Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335

Monocyte and macrophage heterogeneity

Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190

Macrophage biology in development, homeostasis and disease

Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684

Development of Monocytes, Macrophages, and Dendritic Cells

Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049

The accessible chromatin landscape of the human genome

Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679

Regulation and Function of NF-κB Transcription Factors in the Immune System

Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,635

Histone modifications at human enhancers reflect global cell-type-specific gene expression

Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature · doi:10.1038/nature07829 · Cited by 2,533

Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression

Martínez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,399

A unique chromatin signature uncovers early developmental enhancers in humans

Rada-Iglesias, A., Bajpai, R., Swigut, T., Brugmann, S. A., Flynn, R. A., & Wysocka, J. (2011) · Nature · doi:10.1038/nature09692 · Cited by 2,233

mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Cheng, S.-C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E. J., Martens, J. H. A., Rao, N. A., Aghajanirefah, A., et al. (2014) · Science · doi:10.1126/science.1250684 · Cited by 2,224

Host genetic diversity and genetic variations of SARS-CoV-2 in COVID-19 pathogenesis and the effectiveness of vaccination

Delshad, M., Sanaei, M., Pourbagheri‐Sigaroodi, A., & Bashash, D. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109128 · Cited by 18

Memory-like innate response to booster vaccination with MF-59 adjuvanted influenza vaccine in children

Kazmin, D. A., Clutterbuck, E., Napolitani, G., Wilkins, A. L., Tarlton, A., Thompson, A., Montomoli, E., Lapini, G., Bihari, S., White, R., et al. (2023) · npj Vaccines · doi:10.1038/s41541-023-00702-1 · Cited by 16

Mapping the epigenomic landscape of human monocytes following innate immune activation reveals context-specific mechanisms driving endotoxin tolerance

Amarasinghe, H. E., Zhang, P., Whalley, J. P., Allcock, A., Migliorini, G., Brown, A., Scozzafava, G., & Knight, J. C. (2023) · BMC Genomics · doi:10.1186/s12864-023-09663-0 · Cited by 18

Trained innate immunity in response to nuclear antigens in systemic lupus erythematosus

Yanginlar, C., Rother, N., Post, T. G. J. M., Jacobs, M. M. E., Jonkman, I., Brouns, M., Rinzema, S., Martens, J. H. A., Vermeulen, M., Joosten, L. A. B., et al. (2024) · Journal of Autoimmunity · doi:10.1016/j.jaut.2024.103335 · Cited by 16

Chromatin Remodeling in Monocyte and Macrophage Activation

Schultze, J. L. (2016) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2016.09.001 · Cited by 16

Epigenetic changes related to glucose metabolism in type 1 diabetes after BCG vaccinations: A vital role for KDM2B

Dias, H. F., Kühtreiber, W. M., Nelson, K. J., Ng, N., Zheng, H., & Faustman, D. L. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.04.011 · Cited by 17

Toll-Like Receptor 4 as a Favorable Prognostic Marker in Bladder Cancer: A Multi-Omics Analysis

Lu, J., Xia, Q., Sun, Y., Xun, Y., Hu, H., Liu, C., Sun, J., Xu, J., Hu, J., & Wang, S. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.651560 · Cited by 16

A Pan-Cancer Study of KMT2 Family as Therapeutic Targets in Cancer

Zhu, J., Liu, Z., Liang, X., Wang, L., Wu, D., Mao, W., & Shen, D. (2022) · Journal of Oncology · doi:10.1155/2022/3982226 · Cited by 16

Loss of Antigen Presentation in Adipose Tissue Macrophages or in Adipocytes, but Not Both, Improves Glucose Metabolism

Blaszczak, A. M., Wright, V. P., Anandani, K., Liu, J., Jalilvand, A., Bergin, S. M., Nicoloro, S. M. C., Czech, M., Lafuse, W. P., Deng, T., et al. (2019) · The Journal of Immunology · doi:10.4049/jimmunol.1801470 · Cited by 16

