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Epigenetic programming of monocyte-to-macrophage differentiation and trained innate immunity
Open accessAbstract
Monocyte differentiation into macrophages represents a cornerstone process for host defense. Concomitantly, immunological imprinting of either tolerance or trained immunity determines the functional fate of macrophages and susceptibility to secondary infections. We characterized the transcriptomes and epigenomes in four primary cell types: monocytes and in vitro-differentiated naïve, tolerized, and trained macrophages. Inflammatory and metabolic pathways were modulated in macrophages, including decreased inflammasome activation, and we identified pathways functionally implicated in trained immunity. β-glucan training elicits an exclusive epigenetic signature, revealing a complex network of enhancers and promoters. Analysis of transcription factor motifs in deoxyribonuclease I hypersensitive sites at cell-type-specific epigenetic loci unveiled differentiation and treatment-specific repertoires. Altogether, we provide a resource to understand the epigenetic changes that underlie innate immunity in humans.
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“The same modifications of histone 3 were present in immune relevant gene locations in myeloid cells of humans and mice after induction of trained immunity [8,9,40].”
From Trained Immunity Provides Long-Term Protection against Bacterial Infections in Channel Catfish (2022) · cites this paper as [9]
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“Beta glucan exposure can induce these modifications in mammals, via the dectin-1 receptor [7,8,9].”
From Trained Immunity Provides Long-Term Protection against Bacterial Infections in Channel Catfish (2022) · cites this paper as [9]
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“Trained immunity in mice results from epigenetic reprogramming of monocytes and macrophages through acetylation or methylation of specific lysines in the histone-H3 [8,9].”
From Trained Immunity Provides Long-Term Protection against Bacterial Infections in Channel Catfish (2022) · cites this paper as [9]
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“PCA of our human microglial and published monocyte and macrophage data 30 indicated that these three data sets segregated and that microglia were the most distinct ( Supplementary Figure 1a ).”
From Transcriptomic analysis of purified human cortical microglia reveals age-associated changes (2017) · cites this paper as [30]
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Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
Macrophage biology in development, homeostasis and disease
Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049
The accessible chromatin landscape of the human genome
Thurman, R. E., Rynes, E., Humbert, R., Vierstra, J., Maurano, M. T., Haugen, E., Sheffield, N. C., Stergachis, A. B., Wang, H., Vernot, B., et al. (2012) · Nature · doi:10.1038/nature11232 · Cited by 2,679
Regulation and Function of NF-κB Transcription Factors in the Immune System
Vallabhapurapu, S., & Karin, M. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132641 · Cited by 2,635
Histone modifications at human enhancers reflect global cell-type-specific gene expression
Heintzman, N. D., Hon, G. C., Hawkins, R. D., Kheradpour, P., Stark, A., Harp, L. F., Ye, Z., Lee, L. K., Stuart, R. K., Ching, C. W., et al. (2009) · Nature · doi:10.1038/nature07829 · Cited by 2,533
Martínez, F. O., Gordon, S., Locati, M., & Mantovani, A. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.10.7303 · Cited by 2,399
A unique chromatin signature uncovers early developmental enhancers in humans
Rada-Iglesias, A., Bajpai, R., Swigut, T., Brugmann, S. A., Flynn, R. A., & Wysocka, J. (2011) · Nature · doi:10.1038/nature09692 · Cited by 2,233
mTOR- and HIF-1α–mediated aerobic glycolysis as metabolic basis for trained immunity
Cheng, S.-C., Quintin, J., Cramer, R. A., Shepardson, K. M., Saeed, S., Kumar, V., Giamarellos-Bourboulis, E. J., Martens, J. H. A., Rao, N. A., Aghajanirefah, A., et al. (2014) · Science · doi:10.1126/science.1250684 · Cited by 2,224
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Items 401–500 of 1,003
Burton, M. J., Rajak, S. N., Hu, V. H., Ramadhani, A. M., Habtamu, E., Massae, P., Tadesse, Z., Callahan, K., Emerson, P. M., Khaw, P. T., et al. (2015) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0003763 · Cited by 68
New Insights Into Tissue Macrophages: From Their Origin to the Development of Memory
Italiani, P., & Boraschi, D. (2015) · Immune Network · doi:10.4110/in.2015.15.4.167 · Cited by 68
Borriello, F., Iannone, R., Somma, S. D., Loffredo, S., Scamardella, E., Galdiero, M. R., Varricchi, G., Granata, F., Portella, G., & Marone, G. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00680 · Cited by 67
Innate allorecognition by monocytic cells and its role in graft rejection
Lakkis, F. G., & Li, X. C. (2017) · American Journal of Transplantation · doi:10.1111/ajt.14436 · Cited by 64
Binnie, A., Walsh, C. J., Hu, P., Dwivedi, D. J., Fox‐Robichaud, A., Liaw, P. C., Tsang, J. L. Y., Batt, J. A. E., Carrasqueiro, G., Gupta, S., et al. (2019) · Critical Care Medicine · doi:10.1097/ccm.0000000000004097 · Cited by 65
HIV and cardiovascular disease: the role of inflammation
Dirajlal‐Fargo, S., & Funderburg, N. (2022) · Current Opinion in HIV and AIDS · doi:10.1097/coh.0000000000000755 · Cited by 65
The Epigenetic Memory of Monocytes and Macrophages as a Novel Drug Target in Atherosclerosis
Bekkering, S., Joosten, L. A. B., van der Meer, J. W. M., Netea, M. G., & Riksen, N. P. (2015) · Clinical Therapeutics · doi:10.1016/j.clinthera.2015.01.008 · Cited by 65
Self-citationAerosol vaccination with Bacille Calmette-Guerin induces a trained innate immune phenotype in calves
Guerra-Maupome, M., Vang, D. X., & McGill, J. L. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212751 · Cited by 65
Seufert, A. L., Hickman, J. W., Traxler, S. K., Peterson, R. M., Waugh, T. A., Lashley, S. J., Shulzhenko, N., Napier, R. J., & Napier, B. A. (2022) · eLife · doi:10.7554/elife.76744 · Cited by 72
Huang, M., Malovic, E., Ealy, A., Jin, H., Anantharam, V., Kanthasamy, A., & Kanthasamy, A. G. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1052925 · Cited by 64
Metabolism and acetylation in innate immune cell function and fate
Cameron, A. M., Lawless, S. J., & Pearce, E. J. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.10.003 · Cited by 65
Innate Immunomodulation in Food Animals: Evidence for Trained Immunity?
