Cited by 764PI3K/AKT/mTOR signaling in cancerAutophagy in Disease and TherapyMetabolism, Diabetes, and Cancer

The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.

Differential regulation of mTORC1 by leucine and glutamine

Open access

Jewell, Jenna L., Kim, Young Chul, Russell, Ryan C., Yu, Fa-Xing, Park, Hyun Woo, Plouffe, Steven W., Tagliabracci, Vincent S., Guan, Kun-Liang·2015·Science

DOI 10.1126/science.1259472PMC PMC4384888

Open this paper in CoChat — free account

Abstract

Getting specific about amino acid sensing: The protein kinase complex mTORC1 regulates growth and metabolism, and its activity is controlled in response to the abundance of cellular amino acids. Jewell et al. report that control of mTORC1 in response to glutamine does not require the Rag guanosine triphosphatase (GTPase) implicated in the sensing of other amino acids such as leucine (see the Perspective by Abraham). For sensing of glutamine, another GTPase, Arf1, was required. Distinct mechanisms thus appear to couple various amino acids to signaling by the mTORC1 complex. Science , this issue p. 194 ; see also p. 128

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1126/science.1259472

Cites

35 of 35 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Jinek, M., Chylinski, K., Fonfara, I., Hauer, M., Doudna, J. A., & Charpentier, E. (2012) · Science · doi:10.1126/science.1225829 · Cited by 17,116
Multiplex Genome Engineering Using CRISPR/Cas Systems
Cong, L., Ran, F. A., Cox, D., Lin, S., Barretto, R., Habib, N., Hsu, P. D., Wu, X., Jiang, W., Marraffini, L. A., et al. (2013) · Science · doi:10.1126/science.1231143 · Cited by 15,339
RNA-Guided Human Genome Engineering via Cas9
Mali, P., Yang, L., Esvelt, K. M., Aach, J., Guell, M., DiCarlo, J. E., Norville, J. E., & Church, G. M. (2013) · Science · doi:10.1126/science.1232033 · Cited by 9,210
mTOR Signaling in Growth Control and Disease
Laplante, M., & Sabatini, D. M. (2012) · Cell · doi:10.1016/j.cell.2012.03.017 · Cited by 8,509
DNA targeting specificity of RNA-guided Cas9 nucleases
Hsu, P. D., Scott, D. A., Weinstein, J. A., Ran, F. A., Konermann, S., Agarwala, V., Li, Y., Fine, E. J., Wu, X., Shalem, O., et al. (2013) · Nature Biotechnology · doi:10.1038/nbt.2647 · Cited by 4,741
The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1
Sancak, Y., Peterson, T. R., Shaul, Y. D., Lindquist, R. A., Thoreen, C. C., Bar-Peled, L., & Sabatini, D. M. (2008) · Science · doi:10.1126/science.1157535 · Cited by 2,773
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Sancak, Y., Bar-Peled, L., Zoncu, R., Markhard, A. L., Nada, S., & Sabatini, D. M. (2010) · Cell · doi:10.1016/j.cell.2010.02.024 · Cited by 2,464
RNA-programmed genome editing in human cells
Jinek, M., East, A., Cheng, A., Lin, S., Ma, E., & Doudna, J. (2013) · eLife · doi:10.7554/elife.00471 · Cited by 2,098
Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy
Nicklin, P., Bergman, P., Zhang, B., Triantafellow, E., Wang, H., Nyfeler, B., Yang, H., Hild, M., Kung, C., Wilson, C., et al. (2009) · Cell · doi:10.1016/j.cell.2008.11.044 · Cited by 1,798
mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H + -ATPase
Zoncu, R., Bar-Peled, L., Efeyan, A., Wang, S., Sancak, Y., & Sabatini, D. M. (2011) · Science · doi:10.1126/science.1207056 · Cited by 1,673

