Genome-scale CRISPR-Cas9 knockout screening in human cells
Shalem, Ophir, Sanjana, Neville E., Hartenian, Ella, Shi, Xi, Scott, David A., Mikkelsen, Tarjei S., Heckl, Dirk, Ebert, Benjamin L. +3 more·2014·Science
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- The ERK cascade inhibitors: Towards overcoming resistanceGalia Maik-Rachline, Rony Seger · 2016 · Drug Resistance Updates
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- Generalizable sgRNA design for improved CRISPR/Cas9 editing efficiencyKasidet Hiranniramol, Yuhao Chen, Weijun Liu, Xiaowei Wang · 2020 · Bioinformatics
- CRISPR/Cas9: A powerful genome editing technique for the treatment of cancer cells with present challenges and future directionsAbu Hazafa, Muhammad Mumtaz, Muhammad Fras Farooq, Shahid Bilal, Sundas Nasir Chaudhry, Musfira Firdous, Huma Naeem, Muhammad Obaid Ullah, Muhammad Yameen, Muhammad Mukhtiar et al. · 2020 · Life Sciences
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- The cargo receptor SURF4 promotes the efficient cellular secretion of PCSK9Brian T. Emmer, Geoffrey G. Hesketh, Emilee N. Kotnik, Vi T. Tang, Paul J. Lascuna, Jie Xiang, Anne‐Claude Gingras, Xiao-Wei Chen, David Ginsburg · 2018 · eLife
- A CRISPR knockout screen identifies SETDB1-target retroelement silencing factors in embryonic stem cellsKei Fukuda, Akihiko Okuda, Kosuke Yusa, Yoichi Shinkai · 2018 · Genome Research
- CRISPR Approaches to Small Molecule Target IdentificationJost, Marco, Weissman, Jonathan S. · 2018 · ACS Chemical Biology
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- Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin SignalingKoichiro Mihara, Rithwik Ramachandran, Mahmoud Saifeddine, Kristina K. Hansen, Bernard S. RENAUX, Danny Polley, Stacy Gibson, Christina Vanderboor, Morley Donald Hollenberg · 2016 · Molecular Pharmacology
- A Whole-genome CRISPR Screen Identifies a Role of MSH2 in Cisplatin-mediated Cell Death in Muscle-invasive Bladder CancerAndrew E. Goodspeed, Annie Jean, James C. Costello · 2018 · European Urology
- Scalable Design of Paired CRISPR Guide RNAs for Genomic DeletionCarlos Pulido-Quetglas, Estel Aparicio-Prat, Carme Arnan, Taisia Polidori, Antonio Hermoso, Emilio Palumbo, Julia V. Ponomarenko, Roderic Guigó, Rory Johnson · 2017 · PLoS Computational Biology
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- Understanding functional miRNA–target interactions in vivo by site-specific genome engineeringAndrew Roger Bassett, Ghows Azzam, Lucy Wheatley, Charlotte Tibbit, Timothy Rajakumar, Simon J. McGowan, Nathan Stanger, Philip Ewels, Stephen Taylor, Chris Paul Ponting et al. · 2014 · Nature Communications
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- Roles of Capsid-Interacting Host Factors in Multimodal Inhibition of HIV-1 by PF74Akatsuki Saito, Damien Ferhadian, Gregory A. Sowd, Erik Serrao, Jiong Shi, Upul D. Halambage, Samantha Teng, Juan Soto, Mohammad Adnan Siddiqui, Alan Engelman et al. · 2016 · Journal of Virology
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- High-throughput genotyping of CRISPR/Cas9-mediated mutants using fluorescent PCR-capillary gel electrophoresisMuhammad Khairul Ramlee, Tingdong Yan, Alice Man Sze Cheung, Charles T. H. Chuah, Shang Li · 2015 · Scientific Reports
- Emerging Mitochondrial Therapeutic Targets in Optic NeuropathiesMaria Isabel G. Lopez Sanchez, Jonathan Guy Crowston, David Anthony Mackey, Ian Andrew Trounce · 2016 · Pharmacology & Therapeutics