Byrne, K. A., Loving, C. L., & McGill, J. L. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01099 · Cited by 65
Hajishengallis, G., Li, X., Divaris, K., & Chavakis, T. (2022) · Periodontology 2000 · doi:10.1111/prd.12421 · Cited by 70
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Yamaguchi, Y., Kato, Y., Edahiro, R., Søndergaard, J. N., Murakami, T., Amiya, S., Nameki, S., Yoshimine, Y., Morita, T., Takeshima, Y., et al. (2022) · JCI Insight · doi:10.1172/jci.insight.163347 · Cited by 65
Zhang, Z., Shi, L., Dawany, N. B., Kelsen, J. R., Petri, M., & Sullivan, K. E. (2016) · Clinical Epigenetics · doi:10.1186/s13148-016-0179-4 · Cited by 64
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Duan, M., Hibbs, M. L., & Chen, W. (2016) · Immunology and Cell Biology · doi:10.1038/icb.2016.97 · Cited by 64
Fan, Y., Cui, L., Peng, X., Jiang, N., Hu, L., Gu, L., Zhu, G., Zhao, G., & Lin, J. (2020) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.61.6.51 · Cited by 63
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Boneva, S., Wolf, J., Rosmus, D.-D., Schlecht, A., Prinz, G., Laich, Y., Boeck, M., Zhang, P., Hilgendorf, I., Stahl, A., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.567274 · Cited by 62
Booth, D. R., Ding, N., Parnell, G. P., Shahijanian, F., Coulter, S., Schibeci, S. D., Atkins, A. R., Stewart, G. J., Evans, R. M., Downes, M., et al. (2016) · Genes and Immunity · doi:10.1038/gene.2016.12 · Cited by 62
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Traven, A., & Naderer, T. (2019) · EMBO Reports · doi:10.15252/embr.201947995 · Cited by 60
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Raşid, O., Chevalier, C., Camarasa, T., Fitting, C., Cavaillon, J., & Hamon, M. A. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.043 · Cited by 67
Bakker, N. V. T., & Pearce, E. J. (2020) · Immunological Reviews · doi:10.1111/imr.12848 · Cited by 62
Mahmoud, A. H., Slate, J. R., Hong, S., Yoon, I., & McGill, J. L. (2020) · Journal of Animal Science · doi:10.1093/jas/skaa252 · Cited by 63
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Govers, C., Calder, P. C., Savelkoul, H. F. J., Albers, R., & van Neerven, R. J. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.841532 · Cited by 71
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Ma, W.-Y., Wu, Q.-L., Wang, S., Wang, H., Ye, J.-R., Sun, H., Feng, Z., He, W., Chu, S., Zhang, Z., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02779-w · Cited by 62
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Noe, J. T., & Mitchell, R. A. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ru1218-496r · Cited by 63
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Horneck Johnston, C. J. H., Ledwith, A. E., Lundahl, M. L. E., Charles-Messance, H., Hackett, E. E., O’Shaughnessy, S. D., Clegg, J., Prendeville, H., McGrath, J. P., Walsh, A. M., et al. (2024) · iScience · doi:10.1016/j.isci.2024.109030 · Cited by 67
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Gupta, S., Jain, A., Syed, S. N., Snodgrass, R. G., Pflüger‐Müller, B., Leisegang, M. S., Weigert, A., Brandes, R. P., Ebersberger, I., Brüne, B., et al. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1494110 · Cited by 59
Li, K., Zhang, Y., Liu, X., Liu, Y., Gu, Z., Cao, H., Dickerson, K. E., Chen, M., Chen, W., Shao, Z., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1128 · Cited by 61
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Heng, Y., Zhang, X., Borggrewe, M., van Weering, H. R. J., Brummer, M. L., Nijboer, T. W., Joosten, L. A. B., Netea, M. G., Boddeke, E., Laman, J. D., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02103-4 · Cited by 61
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Leonhardt, J., Größe, S., Marx, C., Siwczak, F., Stengel, S., Bruns, T., Bauer, R., Kiehntopf, M., Williams, D. L., Wang, Z., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02818 · Cited by 59
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Self-citationZhang, L., Fu, Y., Wang, H., Guan, Y., Zhu, W., Guo, M., Zheng, N., & Wu, Z. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01095 · Cited by 59
