Genome-scale CRISPR-Cas9 knockout screening in human cells
Shalem, Ophir, Sanjana, Neville E., Hartenian, Ella, Shi, Xi, Scott, David A., Mikkelsen, Tarjei S., Heckl, Dirk, Ebert, Benjamin L. +3 more·2014·Science
Cited by (1,041)
Items 501–600 of 1,041
- Metabolic reprogramming and dysregulated metabolism: cause, consequence and/or enabler of environmental carcinogenesis?R. Brooks Robey, Judith Weisz, Nancy B. Kuemmerle, Anna C. Salzberg, Arthur S Berg, Dustin G. Brown, Laura L. Maurer, Roberta Palorini, Fahd Al‐Mulla, Rabeah Abbas Al-Temaimi et al. · 2015 · Carcinogenesis
- CRISPR-UMI: single-cell lineage tracing of pooled CRISPR–Cas9 screensGeorg Michlits, Maria Hubmann, Szu-Hsien Sam Wu, Gintautas Vainorius, Elena Budusan, Sergei Zhuk, Thomas Rainer Burkard, Maria Novatchkova, Martin Aichinger, YiQing Lü et al. · 2017 · Nature Methods
- Addition of m6A to SV40 late mRNAs enhances viral structural gene expression and replicationKevin Tsai, David Courtney, Bryan R. Cullen · 2018 · PLoS Pathogens
- Modeling Human Digestive Diseases With CRISPR-Cas9–Modified OrganoidsMasayuki Fujii, Hans C. Clevers, Toshiro Sato · 2018 · Gastroenterology
- Spatial and single-cell transcriptomics decipher the cellular environment containing HLA-G+ cancer cells and SPP1+ macrophages in colorectal cancerYuki Ozato, Yasuhiro Kojima, Yuta Kobayashi, Yuuichi Hisamatsu, Takeo Toshima, Yusuke Yonemura, Takaaki Masuda, Kouichi Kagawa, Yasuhiro Goto, Mitsuaki Utou et al. · 2023 · Cell Reports
- CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG TranslationCheng, Weiwei, Wang, Shaopeng, Zhang, Zhe, Morgens, David W., Hayes, Lindsey R., Lee, Soojin, Portz, Bede, Xie, Yongzhi, Nguyen, Baotram V., Haney, Michael S. et al. · 2019 · Neuron
- High-Throughput Genome Editing and Phenotyping Facilitated by High Resolution Melting Curve AnalysisHolly R. Thomas, Stefanie M. Percival, Bradley K. Yoder, John M. Parant · 2014 · PLoS ONE
- The mitogen-activated protein kinase pathway in melanoma part I – Activation and primary resistance mechanisms to BRAF inhibitionTeresa Maria Santos Amaral, Tobias W. Sinnberg, Friedegund Elke Meier, Clemens Krepler, Mitchell Paul Levesque, Heike Niessner, Claus Garbe · 2017 · European Journal of Cancer
- Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPSTakuji Yamauchi, Takeshi Masuda, Matthew C. Canver, Michael Seiler, Yuichiro Semba, Mohammad Shboul, Mohammed Al‐Raqad, Manami Maeda, Vivien A. C. Schoonenberg, Mitchel A. Cole et al. · 2018 · Cancer Cell
- Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritisLiping Deng, Ruotong Ren, Zunpeng Liu, Moshi Song, Jingyi Li, Zeming Wu, Xiaoqing Ren, Lina Fu, Wei Li, Weiqi Zhang et al. · 2019 · Nature Communications
- Genetic screens in isogenic mammalian cell lines without single cell cloningPeter C. DeWeirdt, Annabel K. Sangree, Ruth E. Hanna, Kendall R Sanson, Mudra Hegde, Christine Strand, Nicole S. Persky, John G. Doench · 2020 · Nature Communications
