Intracranial Self-Stimulation in Man

Bishop, M. P.; Elder, S. Thomas; Heath, Robert G.

doi:10.1126/science.140.3565.394

Cited by 142Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesNeurological disorders and treatments

Intracranial Self-Stimulation in Man

Bishop, M. P., Elder, S. Thomas, Heath, Robert G.·1963·Science

DOI 10.1126/science.140.3565.394

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Abstract

Intracranial self-stimulation techniques, modified for use with neuropsychiatric patients, provide data suggestive of positive and negative reinforcing properties of brief electrical stimulation to various subcortical structures of the human brain.

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Crossref · 10.1126/science.140.3565.394

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The LS is part of the brain reward system.
“other studies indicating that the LS is part of the brain reward system.”
From Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin (2018) · cites this paper as [35]
The LS is associated with electrical self-stimulation in rats and humans.
“the LS is associated with electrical self-stimulation in rats and humans [34,35]”
From Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin (2018) · cites this paper as [35]

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“Rats (Olds and Milner, 1954; Wise, 1996), mice (Cazala et al., 1974; Stoker andMarkou, 2011a), nonhuman primates (Rolls et al., 1980), and humans (Bishop et al., 1963; Heath, 1963) will all respond avidly for electrical stimulation of some brain areas.”
Background
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The Puzzle of Pain
Murray, J. B. (1969) · Perceptual and Motor Skills · doi:10.2466/pms.1969.28.3.887 · Cited by 189 · see citing works
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Fulton, S. (2009) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2009.10.003 · Cited by 158 · see citing works
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Schlaepfer, T. E., Bewernick, B. H., Kayser, S., Hurlemann, R., & Coenen, V. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.28 · Cited by 160 · see citing works
Effects of the availability of rewarding septal and hypothalamic stimulation on bar pressing for food under conditions of deprivation.
Routtenberg, A., & Lindy, J. (1965) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0022365 · Cited by 160 · see citing works
The central basis of motivation: intracranial self-stimulation studies.
Olds, M., & Fobes, J. (1981) · Annual Review of Psychology · doi:10.1146/annurev.ps.32.020181.002515 · Cited by 160 · see citing works
Placebo mechanisms and reward circuitry: clues from Parkinson's disease
de la Fuente‐Fernández, R., Schulzer, M., & Stoessl, A. J. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2003.11.019 · Cited by 133 · see citing works
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Moll, J., Zahn, R., de Oliveira-Souza, R., Bramati, I., Krueger, F., Tura, B., Cavanagh, A., & Grafman, J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.08.026 · Cited by 131 · see citing works
“Controls scored the prosocial and other-critical categories with comparable accuracy, indicating that these categories were matched in difficulty (t=0.36, p=0.74).”
BackgroundInfluential
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Choi, K. S., Riva‐Posse, P., Gross, R. E., & Mayberg, H. S. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.2564 · Cited by 133 · see citing works
“, 7 of the 9 subjects for a best response) was generated for (1) the ‘Best’ contacts (regardless of hemisphere), (2) the non-best but Choi et al.”
Background
The paleocerebellum and the integration of behavioral function
Berntson, G., & Torello, M. (1982) · Physiological Psychology · doi:10.3758/bf03327003 · Cited by 114 · see citing works
