracing of pooled CRISPR–Cas9 screens
    Georg Michlits, Maria Hubmann, Szu-Hsien Sam Wu, Gintautas Vainorius, Elena Budusan, Sergei Zhuk, Thomas Rainer Burkard, Maria Novatchkova, Martin Aichinger, YiQing Lü et al. · 2017 · Nature Methods
  3. Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replication
    Kevin Tsai, David Courtney, Bryan R. Cullen · 2018 · PLoS Pathogens
  4. Modeling Human Digestive Diseases With CRISPR-Cas9–Modified Organoids
    Masayuki Fujii, Hans C. Clevers, Toshiro Sato · 2018 · Gastroenterology
  5. Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancer
    Yuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, Yuuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Kouichi Kagawa, Yasuhiro Goto, Mitsuaki Utou et al. · 2023 · Cell Reports
  6. CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation
    Cheng, Weiwei, Wang, Shaopeng, Zhang, Zhe, Morgens, David W., Hayes, Lindsey R., Lee, Soojin, Portz, Bede, Xie, Yongzhi, Nguyen, Baotram V., Haney, Michael S. et al. · 2019 · Neuron
  7. High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve Analysis
    Holly R. Thomas, Stefanie M. Percival, Bradley K. Yoder, John M. Parant · 2014 · PLoS ONE
  8. The mitogen-activated protein kinase pathway in melanoma part I – Activation and primary resistance mechanisms to BRAF inhibition
    Teresa Maria Santos Amaral, Tobias W. Sinnberg, Friedegund Elke Meier, Clemens Krepler, Mitchell Paul Levesque, Heike Niessner, Claus Garbe · 2017 · European Journal of Cancer
  9. Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS
    Takuji Yamauchi, Takeshi Masuda, Matthew C. Canver, Michael Seiler, Yuichiro Semba, Mohammad Shboul, Mohammed Al‐Raqad, Manami Maeda, Vivien A. C. Schoonenberg, Mitchel A. Cole et al. · 2018 · Cancer Cell
  10. Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis
    Liping Deng, Ruotong Ren, Zunpeng Liu, Moshi Song, Jingyi Li, Zeming Wu, Xiaoqing Ren, Lina Fu, Wei Li, Weiqi Zhang et al. · 2019 · Nature Communications
  11. Genetic screens in isogenic mammalian cell lines without single cell cloning
    Peter C. DeWeirdt, Annabel K. Sangree, Ruth E. Hanna, Kendall R Sanson, Mudra Hegde, Christine Strand, Nicole S. Persky, John G. Doench · 2020 · Nature Communications
  12. CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in glioma
    Siyuan John Liu, Martina Malatesta, Brian V. Lien, Parna Saha, Shivani S. Thombare, Sung Jun Hong, Leslie Pedraza, Mark Koontz, Kyounghee Seo, Max A. Horlbeck et al. · 2020 · Genome biology
  13. Interleukin-13 drives metabolic conditioning of muscle to endurance exercise
    Knudsen, Nelson H., Stanya, Kristopher J., Hyde, Alexander L., Chalom, Mayer M., Alexander, Ryan K., Liou, Yae-Huei, Starost, Kyle A., Gangl, Matthew R., Jacobi, David, Liu, Sihao et al. · 2020 · Science
  14. The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia
    Thilini R. Fernando, Jorge R. Contreras, Matteo Zampini, Norma Iris Rodriguez-Malave, Michael O. Alberti, Jaime Anguiano, Tiffany M. Tran, Jayanth Kumar Palanichamy, Jasmine Gajeton, Nolan M. Ung et al. · 2017 · Molecular Cancer
  15. Long Terminal Repeat CRISPR-CAR-Coupled “Universal” T Cells Mediate Potent Anti-leukemic Effects
    Christos Georgiadis, Roland Preece, Lauren E. Nickolay, Annie Etuk, Anastasia Petrova, Dariusz Ładoń, Alexandra Danyi, Neil Humphryes-Kirilov, Ayokunmi Ajetunmobi, Daesik Kim et al. · 2018 · Molecular Therapy
  16. Interfacial actin protrusions mechanically enhance killing by cytotoxic T cells
