The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53
Open accessAbstract
Tumor suppressor p53 linked to immune function: We thought we knew all we needed to about the tumor suppressor p53. However, Yoon et al. now describe a previously unrecognized function of p53 (see the Perspective by Zitvogel and Kroemer). p53 induces expression of the gene encoding DD1α, a receptor-like transmembrane protein of the immunoglobulin superfamily. In conditions of stress, p53 activation can lead to cell death. p53-induced expression of DD1α also promotes the clearance of dead cells by promoting engulfment by macrophages. Furthermore, expression of DD1α on T cells inhibits T cell function. Thus, p53 offers protection from inflammatory disease caused by the accumulation of apoptotic cells, and its suppression of T cells might help cancer cells to escape immune detection. Science , this issue 10.1126/science.1261669 ; see also p. 476
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Cites
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“In a normal immune system, phagocytic engulfment of apoptotic cells is accompanied by induction of a certain degree of immune tolerance in order to prevent self-antigen recognition (53, 61).”
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“p53 functions as a transcription factor that is activated by various cellular stresses and governs multiple core programs in cells, including cell cycle arrest and apoptosis (17, 18).”
BackgroundIdentification of a factor that links apoptotic cells to phagocytes
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Phagocytosis and clearance of apoptotic cells is mediated by MER
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Morioka, S., Maueröder, C., & Ravichandran, K. S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.018 · Cited by 391
Immunological impact of cell death signaling driven by radiation on the tumor microenvironment
Rodriguez-Ruiz, M. E., Vitale, I., Harrington, K. J., Melero, I., & Galluzzi, L. (2020) · Nature Immunology · doi:10.1038/s41590-019-0561-4 · Cited by 385
Novikova, G., Kapoor, M., TCW, J., Abud, E. M., Efthymiou, A. G., Chen, S. X., Cheng, H., Fullard, J. F., Bendl, J., Liu, Y., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-21823-y · Cited by 214
VISTA: an immune regulatory protein checking tumor and immune cells in cancer immunotherapy
Huang, X., Zhang, X., Li, E., Zhang, G., Wang, X., Tang, T., Bai, X., & Liang, T. (2020) · Journal of Hematology & Oncology · doi:10.1186/s13045-020-00917-y · Cited by 231
Deng, J., Li, J., Sarde, A., Lines, J. L., Lee, Y.-C., Qian, D. C., Pechenick, D. A., Manivanh, R., Le Mercier, I., Lowrey, C. H., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0507 · Cited by 224
Metadata
- Authors
- Yoon, K. W., Byun, S., Kwon, E., Hwang, S.-Y., Chu, K., Hiraki, M., Jo, S.-H., Weins, A., Hakroush, S., Cebulla, A., Sykes, D. B., Greka, A., Mundel, P., Fisher, D. E., Mandinova, A., & Lee, S. W.
- Venue
- Science
- Published
- 2015-07-31
- Volume
- 349
- Issue
- 6247
- Pages
- 1261669-1261669
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1951816892
- Cited by
- 224
- References
- 16
- FWCI
- 8.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Yoon, K. W., Byun, S., Kwon, E., Hwang, S.-Y., Chu, K., Hiraki, M., Jo, S.-H., Weins, A., Hakroush, S., Cebulla, A., Sykes, D. B., Greka, A., Mundel, P., Fisher, D. E., Mandinova, A., & Lee, S. W. (2015). Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53. Science. https://doi.org/10.1126/science.1261669
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