Zfp423 Expression Identifies Committed Preadipocytes and Localizes to Adipose Endothelial and Perivascular Cells
Open accessAbstract
Progress has been made in elucidating the cell-surface phenotype of primary adipose progenitors; however, specific functional markers and distinct molecular signatures of fat depot-specific preadipocytes have remained elusive. In this study, we label committed murine adipose progenitors through expression of GFP from the genetic locus for Zfp423, a gene controlling preadipocyte determination. Selection of GFP-expressing fibroblasts from either subcutaneous or visceral adipose-derived stromal vascular cultures isolates stably committed preadipocytes that undergo robust adipogenesis. Immunohistochemistry for Zfp423-driven GFP expression in vivo confirms a perivascular origin of preadipocytes within both white and brown adipose tissues. Interestingly, a small subset of capillary endothelial cells within white and brown fat also express this marker, suggesting a contribution of specialized endothelial cells to the adipose lineage. Zfp423(GFP) mice represent a simple tool for the specific localization and isolation of molecularly defined preadipocytes from distinct adipose tissue depots.
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From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [22]
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From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [22]
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From The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis. (2017) · cites this paper as [22]
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Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
A perivascular origin for mesenchymal stem cells in multiple human organs
Crisan, M., Yap, S., Casteilla, L., Chen, C.-W., Corselli, M., Park, T. S., Andriolo, G., Sun, B., Zheng, B., Zhang, L., et al. (2008) · Cell Stem Cell · doi:10.1016/j.stem.2008.07.003 · Cited by 3,991 · see citing works
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., & Kliewer, S. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.12953 · Cited by 3,626 · see citing works
Stimulation of adipogenesis in fibroblasts by PPARγ2, a lipid-activated transcription factor
Tontonoz, P., Hu, E., & Spiegelman, B. M. (1994) · Cell · doi:10.1016/0092-8674(94)90006-x · Cited by 3,533 · see citing works
Self-citationModel-based analysis of oligonucleotide arrays: Expression index computation and outlier detection.
Li, C., & Wong, W. H. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.1.31 · Cited by 3,133 · see citing works
Expression monitoring by hybridization to high-density oligonucleotide arrays
Lockhart, D. J., Dong, H., Byrne, M. C., Follettie, M. T., Gallo, M. V., Chee, M. S., Mittmann, M., Wang, C., Kobayashi, M., Norton, H., et al. (1996) · Nature Biotechnology · doi:10.1038/nbt1296-1675 · Cited by 2,841 · see citing works
PRDM16 controls a brown fat/skeletal muscle switch
Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · cited 1× · see citing works
“This data suggest that despite the distinct origin of WAT and classical BAT depots during early embryogenesis (Seale et al., 2008), committed brown and white adipocytes may independently pass through a pericyte lineage.”
BackgroundSelf-citationAdipocytes as regulators of energy balance and glucose homeostasis
Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170 · cited 1× · see citing works
“Fat cells secrete a large number of polypeptides (adipokines) that affect various aspects of energy homeostasis, including food intake, insulin sensitivity, and blood pressure (Rosen and Spiegelman, 2006).”