- CRISPRi-based radiation modifier screen identifies long non-coding RNA therapeutic targets in gliomaSiyuan John Liu, Martina Malatesta, Brian V. Lien, Parna Saha, Shivani S. Thombare, Sung Jun Hong, Leslie Pedraza, Mark Koontz, Kyounghee Seo, Max A. Horlbeck et al. · 2020 · Genome biology
- Interleukin-13 drives metabolic conditioning of muscle to endurance exerciseKnudsen, Nelson H., Stanya, Kristopher J., Hyde, Alexander L., Chalom, Mayer M., Alexander, Ryan K., Liou, Yae-Huei, Starost, Kyle A., Gangl, Matthew R., Jacobi, David, Liu, Sihao et al. · 2020 · Science
- The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemiaThilini R. Fernando, Jorge R. Contreras, Matteo Zampini, Norma Iris Rodriguez-Malave, Michael O. Alberti, Jaime Anguiano, Tiffany M. Tran, Jayanth Kumar Palanichamy, Jasmine Gajeton, Nolan M. Ung et al. · 2017 · Molecular Cancer
- Long Terminal Repeat CRISPR-CAR-Coupled “Universal” T Cells Mediate Potent Anti-leukemic EffectsChristos Georgiadis, Roland Preece, Lauren E. Nickolay, Annie Etuk, Anastasia Petrova, Dariusz Ładoń, Alexandra Danyi, Neil Humphryes-Kirilov, Ayokunmi Ajetunmobi, Daesik Kim et al. · 2018 · Molecular Therapy
- Interfacial actin protrusions mechanically enhance killing by cytotoxic T cellsFella Tamzalit, Mitchell S. Wang, Weiyang Jin, María Tello‐Lafoz, Vitaly P. Boyko, John M. Heddleston, Charles T. Black, Lance Cameron Kam, Morgan Huse · 2019 · Science Immunology
- A curative combination cancer therapy achieves high fractional cell killing through low cross-resistance and drug additivityAdam Christopher Palmer, Christopher Chidley, Peter Karl Sorger · 2018 · eLife
- CRISPR screens in physiologic medium reveal conditionally essential genes in human cellsNicholas J. Rossiter, Kimberly S. Huggler, Charles H. Adelmann, Heather R. Keys, Ross W. Soens, David M. Sabatini, Jason R. Cantor · 2021 · Cell Metabolism
- A deep insight into CRISPR/Cas9 application in CAR-T cell-based tumor immunotherapiesEhsan Razeghian, Mahyuddin K. M. Nasution, Heshu Sulaiman Rahman, Zhanna R. Gardanova, Walid Kamal Abdelbasset, Aravindhan Surendar, Dmitry Olegovich Bokov, Wanich Suksatan, Pooria Nakhaei, Siavash Shariatzadeh et al. · 2021 · Stem Cell Research & Therapy
- Targeting SAMHD1 with the Vpx protein to improve cytarabine therapy for hematological malignanciesNikolas Herold, Sean G. Rudd, Linda M. Ljungblad, Kumar Sanjiv, Ida Hed Myrberg, Cynthia B. J. Paulin, Yaser Heshmati, Anna Hagenkort, Juliane Kutzner, Brent D. G. Page et al. · 2017 · Nature Medicine
- In Vivo Genome Editing Restores Dystrophin Expression and Cardiac Function in Dystrophic MiceMona El Refaey, Li ming Xu, Yandi Gao, Benjamin D. Canan, T. M. Ayodele Adesanya, Sarah C. Warner, Keiko Akagi, David E. Symer, Peter J. Mohler, Jianjie Ma et al. · 2017 · Circulation Research
- Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumorsGrace R. Anderson, Suzanne E. Wardell, Merve Çakır, Catherine Yip, Yeong-ran Ahn, Moiez Ali, Alexander P. Yllanes, Christina Chao, Donald Patrick McDonnell, Kris C. Wood · 2018 · Nature Communications
