Cited by 471Antimicrobial Peptides and ActivitiesPeroxisome Proliferator-Activated ReceptorsDermatology and Skin Diseases

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Dermal adipocytes protect against invasive Staphylococcus aureus skin infection

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Zhang, Ling-juan, Guerrero-Juarez, Christian F., Hata, Tissa, Bapat, Sagar P., Ramos, Raul, Plikus, Maksim V., Gallo, Richard L.·2015·Science

DOI 10.1126/science.1260972PMC PMC4318537

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Abstract

Skin infection triggers fat responses: Obesity is associated with chronic inflammation, but does fat tissue offer protection during infection? Zhang et al. noticed that the fat layers in the skin of mice thickened after inoculation with the pathogenic bacterium Staphylococcus aureus (see the Perspective by Alcorn and Kolls). Mutant mice incapable of forming new fat cells were more susceptible to infection. The differentiating fat cells secreted a small-molecule peptide called cathelicidin, specifically in response to the infection. By contrast, mature fat cells produce less cathelicidin, and are thus less protective. Science , this issue p. 67 ; see also p. 26

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Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237
Atopic Dermatitis: Global Epidemiology and Risk Factors
Nutten, S. (2015) · Annals of Nutrition and Metabolism · doi:10.1159/000370220 · Cited by 3,124
Endogenous Antimicrobial Peptides and Skin Infections in Atopic Dermatitis
Ong, P. Y., Ohtake, T., Brandt, C., Strickland, I., Boguniewicz, M., Ganz, T., Gallo, R. L., & Leung, D. Y. M. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa021481 · Cited by 1,960
Self-citation
Skin immune sentinels in health and disease
Nestle, F. O., Meglio, P. D., Qin, J., & Nickoloff, B. J. (2009) · Nature reviews. Immunology · doi:10.1038/nri2622 · Cited by 1,520
An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversion
Green, H., & Kehinde, O. (1975) · Cell · doi:10.1016/0092-8674(75)90087-2 · Cited by 1,381
Distinct fibroblast lineages determine dermal architecture in skin development and repair
Driskell, R. R., Lichtenberger, B. M., Hoste, E., Kretzschmar, K., Simons, B. D., Charalambous, M., Ferron, S. R., Herault, Y., Pavlovic, G., Ferguson-Smith, A. C., et al. (2013) · Nature · doi:10.1038/nature12783 · Cited by 1,291
Innate antimicrobial peptide protects the skin from invasive bacterial infection
Nizet, V., Ohtake, T., Lauth, X., Trowbridge, J., Rudisill, J., Dorschner, R. A., Pestonjamasp, V., Piraino, J., Huttner, K., & Gallo, R. L. (2001) · Nature · doi:10.1038/35106587 · Cited by 1,198
Self-citation
Antibacterial peptides: basic facts and emerging concepts
Boman, H. G. (2003) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2003.01228.x · Cited by 1,171
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F., & Daley, G. Q. (2009) · Nature · doi:10.1038/nature08099 · Cited by 1,129
Wnt-dependent de novo hair follicle regeneration in adult mouse skin after wounding
Ito, M., Yang, Z., Andl, T., Cui, C., Kim, N., Millar, S. E., & Cotsarelis, G. (2007) · Nature · doi:10.1038/nature05766 · Cited by 1,064

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Authors: Zhang, L.-J., Guerrero-Juarez, C. F., Hata, T., Bapat, S. P., Ramos, R., Plikus, M. V., & Gallo, R. L.
Affiliations: University of California San Diego (US)
Department of Developmental and Cell Biology, Sue and Bill Gross Stem Cell Research Center, University of California, Irvine, Irvine, CA 92697, USA.
Salk Institute for Biological Studies (US)
University of California, Irvine (US)
Corresponding author: Gallo, Richard L.
ORCID: Zhang, Ling-juan
Hata, Tissa
Bapat, Sagar P.
Plikus, Maksim V.
Gallo, Richard L.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-01-02
Volume: 347
Issue: 6217
Pages: 67-71
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1260972
PMC: PMC4318537
OpenAlex: W2021691433
Cited by: 471
References: 38
Citations by year: 2026: 30 · 2025: 37 · 2024: 47 · 2023: 43 · 2022: 46 · 2021: 52 · 2020: 36 · 2019: 44 · 2018: 45 · 2017: 36 · 2016: 30 · 2015: 25
FWCI: 38.20
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 365 d)
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
eScholarship (California Digital Library) (submittedVersion)
Funders: NIH (R01 AI083358, R01AI052453, AR052728, DK096828)
California Institute for Regenerative Medicine (TG2-01152)
The Atopic Dermatitis Research Network (HHSN272201000020C)
Edward Mallinckrodt Jr. Foundation Research
Dermatology Foundation Research
NIH NIAMS (R01-AR067273)
NIH MBRS-IMSD (GM055246)
NSF Graduate Research Fellowship (DGE-1321846)
Topics: Life Sciences › Immunology and Microbiology › Microbiology › Antimicrobial Peptides and Activities
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
Keywords: Staphylococcus aureus, skin infections, host defense, adipogenesis, preadipocyte proliferation, cathelicidin, antimicrobial peptides, PPARγ, Zfp423, bacterial virulence
MeSH terms: Animals, DNA-Binding Proteins, Mice, Mutant Strains, Staphylococcal Skin Infections, Staphylococcus aureus, Transcription Factors, Adipocytes, Dermis, Antimicrobial Cationic Peptides, 3T3-L1 Cells, Adipogenesis, Mice, Cathelicidins, Host-Pathogen Interactions

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Dermal adipocytes protect against invasive Staphylococcus aureus skin infection

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