Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity

Macrophage plasticity and polarization: in vivo veritas

Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335

Monocyte and macrophage heterogeneity

Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190

Macrophage biology in development, homeostasis and disease

Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684

Development of Monocytes, Macrophages, and Dendritic Cells

Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049

The accessible chromatin landscape of the human genome

Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679

Regulation and Function of NF-κB Transcription Factors in the Immune System

Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,635

Histone modifications at human enhancers reflect global cell-type-specific gene expression

Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature · doi:10.1038/nature07829 · Cited by 2,533

Transcriptional Profiling of the Human Monocyte-to-Macrophage Differentiation and Polarization: New Molecules and Patterns of Gene Expression

Martínez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,399

A unique chromatin signature uncovers early developmental enhancers in humans

Rada-Iglesias, A., Bajpai, R., Swigut, T., Brugmann, S. A., Flynn, R. A., & Wysocka, J. (2011) · Nature · doi:10.1038/nature09692 · Cited by 2,233

mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity

Cheng, S.-C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E. J., Martens, J. H. A., Rao, N. A., Aghajanirefah, A., et al. (2014) · Science · doi:10.1126/science.1250684 · Cited by 2,224

Review of BCG immunotherapy for bladder cancer

Liatsos, G. D., Mariolis, I., Hadziyannis, E. S., Bamias, A., & Vassilopoulos, D. (2025) · Clinical Microbiology Reviews · doi:10.1128/cmr.00194-23 · Cited by 40

Natural killer cell memory in context

Holmes, T. D., & Bryceson, Y. T. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.05.008 · Cited by 40

Antigenic Variation and Immune Escape in the MTBC

Ernst, J. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-64371-7_9 · Cited by 39

β-glucan administration induces metabolic changes and differential survival rates after bacterial or viral infection in turbot (Scophthalmus maximus)

Librán-Pérez, M., Costa, M. M., Figueras, A. J., & Novoa, B. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.08.005 · Cited by 41

Monocytes from neonates and adults have a similar capacity to adapt their cytokine production after previous exposure to BCG and β-glucan

Namakula, R., de Bree, L. C. J., Tvedt, T. H. A., Netea, M. G., Cose, S., & Hanevik, K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0229287 · Cited by 39

Clinical epigenetics and multidrug-resistant bacterial infections: host remodelling in critical illness

Crimi, E., Benincasa, G., Cirri, S., Mutesi, R., Faenza, M., & Claudio Napoli, A. (2020) · Epigenetics · doi:10.1080/15592294.2020.1748918 · Cited by 38

Cell Therapy With Mesenchymal Stem Cells Induces an Innate Immune Memory Response That Attenuates Experimental Colitis in the Long Term

López‐Santalla, M., Hervás-Salcedo, R., Fernández-García, M., Bueren, J. A., & Garin, M. I. (2020) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjaa079 · Cited by 38

17β-Estradiol Promotes Trained Immunity in Females Against Sepsis via Regulating Nucleus Translocation of RelB

Sun, Z., Pan, Y., Qu, J., Xu, Y., Dou, H., & Hou, Y. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01591 · Cited by 39

The Determinants of the Low COVID-19 Transmission and Mortality Rates in Africa: A Cross-Country Analysis

Bouba, Y., Tsinda, E. K., Fonkou, M. D. M., Mmbando, G. S., Bragazzi, N. L., & Kong, J. D. (2021) · Frontiers in Public Health · doi:10.3389/fpubh.2021.751197 · Cited by 38

Epigenetic adjuvants: durable reprogramming of the innate immune system with adjuvants

Lee, A. W. Q., Wimmers, F., & Pulendran, B. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.102189 · Cited by 36

Single-Cell Transcriptomic Analysis Reveals Neutrophil as Orchestrator during β-Glucan–Induced Trained Immunity in a Teleost Fish

Mu, D., Yang, J., Jiang, Y. J., Wang, Z., Chen, W., Huang, J., Zhang, Y., Liu, Q., & Yang, D. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2200225 · Cited by 38