- RNAi/CRISPR Screens: from a Pool to a Valid HitAnne M. Schuster, Hélène Erasimus, Sabrina Fritah, Petr V. Nazarov, Eric Van Dyck, Simone P. Niclou, Anna Golebiewska · 2018 · Trends in biotechnology
- CRISPR-Cas in Streptococcus pyogenesAnaïs Le Rhun, Andrés Escalera-Maurer, Majda Bratovič, Emmanuelle Charpentier · 2019 · RNA Biology
- Selective endpoint visualized detection of Vibrio parahaemolyticus with CRISPR/Cas12a assisted PCR using thermal cycler for on-site applicationMengyao Zhang, Chengzhi Liu, Ya Shi, Jun Wu, Jian Feng Wu, Huan Chen · 2020 · Talanta
- Improved analysis of CRISPR fitness screens and reduced off-target effects with the BAGEL2 gene essentiality classifierEiru Kim, Traver Hart · 2021 · Genome Medicine
- Crystal structure of the human lysosomal mTORC1 scaffold complex and its impact on signalingde Araujo, Mariana E. G., Naschberger, Andreas, Fürnrohr, Barbara G., Stasyk, Taras, Dunzendorfer-Matt, Theresia, Lechner, Stefan, Welti, Stefan, Kremser, Leopold, Shivalingaiah, Giridhar, Offterdinger, Martin et al. · 2017 · Science
- Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancerYun Pyo Kang, Laura Torrente, Aimee Falzone, Cody M. Elkins, Min Liu, John M. Asara, Christian C. Dibble, Gina M. DeNicola · 2019 · eLife
- GPR108 Is a Highly Conserved AAV Entry FactorAmanda M. Dudek, Nerea Zabaleta, Eric M. Zinn, Sirika Pillay, James R. Zengel, Caryn L. Porter, Jennifer Santos Franceschini, Reynette Estelien, Jan E. Carette, Guo Ling Zhou et al. · 2019 · Molecular Therapy
- Cross-species RNA-seq for deciphering host–microbe interactionsAlexander J. Westermann, Jörg Vogel · 2021 · Nature Reviews Genetics
- Identification of potential drug targets for tuberous sclerosis complex by synthetic screens combining CRISPR-based knockouts with RNAiBenjamin E. Housden, Alexander J. Valvezan, Colleen Kelley, Richelle Sopko, Yanhui Hu, Charles L. Roesel, Shuailiang Lin, Michael Buckner, Rong Tao, Bahar Yilmazel et al. · 2015 · Science Signaling
- Nanomedicine-mediated cancer stem cell therapySong Shen, Jinxing Xia, Jun Wang · 2015 · Biomaterials
- Epigenetic and Transcriptional Control of the Epidermal Growth Factor Receptor Regulates the Tumor Immune Microenvironment in Pancreatic CancerJinyang Li, Salina Yuan, Robert J. Norgard, Fangxue Yan, Yu Huining Sun, Il‐Kyu Kim, Allyson J. Merrell, Yogev Sela, Yanqing Jiang, Natarajan V. Bhanu et al. · 2020 · Cancer Discovery
- A new class of temporarily phenotypic enhancers identified by CRISPR/Cas9-mediated genetic screeningDiao, Yarui, Li, Bin, Meng, Zhipeng, Jung, Inkyung, Lee, Ah Young, Dixon, Jesse, Maliskova, Lenka, Guan, Kun-liang, Shen, Yin, Ren, Bing · 2016 · Genome Research
- ZCCHC3 is a co-sensor of cGAS for dsDNA recognition in innate immune responseHuan Lian, Jin Wei, Ru Zang, Wen Ye, Qing Yang, Xianan Zhang, Yun-Da Chen, Yu-Zhi Fu, Ming‐Ming Hu, Cao‐Qi Lei et al. · 2018 · Nature Communications
- Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse ModelJun Wu, Daniel A. Ryskamp, Xia Liang, Polina A. Egorova, Olga A. Zakharova, Gene Hung, Безпрозванный Илья Борисович · 2016 · Journal of Neuroscience