BackgroundFat and Beyond: The Diverse Biology of PPARγ
Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061307.091829 · Cited by 2,085 · see citing works
Self-citationPPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In Vitro
Rosen, E. D., Sarraf, P., Troy, A. E., Bradwin, G., Moore, K. J., Milstone, D. S., Spiegelman, B. M., & Mortensen, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80211-7 · Cited by 2,081 · see citing works
Self-citationPPARγ Is Required for Placental, Cardiac, and Adipose Tissue Development
Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y., Ruiz‐Lozano, P., Chien, K. R., Koder, A., & Evans, R. M. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80209-9 · Cited by 1,960 · see citing works
Transcriptional control of adipocyte formation
Farmer, S. R. (2006) · Cell Metabolism · doi:10.1016/j.cmet.2006.07.001 · Cited by 1,836 · see citing works
Muscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Joe, A. W. B., Yi, L., Natarajan, A., Le Grand, F., So, L., Wang, J., Rudnicki, M. A., & Rossi, F. M. V. (2010) · Nature Cell Biology · doi:10.1038/ncb2015 · Cited by 1,690 · see citing works
Plasticity of Human Adipose Lineage Cells Toward Endothelial Cells
Planat‐Benard, V., Silvestre, J., Cousin, B., André, M., Nibbelink, M. M., Tamarat, R., Clergue, M., Manneville, C., Barreau, C., Duriez, M., et al. (2004) · Circulation · doi:10.1161/01.cir.0000114522.38265.61 · Cited by 1,381 · see citing works
Barroso, I., Gurnell, M., Crowley, V. E. F., Agostini, M., Schwabe, J. W., Soos, M. A., Maslen, G. L., Williams, T. D. M., Lewis, H., Schafer, A. J., et al. (1999) · Nature · doi:10.1038/47254 · Cited by 1,368 · see citing works
Green, H., & Kehinde, O. (1975) · Cell · doi:10.1016/0092-8674(75)90087-2 · Cited by 1,362 · see citing works
PPARγ Mediates High-Fat Diet–Induced Adipocyte Hypertrophy and Insulin Resistance
Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., 杉山, 拓., et al. (1999) · Molecular Cell · doi:10.1016/s1097-2765(00)80210-5 · Cited by 1,342 · see citing works
Uezumi, A., Fukada, S., Yamamoto, N., Takeda, S., & Tsuchida, K. (2010) · Nature Cell Biology · doi:10.1038/ncb2014 · Cited by 1,315 · see citing works
Regional adiposity and morbidity.
Kissebah, A. H., & Krakower, G. R. (1994) · Physiological Reviews · doi:10.1152/physrev.1994.74.4.761 · Cited by 1,132 · see citing works
White Fat Progenitor Cells Reside in the Adipose Vasculature
Tang, W., Zeve, D., Suh, J. M., Bosnakovski, D., Kyba, M., Hammer, R. E., Tallquist, M. D., & Graff, J. M. (2008) · Science · doi:10.1126/science.1156232 · Cited by 1,113 · see citing works
An established pre-adipose cell line and its differentiation in culture
Green, H., & Meuth, M. (1974) · Cell · doi:10.1016/0092-8674(74)90116-0 · Cited by 1,108 · see citing works
Direct Isolation of Satellite Cells for Skeletal Muscle Regeneration
Montarras, D., Morgan, J., Collins, C., Relaix, F., Zaffran, S., Cumano, A., Partridge, T., & Buckingham, M. (2005) · Science · doi:10.1126/science.1114758 · Cited by 1,100 · see citing works
Identification of White Adipocyte Progenitor Cells In Vivo
Rodeheffer, M. S., Birsoy, K., & Friedman, J. M. (2008) · Cell · doi:10.1016/j.cell.2008.09.036 · Cited by 945 · see citing works
Chawla, A., Schwarz, E. J., Dimaculangan, D. D., & Lazar, M. A. (1994) · Endocrinology · doi:10.1210/endo.135.2.8033830 · Cited by 874 · see citing works
Traktuev, D. O., Merfeld‐Clauss, S., Li, J., Kolonin, M. G., Arap, W., Pasqualini, R., Johnstone, B. H., & March, K. L. (2007) · Circulation Research · doi:10.1161/circresaha.107.159475 · Cited by 839 · see citing works
