Genome-scale CRISPR-Cas9 knockout screening in human cells

Shalem, Ophir, Sanjana, Neville E., Hartenian, Ella, Shi, Xi, Scott, David A., Mikkelsen, Tarjei S., Heckl, Dirk, Ebert, Benjamin L. +3 more·2014·Science

DOI 10.1126/science.1247005

Cited by (1,041)

Items 301–400 of 1,041

Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity
Dufva, Olli, Koski, Jan, Maliniemi, Pilvi, Ianevski, Aleksandr, Klievink, Jay, Leitner, Judith, Pölönen, Petri, Hohtari, Helena, Saeed, Khalid, Hannunen, Tiina et al. · 2020 · Blood
The ADP/ATP translocase drives mitophagy independent of nucleotide exchange
Hoshino, Atsushi, Wang, Wei-jia, Wada, Shogo, McDermott-Roe, Chris, Evans, Chantell S., Gosis, Bridget, Morley, Michael P., Rathi, Komal S., Li, Jian, Li, Kristina et al. · 2019 · Nature
A CRISPR view of development
Melissa M. Harrison, Brian Jenkins, Kate M. O’Connor-Giles, Jill Wildonger · 2014 · Genes & Development
Cas9-chromatin binding information enables more accurate CRISPR off-target prediction
Singh, Ritambhara, Kuscu, Cem, Quinlan, Aaron, Qi, Yanjun, Adli, Mazhar · 2015 · Nucleic Acids Research
Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity
Mahadevan, Navin R., Knelson, Erik H., Wolff, Jacquelyn O., Vajdi, Amir, Saigí, Maria, Campisi, Marco, Hong, Deli, Thai, Tran C., Piel, Brandon, Han, Saemi et al. · 2021 · Cancer Discovery
CRISPR–Cas9 screens in human cells and primary neurons identify modifiers of C9ORF72 dipeptide-repeat-protein toxicity
Kramer, Nicholas J., Haney, Michael S., Morgens, David W., Jovičić, Ana, Couthouis, Julien, Li, Amy, Ousey, James, Ma, Rosanna, Bieri, Gregor, Tsui, C. Kimberly et al. · 2018 · Nature Genetics
Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR
Zandra E. Walton, Chirag H. Patel, Rebekah C. Brooks, Yongjun Yu, Arig Ibrahim‐Hashim, Malini Riddle, Alessandra Porcu, Tianying Jiang, Brett Logan Ecker, Feven Tameire et al. · 2018 · Cell
CRISPR base editors: genome editing without double-stranded breaks
Ayman Eid, Sahar Abdulaziz Alshareef, Magdy M. Mahfouz · 2018 · Biochemical Journal
MAIT cells protect against pulmonary Legionella longbeachae infection
Huimeng Wang, Criselle D’Souza, Xin Yi Lim, Lyudmila Kostenko, Troi J. Pediongco, Sidonia B. G. Eckle, Bronwyn S. Meehan, Mai Shi, Nancy Wang, Shihan Li et al. · 2018 · Nature Communications
LZTR1 is a regulator of RAS ubiquitination and signaling
Johannes W. Bigenzahn, Giovanna M. Collu, Felix Kartnig, Melanie Pieraks, Gregory Ian Vladimer, Leonhard X. Heinz, Vitaly Sedlyarov, Fiorella Schischlik, Astrid Fauster, Manuele Rebsamen et al. · 2018 · Science
Potential of Genome Editing to Improve Aquaculture Breeding and Production
Remi L. Gratacap, Anna Wargelius, Rolf B. Edvardsen, Ross D. Houston · 2019 · Trends in Genetics
Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation
Procopio, Maria-Giuseppina, Laszlo, Csaba, Al Labban, Dania, Kim, Dong Eun, Bordignon, Pino, Jo, Seung-Hee, Goruppi, Sandro, Menietti, Elena, Ostano, Paola, Ala, Ugo et al. · 2015 · Nature Cell Biology
MTHFD2 is a metabolic checkpoint controlling effector and regulatory T cell fate and function
Ayaka Sugiura, Gabriela Andrejeva, Kelsey Voss, Darren R. Heintzman, Xincheng Xu, Matthew Z. Madden, Xiang Ye, Katherine L. Beier, Nowrin U. Chowdhury, Melissa M. Wolf et al. · 2021 · Immunity
A CRISPR-Based Screen Identifies Genes Essential for West-Nile-Virus-Induced Cell Death