Brain reward systems and compulsive drug use
Kenny, P. J. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.01.008 · Cited by 111 · see citing works
Mind Reading and Writing: The Future of Neurotechnology
Roelfsema, P. R., Denys, D., & Klink, P. C. (2018) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2018.04.001 · Cited by 107 · see citing works
“A versatile method to indirectly in ﬂ uence behavior is the activation of neurons that process rewards and punishments [81 – 83].”
Using fMRI to study reward processing in humans: past, present, and future
Wang, K. S., Smith, D. V., & Delgado, M. R. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00333.2015 · Cited by 105 · see citing works
The central nervous system and the reinforcement of behavior.
Olds, J. L. (1969) · American Psychologist · doi:10.1037/h0027145 · Cited by 97 · see citing works
The amygdala's role in human mnemonic processing.
Sarter, M., & Markowitsch, H. (1985) · Cortex; a journal devoted to the study of the nervous system and behavior · doi:10.1016/s0010-9452(85)80013-7 · Cited by 94 · see citing works
Septal stimulation for the initiation of heterosexual behavior in a homosexual male
Moan, C. E., & Heath, R. (1972) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/0005-7916(72)90029-8 · Cited by 86 · see citing works
Self-citation
Voluntary Enhancement of Neural Signatures of Affiliative Emotion Using fMRI Neurofeedback
Moll, J., Weingartner, J., Bado, P., Basílio, R., Sato, J., Melo, B., Bramati, I., de Oliveira-Souza, R., & Zahn, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097343 · Cited by 78 · see citing works
“In addition, stimulation of this region induces positive reinforcement and decreases intra-species aggression [35,36].”
Background
Surgery of the Mind, Mood, and Conscious State: An Idea in Evolution
Robison, A., Taghva, A. S., Liu, C. Y., & Apuzzo, M. L. J. (2013) · World Neurosurgery · doi:10.1016/j.wneu.2013.08.002 · Cited by 83 · see citing works
A Neural Signature of Affiliative Emotion in the Human Septohypothalamic Area
Moll, J., Bado, P., de Oliveira‐Souza, R., Bramati, I. E., Lima, D. O., Paiva, F. F., Sato, J. R., Tovar-Moll, F. F., & Zahn, R. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6508-11.2012 · Cited by 87 · see citing works
“Furthermore, stimulation of this region elicits pleasurable experiences and prosocial behavior (Bishop et al., 1963; Andy and Stephan, 1968; Irvin et al., 1990).”
Background
The Tulane Electrical Brain Stimulation Program A Historical Case Study in Medical Ethics
Baumeister, A. (2000) · Journal of the History of the Neurosciences · doi:10.1076/jhin.9.3.262.1787 · Cited by 69 · see citing works
The neural basis of brain-stimulation reward.
Rolls, E. T. (1975) · Progress in neurobiology · doi:10.1016/0301-0082(74)90005-7 · Cited by 68 · see citing works
The Medial Septum as a Potential Target for Treating Brain Disorders Associated With Oscillopathies
Takeuchi, Y., Nagy, A. J., Barcsai, L., Li, Q., Ohsawa, M., Mizuseki, K., & Berényi, A. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.701080 · Cited by 66 · see citing works
“MS is also known as the pleasure center of the brain (Olds and Milner, 1954; Bishop et al., 1963).”
BackgroundResult
Decision neuroscience: neuroeconomics
Smith, D. V., & Huettel, S. A. (2010) · Wiley Interdisciplinary Reviews Cognitive Science · doi:10.1002/wcs.73 · Cited by 62 · see citing works
The idiosyncratic aspects of the epilepsy of Fyodor Dostoevsky.
Hughes, J. R. (2005) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2005.07.021 · Cited by 60
Deep brain stimulation: a mechanistic and clinical update
Karas, P. J., Mikell, C. B., Christian, E., Liker, M. A., & Sheth, S. A. (2013) · Neurosurgical FOCUS · doi:10.3171/2013.9.focus13383 · Cited by 57 · see citing works