- CRISPR/Cas9: Transcending the Reality of Genome EditingSergiu Chira, Diana Gulei, Amin Hajitou, Alina‐Andreea Zimța, Pierre Cordelier, Ioana Berindan‐Neagoe · 2017 · Molecular Therapy — Nucleic Acids
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- Mapping human cell phenotypes to genotypes with single-cell genomicsJ. Gray Camp, Randall J. Platt, Barbara Treutlein · 2019 · Science
- STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon ProductionDapei Li, Rongsheng Wu, Wen Guo, Lifen Xie, Zigang Qiao, Shengchuan Chen, Jingfei Zhu, Chaohao Huang, Jian An Huang, Bicheng Chen et al. · 2019 · Cell Reports
- Extracellular NAD+ enhances PARP-dependent DNA repair capacity independently of CD73 activityAnna M. Wilk, Faisal Hayat, Richard Cunningham, Jianfeng Li, Silvia Garavaglia, Leila Zamani, Davide M. Ferraris, Peter Sýkora, Joel Andrews, Jennifer Clark et al. · 2020 · Scientific Reports
- Pooled CRISPR screens with imaging on microraft arrays reveals stress granule-regulatory factorsEmily C. Wheeler, Anthony Q. Vu, Jaclyn M. Einstein, Matthew DiSalvo, Noorsher Ahmed, Eric L. Van Nostrand, Alexander A. Shishkin, Wenhao Jin, Nancy L. Allbritton, Gene Wei-Ming Yeo · 2020 · Nature Methods
- High-content imaging-based pooled CRISPR screens in mammalian cellsXiaowei Yan, Nico Stuurman, Susana Abreu Ribeiro, Marvin E. Tanenbaum, Max A. Horlbeck, Christina R. Liem, Marco Jost, Jonathan S. Weissman, Ronald D. Vale · 2020 · The Journal of Cell Biology
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- The mitochondrial Ca2+ uptake regulator, MICU1, is involved in cold stress-induced ferroptosisToshitaka Nakamura, Motoyuki Ogawa, Kazuki Kojima, Saki Takayanagi, Shunya Ishihara, Kazuki Hattori, Isao Naguro, Hidenori Ichijo · 2021 · EMBO Reports
- Unraveling the functional role of DNA demethylation at specific promoters by targeted steric blockage of DNA methyltransferase with CRISPR/dCas9Daniel M. Sapozhnikov, Moshe Szyf · 2021 · Nature Communications
- A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cellsBrian G. Coon, Sushma Timalsina, Matteo Astone, Zhenwu Zhuang, Jennifer Shea‐Ying Fang, Jinah Han, Jurgen Themen, Minhwan Chung, Young Joo Yang-Klingler, Mukesh K. Jain et al. · 2022 · The Journal of Cell Biology
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- Therapeutic relevance of the PP2A-B55 inhibitory kinase MASTL/Greatwall in breast cancerMónica Álvarez‐Fernández, María Sanz‐Flores, Belén Sanz‐Castillo, María Salazar‐Roa, David Partida, Elisabet Zapatero‐Solana, H. Raza Ali, Eusebio Manchado, Scott W. Lowe, Todd L. VanArsdale et al. · 2017 · Cell Death and Differentiation
- TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cellsDana Elster, Marie Tollot, Karin Schlegelmilch, Alessandro Ori, Andreas Rosenwald, Erik A. Sahai, Björn von Eyß · 2018 · Nature Communications
- Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR ScreenEdwin E. Jeng, Varun Bhadkamkar, Nnejiuwa U. Ibe, Haley Gause, Lihua Jiang, Joanne Chan, Ruiqi Jian, David Jimenez‐Morales, Erica J. Stevenson, Nevan J. Krogan et al. · 2019 · Cell Host & Microbe
- TGF‐β‐activated lncRNA LINC00115 is a critical regulator of glioma stem‐like cell tumorigenicityJianming Tang, Bo Yu, Yanxin Li, Weiwei Zhang, Angel A. Alvarez, Bo Hu, Shi‐Yuan Cheng, Haizhong Feng · 2019 · EMBO Reports