Spontaneous heritable changes leading to increased adipose conversion in 3T3 cells
Green, H., & Kehinde, O. (1976) · Cell · doi:10.1016/0092-8674(76)90260-9 · Cited by 833 · see citing works
Conversion of vascular endothelial cells into multipotent stem-like cells
Medici, D., Shore, E. M., Lounev, V. Y., Kaplan, F. S., Kalluri, R., & Olsen, B. R. (2010) · Nature Medicine · doi:10.1038/nm.2252 · Cited by 678 · see citing works
Hauner, H., Entenmann, G., Wabitsch, M., Gaillard, D., Ailhaud, G. P., Négrel, R., & Pfeiffer, E. F. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114345 · Cited by 621 · see citing works
Evidence for a role of developmental genes in the origin of obesity and body fat distribution
Gesta, S., Blüher, M., Yamamoto, Y., Norris, A. W., Berndt, J., Kralisch, S., Boucher, J., Lewis, C. R., & Kahn, C. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601752103 · Cited by 617 · see citing works
Zannettino, A. C. W., Paton, S., Arthur, A., Khor, F., Itescu, S., Gimble, J. M., & Gronthos, S. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21210 · Cited by 553 · see citing works
Transcriptional control of preadipocyte determination by Zfp423
Gupta, R. K., Arany, Z. P., Seale, P., Mepani, R. J., Li, Y., Conroe, H. M., Roby, Y. A., Kulaga, H. M., Reed, R. R., & Spiegelman, B. M. (2010) · Nature · doi:10.1038/nature08816 · Cited by 537 · see citing works
Self-citationStromal vascular progenitors in adult human adipose tissue
Zimmerlin, L., Donnenberg, V. S., Pfeifer, M. E., Meyer, E. M., Péault, B., Rubin, J. P., & Donnenberg, A. D. (2009) · Cytometry Part A · doi:10.1002/cyto.a.20813 · Cited by 497 · see citing works
Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat
Schulz, T. J., Huang, T. L., Tran, T. T., Zhang, H., Townsend, K. L., Shadrach, J. L., Cerletti, M., McDougall, L. E., Giorgadze, N., Tchkonia, T., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1010929108 · Cited by 459 · see citing works
THE DIFFERENTIATION OF WHITE ADIPOSE CELLS
Napolitano, L. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.18.3.663 · Cited by 421 · see citing works
Hata, A., Seoane, J., Lagna, G., Montalvo, E., Hemmati‐Brivanlou, A., & Massagué, J. (2000) · Cell · doi:10.1016/s0092-8674(00)81561-5 · Cited by 420 · see citing works
The Vascular Endothelium of the Adipose Tissue Gives Rise to Both White and Brown Fat Cells
Tran, K., Gealekman, O., Frontini, A., Zingaretti, M. C., Morroni, M., Giordano, A., Smorlesi, A., Perugini, J., Matteis, R. D., Sbarbati, A., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.01.008 · Cited by 381 · see citing works
Self-citationGene expression cascades in pancreatic development
Wilson, M. E., Scheel, D., & German, M. S. (2002) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00333-7 · Cited by 354 · see citing works
A Survey of Genes Differentially Expressed in Subcutaneous and Visceral Adipose Tissue in Men*
Vohl, M., SLADEK, R. M., Robitaille, J., Gurd, S., Marceau, P., Richard, D., Hudson, T. J., & Tchernof, A. (2004) · Obesity Research · doi:10.1038/oby.2004.153 · Cited by 330 · see citing works
Joe, A. W., Yi, L., Even, Y., Vogl, A. W., & Rossi, F. M. V. (2009) · Stem Cells · doi:10.1002/stem.190 · Cited by 278 · see citing works
Crossno, J. T., Majka, S. M., Grazia, T. J., Gill, R. G., & Klemm, D. J. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28510 · Cited by 268 · see citing works
Cytological and enzymological characterization of adult human adipocyte precursors in culture.