Flagged first, then by citations

Show all 35 references

Sorted by citations

Items 701–764 of 764

SIRTifying intestinal nucleotide metabolism
Tiwary, S., Guerena, C. D., & Jewell, J. L. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.07.003
Self-citation
Glutamine availability regulates cDC subsets in tissuePreprint
Lobel, G. P., Han, N., Arocho, W. A. M., Silber, M., Shoush, J., Noji, M., To, T. K. J., Zhai, L., Lesner, N. P., Simon, M. C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.17.613574
Dietary Strategy for Cancer Therapy - Amino Acid Restrictions and beyond
Li, S., & Kang, J. (2024) · BENTHAM SCIENCE PUBLISHERS eBooks · doi:10.2174/9789815223910124090003
The Legionella pneumophila type IVb secretion system effector BinA subverts amino acid transport to sensitize TORC1 signaling in macrophages
Circu, M., Castore, R., Latimer, B., Shames, S., Roy, C., Dragoi, A., & Ivanov, S. (2026) · PLoS Pathogens · doi:10.1371/journal.ppat.1012998
Inflammation-induced lysosomal dysfunction in human iPSC-derived microglia is exacerbated by APOE 4/4 genotypePreprint
Hellén, M., Weert, I., Müller, S. A., Lehtonen, Š., Peitz, M., Fließbach, K., Takalo, M., Koskuvi, M., Lichtenthaler, S. F., Leinonen, V., et al. (2025) · Research Square · doi:10.21203/rs.3.rs-6241569/v1
Hypoxia: A Raptor mutant survives in thin air
Reiner, D. J. (2025) · Current Biology · doi:10.1016/j.cub.2025.05.041
Prenatal liver is resistant to low glucose-induced inhibition of mTORC1Preprint
Zhang, C.-J., Yu, C., Cheng, Y., Pan, J., Ye, L., Tang, Y., Qin, X., Lin, Z., Zhang, C., Ding, G., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.07.21.665892
Sirtuin 6 mediates the therapeutic effect of endometrial regenerative cell-derived exosomes in alleviation of acute transplant rejection by weakening c-myc-dependent glutaminolysis
Liu, T., Sun, C., Liu, X., Zhao, P., Shao, B., Xu, Y., Xiao, Y., Wang, H., Chen, Q., Yang, G., et al. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1564382 · Cited by 1
Association Between In Vitro Blastocyst Production and Blood Amino Acid Levels in Bovines
Kowsar, R., & Ghazi‐Zahedi, S. (2025) · Animal Science Journal · doi:10.1111/asj.70122
Association of SLC7A5/LAT1 Expression with Clinicopathological Parameters and Molecular Subtypes: Could It Be Considered in the Management of Breast Cancer?
Henna, N., Goud, M., Dube, R., Riaz, S., Chughtai, A. S., & Nagi, A. H. (2025) · Journal of Molecular Pathology · doi:10.3390/jmp6040027
Additional file 9 of Glutamine involvement in nitrogen regulation of cellulase production in fungi
Pang, A.-P., Zhang, F., Hu, X., Luo, Y., Wang, H., Durrani, S., Wu, F.-G., Li, B.-Z., Zhou, Z., Lu, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16807799
Additional file 1 of Dietary isoleucine improved flesh quality, muscle antioxidant capacity, and muscle growth associated with AKT/TOR/S6K1 and AKT/FOXO3a signaling in hybrid bagrid catfish (Pelteobagrus vachelli♀ × Leiocassis longirostris♂)
Jiang, Q., Yan, M., Zhao, Y., Zhou, X., Yin, L., Feng, L., Liu, Y., Jiang, W., Wu, P., Wang, Y., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14446000
Additional file 1 of PSMD2 contributes to the progression of esophageal squamous cell carcinoma by repressing autophagy
Liu, Y., Wu, M., Xu, S., Niu, X., Liu, W., Miao, C., Lin, A., Xu, Y., & Yu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26579132
Additional file 2 of PSMD2 contributes to the progression of esophageal squamous cell carcinoma by repressing autophagy
Liu, Y., Wu, M., Xu, S., Niu, X., Liu, W., Miao, C., Lin, A., Xu, Y., & Yu, L. (2024) · Figshare · doi:10.6084/m9.figshare.26579135
Additional file 2 of A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity
Khamsing, D., Lebrun, S., Fanget, I., Larochette, N., Tourain, C., de Sars, V., Brunstein, M., Oheim, M., Carrel, D., Darchen, F., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14955902
Additional file 4 of A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity
Khamsing, D., Lebrun, S., Fanget, I., Larochette, N., Tourain, C., de Sars, V., Brunstein, M., Oheim, M., Carrel, D., Darchen, F., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14955911
Additional file 3 of A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity
Khamsing, D., Lebrun, S., Fanget, I., Larochette, N., Tourain, C., de Sars, V., Brunstein, M., Oheim, M., Carrel, D., Darchen, F., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14955908
Additional file 8 of Glutamine involvement in nitrogen regulation of cellulase production in fungi
Pang, A.-P., Zhang, F., Hu, X., Luo, Y., Wang, H., Durrani, S., Wu, F.-G., Li, B.-Z., Zhou, Z., Lu, Z., et al. (2021) · Figshare · doi:10.6084/m9.figshare.16807796
The small GTPase Arf1 regulates ATP synthesis and mitochondria homeostasis by modulating fatty acid metabolismPreprint
Enkler, L., Pennauer, M., Szentgyörgyi, V., Prescianotto‐Baschong, C., Riezman, I., Więsyk, A., Kucharczyk, R., Spiess, M., Riezman, H., & Spang, A. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.01.26.477847
Additional file 4 of Dietary restriction of amino acids for Cancer therapy
Kang, J.-S. (2020) · Figshare · doi:10.6084/m9.figshare.11984706
Additional file 1 of A role for BDNF- and NMDAR-induced lysosomal recruitment of mTORC1 in the regulation of neuronal mTORC1 activity
Khamsing, D., Lebrun, S., Fanget, I., Larochette, N., Tourain, C., de Sars, V., Brunstein, M., Oheim, M., Carrel, D., Darchen, F., et al. (2021) · Figshare · doi:10.6084/m9.figshare.14955899
Additional file 1 of Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway
Panarsky, R., Crooks, D. R., Lane, A. N., Yang, Y., Cassel, T., Fan, T. W. M., Linehan, W. M., & Moscow, J. A. (2020) · Figshare · doi:10.6084/m9.figshare.12752123
Mitochondrial ETF insufficiency drives neoplastic growth by selectively optimizing cancer bioenergeticsPreprint
Papadopoli, D. J., Palia, R., Jovanović, P., Tabariès, S., Ciccolini, E., Sabourin, V., Igelmann, S., McLaughlan, S., Zhan, L., Kim, H., et al. (2026) · eLife · doi:10.7554/elife.106587.2
Metabolic changes in mTOR pathway-associated cortical malformation
Biswas, A., & Iffland, P. H. (2026) · Frontiers in Neuroscience · doi:10.3389/fnins.2026.1726799
Lysosomal degradation of insulin granules promotes β-cell failure in type 2 diabetes
Pasquier, A. (2016) · theses.fr (ABES) · doi:10.70675/8372a5a5z3353z4089zb052ze42ddeb72bf5
Amino acids regulate hepatic intermediary metabolism-related gene expression via mTORC1-dependent manner in rainbow trout (Oncorhynchus mykiss)
Weiwei, D. (2015) · theses.fr (ABES) · doi:10.70675/3e5359a6z2707z4d77za3a4z84368caf4002
Regulation of Autophagy by Acetyl Coenzime A : From the Mechanisms to a Revised Definition of Caloric Restriction Mimetics
Pietrocola, F. (2015) · theses.fr (ABES) · doi:10.70675/42d6808dzc206z4e0fzb806z29f806b2f781 · Cited by 1
Mécanisme d’activation neuronale de mTORC1 et de son altération par le peptide amyloïde β
Khamsing, D. (2017) · theses.fr (ABES) · doi:10.70675/8081dbf0zf76bz43bdza502z6c0c6c419856
Rôle de CD98hc dans les fibroblastes dermiques au cours de l’homéostasie et de la tumorigenèse cutanées
Tissot, F. S. (2017) · theses.fr (ABES) · doi:10.70675/15252dfez0dfez4a42z83f4z21be7c773c9d
On the edge between cell division and differentiation : role of Seh1 in mouse embryonic stem cells
Gonzalez-Estevez, A. (2019) · doi:10.70675/b5d58998zc8e2z4989z9507zea0715e0efb4
Exploring the Role of Intercellular and Intracellular Signaling in the Sustenance of Glioblastoma Stem-like Cells
Jacobs, K. (2020) · theses.fr (ABES) · doi:10.70675/7d25afb8z3349z41abz9a2fz667e402f1463