Pain-reducing properties of rewarding electrical brain stimulation in the rat.
Rose, M. D. (1974) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0036975 · Cited by 46
What is Psychological Explanation?
Bechtel, W., & Wright, C. (2019) · The Routledge Companion to Philosophy of Psychology · doi:10.4324/9780429244629-8 · Cited by 46 · see citing works
Great Expectations: The Placebo Effect in Parkinson’s Disease
Lidstone, S. C. (2014) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-44519-8_8 · Cited by 46 · see citing works
Neuromodulation in Psychiatric Disorders
Temel, Y., Hescham, S., Jahanshahi, A., Janssen, M. L. F., Tan, S. K. H., van Overbeeke, J. J., Ackermans, L. P. C. M., Oosterloo, M., Duits, A., Leentjens, A. F. G., et al. (2012) · International review of neurobiology · doi:10.1016/b978-0-12-404706-8.00015-2 · Cited by 43 · see citing works
Clonidine reduces the excitability of spinal dorsal horn neurones.
Wolff, M., Heugel, P., Hempelmann, G., Scholz, A., Mühling, J., & Olschewski, A. (2007) · British Journal of Anaesthesia · doi:10.1093/bja/ael379 · Cited by 44
Effects of long-term psychological stress on sexual behavior and brain catecholamine levels.
Sato, Y., Suzuki, N., Horita, H., Wada, H., Shibuya, A., Adachi, H., Tsukamoto, T., Kumamoto, Y., & Yamamoto, M. (1996) · Journal of Andrology · doi:10.1002/j.1939-4640.1996.tb01755.x · Cited by 43 · see citing works
“The hypo- thalamus, which includes the MPOA, also has functions for generation and regulation of emotion (Bishop et al, 1963).”
Background
Self‐stimulation in the rabbit: An anatomical map of stimulation effects
Bruner, A. (1967) · The Journal of comparative neurology · doi:10.1002/cne.901310414 · Cited by 41 · see citing works
The application of conditioning paradigms in the measurement of pain
Li, J. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.03.002 · Cited by 40 · see citing works
“It was soon found that electric stimulation of several brain regions is reinforcing in both animals and humans (Andrew, 1967; Bishop et al., 1963; Wilkinson and Peele, 1963).”
Background
The biochemical bases of the placebo effect
de la Fuente‐Fernández, R., & Stoessl, A. J. (2004) · Science and Engineering Ethics · doi:10.1007/s11948-004-0071-z · Cited by 37 · see citing works
Forward shift of feeding buzz components of dolphins and belugas during associative learning reveals a likely connection to reward expectation, pleasure and brain dopamine activation
Ridgway, S. H., Moore, P., Carder, D., & Romano, T. (2014) · Journal of Experimental Biology · doi:10.1242/jeb.100511 · Cited by 38 · see citing works
“Both rewarding and aversive areas were found in the human brain (Heath, 1963; Bishop et al., 1963).”
Background
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Charlet, K., Beck, A., & Heinz, A. (2011) · Current topics in behavioral neurosciences · doi:10.1007/978-3-642-28720-6_130 · Cited by 51 · see citing works
Reward-associated inhibition and pain-associated excitation lasting seconds in single intralaminar thalamic units.
Keene, J. J. (1973) · Brain Research · doi:10.1016/0006-8993(73)90179-0 · Cited by 35
The placebo response as a reward mechanism
Lidstone, S. C., de la Fuente‐Fernández, R., & Stoessl, A. J. (2005) · Seminars in Pain Medicine · doi:10.1016/j.spmd.2005.02.004 · Cited by 33 · see citing works
Involvement of dopamine, but not norepinephrine, in the sex-specific regulation of juvenile socially rewarding behavior by vasopressin
Bredewold, R., Nascimento, N. F., Ro, G. S., Cieslewski, S. E., Reppucci, C. J., & Veenema, A. H. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0100-2 · Cited by 31 · see citing works
Morphofunctional Alterations of the Hypothalamus and Social Behavior in Autism Spectrum Disorders