Mesenchymal-Stem-Cell–Derived Extracellular Vesicles Mitigate Trained Immunity in the Brain

Feng, Y., Guo, M. A., Zhao, H., Han, S., Dong, Q., & Cui, M. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.599058 · Cited by 16

Epigenetics of Aberrant Cardiac Wound Healing

Russell‐Hallinan, A., Watson, C. J., & Baugh, J. A. (2018) · Comprehensive physiology · doi:10.1002/cphy.c170029 · Cited by 17

Methylation and transcriptomic profiling reveals short term and long term regulatory responses in polarized macrophages

Migliaccio, G., Morikka, J., del Giudice, G., Vaani, M., Möbus, L., Serra, A., Federico, A., & Greco, D. (2024) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2024.08.018 · Cited by 16

BCG-trained macrophages couple LDLR upregulation to type I IFN responses and antiviral immunity

Lai, Y., Yang, X., Wei, D., Wang, X., Sun, R., Li, Y., Ji, P., Bao, Y.-J., Chu, T., Zhang, C., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115493 · Cited by 18

Investigating endogenous immune-mediated monocyte memory in rheumatoid arthritis

Marzeda, A. M., Schwenzer, A., Didov, B. S., Woolcock, K., Richard, J.-B., Jennings, L. K., Julé, A. M., Yang, N., Davidson, S., Sansom, S. C., et al. (2025) · Annals of the Rheumatic Diseases · doi:10.1016/j.ard.2025.03.016 · Cited by 15

The pathway of autophagy in the epigenetic landscape of Mycobacterium -host interactions

Mishra, A., Rawat, V. P. S., Zhang, K., & Jagannath, C. (2025) · Autophagy · doi:10.1080/15548627.2025.2511074 · Cited by 18

The Role of Pattern Recognition Receptors in Epigenetic and Metabolic Reprogramming: Insights into Trained Immunity

Li, Y., Chen, M., Li, J., & Hu, J. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s513325 · Cited by 16

Maladaptive trained immunity in viral infections

Sviridov, D., Netea, M. G., & Bukrinsky, M. (2025) · Journal of Clinical Investigation · doi:10.1172/jci192469 · Cited by 17

The epigenomic landscape of bronchial epithelial cells reveals the establishment of trained immunity

Bigot, J., Legendre, R., Hamroune, J., Jacques, S., Gars, M. L., Millet, N., Guillot, L., Corvol, H., Hennequin, C., Guitard, J., et al. (2025) · Genes and Immunity · doi:10.1038/s41435-025-00357-z · Cited by 15

Tissue-resident macrophage survival depends on mitochondrial function regulated by SerpinB2 in chronic inflammation

Vasamsetti, S. B., Sadaf, S., Uddin, M. A., Shen, J., Johny, E., Mondal, A., Florentin, J., Lei, L., Mannan, A., Rao, K. M. K., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-69196-4 · Cited by 16

Molecular and cellular bases of trained immunity

Sun, S. J., Aguirre‐Gamboa, R., & Barreiro, L. B. (2026) · Immunity · doi:10.1016/j.immuni.2026.03.001 · Cited by 18

Trained Microglia Trigger Memory Loss

Lelios, I., & Greter, M. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.033 · Cited by 15

Warm up, cool down, and tearing apart in NK cell memory

Wu, L. S.-H., & Wang, J. (2018) · Cellular and Molecular Immunology · doi:10.1038/s41423-018-0188-7 · Cited by 15

Bcl6 drives stem-like memory macrophages differentiation to foster tumor progression

Zhang, W., Han, Q., Ding, Y., Zhou, H., Chen, Z., Wang, J., Xiang, J., Song, Z., Abbas, M., & Shi, L. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04660-0 · Cited by 15

Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment

Lowe, K., Small, A., Song, Q., Hao, L., Murray‐Brown, W., Proudman, S., Smith, M., Nagpal, S., & Wechalekar, M. D. (2023) · Scientific Reports · doi:10.1038/s41598-023-29971-5 · Cited by 17

Trained immunity as a potential target for therapeutic immunomodulation in Duchenne muscular dystrophy

Petrof, B. J., Podolsky, T., Bhattarai, S., Tan, J., & Ding, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1183066 · Cited by 16

Potential impact of trained innate immunity on the pathophysiology of metabolic dysfunction-associated fatty liver disease

Kountouras, J., Kazakos, E. I., Pοlyzos, S. A., Papaefthymiou, A., Zavos, C., Tzitiridou‐Chatzopoulou, M., Chatzopoulos, D., Vardaka, E., Gatopoulou, A., Kyrailidi, F., et al. (2023) · Clinical Immunology · doi:10.1016/j.clim.2023.109776 · Cited by 15

Trained Immunity and Trained Tolerance: The Case of Helicobacter pylori Infection

Dore, M. P., & Pes, G. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25115856 · Cited by 15

A preliminary investigation on the protective effects of β-glucan and mannan induced trained immunity in pufferfish Takifugu obscurus

Song, X., Lei, T., Cui, N., Jin, X., Huang, Y. K., Shi, Y., & Zhao, Z. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.110035 · Cited by 15

Linking innate immunity and chronic antibody-mediated allograft rejection

Gill, R. G., & Lin, C. M. (2019) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000708 · Cited by 15

Applying the Host-Microbe Damage Response Framework to Candida Pathogenesis: Current and Prospective Strategies to Reduce Damage

Fidel, P. L., Yano, J., Esher, S. K., & Noverr, M. C. (2020) · Journal of Fungi · doi:10.3390/jof6010035 · Cited by 18

Genome-Wide Histone Modifications and CTCF Enrichment Predict Gene Expression in Sheep Macrophages

Massa, A. T., Mousel, M. R., Herndon, M. K., Herndon, D. R., Murdoch, B. M., & White, S. N. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.612031 · Cited by 15

Immunisation with the BCG and DTPw vaccines induces different programs of trained immunity in mice

Stevens, N. E., van Wolfswinkel, M., Bao, W., Ryan, F. J., Brook, B., Amenyogbe, N., Marshall, H. S., Lynn, M. A., Kollmann, T. R., Tumes, D. J., et al. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.03.084 · Cited by 15

Single-cell sequencing of PBMC characterizes the altered transcriptomic landscape of classical monocytes in BNT162b2-induced myocarditis

Hwang, N., Huh, Y., Bu, S., Seo, K. J., Kwon, S. H., Kim, J. W., Yoon, B. K., Ahn, H., & Fang, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.979188 · Cited by 16

Transcriptome features of innate immune memory in Drosophila

Fuse, N., Okamori, C., Tang, C., Hirai, K., Okaji, R., & Kurata, S. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1010005 · Cited by 15

Innate immune reconstitution with suppression of HIV-1

Scully, E. P., Lockhart, A. A. K., García-Beltrán, W. F., Palmer, C. D., Musante, C. D., Rosenberg, E. S., Allen, T. M., Chang, J. J., Bosch, R. J., & Altfeld, M. A. (2016) · JCI Insight · doi:10.1172/jci.insight.85433 · Cited by 15

Immunomodulation and effects on microbiota after in ovo administration of chicken cathelicidin-2

Cuperus, T., Kraaij, M. D., Zomer, A., van Dijk, A. I. J. M., & Haagsman, H. P. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198188 · Cited by 15

Effects of select dietary supplements on the prevention and treatment of viral respiratory tract infections: a systematic review of randomized controlled trials

Mashhadi, N. S., Kazemi, M., Saadat, S., & Moradi, S. (2021) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2021.1918546 · Cited by 15

