Cited by 431Nuclear Structure and FunctionDNA Repair MechanismsSkin and Cellular Biology Research

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Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

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Larrieu, Delphine, Britton, Sébastien, Demir, Mukerrem, Rodriguez, Raphaël, Jackson, Stephen P.·2014·Science

DOI 10.1126/science.1252651PMC PMC4246063

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Abstract

Remodelin Nuclear Defects: Deregulation of A-type lamin proteins leads to disorganization of chromatin structure and misshapen nuclei, which are believed to underlie the pathologies of various human diseases, including the premature aging disorder Hutchinson Gilford progeria syndrome (HGPS) and various cancers. Larrieu et al. (p. 527 ) developed a small molecule, Remodelin, that not only improved nuclear shape defects of human lamin A/C–depleted cells, HGPS cells, and aged normal cells, but also decreased the levels of a DNA damage marker and improved global cellular fitness.

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Additional file 1 of Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
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Additional file 2 of Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression
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Additional file 2 of Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
Jin, C., Wang, T., Zhang, D., Yang, P., Zhang, C., Peng, W., Jin, K., Wang, L., Zhou, J., Peng, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22612090
Additional file 5 of Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
Jin, C., Wang, T., Zhang, D., Yang, P., Zhang, C., Peng, W., Jin, K., Wang, L., Zhou, J., Peng, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22612099
Additional file 3 of Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
Jin, C., Wang, T., Zhang, D., Yang, P., Zhang, C., Peng, W., Jin, K., Wang, L., Zhou, J., Peng, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22612093
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Zhou, H.-Q., Zhu, Z., Zhang, J.-W., Lin, W.-P., Jin, H.-J., Ding, Y.-Y., Liu, S., & Yin, D. (2025) · eLife · doi:10.7554/elife.108995.1
Additional file 6 of Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
Jin, C., Wang, T., Zhang, D., Yang, P., Zhang, C., Peng, W., Jin, K., Wang, L., Zhou, J., Peng, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22612102
Additional file 4 of Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
Jin, C., Wang, T., Zhang, D., Yang, P., Zhang, C., Peng, W., Jin, K., Wang, L., Zhou, J., Peng, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22612096
Additional file 7 of Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
Jin, C., Wang, T., Zhang, D., Yang, P., Zhang, C., Peng, W., Jin, K., Wang, L., Zhou, J., Peng, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22612105
Additional file 11 of Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
Jin, C., Wang, T., Zhang, D., Yang, P., Zhang, C., Peng, W., Jin, K., Wang, L., Zhou, J., Peng, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22612117
Additional file 10 of Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
Jin, C., Wang, T., Zhang, D., Yang, P., Zhang, C., Peng, W., Jin, K., Wang, L., Zhou, J., Peng, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22612114
Additional file 3 of NAT10 as a potential prognostic biomarker and therapeutic target for HNSCC
Tao, W., Tian, G., Xu, S., Li, J., Zhang, Z., & Li, J. (2021) · Figshare · doi:10.6084/m9.figshare.15128579
Additional file 12 of Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
Jin, C., Wang, T., Zhang, D., Yang, P., Zhang, C., Peng, W., Jin, K., Wang, L., Zhou, J., Peng, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22612120
Additional file 2 of Poly(ADP-ribosyl)ation of acetyltransferase NAT10 by PARP1 is required for its nucleoplasmic translocation and function in response to DNA damage
Liu, H.-Y., Liu, Y.-Y., Zhang, Y.-L., Ning, Y., Zhang, F.-L., & Li, D.-Q. (2022) · Figshare · doi:10.6084/m9.figshare.20521380
Additional file 9 of Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
Jin, C., Wang, T., Zhang, D., Yang, P., Zhang, C., Peng, W., Jin, K., Wang, L., Zhou, J., Peng, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22612111
Additional file 13 of Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