Carìa, A., Ciringione, L., & de Falco, S. (2020) · Brain Sciences · doi:10.3390/brainsci10070435 · Cited by 29 · see citing works
“In addition, hypothalamic stimulation can also induce pleasurable experiences and prosocial behavior in humans [53,54].”
Background
Animal Models of Addiction and Neuropsychiatric Disorders and Their Role in Drug Discovery: Honoring the Legacy of Athina Markou
Kenny, P. J., Hoyer, D., & Koob, G. F. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.02.009 · Cited by 26 · see citing works
“Subsequently, it was shown that mice (10), cats (11), dogs (12) and even humans (13) will also work hard for ICSS stimulation.”
Brain stimulation and the motivation of behavior.
Olds, J. L. (1976) · Progress in Brain Research · doi:10.1016/s0079-6123(08)61001-8 · Cited by 25 · see citing works
Employing labor-supply theory to measure the reward value of electrical brain stimulation
Conover, K. L., & Shizgal, P. (2004) · Games and Economic Behavior · doi:10.1016/j.geb.2004.08.003 · Cited by 20 · see citing works
“Such rewarding effects have been demonstrated across the ver phylum, from goldfish to humans (Bishop et al., 1963; Boyd and Gardiner, 1962; D 1978; Lilly and Miller, 1962; Olds and Milner, 1954; Porter et al., 1959; Roberts, 19 Figure 1, a summary of brain stimulation reward sites in the rat (Wise,…”
Background
Non-invasive and invasive brain stimulation in alcohol use disorders: A critical review of selected human evidence and methodological considerations to guide future research
Maatoug, R., Bihan, K., Duriez, P., Podevin, P., Silveira-Reis-Brito, L., Benyamina, A., Valero‐Cabré, A., & Millet, B. (2021) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2021.152257 · Cited by 29 · see citing works
“Sometime later, in 1963, Bishop et al. [13], published the first report of deep brain stimulation in humans for neuropsychiatric disorders, pain and movement disorders.”
The ventrolateral hypothalamic area and the parvafox nucleus: Role in the expression of (positive) emotions?
Alvarez-Bolado, G., & Celio, M. R. (2016) · The Journal of comparative neurology · doi:10.1002/cne.23853 · Cited by 20 · see citing works
“Sex, drugs and the brain”: The interaction between drugs of abuse and sexual behavior in the female rat
Guarraci, F. A. (2009) · Hormones and Behavior · doi:10.1016/j.yhbeh.2009.12.002 · Cited by 30 · see citing works
“Even dating back to Heath's famous studies of electrical brain stimulation in people with severe depression (Bishop et al., 1963), one patient who could voluntarily deliver electrical stimulation to her medial forebrain bundle was video taped calling the button that delivered stimulation – “the…”
Background
Psychology of the pain experience.
Murray, J. B. (1971) · The Journal of psychology · doi:10.1080/00223980.1971.9916903 · Cited by 20
Optogenetic Activation of a Lateral Hypothalamic-Ventral Tegmental Drive-Reward Pathway
Gigante, E., Benaliouad, F., Zamora-Olivencia, V., & Wise, R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158885 · Cited by 19 · see citing works
The Cerebral Localization of Pain: Anatomical and Functional Considerations for Targeted Electrical Therapies
Caston, R. M., Smith, E. H., Davis, T., & Rolston, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9061945 · Cited by 18 · see citing works
Positive and Negative Reinforcement from Intracranial Stimulation in Pigeons
Macphail, E. (1967) · Nature · doi:10.1038/213947a0 · Cited by 17
Voluntary Sleep Loss in Rats.
Oonk, M., Krueger, J., & Davis, C. J. (2016) · Sleep · doi:10.5665/sleep.5984 · Cited by 15 · see citing works
When “altering brain function” becomes “mind control”
Koivuniemi, A., & Otto, K. (2014) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2014.00202 · Cited by 15
“This is because neurosurgeons and neurologists cannot make perfectly reliable a priori guesses about what effect a given instance of DBS will have on a given patient.”