About the gut microbiome as a pharmacological target in atherosclerosis

Witjes, J. J., van Raalte, D. H., & Nieuwdorp, M. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.06.023 · Cited by 15

Trained immunity modulators: A new frontier in immunoregulation and disease intervention

Chen, J., Wang, C., Chen, S., Cai, H., Wang, M., Chang, J., Cai, X., Yang, J., & Cao, P. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.09.029 · Cited by 15

Trained Immunity in Health and Disease

Yao, M., Zhou, J., Mei, J., Gao, C., Ding, P., Li, G., Zhang, C., Li, Z., & Gao, J. (2025) · MedComm · doi:10.1002/mco2.70461 · Cited by 16

Systemically inducing trained immunity overcomes solid tumors’ immunosuppressive microenvironment

Priem, B., Willemsen, L., Anbergen, T., van Elsas, Y., Deckers, J., Schrijver, D. P., Hofstraat, S. R. J., Messing, I. V., Munitz, J., Honing, D. Y., et al. (2026) · Science Advances · doi:10.1126/sciadv.adu0292 · Cited by 14

Modeling the crossover behavior of the bacterial infection with the COVID-19 epidemics

Yu, Z., Sohail, A., Arif, R., Nutini, A., Nofal, T. A., & Tunç, S. (2022) · Results in Physics · doi:10.1016/j.rinp.2022.105774 · Cited by 14

GM-CSF distinctly impacts human monocytes and macrophages via ERK1/2-dependent pathways

Farzam‐kia, N., Moratalla, A. C., Lemaître, F., Levert, A., Cal, S. D., Margarido, C., Solorio, Y. C., & Arbour, N. (2023) · Immunology Letters · doi:10.1016/j.imlet.2023.07.009 · Cited by 14

The Role of NLRP3 Inflammasomes in Trained Immunity

Lee, G., Ahn, H., Lee, G., & Lee, G. (2023) · Frontiers in Bioscience-Landmark · doi:10.31083/j.fbl2809210 · Cited by 14

Dietary β-glucan ameliorates metabolic stress caused by a high dietary carbohydrate level in Nile tilapia

Sátiro, T. M., Carli, G. C., Amorim, J. P. D. A., Koch, J. F. A., Zanuzzo, F. S., & Takahashi, L. S. (2023) · Aquaculture · doi:10.1016/j.aquaculture.2023.740186 · Cited by 14

Maternal high-fat diet exacerbates atherosclerosis development in offspring through epigenetic memory

Li, K., Qian, W., Zhang, F., Zhang, W., Lv, H., Quan, M., Sun, W., Liu, R., Cao, X., Xian, Z., et al. (2025) · Nature Cardiovascular Research · doi:10.1038/s44161-025-00622-4 · Cited by 14

Blood monocytes sample M elanA/ MART 1 antigen for long‐lasting cross‐presentation to CD 8+ T cells after differentiation into dendritic cells

Faure, F., Jouve, M. J., Péguillet, I., Sadaka, C., Sepulveda, F. E., Lantz, O. J., Berrè, S., Gaudin, R., Sánchez‐Ramón, S., & Amigorena, S. (2017) · International Journal of Cancer · doi:10.1002/ijc.31037 · Cited by 14

The Diverse Roles of Monocytes in Cryptococcosis

Fu, M. S., & Drummond, R. A. (2020) · Journal of Fungi · doi:10.3390/jof6030111 · Cited by 16

Hematopoietic stem cell (HSC) divisional memory: The journey of mitochondrial metabolism through HSC division

Filippi, M. (2021) · Experimental Hematology · doi:10.1016/j.exphem.2021.01.006 · Cited by 15

Age-related differences in monocyte DNA methylation and immune function in healthy Kenyan adults and children

Dobbs, K. R., Embury, P., Koech, E., Ogolla, S., Munga, S., Kazura, J. W., & Dent, A. E. (2021) · Immunity & Ageing · doi:10.1186/s12979-021-00223-2 · Cited by 13