    Fella Tamzalit, Mitchell S. Wang, Weiyang Jin, María Tello‐Lafoz, Vitaly P. Boyko, John M. Heddleston, Charles T. Black, Lance Cameron Kam, Morgan Huse · 2019 · Science Immunology
  17. A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivity
    Adam Christopher Palmer, Christopher Chidley, Peter Karl Sorger · 2018 · eLife
  18. CRISPR screens in physiologic medium reveal conditionally essential genes in human cells
    Nicholas J. Rossiter, Kimberly S. Huggler, Charles H. Adelmann, Heather R. Keys, Ross W. Soens, David M. Sabatini, Jason R. Cantor · 2021 · Cell Metabolism
  19. A deep insight into CRISPR/Cas9 application in CAR-T cell-based tumor immunotherapies
    Ehsan Razeghian, Mahyuddin K. M. Nasution, Heshu Sulaiman Rahman, Zhanna R. Gardanova, Walid Kamal Abdelbasset, Aravindhan Surendar, Dmitry Olegovich Bokov, Wanich Suksatan, Pooria Nakhaei, Siavash Shariatzadeh et al. · 2021 · Stem Cell Research & Therapy
  20. Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignancies
    Nikolas Herold, Sean G. Rudd, Linda M. Ljungblad, Kumar Sanjiv, Ida Hed Myrberg, Cynthia B. J. Paulin, Yaser Heshmati, Anna Hagenkort, Juliane Kutzner, Brent D. G. Page et al. · 2017 · Nature Medicine
  21. In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic Mice
    Mona El Refaey, Li ming Xu, Yandi Gao, Benjamin D. Canan, T. M. Ayodele Adesanya, Sarah C. Warner, Keiko Akagi, David E. Symer, Peter J. Mohler, Jianjie Ma et al. · 2017 · Circulation Research
  22. Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
    Grace R. Anderson, Suzanne E. Wardell, Merve Çakır, Catherine Yip, Yeong-ran Ahn, Moiez Ali, Alexander P. Yllanes, Christina Chao, Donald Patrick McDonnell, Kris C. Wood · 2018 · Nature Communications
  23. RNAi/CRISPR Screens: from a Pool to a Valid Hit
    Anne M. Schuster, Hélène Erasimus, Sabrina Fritah, Petr V. Nazarov, Eric Van Dyck, Simone P. Niclou, Anna Golebiewska · 2018 · Trends in biotechnology
  24. CRISPR-Cas in Streptococcus pyogenes
    Anaïs Le Rhun, Andrés Escalera-Maurer, Majda Bratovič, Emmanuelle Charpentier · 2019 · RNA Biology
  25. Selective endpoint visualized detection of Vibrio parahaemolyticus with CRISPR/Cas12a assisted PCR using thermal cycler for on-site application
    Mengyao Zhang, Chengzhi Liu, Ya Shi, Jun Wu, Jian Feng Wu, Huan Chen · 2020 · Talanta
  26. Improved analysis of CRISPR fitness screens and reduced off-target effects with the BAGEL2 gene essentiality classifier
    Eiru Kim, Traver Hart · 2021 · Genome Medicine
  27. Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signaling
    de Araujo, Mariana E. G., Naschberger, Andreas, Fürnrohr, Barbara G., Stasyk, Taras, Dunzendorfer-Matt, Theresia, Lechner, Stefan, Welti, Stefan, Kremser, Leopold, Shivalingaiah, Giridhar, Offterdinger, Martin et al. · 2017 · Science
  28. Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer
    Yun Pyo Kang, Laura Torrente, Aimee Falzone, Cody M. Elkins, Min Liu, John M. Asara, Christian C. Dibble, Gina M. DeNicola · 2019 · eLife
  29. GPR108 Is a Highly Conserved AAV Entry Factor
    Amanda M. Dudek, Nerea Zabaleta, Eric M. Zinn, Sirika Pillay, James R. Zengel, Caryn L. Porter, Jennifer Santos Franceschini, Reynette Estelien, Jan E. Carette, Guo Ling Zhou et al. · 2019 · Molecular Therapy
  30. Cross-species RNA-seq for deciphering host–microbe interactions
    Alexander J. Westermann, Jörg Vogel · 2021 · Nature Reviews Genetics