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Riera-Borrull, M., Cuevas, V. D., Alonso, B., Vega, M. A., Joven, J., Izquierdo, E., & Corbí, A. L. (2017) · The Journal of Immunology · doi:10.4049/jimmunol.1700845 · Cited by 64
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Chen, C., Wang, Z., & Qin, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.935536 · Cited by 62
Shi, R., Wang, J., Zhang, Z., Leng, Y., & Chen, A. F. (2023) · Life Sciences · doi:10.1016/j.lfs.2022.121339 · Cited by 57
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Gao, C., Dong, H., Li, T., & Gao, X. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00037 · Cited by 57
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Ohl, K., Fragoulis, A., Klemm, P., Baumeister, J., Klock, W., Verjans, E., Böll, S., Möllmann, J., Lehrke, M., Costa, I. G., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01552 · Cited by 56
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Moorlag, S. J. C. F. M., Matzaraki, V., van Puffelen, J. H., van der Heijden, C. D. C. C., Keating, S., Groh, L. A., Röring, R. J., Bakker, O. B., Mourits, V. P., Koeken, V. A. C. M., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202149577 · Cited by 56
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Cox, D. J., Coleman, A. M., Gogan, K. M., Phelan, J. J., Maoldomhnaigh, C. Ó., Dunne, P. J., Basdeo, S. A., & Keane, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01609 · Cited by 53
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Metadata
- Authors
- Saeed, S., Quintin, J., Kerstens, H. H. D., Rao, N. A., Aghajanirefah, A., Matarese, F., Cheng, S.-C., Ratter, J., Berentsen, K., van der Ent, M. A., Sharifi, N., Janssen-Megens, E. M., Ter Huurne, M., Mandoli, A., van Schaik, T., Ng, A., Burden, F., Downes, K., Frontini, M., Kumar, V., Giamarellos-Bourboulis, E. J., Ouwehand, W. H., van der Meer, J. W. M., Joosten, L. A. B., Wijmenga, C., Martens, J. H. A., Xavier, R. J., Logie, C., Netea, M. G., & Stunnenberg, H. G.
- Affiliations
- Radboud University Nijmegen (NL)
- Radboud University Medical Center (NL)
- Department of Molecular Biology, Faculties of Science and Medicine, Radboud Institute for Molecular Life Sciences, Radboud University, 6500 HB Nijmegen, Netherlands.
- Broad Institute (US)
- National Health Service (GB)
- University Medical Center Groningen (NL)
- Fourth Department of Internal Medicine, University of Athens, Medical School, 1 Rimini Street, 12462 Athens, Greece.
- Department of Internal Medicine, Radboud University Medical Center, 6525 GA Nijmegen, Netherlands.
- Corresponding author
- Saeed, Sadia
- Quintin, Jessica
- Kerstens, Hindrik H. D.
- Rao, Nagesha A.
- Aghajanirefah, Ali
- Logie, Colin
- Netea, Mihai G.
- Stunnenberg, Hendrik G.
- ORCID
- Venue
- Science
- Published
- 2014-09-26
- Volume
- 345
- Issue
- 6204
- Pages
- 1251086-1251086
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC4242194
- OpenAlex
- W2140876277
- Cited by
- 1,761
- References
- 70
- Citations by year
- 2026: 197 · 2025: 162 · 2024: 143 · 2023: 150 · 2022: 174 · 2021: 184 · 2020: 168 · 2019: 134 · 2018: 129 · 2017: 114 · 2016: 120 · 2015: 76 · 2014: 9
- FWCI
- 48.54
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- National Institute for Health and Care Research (NF-SI-0510-10214, RP-PG-0310-1002, NF-SI-0513-10151)
- British Heart Foundation (RG/09/012/28096)
- National Institute of Diabetes and Digestive and Kidney Diseases (P30DK043351)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Keywords
- monocyte-to-macrophage differentiation, trained immunity, immunological imprinting, epigenetic programming, macrophage transcriptome, inflammasome activation, transcription factor binding motifs, innate immunity
- MeSH terms
- Animals, Binding Sites, Cell Differentiation, Deoxyribonuclease I, Humans, Immunity, Innate, Immunologic Memory, Macrophages, Monocytes, Transcription Factors, Genomic Imprinting, Epigenesis, Genetic, beta-Glucans, Mice, Inflammasomes
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