Cord-Blood-Derived Professional Antigen-Presenting Cells: Functions and Applications in Current and Prospective Cell Therapies

Cunningham, S., & Hackstein, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115923 · Cited by 15

Contemplating Dichotomous Nature of Gamma Delta T Cells for Immunotherapy

Bhat, J., Placek, K., & Faissner, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.894580 · Cited by 14

Therapeutic Potentials of Immunometabolomic Modulations Induced by Tuberculosis Vaccination

Rawat, B. S., Kumar, D., Soni, V., & Rosenn, E. H. (2022) · Vaccines · doi:10.3390/vaccines10122127 · Cited by 15

Normalizing the Immune Macroenvironment via Debulking Surgery to Strengthen Tumor Nanovaccine Efficacy and Eliminate Metastasis

Ma, N., Chen, Z., Liu, G., Yue, Y., Li, Y., Cheng, K., Ma, X., Feng, Q., Liang, J., Zhang, T., et al. (2022) · ACS Nano · doi:10.1021/acsnano.2c08880 · Cited by 14

The Effect of Gamma-Ray-Induced Central Nervous System Injury on Peripheral Immune Response: An In Vitro and In Vivo Study

Zhang, P., Chen, Y., Zhu, H., Yan, L., Sun, C., Pei, S., Lodhi, A. F., Ren, H., Gao, Y., Manzoor, R., et al. (2019) · Radiation Research · doi:10.1667/rr15378.1 · Cited by 14

Cytokine-induced memory-like responses in endothelial cells link chronic inflammation to vascular disease risk

Le, K. T. T., Keur, N., Middelkamp, H. H. T., Do, T. L., van den Berg, A., Orlova, V. V., Joosten, L. A. B., Netea, M. G., Wijmenga, C., Jonkers, I. H., et al. (2025) · Molecular Omics · doi:10.1039/d5mo00136f · Cited by 14

CAR-M therapy in the era of tumor immunotherapy: current research progress and engineering strategies

Yang, Y.-M., Ding, Y.-F., Hu, Y.-Y., Fan, F., & Zhao, J.-L. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1723270 · Cited by 14

Epigenetics and tissue immunity—Translating environmental cues into functional adaptations*

Tuong, Z. K., Stewart, B. J., Guo, S. A., & Clatworthy, M. R. (2021) · Immunological Reviews · doi:10.1111/imr.13036 · Cited by 13

Epigenetic and Transcriptional Regulation of Innate Immunity in Cancer

Chen, C., Man, N., Liu, F., Martín, G. M., Itonaga, H., Sun, J., & Nimer, S. D. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-3503 · Cited by 13

Trained Immunity of IL-12-, IL-15-, and IL-18-Induced CD3+CD56+ NKT-Like Cells

Zhu, S., Zhang, C., Sun, Q., Wang, Y., Yu, W., Wei, F., & Ren, X. (2022) · Journal of Oncology · doi:10.1155/2022/8724933 · Cited by 13

Bet-hedging in innate and adaptive immune systems

Tate, A. T., & Cleve, J. V. (2022) · Evolution Medicine and Public Health · doi:10.1093/emph/eoac021 · Cited by 12

Small-molecule screening identifies Syk kinase inhibition and rutaecarpine as modulators of macrophage training and SARS-CoV-2 infection

John, S. P., Singh, A., Sun, J., Pierre, M. J., Alsalih, L., Lipsey, C. C., Traore, Z., Balcom-Luker, S., Bradfield, C. J., Song, J., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111441 · Cited by 14

Trained immunity: a cutting edge approach for designing novel vaccines against parasitic diseases?