Jin, C., Wang, T., Zhang, D., Yang, P., Zhang, C., Peng, W., Jin, K., Wang, L., Zhou, J., Peng, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22612123
Additional file 2 of NAT10 as a potential prognostic biomarker and therapeutic target for HNSCC
Tao, W., Tian, G., Xu, S., Li, J., Zhang, Z., & Li, J. (2021) · Figshare · doi:10.6084/m9.figshare.15128576
Additional file 8 of Acetyltransferase NAT10 regulates the Wnt/β-catenin signaling pathway to promote colorectal cancer progression via ac4C acetylation of KIF23 mRNA
Jin, C., Wang, T., Zhang, D., Yang, P., Zhang, C., Peng, W., Jin, K., Wang, L., Zhou, J., Peng, C., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22612108
Additional file 1 of NAT10 as a potential prognostic biomarker and therapeutic target for HNSCC
Tao, W., Tian, G., Xu, S., Li, J., Zhang, Z., & Li, J. (2021) · Figshare · doi:10.6084/m9.figshare.15128573
Additional file 1 of Helicobacter pylori-induced NAT10 stabilizes MDM2 mRNA via RNA acetylation to facilitate gastric cancer progression
Deng, M., Zhang, L., Zheng, W., Chen, J., Du, N., Li, M., Chen, W., Huang, Y., Zeng, N., Song, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22606685
Medicinal chemistry approaches to modulation of splicing, RNA modifications, and RNA editing in cancer therapeutics
Schirok, H., Lehmann, L., Torianyk, H., Kary, N., Louloupi, A., Nutiu, R., Yu, Y., & Morais, P. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-29808-0.00056-x
Establishment and validation of an UPLC-MS/MS method for the quantitative analysis of remodelin in biological samplesPreprint
Hu, Y., Lin, X., Wu, M.-X., Zhong, Y., Yu, C., Liu, Q., & Wang, L. (2025) · SSRN Electronic Journal · doi:10.2139/ssrn.5869490
NAT10 aggravates psoriasis by promoting keratinocytes fatty acid synthesis via stable FASN transcription
Tang, W., Shen, J., Liu, J., Jiang, C., Liu, W., Xiao, M., Dai, J., Gao, W., Lu, J., Hu, C., et al. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101590
RNA-binding proteins and regulatory networks involved in life-stage, stress temperature, and drug resistance in Leishmania parasitesPreprint
Martínez, E., Aliaga-Tobar, V., Hidalgo-Cabrera, A., Requena, J. M., do Monte‐Neto, R. L., Maracaja‐Coutinho, V., & Martín, A. J. M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.02.16.706094
CTCF β-hydroxybutyrylation catalyzed by NAT10 regulates MHC-II gene expression
Zhou, R., Li, S., Jiang, S., Sui, Y., Ai, H., Su, R., Xiong, X., Qiu, H., Tong, X., & Zhao, W. (2026) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2026.106930
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Authors: Larrieu, D., Britton, S., Demir, M., Rodriguez, R., & Jackson, S. P.
Affiliations: University of Cambridge (GB)
Centre National de la Recherche Scientifique (FR)
Corresponding author: Britton, Sébastien
Rodriguez, Raphaël
Jackson, Stephen P.
ORCID: Larrieu, Delphine
Britton, Sébastien
Rodriguez, Raphaël
Jackson, Stephen P.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2014-05-02
Volume: 344
Issue: 6183
Pages: 527-532
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1252651
PMC: PMC4246063
OpenAlex: W2008052894
Cited by: 431
References: 27
Citations by year: 2026: 51 · 2025: 64 · 2024: 45 · 2023: 45 · 2022: 39 · 2021: 32 · 2020: 22 · 2019: 31 · 2018: 28 · 2017: 26 · 2016: 24 · 2015: 14 · 2014: 10
FWCI: 10.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
HAL (submittedVersion)
Apollo (University of Cambridge) (submittedVersion)
Apollo
Funders: Wellcome Trust (092096/Z/10/Z, WT092096, 092096)
Cancer Research UK (18796, C6/A11224, C6946 /A14492, 11224, A11224)
Medical Research Council (MR/L019116/1)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Structure and Function
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
Keywords: NAT10, lamin A/C, laminopathies, Hutchinson-Gilford progeria syndrome, Remodelin, nuclear organization, chromatin organization, microtubule reorganization, DNA damage, premature aging, histone acetylation
MeSH terms: Cell Nucleus, Chromatin, Enzyme Inhibitors, Humans, Hydrazones, Microtubules, Progeria, Thiazoles, Nocodazole, Protein Structure, Tertiary, RNA, Small Interfering, Lamin Type A, Cell Line, Tumor, N-Terminal Acetyltransferases, N-Terminal Acetyltransferase E

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Chemical Inhibition of NAT10 Corrects Defects of Laminopathic Cells

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