Van, R. L., Bayliss, C. E., & Roncari, D. A. K. (1976) · Journal of Clinical Investigation · doi:10.1172/jci108516 · Cited by 265 · see citing works
Sengenès, C., Lolmède, K., Zakaroff‐Girard, A., Busse, R., & Bouloumié, A. (2005) · Journal of Cellular Physiology · doi:10.1002/jcp.20381 · Cited by 250 · see citing works
Critical Role for Ebf1 and Ebf2 in the Adipogenic Transcriptional Cascade
Jimenez, M. A., Åkerblad, P., Sigvardsson, M., & Rosen, E. D. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01557-06 · Cited by 218 · see citing works
Minireview: Pref-1: Role in Adipogenesis and Mesenchymal Cell Fate
Sul, H. S. (2009) · Molecular Endocrinology · doi:10.1210/me.2009-0160 · Cited by 218 · see citing works
Functional Implications of CD34 Expression in Human Adipose–Derived Stem/Progenitor Cells
Suga, H., Matsumoto, D., Eto, H., Inoue, K., Aoi, N., D, H. K. M., Araki, J., & Yoshimura, K. (2009) · Stem Cells and Development · doi:10.1089/scd.2009.0003 · Cited by 210 · see citing works
Xu, X., Ying, Z., Cai, M., Xu, Z., Li, Y., Jiang, S. Y., Tzan, K., Wang, A., Parthasarathy, S., He, G., et al. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00806.2010 · Cited by 200 · see citing works
CYTOLOGICAL RESPONSES OF BROWN FAT TISSUE IN COLD-EXPOSED RATS
Cameron, I. L., & Smith, R. E. (1964) · The Journal of Cell Biology · doi:10.1083/jcb.23.1.89 · Cited by 163 · see citing works
Perrini, S., Laviola, L., Cignarelli, A., Melchiorre, M., Stefano, F. D., Caccioppoli, C., Natalicchio, A., Orlando, M. R., Garruti, G., Fazio, M. D., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0841-7 · Cited by 141 · see citing works
Majka, S. M., Fox, K. E., Psilas, J. C., Helm, K. M., Childs, C. R., Acosta, A. S., Janssen, R. C., Friedman, J. E., Woessner, B. T., Shade, T. R., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003512107 · Cited by 140 · see citing works
Amos, P. J., Shang, H., Bailey, A. M., et al. (2008) · Stem Cells · doi:10.1634/stemcells.2008-0030 · Cited by 134 · see citing works
Wassermann, F., & McDonald, T. F. (1960) · Cell and Tissue Research · doi:10.1007/bf00336627 · Cited by 130 · see citing works
Hirsch, J., Fried, S. K., Edens, N. K., & Leibel, R. L. (1989) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30693-9 · Cited by 122 · see citing works
Flemming, W. (1871) · Archiv für Mikroskopische Anatomie · doi:10.1007/bf02956045 · Cited by 118 · see citing works
The development of adipose tissue
Wassermann, F. (1965) · Comprehensive physiology · doi:10.1002/cphy.cp050110 · Cited by 116 · see citing works
Åkerblad, P., Lind, U., Liberg, D., Bamberg, K., & Sigvardsson, M. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.22.8015-8025.2002 · Cited by 112 · see citing works
Gene expression in visceral and subcutaneous adipose tissues
Vidal, H. (2001) · Annals of Medicine · doi:10.3109/07853890108995965 · Cited by 97 · see citing works
A morphological study of the adipocyte precursor.
Cinti, S., CIGOLINI, M., Bosello, O., & Björntorp, P. A. (1984) · PubMed · Cited by 85 · see citing works
Self-citationSearch for the adipocyte precursor cell and factors that promote its differentiation.
Hausman, G., Campion, D. R., & Martin, R. J. (1980) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)34794-5 · Cited by 83 · see citing works
Ueber eine neue Art von fettbildenden Organen im lockern Bindegewebe
Poljakoff, P. (1888) · Archiv für Mikroskopische Anatomie · doi:10.1007/bf02956989 · Cited by 81 · see citing works
Concise Review: Adipocyte Origins: Weighing the Possibilities
Majka, S. M., Barak, Y., & Klemm, D. J. (2011) · Stem Cells · doi:10.1002/stem.653 · Cited by 80 · see citing works
Zfp423 Is Required for Normal Cerebellar Development
Warming, S., Rachel, R. A., Jenkins, N. A., & Copeland, N. G. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02255-05 · Cited by 80 · see citing works
"The fat cell; origin and structure".