Shifting the Immune Memory Paradigm: Trained Immunity in Viral Infections

Taks, E., Moorlag, S. J. C. F. M., Netea, M. G., & van der Meer, J. W. M. (2022) · Annual Review of Virology · doi:10.1146/annurev-virology-091919-072546 · Cited by 38

Trained immunity inducers in cancer immunotherapy

Sui, Y., & Berzofsky, J. A. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1427443 · Cited by 41

TCA metabolism regulates DNA hypermethylation in LPS and Mycobacterium tuberculosis –induced immune tolerance

Abhimanyu, A., Longlax, S. C., Nishiguchi, T., Ladki, M., Sheikh, D., Martinez, A. L., Mace, E. M., Grimm, S. L., Caldwell, T., Portillo, A., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2404841121 · Cited by 37

Treatment options for chronic mucocutaneous candidiasis

van de Veerdonk, F. L., & Netea, M. G. (2016) · Journal of Infection · doi:10.1016/j.jinf.2016.04.023 · Cited by 37

Trained innate immunity: a salient factor in the pathogenesis of neuroimmune psychiatric disorders

Salam, A. P., Borsini, A., & Zunszain, P. A. (2017) · Molecular Psychiatry · doi:10.1038/mp.2017.186 · Cited by 39

Trained immunity and diabetic vascular disease

Thiem, K., Stienstra, R., Riksen, N. P., & Keating, S. T. (2019) · Clinical Science · doi:10.1042/cs20180905 · Cited by 37

Is Innate Memory a Double-Edge Sword in Alzheimer's Disease? A Reappraisal of New Concepts and Old Data

Salani, F., Sterbini, V., Sacchinelli, E., Garramone, M., & Bossù, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01768 · Cited by 37

Fibronectin-functionalization of 3D collagen networks supports immune tolerance and inflammation suppression in human monocyte-derived macrophages

Logie, C., van Schaik, T., Pompe, T., & Pietsch, K. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120498 · Cited by 36

An exposomic framework to uncover environmental drivers of aging

Kalia, V., Belsky, D. W., Baccarelli, A., & Miller, G. W. (2022) · Exposome · doi:10.1093/exposome/osac002 · Cited by 39

Extensive epigenomic integration of the glucocorticoid response in primary human monocytes and in vitro derived macrophages

Wang, C., Nanni, L., Novakovic, B., Megchelenbrink, W., Kuznetsova, T., Stunnenberg, H. G., Ceri, S., & Logie, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-39395-9 · Cited by 38

β-glucans from Agaricus bisporus mushroom products drive Trained Immunity

Case, S., O'Brien, T., Ledwith, A. E., Chen, S., Johnston, C. J. H. H., Hackett, E. E., O'Sullivan, M., Charles‐Messance, H., Dempsey, E., Yadav, S., et al. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1346706 · Cited by 37

DAMP-driven trained immunity: metabolic and epigenetic reprogramming in critical illness and chronic inflammation

Kim, H. S., Rincon, J. C., Efron, P. A., & Maile, R. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1669054 · Cited by 40

Macrophage adaptation in airway inflammatory resolution

Kaur, M., Bell, T., Salek‐Ardakani, S., & Hussell, T. (2015) · European Respiratory Review · doi:10.1183/16000617.0030-2015 · Cited by 38

Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing

Lin, J. J., Hu, Y., Núñez, S., Foulkes, A. S., Cieply, B. W., Xue, C., Gerelus, M., Li, W., Zhang, H., Rader, D. J., et al. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307573 · Cited by 41

Induction of Trained Innate Immunity in Human Monocytes by Bovine Milk and Milk-Derived Immunoglobulin G

van Splunter, M. E., van Osch, T. L. J., Brugman, S., Savelkoul, H. F. J., Joosten, L. A. B., Netea, M. G., & van Neerven, R. J. J. (2018) · Nutrients · doi:10.3390/nu10101378 · Cited by 36

Mucosal vaccine efficacy against intrarectal SHIV is independent of anti-Env antibody response