Background
Serendipity and Observations in Functional Neurosurgery: From James Parkinson’s Stroke to Hamani’s & Lozano’s Flashbacks
Hariz, M., Lees, A., Blomstedt, Y., & Blomstedt, P. (2022) · Stereotactic and Functional Neurosurgery · doi:10.1159/000525794 · Cited by 14
Neurobiología de la adicción a las drogas de abuso
Gil-Verona, J., Pastor, J., de Paz, F. D., Barbosa, M., Macias-Fernandez, J. A., Maniega, M., Rami-González, L., & Canizares-Alejos, S. (2003) · doi:10.33588/rn.3604.2002052 · Cited by 14
“Esta técnica, conocida como autoestimulación intracraneal, se ha descrito en ratas [9], en humanos [10] y en muchas especies.”
Background
Inhibition of intracranial self-stimulation in brain stem-transected cats--a proposed mechanism of aversive effects produced by brain stimulation.
Ikegami, S., & Kawamura, H. (1981) · Brain Research · doi:10.1016/0006-8993(81)91008-8 · Cited by 14
Placebo Response: Relevance to the Rheumatic Diseases
Pollo, A., & Benedetti, F. (2008) · Rheumatic Disease Clinics of North America · doi:10.1016/j.rdc.2008.04.002 · Cited by 10 · see citing works
“Activation of electrodes implanted in these regions induces self-stimulation in humans [60], which is associated with dopamine release [61].”
Background
Interactions between rewarding lateral hypothalamic and aversive nucleus reticularis gigantocellularis stimulation.
Diotte, M., Miguelez, M., Miliaressis, E., & Bielajew, C. (2000) · Behavioural Brain Research · doi:10.1016/s0166-4328(00)00268-0 · Cited by 12
A Hypothalamic Perspective of Human Socioemotional Behavior
Carìa, A. (2023) · The Neuroscientist · doi:10.1177/10738584221149647 · Cited by 9 · see citing works
Effects of scopolamine on the rewarding and seizure-inducing properties of amygdaloid stimulation.
Brophy, P. D., Borowski, T., & Kokkinidis, L. (1993) · Pharmacology, Biochemistry and Behavior · doi:10.1016/0091-3057(93)90485-c · Cited by 11
THE NEURAL SUBSTRATE FOR EMOTION
Heath, R. (1986) · Elsevier eBooks · doi:10.1016/b978-0-12-558703-7.50007-3 · Cited by 11 · see citing works
Self-citation
Neural Basis of Pleasure and Reward
Knapp, C. M., & Kornetsky, C. H. (2009) · Wiley eBooks · doi:10.1002/9780470478509.neubb002040 · Cited by 9 · see citing works
Spontaneous activity in the pyramidal tract of chronic cats and monkeys; recorded with indwelling electrodes.
Hardin, W. B. (1965) · Archives of Neurology · doi:10.1001/archneur.1965.00470050049006 · Cited by 10
Animal Studies in Deep Brain Stimulation Research
Feenstra, M., & Denys, D. (2012) · Springer eBooks · doi:10.1007/978-3-642-30991-5_20 · Cited by 9 · see citing works
Placebo
Benedetti, F., & Schedlowski, M. (2014) · Handbook of Experimental Pharmacology · doi:10.1007/978-3-662-44519-8 · Cited by 8 · see citing works
The Riddle of Attractiveness: Looking for an ‘Aesthetic Sense’ Within the Hedonic Mind of the Beholders
Kreutzer, M., & Aebischer, V. (2015) · History, philosophy and theory of the life sciences · doi:10.1007/978-94-017-9585-2_12 · Cited by 7 · see citing works
“Indeed Bishop et al. (1963) using intracranial self-stimulation in man obtained results similar to those of the rat experiments.”
Result
[Psychological stress and sexual behavior in male rats. II. Effect of psychological stress on dopamine and its metabolites in the critical brain areas mediating sexual behavior].
Sato, Y., & Kumamoto, Y. (1992) · Nihon Hinyokika Gakkai zasshi. The japanese journal of urology · doi:10.5980/jpnjurol1989.83.212 · Cited by 6
Influences of dorsal and ventral hippocampus on hypothalamic self-stimulation.
Koreli, A. (1977) · Physiology and Behavior · doi:10.1016/0031-9384(77)90303-1 · Cited by 6 · see citing works
A Brief History of Sensation and Reward