Cg, T. (1960) · PubMed · Cited by 78 · see citing works
Defining Pancreatic Endocrine Precursors and Their Descendants
White, P., May, C. L., Lamounier, R. N., Brestelli, J. E., & Kaestner, K. H. (2007) · Diabetes · doi:10.2337/db07-1362 · Cited by 77 · see citing works
Transcription factor expression dynamics of early T-lymphocyte specification and commitment
David‐Fung, E., Butler, R. R., Buzi, G., Yui, M. A., Diamond, R. A., Anderson, M. K., Rowen, L., & Rothenberg, E. V. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.10.021 · Cited by 68 · see citing works
The ultrastructural differentiation of brown adipose tissue in the rat
Barnard, T. (1969) · Journal of Ultrastructure Research · doi:10.1016/s0022-5320(69)90109-9 · Cited by 62 · see citing works
Pancreatic Islet Progenitor Cells in Neurogenin 3-Yellow Fluorescent Protein Knock-Add-On Mice
Mellitzer, G., Martı́n, M., Sidhoum-Jenny, M., et al. (2004) · Molecular Endocrinology · doi:10.1210/me.2004-0243 · Cited by 60 · see citing works
Differentiation of rabbit adipocyte precursor cells in a serum-free medium
Reyne, Y., Nouguès, J., & Dulor, J. P. (1989) · In Vitro Cellular & Developmental Biology - Plant · doi:10.1007/bf02623728 · Cited by 26 · see citing works
Brown adipocyte precursor cells: a morphological study.
Cinti, S., & Morroni, M. (1995) · PubMed · Cited by 15 · see citing works
Self-citationAn ultrastructural study of adipocyte precursors from epididymal fat pads of adult rats in culture.
Cinti, S., CIGOLINI, M., Gazzanelli, G., & Bosello, O. (1985) · PubMed · Cited by 13 · see citing works
Self-citationDiet-Induced Obesity in Stem Cell Antigen-1 KO Mice
Staszkiewicz, J., Gimble, J. M., Dietrich, M. A., et al. (2011) · Stem Cells and Development · doi:10.1089/scd.2010.0507 · Cited by 5 · see citing works
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Ghaben, A. L., & Scherer, P. E. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0093-z · Cited by 1,395 · see citing works
Adipose tissue browning and metabolic health
Bartelt, A., & Heeren, J. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2013.204 · Cited by 1,177 · see citing works
Ambrosi, T. H., Scialdone, A., Graja, A., Gohlke, S., Jank, A.-M., Bocian, C., Woelk, L., Fan, H., Logan, D. W., Schürmann, A., et al. (2017) · Cell Stem Cell · doi:10.1016/j.stem.2017.02.009 · Cited by 856 · see citing works
The ominous triad of adipose tissue dysfunction: inflammation, fibrosis, and impaired angiogenesis.