  31. Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAi
    Benjamin E. Housden, Alexander J. Valvezan, Colleen Kelley, Richelle Sopko, Yanhui Hu, Charles L. Roesel, Shuailiang Lin, Michael Buckner, Rong Tao, Bahar Yilmazel et al. · 2015 · Science Signaling
  32. Nanomedicine-mediated cancer stem cell therapy
    Song Shen, Jinxing Xia, Jun Wang · 2015 · Biomaterials
  33. Epigenetic and Transcriptional Control of the Epidermal Growth Factor Receptor Regulates the Tumor Immune Microenvironment in Pancreatic Cancer
    Jinyang Li, Salina Yuan, Robert J. Norgard, Fangxue Yan, Yu Huining Sun, Il‐Kyu Kim, Allyson J. Merrell, Yogev Sela, Yanqing Jiang, Natarajan V. Bhanu et al. · 2020 · Cancer Discovery
  34. A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screening
    Diao, Yarui, Li, Bin, Meng, Zhipeng, Jung, Inkyung, Lee, Ah Young, Dixon, Jesse, Maliskova, Lenka, Guan, Kun-liang, Shen, Yin, Ren, Bing · 2016 · Genome Research
  35. ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune response
    Huan Lian, Jin Wei, Ru Zang, Wen Ye, Qing Yang, Xianan Zhang, Yun-Da Chen, Yu-Zhi Fu, Ming‐Ming Hu, Cao‐Qi Lei et al. · 2018 · Nature Communications
  36. Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model
    Jun Wu, Daniel A. Ryskamp, Xia Liang, Polina A. Egorova, Olga A. Zakharova, Gene Hung, Безпрозванный Илья Борисович · 2016 · Journal of Neuroscience
  37. cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus Infection
    Chan‐Wang Jerry Lio, Bryan McDonald, Mariko Takahashi, Rekha Dhanwani, Nikita Sharma, Jenny Huang, Elise Pham, Chris A. Benedict, Sonia Sharma · 2016 · Journal of Virology
  38. Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional Repression
    Maria Rusan, Kapsok Li, Yvonne Y. Li, Camilla Laulund Christensen, Brian J. Abraham, Nicholas P. Kwiatkowski, Kevin A. Buczkowski, Bruno Bockorny, Ting Chen, Shuai Li et al. · 2017 · Cancer Discovery
  39. Ubiquitination of Rheb governs growth factor-induced mTORC1 activation
    Lu Deng, Lei Chen, Linlin Zhao, Yan Xu, Xiao-Ping Peng, Xinbo Wang, Lin Ding, Jiali Jin, Hongqi Teng, Yanming Wang et al. · 2018 · Cell Research
  40. Donafenib and GSK‐J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 Expression
    Chenyang Zheng, Bo Zhang, Yunyun Li, Kejia Liu, Wei Wei, Shuhang Liang, Hongrui Guo, Kun Ma, Yao Liu, Jiabei Wang et al. · 2023 · Advanced Science
  41. Current and future delivery systems for engineered nucleases: ZFN, TALEN and RGEN
    Ain, Qurrat Ul, Chung, Jee Young, Kim, Yong-Hee · 2015 · Journal of Controlled Release
  42. Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse line
    Van Trung Chu, Robin Graf, Tristan Wirtz, Timm Weber, Jérémy Favret, Xun Li, Kerstin Petsch, Ngoc Tung Tran, Michael H. Sieweke, Claudia Berek et al. · 2016 · Proceedings of the National Academy of Sciences
  43. Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF Mutations
    Franklin W. Huang, Juan Miguel Mosquera, Andrea Garofalo, Coyin Oh, Maria B. Baco, Ali Amin‐Mansour, Bokang Rabasha, Samira Bahl, Stephanie Anne Mullane, Brian D. Robinson et al. · 2017 · Cancer Discovery
  44. OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropism
    E Xiaofei, Paul Meraner, Ping Lü, Jill M. Perreira, Aaron M. Aker, William M. McDougall, Ronghua ZhuGe, Gary C. T. Chan, Rachel M. Gerstein, Patrizia Caposio et al. · 2019 · Proceedings of the National Academy of Sciences
  45. Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate Dependencies