Zhu, J., Liu, J., Yan, C., Wang, D., & Pan, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1252554 · Cited by 13

Group 3 innate lymphoid cells: A trained Gutkeeper

Serafini, N., & Santo, J. P. D. (2024) · Immunological Reviews · doi:10.1111/imr.13322 · Cited by 14

A negative feedback loop underlies the Warburg effect

Jaiswal, A., & Singh, R. (2024) · npj Systems Biology and Applications · doi:10.1038/s41540-024-00377-x · Cited by 13

Mucosal Inflammatory Memory in Chronic Rhinosinusitis

Koo, M., Moon, S., & Rha, M. (2024) · Cells · doi:10.3390/cells13231947 · Cited by 14

Hematopoietic stem cell a reservoir of innate immune memory

Ruffinatto, L., Groult, Y., Iacono, J., Sarrazin, S., & de Laval, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1491729 · Cited by 14

A hyper-dynamic nature of bivalent promoter states underlies coordinated developmental gene expression modules

Shah, A., Oldenburg, A. R., & Collas, P. (2014) · BMC Genomics · doi:10.1186/1471-2164-15-1186 · Cited by 13

Trained Innate Immunity in Hematopoietic Stem Cell and Solid Organ Transplantation

Cunningham, K. T., & Mills, K. H. G. (2021) · Transplantation · doi:10.1097/tp.0000000000003673 · Cited by 14

Single‐cell transcriptomics of mouse lung reveal inflammatory memory neutrophils in allergic asthma

Li, Z., Feng, Y., Liu, H., Yang, H., Li, J., Zhou, Y., Pang, J., Yang, P. B., Zhao, H., & Wang, J. (2022) · Allergy · doi:10.1111/all.15286 · Cited by 13

Trained Immunity in Perivascular Adipose Tissue of Abdominal Aortic Aneurysm—A Novel Concept for a Still Elusive Disease

Piacentini, L., Vavassori, C., & Colombo, G. I. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.886086 · Cited by 13

Innate Immune Training of Human Macrophages by Cathelicidin Analogs

van Dijk, A. I. J. M., Anten, J., Bakker, A., Evers, N., Hoekstra, A. T., Chang, J., Scheenstra, M. R., Veldhuizen, E. J. A., Netea, M. G., Berkers, C. R., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.777530 · Cited by 13

Trained Immunity as a Prospective Tool against Emerging Respiratory Pathogens

Joseph, J. (2022) · Vaccines · doi:10.3390/vaccines10111932 · Cited by 12

Monocytes primed with GTS-21/α7 nAChR (nicotinic acetylcholine receptor) agonist develop anti-inflammatory memory

Yang, X., Zhao, C., Chen, X., Jiang, L., & Su, X. (2017) · QJM · doi:10.1093/qjmed/hcx014 · Cited by 13

UV Irradiation of Skin Enhances Glycolytic Flux and Reduces Migration Capabilities in Bone Marrow–Differentiated Dendritic Cells

McGonigle, T. A., Keane, K. N., Ghaly, S., Carter, K. W., Anderson, D. R., Scott, N. M., Goodridge, H. S., Dwyer, A. R., Greenland, E. L., Pixley, F. J., et al. (2017) · American Journal Of Pathology · doi:10.1016/j.ajpath.2017.06.003 · Cited by 13

Designer macrophages: Pitfalls and opportunities for modelling macrophage phenotypes from pluripotent stem cells

Rajab, N., Rutar, M., Laslett, A. L., & Wells, C. A. (2018) · Differentiation · doi:10.1016/j.diff.2018.10.001 · Cited by 13

Epigenetic memory in gene regulation and immune response

Kim, M. Y., Lee, J. E., Kim, L. K., & Kim, T. S. (2019) · BMB Reports · doi:10.5483/bmbrep.2019.52.2.257 · Cited by 13

The Potential of Intravenous Immunoglobulins for Cancer Therapy: A Road that is Worth Taking?