Crewe, C., An, Y. A., & Scherer, P. E. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88883 · Cited by 732 · see citing works
Identification of a mesenchymal progenitor cell hierarchy in adipose tissue
Merrick, D., Sakers, A., Irgebay, Z., Okada, C., Calvert, C., Morley, M. P., Percec, I., & Seale, P. (2019) · Science · doi:10.1126/science.aav2501 · Cited by 664 · see citing works
Regeneration of fat cells from myofibroblasts during wound healing
Plikus, M. V., Guerrero-Juarez, C. F., Ito, M., Li, Y. R., Dedhia, P. H., Zheng, Y., Shao, M., Gay, D. L., Ramos, R., Hsi, T.-C., et al. (2017) · Science · doi:10.1126/science.aai8792 · Cited by 584 · see citing works
Self-citationContribution of adipogenesis to healthy adipose tissue expansion in obesity
Vishvanath, L., & Gupta, R. K. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129191 · Cited by 558 · see citing works
Self-citationThe cell biology of fat expansion
Rutkowski, J. M., Stern, J. H., & Scherer, P. E. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201409063 · Cited by 541 · see citing works
Dermal adipocytes protect against invasive <i>Staphylococcus aureus</i> skin infection
Zhang, L.-J., Guerrero-Juarez, C. F., Hata, T., Bapat, S. P., Ramos, R., Plikus, M. V., & Gallo, R. L. (2015) · Science · doi:10.1126/science.1260972 · Cited by 471 · see citing works
Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity
Hammarstedt, A., Gogg, S., Hedjazifar, S., Nerstedt, A., & Smith, U. (2018) · Physiological Reviews · doi:10.1152/physrev.00034.2017 · Cited by 462 · see citing works
Adipose tissue plasticity: how fat depots respond differently to pathophysiological cues
Pellegrinelli, V., Carobbio, S., & Vidal-Puig, A. (2016) · Diabetologia · doi:10.1007/s00125-016-3933-4 · Cited by 432 · see citing works
The regulation of adipose tissue health by estrogens
Steiner, B. M., & Berry, D. C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.889923 · Cited by 171 · see citing works
Brown adipose tissue: Development, metabolism and beyond
Schulz, T. J., & Tseng, Y.-H. (2013) · Biochemical Journal · doi:10.1042/bj20130457 · Cited by 173 · see citing works
Macrophages and the Regulation of Adipose Tissue Remodeling
Martinez-Santibañez, G., & Nien-Kai Lumeng, C. (2014) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071812-161113 · Cited by 111 · see citing works
Molecular Nutrition Research—The Modern Way Of Performing Nutritional Science
Norheim, F., Gjelstad, I., Hjorth, M., Vinknes, K., Langleite, T., Holen, T., Jensen, J., Dalen, K., Karlsen, A., Kielland, A., et al. (2012) · Nutrients · doi:10.3390/nu4121898 · Cited by 83 · see citing works
Hypothalamic control of adipose tissue
Stefanidis, A., Wiedmann, N. M., Adler, E. S., & Oldfield, B. J. (2014) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2014.08.001 · Cited by 22 · see citing works
- Authors
- Gupta, R. K., Mepani, R. J., Kleiner, S., Lo, J. C., Khandekar, M. J., Cohen, P., Frontini, A., Bhowmick, D. C., Ye, L., Cinti, S., & Spiegelman, B. M.
- Affiliations
- Harvard University (US)
- Marche Polytechnic University (IT)
- Corresponding author
- Spiegelman, Bruce M.
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 15
- Issue
- 2
- Pages
- 230-239
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC3366493
- OpenAlex
- W2090535095
- Cited by
- 426
- References
- 70
- Citations by year
- 2026: 16 · 2025: 11 · 2024: 19 · 2023: 24 · 2022: 30 · 2021: 22 · 2020: 35 · 2019: 29 · 2018: 38 · 2017: 41 · 2016: 30 · 2015: 34 · 2014: 31 · 2013: 41 · 2012: 24
- FWCI
- 27.88
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Università Politecnica delle Marche (Università Politecnica delle Marche) (submittedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (T32HL007604)
- National Institute of Diabetes and Digestive and Kidney Diseases (K01DK090120, R01DK031405, DK-31405, R37DK031405)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- Zfp423, preadipocytes, adipogenesis, perivascular cells, white adipose tissue, brown adipose tissue, adipose tissue depots, GFP reporter mice, lineage tracing
- MeSH terms
- Animals, Cell Differentiation, DNA-Binding Proteins, Flow Cytometry, Immunohistochemistry, Mice, Transgenic, Stem Cells, Transcription Factors, Adipocytes, Cell Lineage, Pericytes, Gene Expression Profiling, Endothelial Cells, Green Fluorescent Proteins, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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