- cGAS-STING Signaling Regulates Initial Innate Control of Cytomegalovirus InfectionChan‐Wang Jerry Lio, Bryan McDonald, Mariko Takahashi, Rekha Dhanwani, Nikita Sharma, Jenny Huang, Elise Pham, Chris A. Benedict, Sonia Sharma · 2016 · Journal of Virology
- Suppression of Adaptive Responses to Targeted Cancer Therapy by Transcriptional RepressionMaria Rusan, Kapsok Li, Yvonne Y. Li, Camilla Laulund Christensen, Brian J. Abraham, Nicholas P. Kwiatkowski, Kevin A. Buczkowski, Bruno Bockorny, Ting Chen, Shuai Li et al. · 2017 · Cancer Discovery
- Ubiquitination of Rheb governs growth factor-induced mTORC1 activationLu Deng, Lei Chen, Linlin Zhao, Yan Xu, Xiao-Ping Peng, Xinbo Wang, Lin Ding, Jiali Jin, Hongqi Teng, Yanming Wang et al. · 2018 · Cell Research
- Donafenib and GSK‐J4 Synergistically Induce Ferroptosis in Liver Cancer by Upregulating HMOX1 ExpressionChenyang Zheng, Bo Zhang, Yunyun Li, Kejia Liu, Wei Wei, Shuhang Liang, Hongrui Guo, Kun Ma, Yao Liu, Jiabei Wang et al. · 2023 · Advanced Science
- Current and future delivery systems for engineered nucleases: ZFN, TALEN and RGENAin, Qurrat Ul, Chung, Jee Young, Kim, Yong-Hee · 2015 · Journal of Controlled Release
- Efficient CRISPR-mediated mutagenesis in primary immune cells using CrispRGold and a C57BL/6 Cas9 transgenic mouse lineVan Trung Chu, Robin Graf, Tristan Wirtz, Timm Weber, Jérémy Favret, Xun Li, Kerstin Petsch, Ngoc Tung Tran, Michael H. Sieweke, Claudia Berek et al. · 2016 · Proceedings of the National Academy of Sciences
- Exome Sequencing of African-American Prostate Cancer Reveals Loss-of-Function ERF MutationsFranklin W. Huang, Juan Miguel Mosquera, Andrea Garofalo, Coyin Oh, Maria B. Baco, Ali Amin‐Mansour, Bokang Rabasha, Samira Bahl, Stephanie Anne Mullane, Brian D. Robinson et al. · 2017 · Cancer Discovery
- OR14I1 is a receptor for the human cytomegalovirus pentameric complex and defines viral epithelial cell tropismE Xiaofei, Paul Meraner, Ping Lü, Jill M. Perreira, Aaron M. Aker, William M. McDougall, Ronghua ZhuGe, Gary C. T. Chan, Rachel M. Gerstein, Patrizia Caposio et al. · 2019 · Proceedings of the National Academy of Sciences
- Essential Gene Profiles for Human Pluripotent Stem Cells Identify Uncharacterized Genes and Substrate DependenciesBarbara Mair, Jelena Tomic, Sanna N. Masud, Peter J. Tonge, Alexander Weiss, Matej Ušaj, Amy H.Y. Tong, Jamie J. Kwan, Kevin R. Brown, Emily Titus et al. · 2019 · Cell Reports
- Responsive Nanocarriers as an Emerging Platform for Cascaded Delivery of Nucleic Acids to CancerYang Liu, Cong‐Fei Xu, Shoaib Iqbal, Xianzhu Yang, Jun Wang · 2017 · Advanced Drug Delivery Reviews
- Widespread Influence of 3′-End Structures on Mammalian mRNA Processing and StabilityXuebing Wu, David P. Bartel · 2017 · Cell
- MiR-135 suppresses glycolysis and promotes pancreatic cancer cell adaptation to metabolic stress by targeting phosphofructokinase-1Ying Yang, Mari B. Ishak Gabra, Eric Allan Hanse, Xazmin H. Lowman, Thai Q. Tran, Haiqing Li, Neta Milman, Juan Liu, Michael A. Reid, Jason W. Locasale et al. · 2019 · Nature Communications