    Barbara Mair, Jelena Tomic, Sanna N. Masud, Peter J. Tonge, Alexander Weiss, Matej Ušaj, Amy H.Y. Tong, Jamie J. Kwan, Kevin R. Brown, Emily Titus et al. · 2019 · Cell Reports
  46. Responsive Nanocarriers as an Emerging Platform for Cascaded Delivery of Nucleic Acids to Cancer
    Yang Liu, Cong‐Fei Xu, Shoaib Iqbal, Xianzhu Yang, Jun Wang · 2017 · Advanced Drug Delivery Reviews
  47. Widespread Influence of 3′-End Structures on Mammalian mRNA Processing and Stability
    Xuebing Wu, David P. Bartel · 2017 · Cell
  48. MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1
    Ying Yang, Mari B. Ishak Gabra, Eric Allan Hanse, Xazmin H. Lowman, Thai Q. Tran, Haiqing Li, Neta Milman, Juan Liu, Michael A. Reid, Jason W. Locasale et al. · 2019 · Nature Communications
  49. The application of the CRISPR-Cas9 genome editing machinery in food and agricultural science: Current status, future perspectives, and associated challenges
    İsmail Eş, Mohsen Gavahian, Francisco J. Martí-Quijal, José Manuel Lorenzo, Amin Mousavi Khaneghah, Christos Tsatsanis, Sotirios C. Kampranis, Francisco J. Barba · 2019 · Biotechnology Advances
  50. Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease Genes
    Zhou Fang, Chen Weng, Haiyan Li, Ran Tao, Weihua Mai, Xiaoxiao Liu, Leina Lu, Sisi Lai, Qing Duan, Carlos Alfonso Álvarez‐González et al. · 2019 · Cell Reports
  51. An ARF6–Exportin-5 axis delivers pre-miRNA cargo to tumour microvesicles
    James W. Clancy, Ye Zhang, Colin S. Sheehan, Crislyn D’Souza‐Schorey · 2019 · Nature Cell Biology
  52. Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy
    Dongli Cai, Jiaming Li, Dingfeng Liu, Shanjuan Hong, Qin Qiao, Qinli Sun, Pingping Li, Nanan Lyu, Tiantian Sun, Shan Xie et al. · 2019 · Cellular and Molecular Immunology
  53. Computational Tools and Resources for CRISPR/Cas Genome Editing
    Chao Li, Wen Chu, Rafaqat A. Gill, Shifei Sang, Yuqin Shi, Xuezhi Hu, Yuting Yang, Qamar U. Zaman, Baohong Zhang · 2022 · Genomics Proteomics & Bioinformatics
  54. CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer
    Mostafa Vaghari‐Tabari, Parisa Hassanpour, Fatemeh Sadeghsoltani, Faezeh Malakoti, Forough Alemi, Durdi Qujeq, Zatollah Asemi, Bahman Yousefi · 2022 · Cellular & Molecular Biology Letters
  55. SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processing
    Sifan Chen, Maximilian Felix Blank, Aishwarya Iyer-Bierhoff, Bingding Huang, Lin Wang, Ingrid Grummt, Renate Voit · 2016 · Nature Communications
  56. ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway Inhibition
    Belinda Wang, Elsa Beyer Krall, Andrew J. Aguirre, Mi‐Ju Kim, Hans R. Widlund, Mihir B. Doshi, Ewa Sicińska, Rita Sulahian, Amy B. Goodale, Glenn S. Cowley et al. · 2017 · Cell Reports
  57. In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapy
    Meiou Dai, Gang Yan, Ni Wang, Girija Daliah, Ashlin M. Edick, Sophie Poulet, Julien Boudreault, Suhad Ali, Sergio A. Burgos, J J Lebrun · 2021 · Nature Communications
  58. Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
    Feng Tian, Yuyan Cheng, Songlin Zhou, Qianbin Wang, Aboozar Monavarfeshani, Kun Gao, Weiqian Jiang, Riki Kawaguchi, Qing Wang, Mingjun Tang et al. · 2022 · Neuron
  59. Prediction of efficiencies for diverse prime editing systems in multiple cell types
    Goosang Yu, Hui Kwon Kim, Jinman Park, Hyunjong Kwak, Yumin Cheong, Dongyoung Kim, Ji-Yun Kim, Jisung Kim, Hyongbum Henry Kim · 2023 · Cell
