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Multiplex Genome Engineering Using CRISPR/Cas Systems

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mTOR Signaling in Growth Control and Disease

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The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

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Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

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Bidirectional Transport of Amino Acids Regulates mTOR and Autophagy

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Polarization and asymmetry in T cell metabolism

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Glutamine-dependent lysosome homeostatic changes induced by starvation and lysosome inhibition

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5q35 duplication presents with psychiatric and undergrowth phenotypes mediated by NSD1 overexpression and mTOR signaling downregulation

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Glutaminolysis is involved in the activation of mTORC1 in in vitro‐produced porcine embryos

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The role of mechanistic target of rapamycin in maintenance of glomerular epithelial cells

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Lysine is required for growth factor-induced mTORC1 activation

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Spatially distinct pools of TORC1 balance protein homeostasis

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Intestinal amino acid metabolic response and its roles in inflammatory bowel disease

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Crosstalk between the mTOR pathway and primary cilia in human diseases

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BmSLC7A5 is essential for silk protein synthesis and larval development in Bombyx mori

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Effects of Prickly Ash Seed Dietary Supplementation on Meat Quality, Antioxidative Capability, and Metabolite Characteristics of Hu Lambs

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Regulation of autophagy and its role in late preimplantation during mouse embryo development

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Metabolic Regulation of T Cell Immunity

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RNA helicase DHX15 exemplifies a unique dependency in acute leukemia

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TOR Signaling in Budding Yeast

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Amino acid-dependent signaling via S6K1 and MYC is essential for regulation of rDNA transcription

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Identification of Key Pro-Survival Proteins in Isolated Colonic Goblet Cells of Winnie, a Murine Model of Spontaneous Colitis

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Glutamine supports the protection of tissue cells against the damage caused by cholesterol-dependent cytolysins from pathogenic bacteria

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Influence of Age on Skeletal Muscle Hypertrophy and Atrophy Signaling: Established Paradigms and Unexpected Links

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Beyond protein synthesis: non-translational functions of threonyl-tRNA synthetases

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Optimizing glutamine concentration enhances ex vivo expansion of natural killer cells through improved redox status

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Gα13 restricts nutrient driven proliferation in mucosal germinal centers

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The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness

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Target of Rapamycin (TOR) Regulates Growth in Response to Nutritional Signals

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Construction and Investigation of circRNA-associated ceRNA Regulatory Network in Molecular Subtypes of Breast Cancer

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Hypoxic Stress Upregulates the Expression of Slc38a1 in Brown Adipocytes via Hypoxia-Inducible Factor-1α

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Protein: what’s on in research on clinical nutrition

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FYVE1/FREE1 is involved in glutamine-responsive TORC1 activation in plants

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Evaluating the mTOR Pathway in Physiological and Pharmacological Settings

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Foxo3a tempers excessive glutaminolysis in activated T cells to prevent fatal gut inflammation in the murine IL-10−/− model of colitis

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Overview of Glutamine Dependency and Metabolic Rescue Protocols

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Glutamine confers renoprotection by normalizing lipid and glutathione content in insulin-resistant pregnant rats

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Myotube Protein Content Associates with Intracellular L-Glutamine Levels

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Oncogenic Control of MetabolismPreprint

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Glutaminolysis and peripheral CD4+ T cell differentiation: from mechanism to intervention strategy

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Autophagy: Are Amino Acid Signals Dependent on the mTORC1 Pathway or Independent?

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An economic demand-based framework for prioritization strategies in response to transient amino acid limitations

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Dietary glutamine supplementation improves both Th1 and Th17 responses via CARD11-mTORC1 pathway in murine model of atopic dermatitis

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Aberrant BCAT1 expression augments MTOR activity and accelerates disease progression in chronic lymphocytic leukemia

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Cellular Signaling of Amino Acid Metabolism in Prostate Cancer

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Branched-Chain Amino Acid Catabolism Promotes Ovarian Cancer Cell Proliferation via Phosphorylation of mTOR

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Crosstalk of glutamine metabolism between cancer-associated fibroblasts and cancer cells

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Metabolism and Immune Suppressive Response in Liver Cancer

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SFPQ-TFE3 reciprocally regulates mTORC1 and induces lineage plasticity in a mouse model of renal tumorigenesis

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Dietary Plant Protein Intake Can Reduce Maternal Insulin Resistance during Pregnancy

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Mycobacterium manipulate glutaminase 1 mediated glutaminolysis to regulate macrophage autophagy for bacteria intracellular survival

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Alcohol Acutely Antagonizes Refeeding-Induced Alterations in the Rag GTPase-Ragulator Complex in Skeletal Muscle

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Recycling of SLC38A1 to the plasma membrane by DSCR3 promotes acquired temozolomide resistance in glioblastoma

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Reduced branched-chain aminotransferase activity alleviates metabolic vulnerability caused by dim light exposure at night in Drosophila

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Glycosylation affects the stability and subcellular distribution of human PAT 1 protein

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Inhibition of Autophagy In Vivo Extends Methamphetamine Toxicity to Mesencephalic Cell Bodies

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Target of rapamycin signaling in pea embryos is dependent on glutamine but detached from seed storage protein biosynthesis

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Extracellular Glutamine Promotes Intestinal Porcine Epithelial Cell Proliferation via Arf1-mTORC1 Pathway Independently of Rag GTPases

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The endocrine and epigenetic impact of persistent cow milk consumption on prostate carcinogenesis

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Development and internal validation of nomograms based on plasma metabolites to predict non‐small cell lung cancer risk in smoking and nonsmoking populations

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Extracellular Vehicles of Oxygen-Depleted Mesenchymal Stromal Cells: Route to Off-Shelf Cellular Therapeutics?