Implication de la GTPase RagA dans l’activation et la polarisation de la réponse lymphocytaire T
Attia, M. (2017) · theses.fr (ABES) · doi:10.70675/54b64a32zdbe2z447dzaab4z42858c3a25e6
Role of p27/Kip1 in auphagy under metabolic stress conditions
Nowosad, A. (2018) · theses.fr (ABES) · doi:10.70675/11eb36d1zc3baz4d74z8d00zc049667c5976
Biochemical characterization of mTORC1 regulation by glutamine metabolism
Bodineau, C. (2020) · theses.fr (ABES) · doi:10.70675/9d5aaabdz81bdz4118zb3edze237bdd8dee0
Étude de l’influence de la glutaminolyse des macrophages dans les maladies cardio-métaboliques
Merlin, J. (2020) · theses.fr (ABES) · doi:10.70675/68e10f28zf840z48bfz9bacz5511a3a2b208
The role of GATOR1 complex, upstream regulator of mTORC1 pathway, in mitochondrial function
Loissell-Baltazar, Y. A. (2022) · theses.fr (ABES) · doi:10.70675/1f481059zb480z4ff6zb971z48706d3ff583
Etude de l'effet biostimulant des acides aminés individuels sur l'AAUE des plantes et exploration des bases génétiques de l'AAUE des plantes en présence de leucine
Lardos, M. (2024) · doi:10.70675/bf406a90z2f5ez4efez9d10z3b97ca7dd67f
Deciphering the metabolic bases of Drosophila intestinal tumors
Delamotte, P. (2024) · theses.fr (ABES) · doi:10.70675/c62595f4zbfe2z4ee5zba1az272c10f57e2a
The role of the GATOR1 complex in mitochondrial function and quality control
Zhang, H. (2025) · theses.fr (ABES) · doi:10.70675/1dad907cz4477z4068z81c2z087317cd244e
Slc7a5 protein expression in breast cancer samples, relationship with clinical and morphological parameters of the tumor and its regional metastasis
Кометова, В. В., Mikhaleva, L. M., Родионов, В. А., & Андреевич, К. А. (2026) · Russian Journal of Archive of Pathology · doi:10.17116/patol20268802114
Signal sensing and transmission of amino acids in mTORC1 regulation
Zeng, H., Li, R., Li, J., Song, X., & Su, M.-Y. (2026) · Oral Science and Homeostatic Medicine · doi:10.26599/oshm.2026.9610046
TORC1 spatial segregation and hysteresis are regulated by the small GTPase Arf1Preprint
Enkler, L., Nuredini, T., Mironov, A., Ritz, D., Wang, C., Zavolan, M., & Spang, A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.29.721593
Glutamine-Dependent Downregulation of FLT3-ITD is a Mechanism of FLT3 Inhibitor Resistance in FLT3-ITD AML in HypoxiaPreprint
Silvestri, G., Chatterjee, A., Rendina, B. P., Bar, E. E., & Baer, M. R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.02.722336
Dietary effects of early nutrition on muscle mass and accretion in mammals
Ghaffari, M. H., Malik, A., Nisha, N., Sauerwein, H., & Hammon, H. M. (2026) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2026.102111
Integrated transcriptomic and metabolomic analyses provide mechanistic insights into the pro-proliferative role of DARS in human MPN cell models
Xiong, H., Zhang, H., Zhang, L., Wang, X., Wan, F., Li, Y., Bai, J., Zhang, J., Wang, Y., Li, L., et al. (2026) · Cell Cycle · doi:10.1080/15384101.2026.2674079
Glutamine-Linked Cellular Stress Responses in Viral Infection: Mechanisms, Crosstalk, and Future Perspectives
Pham, N. T. K., Trinh, Q. D., Ushijima, H., Komine‐Aizawa, S., & Yoshimune, K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27114717
Leucyl-tRNA synthetase as a molecular target of isobutanol-mediated growth inhibition in Saccharomyces cerevisiae
Hasegawa, M., Oshimura, N., Hitomi, K., Furukawa, A., Sugase, K., & Kuroda, K. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113228
Glutamine Depletion Induced Senescence-Associated β-Galactosidase Activity and Impaired Functional Properties of Ea.hy926 Endothelial Cells
Haider, J., Huang, X., Xu, C., & Leung, T. (2026) · Cells · doi:10.3390/cells15121116
Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity
Strehlau, C., Broghammer, H., Gebhardt, C., Hoffmann, A., Hagemann, T., Midilli, Ş., Zimmer, R. S., Schubert, K. A., Karagiannakou, V., Georgiadi, A., et al. (2026) · Advanced Science · doi:10.1002/advs.76191
Selenomethionine optimizes muscle growth and metabolic homeostasis via mTOR and Nrf2 signaling in juvenile Micropterus salmoides
Shuai, M.-Q., Xu, Y., Liu, M., Jiang, S., Dou, S.-L., Wang, Y., Qi, Y. M., Hou, Z.-G., Khor, W., Zhang, L., et al. (2026) · Frontiers in Animal Science · doi:10.3389/fanim.2026.1843427
Targeting ROAM1 with UDP-GlcNAc nanosheets selective activates lysosomal AMPK to resolve metabolic dysfunction-associated steatotic liver disease
Zhu, J., Sun, T., Wei, F., Wang, D., Liu, F., Chen, D., Liu, X. X., Wang, C., Deng, S., Yang, Y., et al. (2026) · Bioactive Materials · doi:10.1016/j.bioactmat.2026.06.047
Rag GTPases and mTORC1 regulate intestinal stem cell activity in response to nutrient availability
Fan, W., Ge, C., Niu, C., Liu, S., Wang, P., Li, H., Yang, C., Lu, Y., & Wei, Y. (2026) · The Journal of Cell Biology · doi:10.1083/jcb.202510172
Mitochondrial control of amino acid catabolism by a fasting-inducible mitochondrial carrier
Oikawa, S., Yamamuro, T., Nishida, H., Katoh, D., Wang, D., Fujimoto, M., & Kajimura, S. (2026) · Science Advances · doi:10.1126/sciadv.aef0140
Inhibiting Wnt/β-catenin-mTOR signaling enhances autophagy and porphyrin clearance in murine porphyrias with hepatic involvement
Balogun, O., Cornuet, P. K., Lee, E., Patel, G., Raheem, A.-S., Zhu, J., Vandevender, A. M., Ashokan, A. P., Nasrollahi, R., West, R. E., et al. (2026) · Autophagy · doi:10.1080/15548627.2026.2716960
Unraveling the role of glutamine metabolism in cancer: from cell death mechanisms to tumor microenvironment modulation
Peng, X., Liu, S., & Tao, Y. (2026) · Experimental Hematology and Oncology · doi:10.1186/s40164-026-00812-1
Glutaminolysis and mTOR-C/EBPβ Signaling Drives the Differentiation of Novel IL-10-Producing Regulatory T Cells
Tajima, M., Fuss, I. J., Ikuta, N., Mao, L., Myers, T. G., Gardina, P. J., Kitani, A., & Strober, W. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27198447
Pathogenic mutations in ATAD3A cause dysregulation of RagC/D-TFEB axis and disrupt lysosomal homeostasisPreprint
McDougal, M. B., Sandoval, A., Kinter, M., Jain, A., Lee, S., Jung, S. Y., & Yoon, W. H. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.09.23.753918
Developing Metal–Polyphenol Network‐Based Single‐Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia
Zhang, Y., Zhang, Y., Ai, Y., Lu, Y., Quan, H., Zhang, Z., Wang, Y., Luo, Y., Zhang, X., Lin, Y., et al. (2026) · Advanced Science · doi:10.1002/advs.77951
Glutamine metabolism in health and disease
Zhao, J., Lin, Y., Gao, R., Gao, H., & Li, L. (2026) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-026-02981-1
Exercise Is Associated with Skeletal Muscle Autophagy–Lysosome-Related Markers and Nrf2/ARF1 Signaling in HFD Mice
Hu, S., Liu, X., Xia, R., & Wang, X. (2026) · Nutrients · doi:10.3390/nu18203329
Nutrients and Their Role in Autophagy Regulation
Wilson, N., Koçak, G., Sarkar, S., Ruiz, Y. R., & Korolchuk, V. I. (2026) · Biochemistry · doi:10.1021/acs.biochem.6c00482
BindingDB Entry 50021500: MNK, mTOR or eIF4E-selecting the best anti-tumor target for blocking translation initiation.
BindingDB (2025) · UC San Diego · doi:10.7270/q23201hc
BindingDB Entry 50007250: Discovery and development of small molecule modulators targeting glutamine metabolism.
BindingDB (2021) · UC San Diego · doi:10.7270/q2n87f26
Theoretical Considerations Regarding the Role of Hyperinsulinemia and Insulin/IGF Signaling in Cancer Metabolic Reprogramming: Potential Mechanisms and Therapeutic Vulnerabilities
Chae, B. S. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27219598