Hongming Ma, Ying Dang, Yonggan Wu, Gengxiang Jia, Edgar Anaya, Junli Zhang, Sojan Abraham, Jang-Gi Choi, Guojun Shi, Ling Qi et al. · 2015 · Cell Reports
CCAT1 is an enhancer-templated RNA that predicts BET sensitivity in colorectal cancer
Mark L. McCleland, Kathryn Mesh, Edward G. Lorenzana, Vivek S. Chopra, Ehud Segal, Colin K. Watanabe, Benjamin Haley, Oleg Mayba, Murat Yaylaoglu, Florian Gnad et al. · 2016 · Journal of Clinical Investigation
Pooled In Vitro and In Vivo CRISPR-Cas9 Screening Identifies Tumor Suppressors in Human Colon Organoids
Michels, Birgitta E., Mosa, Mohammed H., Streibl, Barbara I., Zhan, Tianzuo, Menche, Constantin, Abou-El-Ardat, Khalil, Darvishi, Tahmineh, Członka, Ewelina, Wagner, Sebastian, Winter, Jan et al. · 2020 · Cell Stem Cell
RNA-guided endonuclease provides a therapeutic strategy to cure latent herpesviridae infection
Wang, Jianbin, Quake, Stephen R. · 2014 · Proceedings of the National Academy of Sciences
Inhibition of HIV-1 infection of primary CD4+ T-cells by gene editing of CCR5 using adenovirus-delivered CRISPR/Cas9
Chang Li, Xinmeng Guan, Tao Du, Wei Jin, Biao Wu, Yalan Liu, Ping Wang, Bodan Hu, George Edward Griffin, Robin J. Shattock et al. · 2015 · Journal of General Virology
Loss-of-function genetic tools for animal models: cross-species and cross-platform differences
Benjamin E. Housden, Matthias Muhar, Matthew P. Gemberling, Charles A. Gersbach, Didier Y. R. Stainier, Géraldine Seydoux, Stephanie Elizabeth Mohr, Johannes A. Zuber, Norbert Perrimon · 2016 · Nature Reviews Genetics
Genome-wide CRISPR screen identifies TMEM41B as a gene required for autophagosome formation
Keigo Morita, Yutaro Hama, Tamaki Izume, Norito Tamura, Toshihide Ueno, Yoshihiro Yamashita, Yuriko Sakamaki, Kaito Mimura, Hideaki Morishita, Wataru Shihoya et al. · 2018 · The Journal of Cell Biology
DYNLL1 binds to MRE11 to limit DNA end resection in BRCA1-deficient cells
Yizhou Joseph He, Khyati A. Meghani, Marie‐Christine Caron, Chunyu Yang, Daryl A. Ronato, Jie Bian, Anchal Sharma, Jessica L. Moore, Niraj Joshi, Alexandre Detappe et al. · 2018 · Nature
Identifying chemogenetic interactions from CRISPR screens with drugZ
Medina Colic, Gang Wang, Michal Zimmermann, Keith S. Mascall, Megan E. McLaughlin, Lori L. Bertolet, W. Frank Lenoir, Jason Moffat, Stéphane Angers, Daniel Durocher et al. · 2019 · Genome Medicine
Hacking the Cancer Genome: Profiling Therapeutically Actionable Long Non-coding RNAs Using CRISPR-Cas9 Screening
Roberta Esposito, Núria Bosch, Andrés Lanzós, Taisia Polidori, Carlos Pulido-Quetglas, Rory Johnson · 2019 · Cancer Cell
Cellular locomotion using environmental topography
Anne Reversat, Florian Gaertner, Jack Merrin, Julian Stopp, Saren Tasciyan, Juan Aguilera-Servin, Ingrid de Vries, Robert Hauschild, Miroslav Hons, Matthieu Piel et al. · 2020 · Nature
Optimization of AsCas12a for combinatorial genetic screens in human cells
Peter C. DeWeirdt, Kendall R Sanson, Annabel K. Sangree, Mudra Hegde, Ruth E. Hanna, Marissa N. Feeley, Audrey L Griffith, Teng Teng, Samantha M. Borys, Christine Strand et al. · 2020 · Nature Biotechnology
Lipid nanoparticle-mediated efficient delivery of CRISPR/Cas9 for tumor therapy
Zhang, Lingmin, Wang, Peng, Feng, Qiang, Wang, Nuoxin, Chen, Zitian, Huang, Yanyi, Zheng, Wenfu, Jiang, Xingyu · 2017 · NPG Asia Materials
