The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Functional heterogeneity of human memory CD4 + T cell clones primed by pathogens or vaccines
Abstract
For T cells, variety is the spice of life: CD4 + helper T cells come in a variety of flavors. This allows them to respond in a manner that is tailored to the pathogen they encounter. Becattini et al. wondered whether multiple “flavors” of human CD4 + T cells respond to specific stimuli or if just one flavor dominates. To find out, they stimulated human memory CD4 + T cells with a fungus, a bacteria, or a vaccine antigen. Multiple helper cell subsets participated in each response. T cell receptor sequencing revealed that in some cases, T cells with the same specificity acquired different helper cell fates. Thus, there is more heterogeneity in human T cell responses than previously appreciated. Science , this issue p. 400
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Self-citationHarnessing the plasticity of CD4+ T cells to treat immune-mediated disease
DuPage, M., & Bluestone, J. A. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2015.18 · Cited by 513
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Metadata
- Authors
- Becattini, S., Latorre, D., Mele, F., Foglierini, M., De Gregorio, C., Cassotta, A., Fernandez, B., Kelderman, S., Schumacher, T. N., Corti, D., Lanzavecchia, A., & Sallusto, F.
- Venue
- Science
- Published
- 2015-01-23
- Volume
- 347
- Issue
- 6220
- Pages
- 400-406
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024362866
- Cited by
- 314
- References
- 36
- FWCI
- 14.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Becattini, S., Latorre, D., Mele, F., Foglierini, M., De Gregorio, C., Cassotta, A., Fernandez, B., Kelderman, S., Schumacher, T. N., Corti, D., Lanzavecchia, A., & Sallusto, F. (2015). Functional heterogeneity of human memory CD4 + T cell clones primed by pathogens or vaccines. Science. https://doi.org/10.1126/science.1260668
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