- The application of the CRISPR-Cas9 genome editing machinery in food and agricultural science: Current status, future perspectives, and associated challengesİsmail Eş, Mohsen Gavahian, Francisco J. Martí-Quijal, José Manuel Lorenzo, Amin Mousavi Khaneghah, Christos Tsatsanis, Sotirios C. Kampranis, Francisco J. Barba · 2019 · Biotechnology Advances
- Single-Cell Heterogeneity Analysis and CRISPR Screen Identify Key β-Cell-Specific Disease GenesZhou Fang, Chen Weng, Haiyan Li, Ran Tao, Weihua Mai, Xiaoxiao Liu, Leina Lu, Sisi Lai, Qing Duan, Carlos Alfonso Álvarez‐González et al. · 2019 · Cell Reports
- An ARF6–Exportin-5 axis delivers pre-miRNA cargo to tumour microvesiclesJames W. Clancy, Ye Zhang, Colin S. Sheehan, Crislyn D’Souza‐Schorey · 2019 · Nature Cell Biology
- Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapyDongli Cai, Jiaming Li, Dingfeng Liu, Shanjuan Hong, Qin Qiao, Qinli Sun, Pingping Li, Nanan Lyu, Tiantian Sun, Shan Xie et al. · 2019 · Cellular and Molecular Immunology
- Computational Tools and Resources for CRISPR/Cas Genome EditingChao Li, Wen Chu, Rafaqat A. Gill, Shifei Sang, Yuqin Shi, Xuezhi Hu, Yuting Yang, Qamar U. Zaman, Baohong Zhang · 2022 · Genomics Proteomics & Bioinformatics
- CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancerMostafa Vaghari‐Tabari, Parisa Hassanpour, Fatemeh Sadeghsoltani, Faezeh Malakoti, Forough Alemi, Durdi Qujeq, Zatollah Asemi, Bahman Yousefi · 2022 · Cellular & Molecular Biology Letters
- SIRT7-dependent deacetylation of the U3-55k protein controls pre-rRNA processingSifan Chen, Maximilian Felix Blank, Aishwarya Iyer-Bierhoff, Bingding Huang, Lin Wang, Ingrid Grummt, Renate Voit · 2016 · Nature Communications
- ATXN1L, CIC, and ETS Transcription Factors Modulate Sensitivity to MAPK Pathway InhibitionBelinda Wang, Elsa Beyer Krall, Andrew J. Aguirre, Mi‐Ju Kim, Hans R. Widlund, Mihir B. Doshi, Ewa Sicińska, Rita Sulahian, Amy B. Goodale, Glenn S. Cowley et al. · 2017 · Cell Reports
- In vivo genome-wide CRISPR screen reveals breast cancer vulnerabilities and synergistic mTOR/Hippo targeted combination therapyMeiou Dai, Gang Yan, Ni Wang, Girija Daliah, Ashlin M. Edick, Sophie Poulet, Julien Boudreault, Suhad Ali, Sergio A. Burgos, J J Lebrun · 2021 · Nature Communications
- Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cellsFeng Tian, Yuyan Cheng, Songlin Zhou, Qianbin Wang, Aboozar Monavarfeshani, Kun Gao, Weiqian Jiang, Riki Kawaguchi, Qing Wang, Mingjun Tang et al. · 2022 · Neuron
- Prediction of efficiencies for diverse prime editing systems in multiple cell typesGoosang Yu, Hui Kwon Kim, Jinman Park, Hyunjong Kwak, Yumin Cheong, Dongyoung Kim, Ji-Yun Kim, Jisung Kim, Hyongbum Henry Kim · 2023 · Cell
- Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cellsJia Liu, Thomas Gaj, Yifeng Yang, Nan Wang, Sailan Shui, Sojung Kim, Chidananda Nagamangala Kanchiswamy, Jin‐Soo Kim, Carlos F. Barbas · 2015 · Nature Protocols
- Modeling Alzheimer's disease with human induced pluripotent stem (iPS) cellsAlison E. Mungenast, Sandra Siegert, Li‐Huei Tsai · 2015 · Molecular and Cellular Neuroscience
- CRISPR–Cas9 genome engineering of primary CD4+ T cells for the interrogation of HIV–host factor interactionsJudd F. Hultquist, Joseph B Hiatt, Kathrin Schumann, Michael McGregor, Theodore L. Roth, Paige Haas, Jennifer A. Doudna, Alexander Marson, Nevan J. Krogan · 2018 · Nature Protocols
- CRISPR-Cas: Converting A Bacterial Defence Mechanism into A State-of-the-Art Genetic Manipulation ToolLoureiro, Alexandre, da Silva, Gabriela Jorge · 2019 · Antibiotics
- Ki-67 regulates global gene expression and promotes sequential stages of carcinogenesisKarim Mrouj, Nuria Andrés-Sánchez, Geronimo Dubra, Priyanka Singh, Michal Sobecki, Dhanvantri Chahar, Emile Alghoul, Ana Bella Aznar, Susana Prieto, Nelly Pirot et al. · 2021 · Proceedings of the National Academy of Sciences
- Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesisYan‐Hong Cui, Seungwon Yang, Jiangbo Wei, Christopher R. Shea, Wen Zhong, Fang Wang, Palak Shah, Muhammad Ghulam Kibriya, Xiaolong Cui, Habibul Ahsan et al. · 2021 · Nature Communications
- Targets of Immune Escape Mechanisms in Cancer: Basis for Development and Evolution of Cancer Immune Checkpoint InhibitorsShovan Dutta, Anirban Ganguly, Kaushiki Chatterjee, Sheila Spada, Sumit Mukherjee · 2023 · Biology
- Serine-129 phosphorylation of α-synuclein is an activity-dependent trigger for physiologic protein-protein interactions and synaptic function2023
- High-Throughput Single-Cell Sequencing with Linear AmplificationYi A. Yin, Yue Jiang, Kwan-Wood Gabriel Lam, Joel B. Berletch, Christine M. Distèche, William Stafford Noble, Frank J. Steemers, R. Daniel Camerini‐Otero, Andrew Adey, Jay Shendure · 2019 · Molecular Cell
- Sequence-specific prediction of the efficiencies of adenine and cytosine base editorsMyungjae Song, Hui Kwon Kim, Sungtae Lee, Younggwang Kim, Sang-Yeon Seo, Jinman Park, Jae Woo Choi, Hyewon Jang, Jeong Hong Shin, Seonwoo Min et al. · 2020 · Nature Biotechnology
- Targeting HNRNPU to overcome cisplatin resistance in bladder cancerZhenduo Shi, Lin Hao, Xiaoxiao Han, Zhuo‐Xun Wu, Kun Pang, Yang Dong, Jiaxin Qin, Guangyue Wang, Xuanming Zhang, Tian Xia et al. · 2022 · Molecular Cancer
- Disrupting the phase separation of KAT8–IRF1 diminishes PD-L1 expression and promotes antitumor immunityYuanzhong Wu, Liwen Zhou, Yezi Zou, Yijun Zhang, Meifang Zhang, Liping Xu, Lisi Zheng, Wenting He, Kuai Yu, Ting Li et al. · 2023 · Nature Cancer
- Cell death during crisis is mediated by mitotic telomere deprotectionHayashi, Makoto T., Cesare, Anthony J., Rivera, Teresa, Karlseder, Jan · 2015 · Nature
- CRISPR-Cas9-Mediated Genetic Screening in Mice with Haploid Embryonic Stem Cells Carrying a Guide RNA LibraryCuiqing Zhong, Qi Yin, Zhenfei Xie, Meizhu Bai, Rui Dong, Wei Tang, Yu‐Hang Xing, Hongling Zhang, Suming Yang, Ling‐Ling Chen et al. · 2015 · Cell stem cell
- Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levelsDavid Novo, Nikki Heath, Louise E. Mitchell, Giuseppina Caligiuri, Amanda MacFarlane, Dide Reijmer, Laura Charlton, John R. P. Knight, Monika Calka, Ewan James McGhee et al. · 2018 · Nature Communications