- Resistance mechanisms to targeted therapy in BRAF-mutant melanoma - A mini reviewLokeswari Prathyusha Tangella, Michael E. Clark, Elin Solomonovna Gray · 2020 · Biochimica et Biophysica Acta (BBA) - General Subjects
- Minimal genome-wide human CRISPR-Cas9 libraryEmanuel Gonçalves, Mark Thomas, Fiona M. Behan, Gabriele Picco, Clare Pacini, Felicity R. Allen, Alessandro Vinceti, Mamta Sharma, David A. Jackson, Stacey Price et al. · 2021 · Genome biology
- MAFF confers vulnerability to cisplatin-based and ionizing radiation treatments by modulating ferroptosis and cell cycle progression in lung adenocarcinomaJiaqi Liang, Guoshu Bi, Yiwei Huang, Guangyin Zhao, Qihai Sui, Huan Zhang, Yunyi Bian, Jiacheng Yin, Qun Wang, Zhencong Chen et al. · 2024 · Drug Resistance Updates
- Guide RNA engineering for versatile Cas9 functionalityChance M. Nowak, Seth Lawson, Megan Zerez, Leonidas G. Bleris · 2016 · Nucleic Acids Research
- Amphipathic α-Helices in Apolipoproteins Are Crucial to the Formation of Infectious Hepatitis C Virus ParticlesTakasuke Fukuhara, Masami Wada, Shota Nakamura, Chikako Ono, Mai Shiokawa, Satomi Yamamoto, Takashi Motomura, Toru Okamoto, Daisuke Okuzaki, Masahiro Yamamoto et al. · 2014 · PLoS Pathogens
- Hallmarks of cancer: The CRISPR generationColette Moses, Benjamín García‐Bloj, Alan R. Harvey, Pilar Blancafort · 2018 · European Journal of Cancer
- Single-Cell Multi-omics: An Engine for New Quantitative Models of Gene RegulationJonathan S. Packer, Cole Trapnell · 2018 · Trends in Genetics
- Role of PDGF receptor-α during human cytomegalovirus entry into fibroblastsKai Wu, Adam Oberstein, Wei Wang, Thomas E. Shenk · 2018 · Proceedings of the National Academy of Sciences
- CRISPR/Cas9 screening using unique molecular identifiersBernhard Schmierer, Sandeep Kumar Botla, Jilin Zhang, Mikko M. Turunen, Teemu Kivioja, Jussi Taipale · 2017 · Molecular Systems Biology
- Integrative genomic analyses reveal mechanisms of glucocorticoid resistance in acute lymphoblastic leukemiaRobert J. Autry, Steven W. Paugh, Robert Carter, Lei Gang Shi, Jingjing Liu, Daniel C. J. Ferguson, Calvin E. Lau, Erik J. Bonten, Wenjian Yang, Joseph Robert McCorkle et al. · 2020 · Nature Cancer
- miR-486-3p mediates hepatocellular carcinoma sorafenib resistance by targeting FGFR4 and EGFRLin Ji, Zhongjie Lin, Zhe Wan, Shunjie Xia, Jiang Shi, Dong Cen, Liuxin Cai, Junjie Xu, Xiujun Cai · 2020 · Cell Death and Disease
- Organoids as Models for Neoplastic TransformationJames T. Neal, Calvin Jay Kuo · 2016 · Annual Review of Pathology Mechanisms of Disease
- CRISPR/Cas9‐induced disruption of gene expression in mouse embryonic brain and single neural stem cells in vivoNereo Kalebic, Elena Taverna, Stefania Tavano, Fong Kuan Wong, Dana Suchold, Sylke Winkler, Wieland Β. Huttner, Mihail Sarov · 2016 · EMBO Reports
- Integrated design, execution, and analysis of arrayed and pooled CRISPR genome-editing experimentsMatthew C. Canver, Maximilian Haeussler, Daniel E. Bauer, Stuart H. Orkin, Neville E. Sanjana, Ophir Shalem, Guo‐Cheng Yuan, Feng Zhang, Jean‐Paul Concordet, Luca Pinello · 2018 · Nature Protocols
- RB constrains lineage fidelity and multiple stages of tumour progression and metastasisDavid M. Walter, Travis J. Yates, Miguel Ruiz-Torres, Caroline Kim-Kiselak, A. Andrea Gudiel, Charuhas G. Deshpande, Walter Wang, Michelle Cicchini, Kate L. Stokes, John W. Tobias et al. · 2019 · Nature