Pathways and therapeutic targets in melanoma
Emma Shtivelman, Michael A. Davies, Patrick Hwu, James Chih-Hsin Yang, Michal Lotem, Moshe Oren, Keith T. Flaherty, David E. Fisher · 2014 · Oncotarget
A Systematic Evaluation of Methods for Tailoring Genome-Scale Metabolic Models
Sjoerd Opdam, Anne Richelle, Benjamin P. Kellman, Shanzhong Li, Daniel Craig Zielinski, Nathan E. Lewis · 2017 · Cell Systems
NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism
Douglas B. Fox, Nina Marie G. Garcia, Brock J. McKinney, Ryan Lupo, Laura C. Noteware, Rachel Newcomb, Juan Liu, Jason W. Locasale, Matthew D. Hirschey, James V. Alvarez · 2020 · Nature Metabolism
The CRISPR/Cas9 system inactivates latent HIV-1 proviral DNA
Weijun Zhu, Rongyue Lei, Yann Le Duff, Jian Li, Fei Guo, Mark A. Wainberg, Chen Liang · 2015 · Retrovirology
Small RNAs: A New Paradigm in Plant-Microbe Interactions
Arne Weiberg, Ming Wang, Marschal Bellinger, Hailing Jin · 2014 · Annual Review of Phytopathology
53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis
Chii Shyang Fong, Gregory Mazo, Tuhin Das, Joshua H. Goodman, Minhee Kim, Brian P O'Rourke, Denisse Izquierdo, Meng-Fu Bryan Tsou · 2016 · eLife
Application of CRISPR-Cas9 genome editing technology in various fields: A review
Arif Nur Muhammad Ansori, Yulanda Antonius, Raden Joko Kuncoroningrat Susilo, Suhailah Hayaza, Viol Dhea Kharisma, Arli Aditya Parikesit, Rahadian Zainul, Vikash Jakhmola, Taru Saklani, Максим Борисович Ребезов et al. · 2023 · Narra J
STING enhances cell death through regulation of reactive oxygen species and DNA damage
Thomas J. Hayman, Marta Baro, Tyler MacNeil, Chatchai Phoomak, Thazin Nwe Aung, Wei Cui, Kevin Leach, Radhakrishnan P. Iyer, Sreerupa Challa, Teresa Sandoval-Schaefer et al. · 2021 · Nature Communications
CRISPR/Cas9 and Genome Editing in Drosophila
Andrew Roger Bassett, Ji‐Long Liu · 2013 · Journal of genetics and genomics/Journal of Genetics and Genomics
CRISPR-ERA: a comprehensive design tool for CRISPR-mediated gene editing, repression and activation: Fig. 1.
Honglei Liu, Wei Zheng, Antonia A. Dominguez, Yanda Li, Xiaowo Wang, Lei S. Qi · 2015 · Computer applications in the biosciences
Genome editing of CXCR4 by CRISPR/cas9 confers cells resistant to HIV-1 infection
Panpan Hou, Shuliang Chen, Shilei Wang, Xiao Yu, Yu Zheng Chen, Meng Jiang, Ke Zhuang, Wen‐Zhe Ho, Wei Hou, Jian Yuan Huang et al. · 2015 · Scientific Reports
Prediction of the sequence-specific cleavage activity of Cas9 variants
Kim, Nahye, Kim, Hui Kwon, Lee, Sungtae, Seo, Jung Hwa, Choi, Jae Woo, Park, Jinman, Min, Seonwoo, Yoon, Sungroh, Cho, Sung-Rae, Kim, Hyongbum Henry · 2020 · Nature Biotechnology
High-throughput Phenotyping of Lung Cancer Somatic Mutations
Alice H. Berger, Angela Norie Brooks, Xiaoyun Wu, Yashaswi Shrestha, Candace R. Chouinard, Federica Piccioni, Mukta Bagul, Atanas Kamburov, Marcin B. Imielinski, Larson J. Hogstrom et al. · 2016 · Cancer Cell
Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting
H. Furkan Alkan, Katharina E. Walter, Alba Luengo, Corina T. Madreiter‐Sokolowski, Sarah Stryeck, Allison N. Lau, Wael Al Zoughbi, Caroline A. Lewis, Craig J. Thomas, Gerald Höefler et al. · 2018 · Cell Metabolism
CRISPR Activation Screens Systematically Identify Factors that Drive Neuronal Fate and Reprogramming