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Nutrient Digestion, Absorption, and Sensing

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90th Anniversary Commentary: The mTORC1 Complex—A Central Player in the Control and Regulation of Amino Acid Sufficiency

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Integrins and Cell Metabolism: An Intimate Relationship Impacting Cancer

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ODE-based models of signaling networks in autophagy

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EGO complex at 20: The Rag GTPase-TORC1 nutrient-sensing blueprint

VIRGILIO, C. D. (2026) · Molecular Cell · doi:10.1016/j.molcel.2025.12.018 · Cited by 6

RagC GTPase regulates mTOR to promote chemoresistance in senescence-like HepG2 cells

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Arf5-mediated regulation of mTORC1 at the plasma membrane

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Inhibition of Amino Acids Influx into Proximal Tubular Cells Improves Lysosome Function in Diabetes

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Effects of electrolyte balance on intestinal barrier, amino acid metabolism, and mTORC1 signaling pathway in piglets fed low-protein diets

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Transcriptional landscape and chromatin accessibility reveal key regulators for liver regenerative initiation and organoid formation

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Vacuolar ATPase in Physiology and Pathology: Roles in Neurobiology, Infectious Disease, and Cancer

Fordyce, C. A., Grimes, M. M., Licon-Munoz, Y., Chan, C.-Y., & Parra, K. (2016) · Springer eBooks · doi:10.1007/978-3-319-24780-9_17 · Cited by 6

Conceptualizing Eukaryotic Metabolic Sensing and Signaling

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The influence of combinations of encoded amino acids on associative learning in the honeybee Apis mellifera L.

Lopatina, N. G., Зачепило, Т. Г., Камышев, Н. Г., & Chalisova, N. I. (2017) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s1234567817020045 · Cited by 5

Interplay Between Metabolic Sensors and Immune Cell Signaling

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Fumarate hydratase-deficient renal cell carcinoma cells respond to asparagine by activation of the unfolded protein response and stimulation of the hexosamine biosynthetic pathway

Panarsky, R., Crooks, D. R., Lane, A. N., Yang, Y., Cassel, T., Fan, T. W. ‐., Linehan, W. M., & Moscow, J. A. (2020) · Cancer & Metabolism · doi:10.1186/s40170-020-00214-9 · Cited by 5

Disrupting porcine glutaminase does not block preimplantation development and elongation nor decrease mTORC1 activation in conceptuses

Chen, P. R., Lucas, C. G., Cecil, R. F., Pfeiffer, C. A., Fudge, M. A., Samuel, M., Zigo, M., Seo, H., Spate, L. D., Whitworth, K. M., et al. (2021) · Biology of Reproduction · doi:10.1093/biolre/ioab165 · Cited by 5

Analyzing the impact of autotrophic and heterotrophic metabolism on the nutrient regulation of TOR

Mallén‐Ponce, M. J., Pérez‐Pérez, M. E., & Crespo, J. L. (2022) · New Phytologist · doi:10.1111/nph.18450 · Cited by 5

Arf1 facilitates mast cell proliferation via the mTORC1 pathway

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Metabolic deregulation associated with aging modulates protein aggregation in the yeast model of Huntington’s disease

Pradhan, S. S., Saiswaroop, R., Kanikaram, S. P., M., D. D. V., Pargaonkar, A., Dandamudi, R. B., & Sivaramakrishnan, V. (2023) · Journal of Biomolecular Structure and Dynamics · doi:10.1080/07391102.2023.2257322 · Cited by 5

Twists and turns—How we stepped into and had fun in the “boring” lipid field

Han, M. (2015) · Science China Life Sciences · doi:10.1007/s11427-015-4949-6 · Cited by 5

The rapamycin sTORy: 50-year journey from Easter Island to the frontiers of biology and medicine

Xiao, X., & Dokudovskaya, S. (2026) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2026.02.004 · Cited by 4

Interpreting protein abundance in Saccharomyces cerevisiae through relational learning

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The role of leucine in the activation of cellular metabolism: a large integrative review

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A new insight into mechanism of colchicine poisoning based on untargeted metabolomics

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Imaging the uptake and metabolism of glutamine in prostate tumor models using CEST MRI

Hodo, Y., Tressler, C. M., Ghaemi, B., Thomas, R. L., Webster, A. S., Williams, K. N. B., Li, Y., Pomper, M. G., Dang, C. V., Bhujwalla, Z. M., et al. (2025) · npj Imaging · doi:10.1038/s44303-025-00100-3 · Cited by 4

mTOR, Autophagy, Aminoacidopathies, and Human Genetic Disorders

Ainslie, G. R., Gibson, K. M., & Vogel, K. R. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802733-2.00010-4 · Cited by 4

Investigação da rotulagem e informação nutricional de suplementos proteicos voltados para atletas veganos

Souza, R. P., Libânio, J. A., Branco, R. R. D. O. C., dos Santos, A. B., Pereira, L. C. A., Matos, R. P. D. S., Rodrigues, H. S., de Melo, D. S., & Sales, S. C. D. S. (2020) · Research Society and Development · doi:10.33448/rsd-v9i8.5398 · Cited by 3

Inhibition of the mTORC1/NF‐κB Axis Alters Amino Acid Metabolism in Human Hepatocytes

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