Sui, Y., Lewis, G. K., Wang, Y., Berckmueller, K., Frey, B. F., Dzutsev, A. H., Vargas‐Inchaustegui, D. A., Mohanram, V., Musich, T., Shen, X., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci122110 · Cited by 35

Oral administration of Debaryomyces hansenii CBS8339-β-glucan induces trained immunity in newborn goats

Angulo, M., Reyes‐Becerril, M., Cepeda-Palacios, R., & Angulo, C. (2019) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2019.103597 · Cited by 36

Emerging technologies for systems vaccinology — multi-omics integration and single-cell (epi)genomic profiling

Wimmers, F., & Pulendran, B. (2020) · Current Opinion in Immunology · doi:10.1016/j.coi.2020.05.001 · Cited by 37

Exposome and Immunity Training: How Pathogen Exposure Order Influences Innate Immune Cell Lineage Commitment and Function

Adams, K., Weber, K. S., & Johnson, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228462 · Cited by 37

Diabetes and Metabolic Drivers of Trained Immunity

Choudhury, R. P., Edgar, L., Rydén, M., & Fisher, E. A. A. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314211 · Cited by 37

Immunological effector mechanisms in HIV-1 elite controllers

Hartana, C. A., & Yu, X. G. (2021) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000693 · Cited by 36

LPS Induces Opposing Memory-like Inflammatory Responses in Mouse Bone Marrow Neutrophils

Lajqi, T., Braun, M., Kranig, S. A., Frommhold, D., Pöschl, J. M. B., & Hudalla, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22189803 · Cited by 38

Single-Cell Sequencing of Immune Cells in Human Aortic Dissection Tissue Provides Insights Into Immune Cell Heterogeneity

Liu, Y., Zou, L., Tang, H., Li, J., Liu, H., Jiang, X., Jiang, B., Dong, Z., & Fu, W. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.791875 · Cited by 36

Deciphering the Molecular Signature of Human Hyalocytes in Relation to Other Innate Immune Cell Populations

Wolf, J., Boneva, S., Rosmus, D.-D., Agostini, H. T., Schlunck, G., Wieghofer, P., Schlecht, A., & Lange, C. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.3.9 · Cited by 36

Epigenomic analysis reveals a dynamic and context-specific macrophage enhancer landscape associated with innate immune activation and tolerance

Zhang, P., Amarasinghe, H. E., Whalley, J. P., Tay, C., Fang, H., Migliorini, G., Brown, A., Allcock, A., Scozzafava, G., Rath, P., et al. (2022) · Genome biology · doi:10.1186/s13059-022-02702-1 · Cited by 37

The evolution of our understanding of macrophages and translation of findings toward the clinic

Martínez, F. O., & Gordon, S. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2015.985658 · Cited by 43

An Integrated Platform for Genome-wide Mapping of Chromatin States Using High-throughput ChIP-sequencing in Tumor Tissues

Terranova, C. J., Tang, M., Orouji, E., Maitituoheti, M., Raman, A. T., Amin, S. B., Liu, Z., & Rai, K. (2018) · Journal of Visualized Experiments · doi:10.3791/56972 · Cited by 38

Nontuberculous Mycobacteria and Heterologous Immunity to Tuberculosis

Shah, J. A., Arlehamn, C. S. L., Horne, D. J. D. L., Sette, A., & Hawn, T. R. (2019) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiz285 · Cited by 35

Comparative transcriptome analysis reveals the mechanism of β-glucan in protecting rainbow trout (Oncorhynchus mykiss) from Aeromonas salmonicida infection

Ji, L., Sun, G., Li, X., & Liu, Y. (2019) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2019.12.022 · Cited by 35

Training of Primary Chicken Monocytes Results in Enhanced Pro-Inflammatory Responses

Verwoolde, M. B., van den Biggelaar, R. H. G. A., van Baal, J., Jansen, C. A., & Lammers, A. (2020) · Veterinary Sciences · doi:10.3390/vetsci7030115 · Cited by 36