Yanxia Liu, Yu Chen, Timothy Daley, Fangyuan Wang, William Cao, Salil S. Bhate, Xueqiu Lin, Chris Still, Honglei Liu, Dehua Zhao et al. · 2018 · Cell stem cell
CRISPR-Cas: New Tools for Genetic Manipulations from Bacterial Immunity Systems
Wenyan Jiang, Luciano A. Marraffini · 2015 · Annual Review of Microbiology
Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma
Sophia Gayle, Sean F. Landrette, Neil Beeharry, Chris Conrad, Marylens Hernandez, Paul Beckett, Shawn M. Ferguson, Talya F. Mandelkern, Meiling Zheng, Tian Xu et al. · 2017 · Blood
Challenges of CRISPR/Cas9 applications for long non-coding RNA genes
Ashish Goyal, Ksenia Myacheva, Matthias Groß, Marcel Klingenberg, Berta Duran Arqué, Sven Diederichs · 2016 · Nucleic Acids Research
Automated multiplex genome-scale engineering in yeast
Tong Si, Ran Chao, Yuhao Min, Yuying Wu, Wen Ren, Huimin Zhao · 2017 · Nature Communications
Ten years of progress and promise of induced pluripotent stem cells: historical origins, characteristics, mechanisms, limitations, and potential applications
Adekunle Ebenezer Omole, Adegbenro Omotuyi John Fakoya · 2018 · PeerJ
Omics Advances in Ecotoxicology
Xiaowei Zhang, Pu Xia, Pingping Wang, Jianghu Yang, Donald J. Baird · 2018 · Environmental Science & Technology
Reduced NF1 Expression Confers Resistance to EGFR Inhibition in Lung Cancer
Elza C. de Bruin, Catherine Cowell, Patricia H. Warne, Ming Zuo Jiang, Rebecca E. Saunders, Mary Ann Melnick, Scott N. Gettinger, Zenta Walther, Anna Wurtz, Guus J.J.E. Heynen et al. · 2014 · Cancer Discovery
Genome-Scale CRISPR Screening in Human Intestinal Organoids Identifies Drivers of TGF-β Resistance
Ringel, Till, Frey, Nina, Ringnalda, Femke, Janjuha, Sharan, Cherkaoui, Sarah, Butz, Stefan, Srivatsa, Sumana, Pirkl, Martin, Russo, Giancarlo, Villiger, Lukas et al. · 2020 · Cell Stem Cell
The sound of silence: Transgene silencing in mammalian cell engineering
Alan Cabrera, Hailey I. Edelstein, Fokion Glykofrydis, Kasey S. Love, Sebastian Palacios, Josh Tycko, Meng Zhang, Sarah Lensch, Cara E. Shields, Mark Livingston et al. · 2022 · Cell Systems
Pseudouridine synthases modify human pre-mRNA co-transcriptionally and affect pre-mRNA processing
Nicole M. Martínez, Amanda Su, Margaret C. Burns, Julia K. Nussbacher, Cassandra Schaening-Burgos, Shashank Sathe, Gene Wei-Ming Yeo, Wendy V. Gilbert · 2022 · Molecular Cell
In vivo CRISPR screening in CD8 T cells with AAV–Sleeping Beauty hybrid vectors identifies membrane targets for improving immunotherapy for glioblastoma
Lupeng Ye, Jonathan Joon-Young Park, Matthew B. Dong, Quanjun Yang, Ryan Dz-Wei Chow, Lei Peng, Yaying Du, Jianjian Guo, Xiaoyun Dai, Guangchuan Wang et al. · 2019 · Nature Biotechnology
TMEM41B Is a Pan-flavivirus Host Factor
Hans-Heinrich Hoffmann, William M. Schneider, Kathryn Rozen-Gagnon, Linde A. Miles, Felix Schuster, Brandon S. Razooky, Eliana Jacobson, Xianfang Wu, Soon Yi, Charles M. Rudin et al. · 2020 · Cell
Comparison of non-canonical PAMs for CRISPR/Cas9-mediated DNA cleavage in human cells
Yilan Zhang, Xianglian Ge, Fayu Yang, Liping Zhang, Jiayong Zheng, Xuefang Tan, Zi‐Bing Jin, Jia Qu, Feng Gu · 2014 · Scientific Reports
The SKIV2L RNA exosome limits activation of the RIG-I-like receptors
Sterling C. Eckard, Gillian Rice, Alexandre Fabre, Catherine Badens, Elizabeth E. Gray, Jane Hartley, Yanick Joseph Crow, Daniel B. Stetson · 2014 · Nature Immunology