Corbí, A. L., Sánchez‐Ramón, S., & Domínguez‐Soto, Á. (2016) · Immunotherapy · doi:10.2217/imt.16.9 · Cited by 13

The Aging Microenvironment Shapes Alveolar Macrophage Identity in AgingPreprint

McQuattie‐Pimentel, A. C., Ren, Z., Joshi, N., Watanabe, S., Stoeger, T., Chi, M., Lu, Z., Sichizya, L., Aillon, R. P., Chen, C.-I., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/717033 · Cited by 13

A dual nature of γδ T cell immune memory responses

Suen, T. K., Al, B., Scarpa, A., Dorhoi, A., Netea, M. G., & Placek, K. (2025) · eLife · doi:10.7554/elife.104887 · Cited by 12

Infection by a helminth parasite is associated with changes in DNA methylation in the house sparrow

Lundregan, S. L., Mäkinen, H., Buer, A., Holand, H., Jensen, H., & Husby, A. (2022) · Ecology and Evolution · doi:10.1002/ece3.9539 · Cited by 9

Fibronectin leucine-rich transmembrane protein 2 drives monocyte differentiation into macrophages via the UNC5B-Akt/mTOR axis

Fang, Y., Ma, K., Huang, Y.-M., Dang, Y., Liu, Z., Xu, Y., Zheng, X., Yang, X., Huo, Y., & Dai, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1162004 · Cited by 13

Current Understanding of Bacillus Calmette-Guérin-Mediated Trained Immunity and Its Perspectives for Controlling Intracellular Infections

de Araujo, A. C. V. S. C., Mambelli, F., Sanches, R. C. O., Marinho, F. V., & Oliveira, S. C. (2023) · Pathogens · doi:10.3390/pathogens12121386 · Cited by 12

Serine metabolism in macrophage polarization

Huang, X., Yang, X. F., Li, X., & Chen, Y. (2023) · Inflammation Research · doi:10.1007/s00011-023-01815-y · Cited by 14

BCG vaccination-induced acquired control of mycobacterial growth differs from growth control preexisting to BCG vaccination

van Meijgaarden, K. E., Li, W., Moorlag, S. J. C. F. M., Koeken, V. A. C. M., Koenen, H. J. P. M., Joosten, L. A. B., Vyakarnam, A., Ahmed, A., Rakshit, S., Adiga, V., et al. (2024) · Nature Communications · doi:10.1038/s41467-023-44252-5 · Cited by 12

Variation in the basal immune state and implications for disease

Souquette, A. H., & Thomas, P. G. (2024) · eLife · doi:10.7554/elife.90091 · Cited by 12

From metabolic to epigenetic: Insight into trained macrophages in atherosclerosis (Review)

Li, T., Feng, W., Yan, W., & Wang, T. (2024) · Molecular Medicine Reports · doi:10.3892/mmr.2024.13269 · Cited by 13

Innate immune response in acute critical illness: a narrative review

Stiel, L., Gaudet, A., Thietart, S., Vallet, H., Bastard, P., Voiriot, G., Oualha, M., Sarton, B., Kallel, H., Bréchot, N., et al. (2024) · Annals of Intensive Care · doi:10.1186/s13613-024-01355-6 · Cited by 13

Epigenomic Reprogramming in Gout

Straton, A. R., Kischkel, B., Crișan, T. O., & Joosten, L. A. B. (2024) · Gout Urate and Crystal Deposition Disease · doi:10.3390/gucdd2040023 · Cited by 12

The Role of Dectin-1-Akt-RNF146 Pathway in β-Glucan Induced Immune Trained State of Monocyte in Sepsis

Guo, C., Xu, P., Luo, W., Zhang, J., Sun, X., Hoang, H., Ma, D., Wu, D., Zhong, J., & Miao, C. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s482213 · Cited by 11

Trained Immunity Causes Myeloid Cell Hypercoagulability

Rehill, A. M., McCluskey, S., Ledwith, A. E., Ryan, T. A. J., Ünlü, B., Leon, G., Charles-Messance, H., Gilbert, E. H., Klavina, P., Day, E. A., et al. (2025) · Science Advances · doi:10.1126/sciadv.ads0105 · Cited by 12