Immunometabolism in fungal infections: the need to eat to compete

Weerasinghe, H., & Traven, A. (2020) · Current Opinion in Microbiology · doi:10.1016/j.mib.2020.07.001 · Cited by 36

M1/M2 polarization in major depressive disorder: Disentangling state from trait effects in an individualized cell-culture-based approach

Cosma, N. C., Üsekes, B., Otto, L. R., Gerike, S., Heuser, I., Regen, F., & Hellmann‐Regen, J. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.02.009 · Cited by 37

Microbial colonization induces histone acetylation critical for inherited gut-germline-neural signaling

Hong, C., Lalsiamthara, J., Ren, J., Sang, Y., & Aballay, A. (2021) · PLoS Biology · doi:10.1371/journal.pbio.3001169 · Cited by 32

IFN-γ-dependent epigenetic regulation instructs colitogenic monocyte/macrophage lineage differentiation in vivo

Nakanishi, Y., Sato, T., Takahashi, K., & Ohteki, T. (2018) · Mucosal Immunology · doi:10.1038/mi.2017.104 · Cited by 35

Screening of compounds to identify novel epigenetic regulatory factors that affect innate immune memory in macrophages

Benjaskulluecha, S., Boonmee, A., Pattarakankul, T., Wongprom, B., Klomsing, J., & Palaga, T. (2022) · Scientific Reports · doi:10.1038/s41598-022-05929-x · Cited by 34

MicroRNA mediated regulation of immunity against gram-negative bacteria

Keck, J., Gupta, R., Christenson, L. K., & Arulanandam, B. P. (2017) · International Reviews of Immunology · doi:10.1080/08830185.2017.1347649 · Cited by 34

Early-life peripheral infections reprogram retinal microglia and aggravate neovascular age-related macular degeneration in later life

Hata, M., Hata, M., Andriessen, E. M. M. A., Juneau, R., Pilon, F., Crespo‐Garcia, S., Diaz-Marin, R., Guber, V., Binet, F., Fournier, F., et al. (2023) · Journal of Clinical Investigation · doi:10.1172/jci159757 · Cited by 35

Proinflammatory polarization of monocytes by particulate air pollutants is mediated by induction of trained immunity in pediatric asthma

Movassagh, H., Prunicki, M. M., Kaushik, A., Zhou, X., Dunham, D., Smith, E. M., He, Z., Muench, G. R. A., Shi, M., Weimer, A. K. K., et al. (2023) · Allergy · doi:10.1111/all.15692 · Cited by 34

Irreversible electroporation augments β-glucan induced trained innate immunity for the treatment of pancreatic ductal adenocarcinoma

Woeste, M. R., Shrestha, R., Geller, A. E., Li, S., Montoya-Durango, D. E., Ding, C., Hu, X., Li, H., Puckett, A. H., Mitchell, R. A., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-006221 · Cited by 32

Trained immunity-inducing vaccines: Harnessing innate memory for vaccine design and delivery

Baydemir, İ., Dulfer, E. A., Netea, M. G., & Domínguez‐Andrés, J. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.109930 · Cited by 37

Reprogramming mitochondrial metabolism and epigenetics of macrophages via miR-10a liposomes for atherosclerosis therapy

Fang, F., Wang, E., Yang, H., Zhao, T., Wang, Q., Zhang, Z., Song, Y., & Liu, X. (2025) · Nature Communications · doi:10.1038/s41467-025-64201-8 · Cited by 34

Induction of Innate Immune Memory by Engineered Nanoparticles: A Hypothesis That May Become True

Italiani, P., & Boraschi, D. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00734 · Cited by 34

Fungal mediated innate immune memory, what have we learned?