Cytokines in cancer drug resistance: Cues to new therapeutic strategies
Valerie Sloane Jones, Ren-Yu Huang, Li-Pai Chen, Zhe‐Sheng Chen, Liwu Fu, Ruo-Pan Huang · 2016 · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
Engineering biological systems using automated biofoundries
Ran Chao, Shekhar Mishra, Tong Si, Huimin Zhao · 2017 · Metabolic Engineering
Genetic Screens Reveal FEN1 and APEX2 as BRCA2 Synthetic Lethal Targets
Kristen E. Mengwasser, Richard O. Adeyemi, Yumei Leng, Mei Yuk Choi, Connor S. Clairmont, Alan D. D’Andrea, Stephen Joseph Elledge · 2019 · Molecular Cell
Various Aspects of a Gene Editing System—CRISPR–Cas9
Edyta Janik, Marcin Niemcewicz, Michał Ceremuga, Łukasz Krzowski, Joanna Saluk, Michał Bijak · 2020 · International Journal of Molecular Sciences
Highly Parallel Profiling of Cas9 Variant Specificity
Schmid-Burgk, Jonathan L., Gao, Linyi, Li, David, Gardner, Zachary, Strecker, Jonathan, Lash, Blake, Zhang, Feng · 2020 · Molecular Cell
LRRC8A:C/E Heteromeric Channels Are Ubiquitous Transporters of cGAMP
Lauren J. Lahey, Rachel E. Mardjuki, Xianlan Wen, Gaelen T. Hess, Christopher Ritchie, Jacqueline A. Carozza, Volker Böhnert, Merritt C. Maduke, Michael Cory Bassik, Lingyin Li · 2020 · Molecular Cell
CRISPR-Cas9-Mediated Genome Editing in Leishmania donovani
Wen‐Wei Zhang, Greg Matlashewski · 2015 · mBio
Comparison of TALE designer transcription factors and the CRISPR/dCas9 in regulation of gene expression by targeting enhancers
Xuefei Gao, Jason C.H. Tsang, Fortis Gaba, Donghai Wu, Liming Lu, Pentao Liu · 2014 · Nucleic Acids Research
Differential Stoichiometry among Core Ribosomal Proteins
Nikolai Slavov, Stefan Semrau, Edoardo M. Airoldi, Bogdan Budnik, Alexander van Oudenaarden · 2015 · Cell Reports
Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells
Chad M. Toledo, Yu Ding, Pia Hoellerbauer, Ryan J. Davis, Ryan Basom, Emily J. Girard, Eunjee Lee, Philip D. Corrin, Traver Hart, Hamid Bolouri et al. · 2015 · Cell Reports
Quantitative CRISPR interference screens in yeast identify chemical-genetic interactions and new rules for guide RNA design
Justin Smith, Sundari Suresh, Ulrich Schlecht, Manhong Wu, Omar Wagih, Gary Peltz, Ronald Wayne Davis, Lars Michael Steinmetz, Leopold Parts, Robert P. St.Onge · 2016 · Genome biology
A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies
David K. Breslow, Sascha Hoogendoorn, Adam R. Kopp, David W. Morgens, Brandon K. Vu, Margaret C. Kennedy, Kyuho Han, Amy Li, Gaelen T. Hess, Michael Cory Bassik et al. · 2018 · Nature Genetics
A LncRNA-MAF:MAFB transcription factor network regulates epidermal differentiation
Lopez-Pajares, Vanessa, Qu, Kun, Zhang, Jiajing, Webster, Dan E., Barajas, Brook C., Siprashvili, Zurab, Zarnegar, Brian J., Boxer, Lisa D., Rios, Eon J., Tao, Shiying et al. · 2015 · Developmental Cell
The oxidized phospholipid oxPAPC protects from septic shock by targeting the non-canonical inflammasome in macrophages
Lan H. Chu, Mohanalaxmi Indramohan, Rojo A. Ratsimandresy, Anu Gangopadhyay, Emily P. Morris, Denise M. Monack, Andrea Dorfleutner, Christian Stehlik · 2018 · Nature Communications
Evaluation of RNAi and CRISPR technologies by large-scale gene expression profiling in the Connectivity Map