Microbial-induced trained immunity for cancer immunotherapy

Vuscan, P., Kischkel, B., Joosten, L. A. B., & Netea, M. G. (2025) · Pharmacological Reviews · doi:10.1016/j.pharmr.2025.100074 · Cited by 14

Long-term DNA methylation changes mediate heterologous cytokine responses after BCG vaccination

Qi, C., Liu, Z., Kılıç, G., Sarlea, A. S., Debisarun, P. A., Liu, X., Mekonnen, Y. A., Li, W., Graßhoff, M., Alaswad, A., et al. (2025) · Genome biology · doi:10.1186/s13059-025-03611-9 · Cited by 12

Changes in H3K27ac following lipopolysaccharide stimulation of nasopharyngeal epithelial cells

Borghini, L., Hibberd, M. L., & Dávila, S. (2018) · BMC Genomics · doi:10.1186/s12864-018-5295-4 · Cited by 11

Dynamic LTR retrotransposon transcriptome landscape in septic shock patients

MIPrea Study Group, Mommert, M., REALISM Study Group, Tabone, O., Guichard, A., Oriol, G., Cerrato, E., Denizot, M., Cheynet, V., Pachot, A., et al. (2020) · Critical Care · doi:10.1186/s13054-020-2788-8 · Cited by 13

Central gene transcriptional regulatory networks shaping monocyte development in bone marrow

Zhang, Z., Bossila, E. A., Li, L., Hu, S., & Zhao, Y. X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1011279 · Cited by 12

Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections

Maizels, R. M., & Hewitson, J. P. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0043-2016 · Cited by 11

Extrinsic and Intrinsic Immunometabolism Converge: Perspectives on Future Research and Therapeutic Development for Obesity

Caslin, H. L., & Hasty, A. H. (2019) · Current Obesity Reports · doi:10.1007/s13679-019-00344-2 · Cited by 13

Long-Lasting Transcriptional Changes in Circulating Monocytes of Acute Q Fever Patients

Raijmakers, R. P. H., Stenos, J., Keijmel, S. P., ter Horst, R., Novakovic, B., Nguyen, C., van der Meer, J. W., Netea, M. G., Bleeker‐Rovers, C. P., Joosten, L. A. B., et al. (2019) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofz296 · Cited by 12

Compartment models for vaccine effectiveness and non-specific effects for Tuberculosis

Treibert, S. M., 1 Albert-Ludwigs-Universität Freiburg, E.-Z. S. 1., Brunner, H., Ehrhardt, M., & 4 Lehrstuhl für Angewandte Mathematik und Numerische Analysis, B. U. W. (2019) · Mathematical Biosciences & Engineering · doi:10.3934/mbe.2019364 · Cited by 12

Innate Immune Cell Phenotypes Are Dictated by Distinct Epigenetic Reprogramming

Adams, K. (2018) · ScholarsArchive (Brigham Young University)

Epigenetic regulation in trained and tolerized macrophages

Benjaskulluecha, S. (2022) · doi:10.58837/chula.the.2022.236

Single-cell RNA sequencing reveals induction of distinct trained-immunity programs in human monocytes

Zhang, B., Moorlag, S. J. C. F. M., Dominguez-Andres, J., Bulut, O. P., Kilic, G., Liu, Z., van Crevel, R., Xu, C.-J., Joosten, L. A. B., Netea, M. G., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci147719 · Cited by 111

Innate immune memory: The evolving role of macrophages in therapy

Damani‐Yokota, P., & Khanna, K. M. (2025) · eLife · doi:10.7554/elife.108276 · Cited by 22

Molecular and cellular bases of trained immunity

Sun, S. J., Aguirre‐Gamboa, R., & Barreiro, L. B. (2026) · Immunity · doi:10.1016/j.immuni.2026.03.001 · Cited by 18