  60. Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells
    Jia Liu, Thomas Gaj, Yifeng Yang, Nan Wang, Sailan Shui, Sojung Kim, Chidananda Nagamangala Kanchiswamy, Jin‐Soo Kim, Carlos F. Barbas · 2015 · Nature Protocols
  61. Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cells
    Alison E. Mungenast, Sandra Siegert, Li‐Huei Tsai · 2015 · Molecular and Cellular Neuroscience
  62. CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactions
    Judd F. Hultquist, Joseph B Hiatt, Kathrin Schumann, Michael McGregor, Theodore L. Roth, Paige Haas, Jennifer A. Doudna, Alexander Marson, Nevan J. Krogan · 2018 · Nature Protocols
  63. CRISPR-Cas: Converting A Bacterial Defence Mechanism into A State-of-the-Art Genetic Manipulation Tool
    Loureiro, Alexandre, da Silva, Gabriela Jorge · 2019 · Antibiotics
  64. Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesis
    Karim Mrouj, Nuria Andrés-Sánchez, Geronimo Dubra, Priyanka Singh, Michal Sobecki, Dhanvantri Chahar, Emile Alghoul, Ana Bella Aznar, Susana Prieto, Nelly Pirot et al. · 2021 · Proceedings of the National Academy of Sciences
  65. Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis
    Yan‐Hong Cui, Seungwon Yang, Jiangbo Wei, Christopher R. Shea, Wen Zhong, Fang Wang, Palak Shah, Muhammad Ghulam Kibriya, Xiaolong Cui, Habibul Ahsan et al. · 2021 · Nature Communications
  66. Targets of Immune Escape Mechanisms in Cancer: Basis for Development and Evolution of Cancer Immune Checkpoint Inhibitors
    Shovan Dutta, Anirban Ganguly, Kaushiki Chatterjee, Sheila Spada, Sumit Mukherjee · 2023 · Biology
  67. Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function
    2023
  68. High-Throughput Single-Cell Sequencing with Linear Amplification
    Yi A. Yin, Yue Jiang, Kwan-Wood Gabriel Lam, Joel B. Berletch, Christine M. Distèche, William Stafford Noble, Frank J. Steemers, R. Daniel Camerini‐Otero, Andrew Adey, Jay Shendure · 2019 · Molecular Cell
  69. Sequence-specific prediction of the efficiencies of adenine and cytosine base editors
    Myungjae Song, Hui Kwon Kim, Sungtae Lee, Younggwang Kim, Sang-Yeon Seo, Jinman Park, Jae Woo Choi, Hyewon Jang, Jeong Hong Shin, Seonwoo Min et al. · 2020 · Nature Biotechnology
  70. Targeting HNRNPU to overcome cisplatin resistance in bladder cancer
    Zhenduo Shi, Lin Hao, Xiaoxiao Han, Zhuo‐Xun Wu, Kun Pang, Yang Dong, Jiaxin Qin, Guangyue Wang, Xuanming Zhang, Tian Xia et al. · 2022 · Molecular Cancer
  71. Disrupting the phase separation of KAT8–IRF1 diminishes PD-L1 expression and promotes antitumor immunity
    Yuanzhong Wu, Liwen Zhou, Yezi Zou, Yijun Zhang, Meifang Zhang, Liping Xu, Lisi Zheng, Wenting He, Kuai Yu, Ting Li et al. · 2023 · Nature Cancer
  72. Cell death during crisis is mediated by mitotic telomere deprotection
    Hayashi, Makoto T., Cesare, Anthony J., Rivera, Teresa, Karlseder, Jan · 2015 · Nature
  73. CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide RNA Library
    Cuiqing Zhong, Qi Yin, Zhenfei Xie, Meizhu Bai, Rui Dong, Wei Tang, Yu‐Hang Xing, Hongling Zhang, Suming Yang, Ling‐Ling Chen et al. · 2015 · Cell stem cell
  74. Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels
    David Novo, Nikki Heath, Louise E. Mitchell, Giuseppina Caligiuri, Amanda MacFarlane, Dide Reijmer, Laura Charlton, John R. P. Knight, Monika Calka, Ewan James McGhee et al. · 2018 · Nature Communications
  75. eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancer
    Shruthy Suresh, Beibei Chen, Jingfei Zhu, Ryan J. Golden, Changzheng Lu, Bret M. Evers, Nicole Novaresi, Bethany Smith, Xiaowei Zhan, Vanessa Schmid et al. · 2020 · Nature Cancer
  76. CRISPR/Cas9: Principle, Applications, and Delivery through Extracellular Vesicles
    Katarzyna Horodecka, Markus Düchler · 2021 · International Journal of Molecular Sciences
  77. Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activity
    Sievers, Quinlan L., Gasser, Jessica A., Cowley, Glenn S., Fischer, Eric S., Ebert, Benjamin L. · 2018 · Blood
  78. CRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targeting
    David Courtney, Jonathan Edward Moore, Sarah D. Atkinson, Eleonora Maurizi, Edwin H. A. Allen, Deena M. Leslie Pedrioli, W.H. Irwin McLean, M. Andrew Nesbit, Tara Moore · 2015 · Gene Therapy
  79. Epigenetic Control of Smooth Muscle Cell Identity and Lineage Memory
    Delphine A Gomez, Pamela Swiatlowska, Gary K. Owens · 2015 · Arteriosclerosis Thrombosis and Vascular Biology
  80. Characterization of noncoding regulatory DNA in the human genome
    Ran Elkon, Reuven Agami · 2017 · Nature Biotechnology
  81. The Current State and Future of CRISPR-Cas9 gRNA Design Tools
    Laurence O. W. Wilson, Aidan R. O’Brien, Denis C. Bauer · 2018 · Frontiers in Pharmacology
  82. CRISPR/Cas9 for Cancer Therapy: Hopes and Challenges
    Marta Martínez-Lage, Pilar Puig-Serra, Pablo R. Menéndez, Raúl Torres-Ruiz, Sandra Rodríguez · 2018 · Biomedicines
  83. Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins
    Shirasaki, Ryosuke, Matthews, Geoffrey M., Gandolfi, Sara, de Matos Simoes, Ricardo, Buckley, Dennis L., Raja Vora, Joseline, Sievers, Quinlan L., Brüggenthies, Johanna B., Dashevsky, Olga, Poarch, Haley et al. · 2021 · Cell Reports
  84. Acetate controls endothelial-to-mesenchymal transition
    Xiaolong Zhu, Yunyun Wang, Ioana Soaita, Heon‐Woo Lee, Hosung Bae, Nabil E. Boutagy, Anna Bostwick, Rong‐Mo Zhang, Caitlyn E. Bowman, Yanying Xu et al. · 2023 · Cell Metabolism
  85. A Sorghum Mutant Resource as an Efficient Platform for Gene Discovery in Grasses
    Yinping Jiao, JOHN J. BURKE, Ratan Chopra, Gloria B. Burow, Junping Chen, Bo Wang, Chad M. Hayes, Yves Y. Emendack, Doreen Ware, Zhanguo Xin · 2016 · The Plant Cell
  86. Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice
    Chun‐Qing Song, Yingxiang Li, Haiwei Mou, Jill E. Moore, Angela Park, Yotsawat Pomyen, Soren H. Hough, Zachary Kennedy, Andrew H. Fischer, Hao Yin et al. · 2016 · Gastroenterology
  87. Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development
    Len Neckers, Brian S. J. Blagg, Timothy Haystead, Jane B. Trepel, Luke J. Whitesell, Didier Picard · 2018 · Cell Stress and Chaperones
  88. A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell Function
    Chin-San Loo, Jovylyn Gatchalian, Yuqiong Liang, Mathias Leblanc, Mingjun Xie, Josephine Ho, Bhargav Venkatraghavan, Diana C. Hargreaves, Ye Zheng · 2020 · Immunity
  89. Imaging-based pooled CRISPR screening reveals regulators of lncRNA localization
    Wang, Chong, Lu, Tian, Emanuel, George, Babcock, Hazen P., Zhuang, Xiaowei · 2019 · Proceedings of the National Academy of Sciences
  90. Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways
    Vikram Khurana, Jian Peng, Chee Yeun Chung, Pavan Kumar Auluck, Saranna Fanning, Daniel F. Tardiff, Theresa Bartels, Martina Koeva, Stephen W. Eichhorn, Hadar Benyamini et al. · 2017 · Cell Systems
  91. Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors.
