Cited by 170Antibiotic Use and ResistancePharmaceutical Economics and PolicyAntibiotic Resistance in Bacteria

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Antibiotic effectiveness: Balancing conservation against innovation

Laxminarayan, Ramanan·2014·Science

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Abstract

Antibiotic effectiveness is a natural societal resource that is diminished by antibiotic use. As with other such assets, keeping it available requires both conservation and innovation. Conservation encompasses making the best use of current antibiotic effectiveness by reducing demand through vaccination, infection control, diagnostics, public education, incentives for clinicians to prescribe fewer antibiotics, and restrictions on access to newer, last-resort antibiotics. Innovation includes improving the efficacy of current drugs and replenishing effectiveness by developing new drugs. In this paper, I assess the relative benefits and costs of these two approaches to maintaining our ability to treat infections.

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M. Sweidan Y. Zhang K. Harvey Y. Yang X. Shen K. Yao in Proceedings of the 2nd National Workshop on Rational Use of Antibiotics in China (Beijing Children's Hospital Beijing China 2005) pp. 1–18.

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Authors: Laxminarayan, R.
Affiliations: Center for Disease Dynamics, Economics & Policy (US)
Corresponding author: Laxminarayan, Ramanan
ORCID: Laxminarayan, Ramanan
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2014-09-12
Volume: 345
Issue: 6202
Pages: 1299-1301
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1254163
OpenAlex: W2004486295
Cited by: 170
References: 31
Citations by year: 2026: 3 · 2025: 9 · 2024: 7 · 2023: 10 · 2022: 19 · 2021: 12 · 2020: 27 · 2019: 19 · 2018: 14 · 2017: 21 · 2016: 15 · 2015: 10 · 2014: 4
FWCI: 14.15
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Infectious Diseases › Antibiotic Use and Resistance
Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Pharmaceutical Economics and Policy
Health Sciences › Medicine › Microbiology (medical) › Antibiotic Resistance in Bacteria
Keywords: antibiotic effectiveness, antibiotic resistance, new antibiotic development, demand reduction, vaccination, infection control, antimicrobial diagnostics, prescribing incentives
MeSH terms: Animals, Animal Husbandry, Anti-Bacterial Agents, Communicable Disease Control, Communicable Diseases, Humans, Vaccination, Drug Resistance, Bacterial, Livestock

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Antibiotic effectiveness: Balancing conservation against innovation

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