Quintin, J. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.05.023 · Cited by 34

Immuno-Modulation of Hematopoietic Stem and Progenitor Cells in Inflammation

Sezaki, M., Hayashi, Y., Wang, Y., Johansson, A., Umemoto, T., & Takizawa, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.585367 · Cited by 38

Deficiency of histone lysine methyltransferase SETDB2 in hematopoietic cells promotes vascular inflammation and accelerates atherosclerosis

Zhang, X., Sun, J., Canfrán‐Duque, A., Aryal, B. K., Tellides, G., Chang, Y. J., Suárez, Y., Osborne, T. F., & Fernandez-Hernando, C. F. (2021) · JCI Insight · doi:10.1172/jci.insight.147984 · Cited by 34

Macrophages

Mallat, Z. (2014) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.114.304794 · Cited by 34

'Trained immunity: consequences for lymphoid malignancies

Stevens, W. B. C., Netea, M. G., Kater, A. P., & van der Velden, W. J. F. M. (2016) · Haematologica · doi:10.3324/haematol.2016.149252 · Cited by 34

Developing Novel Host-Based Therapies Targeting Microbicidal Responses in Macrophages and Neutrophils to Combat Bacterial Antimicrobial Resistance

Watson, K., Russell, C. D., Baillie, J. K., Dhaliwal, K., Fitzgerald, J. R., Mitchell, T. J., Simpson, A. J., Renshaw, S. A., & Dockrell, D. H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00786 · Cited by 33

Impact of Immunity on Coronary Artery Disease: An Updated Pathogenic Interplay and Potential Therapeutic Strategies

Laera, N., Malerba, P., Vacanti, G., Nardin, S., Pagnesi, M., & Nardin, M. (2023) · Life · doi:10.3390/life13112128 · Cited by 34

Processing stimulus dynamics by the NF-κB network in single cells

Son, M., Wang, A. G., Keisham, B., & Tay, S. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01133-7 · Cited by 31

Polysaccharide of Asparagus cochinchinensis (Lour.) Merr regulates macrophage immune response and epigenetic memory through TLR4-JNK/p38/ERK signaling pathway and histone modification

Xie, X., Tang, M., Yi, S., He, Y., Chen, S., Zhao, Y., Chen, Q., Cao, M., Yu, M., Wei, Y., et al. (2023) · Phytomedicine · doi:10.1016/j.phymed.2023.155294 · Cited by 33

Epigenetic and metabolic regulation of macrophage responsiveness and memory

Daskalaki, M., Lapi, I., Hurst, A. E., Al-Qahtani, A. A., Vergadi, E., & Tsatsanis, C. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf135 · Cited by 39

Trained Innate Immunity Not Always Amicable

Włodarczyk, M., Druszczyńska, M., & Fol, M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20102565 · Cited by 34

DNA Methylation Analysis to Unravel Altered Genetic Pathways Underlying Early Onset and Late Onset Neonatal Sepsis. A Pilot Study

Lorente-Pozo, S., Navarrete, P., Garzón, M. J., Lara‐Cantón, I., Beltrán-García, J., Osca-Verdegal, R., Mena, S., García-López, E., Vento, M., Pallardó, F. V., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.622599 · Cited by 33

Integration of transcriptional and metabolic control in macrophage activation

Natoli, G., Pileri, F., Gualdrini, F., & Ghisletti, S. (2021) · EMBO Reports · doi:10.15252/embr.202153251 · Cited by 33

Train the Trainer: Hematopoietic Stem Cell Control of Trained Immunity

Zuani, M. D., & Frič, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.827250 · Cited by 35

Blood Count-Derived Inflammatory Markers and Acute Complications of Ischemic Heart Disease in Elderly Women

Dziedzic, E. A., Gąsior, J. S., Tuzimek, A., & Kochman, W. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12041369 · Cited by 35

Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages

Bencheikh, L., Diop, M. K., Rivière, J., Imanci, A., Pierron, G., Souquère, S., Naimo, A., Morabito, M., Dussiot, M., Leeuw, F. D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09970-9 · Cited by 34

Gut commensal Limosilactobacillus reuteri induces atypical memory-like phenotype in human dendritic cells in vitro

Lasaviciute, G., Barz, M., van der Heiden, M., Arasa, C., Tariq, K., Quin, J. E., Farrants, A. Ö., & Sverremark‐Ekström, E. (2022) · Gut Microbes · doi:10.1080/19490976.2022.2045046 · Cited by 32