    Jingjing Gan, Y. Dou, Yu-Rong Li, Zhen-Zhen Wang, Lintao Wang, Shang Liu, Qiu Li, Heran Yu, Chunyan Liu, Congwei Han et al. · 2018 · Biomaterials
  92. Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activity
    Ying-Wei Li, Jian Xu, Guo‐Yuan Zhu, Zhujuan Huang, Yan Lu, Xianqian Li, Neng Wang, Fengxue Zhang · 2018 · Cell Death Discovery
  93. Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting
    Francesco Iorio, Fiona M. Behan, Emanuel Gonçalves, Shriram G. Bhosle, Elisabeth D. Chen, Rebecca Shepherd, Charlotte Beaver, Rizwan Ahmad Ansari, Rachel Pooley, Piers Wilkinson et al. · 2018 · BMC Genomics
  94. Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunity
    Guangchuan Wang, Ryan Dz-Wei Chow, Zhigang Bai, Lvyun Zhu, Youssef Errami, Xiaoyun Dai, Matthew B. Dong, Lupeng Ye, Xiaoya Zhang, Paul A. Renauer et al. · 2019 · Nature Immunology
  95. Ovarian cancer-derived IL-4 promotes immunotherapy resistance
    Gürkan Mollaoglu, Alexander Tepper, Chiara Falcomatà, Hunter T. Potak, Luisanna Pia, Angelo Amabile, Jaime Mateus-Tique, Noam Rabinovich, Matthew D. Park, Nelson M. LaMarche et al. · 2024 · Cell
  96. Clustered Regularly Interspaced Short Palindromic Repeats-Based Genome Surgery for the Treatment of Autosomal Dominant Retinitis Pigmentosa
    Tsai, Yi-Ting, Wu, Wen-Hsuan, Lee, Ting-Ting, Wu, Wei-Pu, Xu, Christine L., Park, Karen S., Cui, Xuan, Justus, Sally, Lin, Chyuan-Sheng, Jauregui, Ruben et al. · 2018 · Ophthalmology
  97. LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning
    Filipek, Przemyslaw A., de Araujo, Mariana E.G., Vogel, Georg F., De Smet, Cedric H., Eberharter, Daniela, Rebsamen, Manuele, Rudashevskaya, Elena L., Kremser, Leopold, Yordanov, Teodor, Tschaikner, Philipp et al. · 2017 · Journal of Cell Biology
  98. DECKO: Single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAs
    Estel Aparicio-Prat, Carme Arnan, Ilaria Sala, Núria Bosch, Roderic Guigó, Rory Johnson · 2015 · BMC Genomics
  99. DrugTargetSeqR: a genomics- and CRISPR-Cas9–based method to analyze drug targets
    Corynn Kasap, Olivier Elemento, Tarun M. Kapoor · 2014 · Nature Chemical Biology
  100. Engineering Delivery Vehicles for Genome Editing
    Christopher E. Nelson, Charles A. Gersbach · 2016 · Annual Review of Chemical and Biomolecular Engineering