Ian C. P. Smith, Peyton Greenside, Ted E. Natoli, David L. Lahr, David Wadden, Itay Tirosh, Rajiv Narayan, David E. Root, Todd R. Golub, Aravind Subramanian et al. · 2017 · PLoS Biology
Mapping the genetic landscape of DNA double-strand break repair
Jeffrey A. Hussmann, Ling Jia, Purnima Ravisankar, Jun Yan, Ann Cirincione, Albert Xu, Danny Simpson, Dian Yang, Anne Bothmer, Cecilia Cotta‐Ramusino et al. · 2021 · Cell
CRISPR/Cas9 somatic multiplex-mutagenesis for high-throughput functional cancer genomics in mice
Julia Weber, Rupert Öllinger, Mathias Friedrich, Ursula Ehmer, Maxim Barenboim, Katja Steiger, Irina Heid, Sebastian Mueller, Roman Maresch, Thomas Engleitner et al. · 2015 · Proceedings of the National Academy of Sciences
Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides
Hana M. Russo, Joseph K. Rathkey, Andrea Boyd Tressler, Michael A Katsnelson, Derek W. Abbott, George Dubyak · 2016 · The Journal of Immunology
Identification of phagocytosis regulators using magnetic genome-wide CRISPR screens
Haney, Michael S., Bohlen, Christopher J., Morgens, David W., Ousey, James A., Barkal, Amira A., Tsui, C. Kimberly, Ego, Braeden K., Levin, Roni, Kamber, Roarke A., Collins, Hannah et al. · 2018 · Nature Genetics
Delivery and Specificity of CRISPR/Cas9 Genome Editing Technologies for Human Gene Therapy
Jennifer L. Gori, Patrick D. Hsu, Morgan L. Maeder, Shen Shen, G. Grant Welstead, David A. Bumcrot · 2015 · Human Gene Therapy
Cytokine therapy reverses NK cell anergy in MHC-deficient tumors
Michele Ardolino, Camillia S. Azimi, Alexandre Iannello, Troy N. Trevino, Lucas H. Horan, Lily Zhang, Weiwen Deng, Aaron M. Ring, Suzanne Fischer, K. Christopher García et al. · 2014 · Journal of Clinical Investigation
A CRISPR toolbox to study virus–host interactions
Andreas S. Puschnik, Karim Majzoub, Yaw Shin Ooi, Jan E. Carette · 2017 · Nature Reviews Microbiology
Systematic perturbation of retroviral LTRs reveals widespread long-range effects on human gene regulation
Daniel Fuentes, Tomek Swigut, Joanna Wysocka · 2018 · eLife
Molecular insights into NF2/Merlin tumor suppressor function
Jonathan M. Cooper, Filippo G. Giancotti · 2014 · FEBS Letters
Fast and sensitive detection of indels induced by precise gene targeting
Yang Zhang, Catharina Steentoft, Camilla Hauge, Lars Hestbjerg Hansen, Allan Lind-Thomsen, Francesco Niola, Malene Bech Vester-Christensen, Morten Frödin, Henrik Clausen, Hans Heugh Wandall et al. · 2015 · Nucleic Acids Research
CRISPy-web: An online resource to design sgRNAs for CRISPR applications
Kai Blin, Lasse Ebdrup Pedersen, Tilmann Weber, Sang Yup Lee · 2016 · Synthetic and Systems Biotechnology
On the Origin of CRISPR-Cas Technology: From Prokaryotes to Mammals
Francisco J. M. Mojica, Lluı́s Montoliu · 2016 · Trends in Microbiology
Gene correction for SCID-X1 in long-term hematopoietic stem cells
Mara Pavel-Dinu, Volker Wiebking, Beruh T. Dejene, Waracharee Srifa, Sruthi Mantri, Carmencita E. Nicolas, Ciaran M. Lee, Gang Bao, Eric Kildebeck, Niraj Punjya et al. · 2019 · Nature Communications
Cellular barcoding: lineage tracing, screening and beyond
Justus M. Kebschull, Anthony M. Zador · 2018 · Nature Methods
Regenerative Reprogramming of the Intestinal Stem Cell State via Hippo Signaling Suppresses Metastatic Colorectal Cancer
Priscilla Cheung, Jordi Xiol, Michael T. Dill, Wei-Chien Yuan, Riccardo Panero, Jatin Roper, Fernando G. Osorio, Dejan Maglic, Qi Li, Basanta Gurung et al. · 2020 · Cell stem cell
