The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.
Antibiotic effectiveness: Balancing conservation against innovation
Abstract
Antibiotic effectiveness is a natural societal resource that is diminished by antibiotic use. As with other such assets, keeping it available requires both conservation and innovation. Conservation encompasses making the best use of current antibiotic effectiveness by reducing demand through vaccination, infection control, diagnostics, public education, incentives for clinicians to prescribe fewer antibiotics, and restrictions on access to newer, last-resort antibiotics. Innovation includes improving the efficacy of current drugs and replenishing effectiveness by developing new drugs. In this paper, I assess the relative benefits and costs of these two approaches to maintaining our ability to treat infections.
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“improving sanitation, expanding the use of vaccines, and strengthening hospital infection control have proven extremely effective tools in reducing the needs for antibiotic therapies.”
From Antibiotic-Induced Changes in the Intestinal Microbiota and Disease (2016) · cites this paper as [116]
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Self-citation
Research works printed but not linked: 1
- M. Sweidan Y. Zhang K. Harvey Y. Yang X. Shen K. Yao in Proceedings of the 2nd National Workshop on Rational Use of Antibiotics in China (Beijing Children's Hospital Beijing China 2005) pp. 1–18.
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Self-citationEnvironmental factors influencing the development and spread of antibiotic resistance
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Antibiotic-Induced Changes in the Intestinal Microbiota and Disease
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Metadata
- Authors
- Laxminarayan, R.
- Affiliations
- Center for Disease Dynamics, Economics & Policy (US)
- Corresponding author
- Laxminarayan, Ramanan
- Venue
- Science
- Published
- 2014-09-12
- Volume
- 345
- Issue
- 6202
- Pages
- 1299-1301
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2004486295
- Cited by
- 170
- References
- 31
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 19 · 2021: 12 · 2020: 27 · 2019: 19 · 2018: 14 · 2017: 21 · 2016: 15 · 2015: 10 · 2014: 4
- FWCI
- 14.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
- Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
- Keywords
- antibiotic effectiveness, antibiotic resistance, new antibiotic development, demand reduction, vaccination, infection control, antimicrobial diagnostics, prescribing incentives
- MeSH terms
- Animals, Animal Husbandry, Anti-Bacterial Agents, Communicable Disease Control, Communicable Diseases, Humans, Vaccination, Drug Resistance, Bacterial, Livestock
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