- eIF5B drives integrated stress response-dependent translation of PD-L1 in lung cancerShruthy Suresh, Beibei Chen, Jingfei Zhu, Ryan J. Golden, Changzheng Lu, Bret M. Evers, Nicole Novaresi, Bethany Smith, Xiaowei Zhan, Vanessa Schmid et al. · 2020 · Nature Cancer
- CRISPR/Cas9: Principle, Applications, and Delivery through Extracellular VesiclesKatarzyna Horodecka, Markus Düchler · 2021 · International Journal of Molecular Sciences
- Genome-wide screen identifies cullin-RING ligase machinery required for lenalidomide-dependent CRL4CRBN activitySievers, Quinlan L., Gasser, Jessica A., Cowley, Glenn S., Fischer, Eric S., Ebert, Benjamin L. · 2018 · Blood
- CRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targetingDavid Courtney, Jonathan Edward Moore, Sarah D. Atkinson, Eleonora Maurizi, Edwin H. A. Allen, Deena M. Leslie Pedrioli, W.H. Irwin McLean, M. Andrew Nesbit, Tara Moore · 2015 · Gene Therapy
- Epigenetic Control of Smooth Muscle Cell Identity and Lineage MemoryDelphine A Gomez, Pamela Swiatlowska, Gary K. Owens · 2015 · Arteriosclerosis Thrombosis and Vascular Biology
- Characterization of noncoding regulatory DNA in the human genomeRan Elkon, Reuven Agami · 2017 · Nature Biotechnology
- The Current State and Future of CRISPR-Cas9 gRNA Design ToolsLaurence O. W. Wilson, Aidan R. O’Brien, Denis C. Bauer · 2018 · Frontiers in Pharmacology
- CRISPR/Cas9 for Cancer Therapy: Hopes and ChallengesMarta Martínez-Lage, Pilar Puig-Serra, Pablo R. Menéndez, Raúl Torres-Ruiz, Sandra Rodríguez · 2018 · Biomedicines
- Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of OncoproteinsShirasaki, Ryosuke, Matthews, Geoffrey M., Gandolfi, Sara, de Matos Simoes, Ricardo, Buckley, Dennis L., Raja Vora, Joseline, Sievers, Quinlan L., Brüggenthies, Johanna B., Dashevsky, Olga, Poarch, Haley et al. · 2021 · Cell Reports
- Acetate controls endothelial-to-mesenchymal transitionXiaolong Zhu, Yunyun Wang, Ioana Soaita, Heon‐Woo Lee, Hosung Bae, Nabil E. Boutagy, Anna Bostwick, Rong‐Mo Zhang, Caitlyn E. Bowman, Yanying Xu et al. · 2023 · Cell Metabolism
- A Sorghum Mutant Resource as an Efficient Platform for Gene Discovery in GrassesYinping Jiao, JOHN J. BURKE, Ratan Chopra, Gloria B. Burow, Junping Chen, Bo Wang, Chad M. Hayes, Yves Y. Emendack, Doreen Ware, Zhanguo Xin · 2016 · The Plant Cell
- Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in MiceChun‐Qing Song, Yingxiang Li, Haiwei Mou, Jill E. Moore, Angela Park, Yotsawat Pomyen, Soren H. Hough, Zachary Kennedy, Andrew H. Fischer, Hao Yin et al. · 2016 · Gastroenterology
- Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical developmentLen Neckers, Brian S. J. Blagg, Timothy Haystead, Jane B. Trepel, Luke J. Whitesell, Didier Picard · 2018 · Cell Stress and Chaperones
- A Genome-wide CRISPR Screen Reveals a Role for the Non-canonical Nucleosome-Remodeling BAF Complex in Foxp3 Expression and Regulatory T Cell FunctionChin-San Loo, Jovylyn Gatchalian, Yuqiong Liang, Mathias Leblanc, Mingjun Xie, Josephine Ho, Bhargav Venkatraghavan, Diana C. Hargreaves, Ye Zheng · 2020 · Immunity
- Imaging-based pooled CRISPR screening reveals regulators of lncRNA localizationWang, Chong, Lu, Tian, Emanuel, George, Babcock, Hazen P., Zhuang, Xiaowei · 2019 · Proceedings of the National Academy of Sciences
- Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular PathwaysVikram Khurana, Jian Peng, Chee Yeun Chung, Pavan Kumar Auluck, Saranna Fanning, Daniel F. Tardiff, Theresa Bartels, Martina Koeva, Stephen W. Eichhorn, Hadar Benyamini et al. · 2017 · Cell Systems
- Producing anti-inflammatory macrophages by nanoparticle-triggered clustering of mannose receptors.Jingjing Gan, Y. Dou, Yu-Rong Li, Zhen-Zhen Wang, Lintao Wang, Shang Liu, Qiu Li, Heran Yu, Chunyan Liu, Congwei Han et al. · 2018 · Biomaterials
- Apigenin suppresses the stem cell-like properties of triple-negative breast cancer cells by inhibiting YAP/TAZ activityYing-Wei Li, Jian Xu, Guo‐Yuan Zhu, Zhujuan Huang, Yan Lu, Xianqian Li, Neng Wang, Fengxue Zhang · 2018 · Cell Death Discovery
- Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targetingFrancesco Iorio, Fiona M. Behan, Emanuel Gonçalves, Shriram G. Bhosle, Elisabeth D. Chen, Rebecca Shepherd, Charlotte Beaver, Rizwan Ahmad Ansari, Rachel Pooley, Piers Wilkinson et al. · 2018 · BMC Genomics
- Multiplexed activation of endogenous genes by CRISPRa elicits potent antitumor immunityGuangchuan Wang, Ryan Dz-Wei Chow, Zhigang Bai, Lvyun Zhu, Youssef Errami, Xiaoyun Dai, Matthew B. Dong, Lupeng Ye, Xiaoya Zhang, Paul A. Renauer et al. · 2019 · Nature Immunology
- Ovarian cancer-derived IL-4 promotes immunotherapy resistanceGürkan Mollaoglu, Alexander Tepper, Chiara Falcomatà, Hunter T. Potak, Luisanna Pia, Angelo Amabile, Jaime Mateus-Tique, Noam Rabinovich, Matthew D. Park, Nelson M. LaMarche et al. · 2024 · Cell
- Clustered Regularly Interspaced Short Palindromic Repeats-Based Genome Surgery for the Treatment of Autosomal Dominant Retinitis PigmentosaTsai, Yi-Ting, Wu, Wen-Hsuan, Lee, Ting-Ting, Wu, Wei-Pu, Xu, Christine L., Park, Karen S., Cui, Xuan, Justus, Sally, Lin, Chyuan-Sheng, Jauregui, Ruben et al. · 2018 · Ophthalmology
- LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioningFilipek, Przemyslaw A., de Araujo, Mariana E.G., Vogel, Georg F., De Smet, Cedric H., Eberharter, Daniela, Rebsamen, Manuele, Rudashevskaya, Elena L., Kremser, Leopold, Yordanov, Teodor, Tschaikner, Philipp et al. · 2017 · Journal of Cell Biology
- DECKO: Single-oligo, dual-CRISPR deletion of genomic elements including long non-coding RNAsEstel Aparicio-Prat, Carme Arnan, Ilaria Sala, Núria Bosch, Roderic Guigó, Rory Johnson · 2015 · BMC Genomics
- DrugTargetSeqR: a genomics- and CRISPR-Cas9–based method to analyze drug targetsCorynn Kasap, Olivier Elemento, Tarun M. Kapoor · 2014 · Nature Chemical Biology
- Engineering Delivery Vehicles for Genome EditingChristopher E. Nelson, Charles A. Gersbach · 2016 · Annual Review of Chemical and Biomolecular Engineering