Cardiac macrophage metabolism in health and disease

Kopecky, B. J., & Lavine, K. J. (2023) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2023.10.011 · Cited by 35

Innate Immune Training Initiates Efferocytosis to Protect against Lung Injury

Kang, Y., Kim, D., Lee, S., Kim, H., Kim, T.-B., Cho, J. A., Lee, T., & Choi, E. Y. (2024) · Advanced Science · doi:10.1002/advs.202308978 · Cited by 36

Persistent epigenetic memory of SARS-CoV-2 mRNA vaccination in monocyte-derived macrophages

Simonis, A., Theobald, S. J., Koch, A. E., Mummadavarapu, R., Mudler, J. M., Pouikli, A., Göbel, U., Acton, R., Winter, S., Albus, A., et al. (2025) · Molecular Systems Biology · doi:10.1038/s44320-025-00093-6 · Cited by 34

Epigenetic Regulation of Dendritic Cell Development and Function

Tian, Y., Meng, L., & Zhang, Y. (2017) · The Cancer Journal · doi:10.1097/ppo.0000000000000280 · Cited by 33

Bromodomain inhibitor I‐BET151 suppresses immune responses during fungal–immune interaction

Domínguez‐Andrés, J., Ferreira, A. V., Jansen, T., Smithers, N. N., Prinjha, R. K., Furze, R. C., & Netea, M. G. (2019) · European Journal of Immunology · doi:10.1002/eji.201848081 · Cited by 33

Associations between Monocyte and T Cell Cytokine Profiles in Autism Spectrum Disorders: Effects of Dysregulated Innate Immune Responses on Adaptive Responses to Recall Antigens in a Subset of ASD Children

Jyonouchi, H., & Geng, L. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194731 · Cited by 33

BCG-induced trained immunity in macrophage: reprograming of glucose metabolism

Liu, Y., Liang, S., Ding, R., Hou, Y., Deng, F., Ma, X., Song, T., & Yan, D. (2020) · International Reviews of Immunology · doi:10.1080/08830185.2020.1712379 · Cited by 32

Does the Gut Microbiota Modulate Host Physiology through Polymicrobial Biofilms?

Yang, J., Yang, Y., Ishii, M., Nagata, M., Aw, W., Obana, N., Tomita, M., Nomura, N., & Fukuda, S. (2020) · Microbes and Environments · doi:10.1264/jsme2.me20037 · Cited by 33

Subconjunctival Injection of Regulatory T Cells Potentiates Corneal Healing Via Orchestrating Inflammation and Tissue Repair After Acute Alkali Burn

Yan, D., Yu, F., Chen, L., Yao, Q., Yan, C., Zhang, S., Wu, N., Gong, D., Sun, H., Fu, Y., et al. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.14.22 · Cited by 32

PAQR11 modulates monocyte‐to‐macrophage differentiation and pathogenesis of rheumatoid arthritis

Lin, Y., Huang, M., Wang, S., You, X., Zhang, L., & Chen, Y. (2021) · Immunology · doi:10.1111/imm.13303 · Cited by 32

Epigenome-wide analysis of long-term air pollution exposure and DNA methylation in monocytes: results from the Multi-Ethnic Study of Atherosclerosis

Chi, G. C., Liu, Y., MacDonald, J. W., Reynolds, L. M., Enquobahrie, D. A., Fitzpatrick, A. L., Kerr, K. F., Budoff, M. J., Lee, S., Siscovick, D. S., et al. (2021) · Epigenetics · doi:10.1080/15592294.2021.1900028 · Cited by 33

Immune modulatory effects of progesterone on oxLDL-induced trained immunity in monocytes

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Fuchs, T., Püellmann, K., Emmert, A., Fleig, J., Oniga, S., Laird, R., Heida, N.-M., Schäfer, K., Neumaier, M., Beham, A. W., et al. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.11.034 · Cited by 31

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