Authors: Jewell, J. L., Kim, Y. C., Russell, R. C., Yu, F.-X., Park, H. W., Plouffe, S. W., Tagliabracci, V. S., & Guan, K.-L.
Affiliations: University of California San Diego (US)
Fudan University (CN)
Corresponding author: Kim, Young Chul
Russell, Ryan C.
Guan, Kun-Liang
ORCID: Jewell, Jenna L.
Kim, Young Chul
Russell, Ryan C.
Yu, Fa-Xing
Park, Hyun Woo
Plouffe, Steven W.
Tagliabracci, Vincent S.
Guan, Kun-Liang
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-01-09
Volume: 347
Issue: 6218
Pages: 194-198
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1259472
PMC: PMC4384888
OpenAlex: W2157760261
Cited by: 757
References: 35
Citations by year: 2026: 37 · 2025: 45 · 2024: 58 · 2023: 62 · 2022: 75 · 2021: 102 · 2020: 81 · 2019: 54 · 2018: 60 · 2017: 57 · 2016: 65 · 2015: 60
FWCI: 35.04
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: cc-by-nc
www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 365 d)
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion, cc-by-nc)
PubMed Central (acceptedVersion, cc-by-nc)
eScholarship (California Digital Library) (submittedVersion, cc-by-nc)
eScholarship (California Digital Library) (submittedVersion)
Funders: NIH (R01GM051586, R01CA108941, T32CA121938, T32GM007752, K99DK099254)
Department of Defense (W81XWH-13-1-055)
The Hartwell Foundation
Canadian Institutes of Health Research
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: mTORC1, leucine, glutamine, Rag GTPases, Ragulator complex, V-ATPase, lysosomal translocation, Arf1, amino acid signaling, cell growth regulation, raga
MeSH terms: Mechanistic Target of Rapamycin Complex 1, Regulatory-Associated Protein of mTOR, Animals, Enzyme Activation, Glutamine, Humans, Leucine, Lysosomes, Mice, Knockout, Monomeric GTP-Binding Proteins, ADP-Ribosylation Factor 1, Protein Transport, Multiprotein Complexes, Adaptor Proteins, Signal Transducing, Mice, Gene Knockdown Techniques, HEK293 Cells, TOR Serine-Threonine Kinases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Differential regulation of mTORC1 by leucine and glutamine

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks