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Wireless magnetothermal deep brain stimulation

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Chen, Ritchie, Romero, Gabriela, Christiansen, Michael G., Mohr, Alan, Anikeeva, Polina·2015·Science

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Abstract

Exciting nerve cells deep inside the brain: Current techniques to stimulate regions inside the brain need a permanently implanted wire or an optical fiber. Working in mice, Chen et al. developed a method to overcome this problem (see the Perspective by Temel and Jahanshahi). They introduced heat-sensitive capsaicin receptors into nerve cells and then injected magnetic nanoparticles into specific brain regions. The nanoparticles could be heated by external alternating magnetic fields, which activated the ion channel–expressing neurons. Thus, cellular signaling deep inside the brain can be controlled remotely without permanent implants. Science , this issue p. 1477 ; see also p. 1418

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Authors: Chen, R., Romero, G., Christiansen, M. G., Mohr, A., & Anikeeva, P.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2015-03-27
Volume: 347
Issue: 6229
Pages: 1477-1480
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.1261821
OpenAlex: W2036632895
Cited by: 685
References: 6
FWCI: 26.39
Type: journal article
Language: en
Open access: green
Licence: www.sciencemag.org/about/science-licenses-journal-article-reuse (vor, 366 d)
Funders: Defense Advanced Research Projects Agency Young Faculty Award (D13AP00043)
McGovern Institute for Brain Research
NSF CAREER (CBET-1253890)

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Wireless magnetothermal deep brain stimulation

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