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis
Nobuaki Takahashi, Patricia Cho, Laura M. Selfors, Hendrik J. Kuiken, Roma Kaul, Takuro Fujiwara, Isaac S. Harris, Tian Zhang, Steven P. Gygi, Joan S. Brugge · 2020 · Molecular Cell
Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs
Zhiyuan Niu, Qian Shi, Wenlong Zhang, Yuxin Shu, Nanfei Yang, Bing Chen, Qingsong Wang, Xuyang Zhao, Jiajia Chen, Nan Cheng et al. · 2017 · Nature Communications
BRAF Mutations in Melanoma: Biological Aspects, Therapeutic Implications, and Circulating Biomarkers
Giorgia Castellani, Mariachiara Buccarelli, Maria Beatrice Arasi, Stefania Rossi, Maria Elena Pisanu, Maria Bellenghi, Carla Lintas, Claudio Tabolacci · 2023 · Cancers
The whole-genome landscape of Burkitt lymphoma subtypes
Razvan Panea, Cassandra Love, Jennifer R. Shingleton, Anupama Reddy, Jeffrey A. Bailey, Ann Marie Moormann, Juliana A. Otieno, John Michael Ong’echa, Cliff I. Oduor, Kristin Schroeder et al. · 2019 · Blood
Pooled Knockin Targeting for Genome Engineering of Cellular Immunotherapies
Roth, Theodore L., Li, P. Jonathan, Blaeschke, Franziska, Nies, Jasper F., Apathy, Ryan, Mowery, Cody, Yu, Ruby, Nguyen, Michelle L.T., Lee, Youjin, Truong, Anna et al. · 2020 · Cell
The CRISPR/Cas9 system and its applications in crop genome editing
Bao, Aili, Burritt, David J., Chen, Haifeng, Zhou, Xinan, Cao, Dong, Tran, Lam-Son Phan · 2019 · Critical Reviews in Biotechnology
Off-target predictions in CRISPR-Cas9 gene editing using deep learning
Lin, Jiecong, Wong, Ka-Chun · 2018 · Bioinformatics
The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface
Kara L. McKinley, Nikolina Sekulić, Lucie Y. Guo, Tonia K. Tsinman, Ben E. Black, Iain M. Cheeseman · 2015 · Molecular Cell
Precision genome editing in the CRISPR era
Jayme Salsman, Graham Dellaire · 2016 · Biochemistry and Cell Biology
Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex
Shen, Hongjie, Xu, Wenqi, Guo, Rui, Rong, Bowen, Gu, Lei, Wang, Zhentian, He, Chenxi, Zheng, Lijuan, Hu, Xin, Hu, Zhen et al. · 2016 · Cell
Parallel shRNA and CRISPR-Cas9 screens enable antiviral drug target identification
Richard M. Deans, D. Morgens, Ayşe Ökesli, S. Pillay, M. Horlbeck, M. Kampmann, Luke A. Gilbert, Amy Li, Roberto Mateo, Mark Smith et al. · 2016 · Nature Chemical Biology
Application of prime editing to the correction of mutations and phenotypes in adult mice with liver and eye diseases
Hyewon Jang, Dong Hyun Jo, Chang Sik Cho, Jeong Hong Shin, Jung Hwa Seo, Goosang Yu, Ramu Gopalappa, Daesik Kim, Sung‐Rae Cho, Jeong Hun Kim et al. · 2021 · Nature Biomedical Engineering
Development of CRISPR-Cas systems for genome editing and beyond
F. Zhang · 2019 · Quarterly Reviews of Biophysics
Inhibition of YTHDF2 triggers proteotoxic cell death in MYC-driven breast cancer
Jaclyn M. Einstein, Mark Perelis, Isaac Alexander Chaim, Jitendra Kumar Meena, Julia K. Nussbacher, Alexandra T. Tankka, Brian A. Yee, Heyuan Li, Assael A. Madrigal, Nicholas J. Neill et al. · 2021 · Molecular Cell
Insert, remove or replace: A highly advanced genome editing system using CRISPR/Cas9
Stanislaus Antony Ceasar, Vinothkumar Rajan, Sergey V. Prykhozhij, Jason N. Berman, Savarimuthu Ignacimuthu S.J. · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research