Marks, L. E. (2011) · Frontiers in neuroscience · doi:10.1201/b10776-4 · Cited by 4 · see citing works
Thirty Years of Global Deep Brain Stimulation: “Plus ça change, plus c’est la même chose”?
Hariz, M., Cif, L., & Blomstedt, P. (2023) · Stereotactic and Functional Neurosurgery · doi:10.1159/000533430 · Cited by 5 · see citing works
“In 1963, the team at Tulane University implanted electrodes in the caudate nucleus, the septal area, the amygdala, the central thalamus, and the hypothalamus and used a ﬁ xed frequency of 100 Hz to study “ rewarding ” and “ aversive ” responses at various current intensities [80].”
Method
Hypocrétines : entre l’envie et le besoin : …ou l’émergence d’une nouvelle voie d’origine hypothalamique impliquée dans la motivation et l’addiction
Boutrel, B. (2006) · médecine/sciences · doi:10.1051/medsci/20062267573 · Cited by 5 · see citing works
“La démonstration, également reproduite chez l’homme [2], fait concevoir le LH comme une des pièces maîtresses de la fonction de récompense cérébrale (FRC)1, fonction qui conditionne les aspects motivationnels de toute stratégie comportementale et pousse à la réalisation d’un objectif donné.”
Background
Self-stimulation and mating behavior in the male rat.
Carlsson, S., & Larsson, K. (1975) · Scandinavian Journal of Psychology · doi:10.1111/j.1467-9450.1975.tb00156.x · Cited by 5 · see citing works
Ressourcenaktivierung und motivorientierte Beziehungsgestaltung: Bedürfnisbefriedigung in der Psychotherapie
Flückiger, C., & Holtforth, M. G. (2007) · Springer eBooks · doi:10.1007/978-3-540-71622-8_3 · Cited by 5 · see citing works
Do Reward and Drive Neurons Exist
Olds, J. L. (1976) · doi:10.1007/978-1-4684-2238-2_4 · Cited by 5
The cognitive basis of intracranial self-stimulation of midbrain dopamine neuronsPreprint
Millard, S. J., Hoang, I. B., Greer, Z., O’Connor, S. L., Wassum, K. M., James, M. H., Barker, D. J., & Sharpe, M. J. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.08.11.503670 · Cited by 4 · see citing works
The use of reward cue-reactivity in predicting real-world self-control failure
Wagner, D. (2017) · doi:10.4324/9781315648576.ch5 · Cited by 4
Negativism to food during self-stimulation in the anterior part of the basal forebrain in dogs.
Sadowski, B. (1974) · Physiology and Behavior · doi:10.1016/0031-9384(74)90235-2 · Cited by 4
Roles of Taste in Feeding and Reward
Yamamoto, T., & Shimura, T. (2008) · Elsevier eBooks · doi:10.1016/b978-012370880-9.00098-0 · Cited by 4 · see citing works
Targeting brain hubs of ictal fast ripple activity to reduce seizures in patients with drug-resistant epilepsy.
Liang, S.-S., Wang, L.-K., Shen, K.-F., Wang, Z., Zheng, X., Duan, Q., Shi, X.-J., Zhang, L., Dai, Y., Zou, Y., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adq4423 · Cited by 3 · see citing works
Hypothalamus, Neuropeptides and Socioemotional Behavior
Carìa, A. (2023) · Brain Science · doi:10.3390/brainsci13091303 · Cited by 3 · see citing works
Current and future directions of post-deep brain stimulation implant magnetic resonance imaging scanning
Aziz, T. (2011) · doi:10.1016/j.wneu.2011.04.006 · Cited by 3
Neurosurgery to Enhance Brain Function: Ethical Dilemmas for the Neuroscientist and Society
Johnson, R., Ridder, D. D., & Gillett, G. (2014) · Advances in human and social aspects of technology book series · doi:10.4018/978-1-4666-6010-6.ch006 · Cited by 3 · see citing works
Intentionality and the neurobiology of pleasure
Hadreas, P. (1999) · Studies in History and Philosophy of Science Part C Studies in History and Philosophy of Biological and Biomedical Sciences · doi:10.1016/s1369-8486(98)00023-5 · Cited by 2 · see citing works
Brain stimulation to treat mental illness and enhance human learning, creativity, performance, altruism, and defenses against suffering.
Mancini, L. (1986) · Medical Hypotheses · doi:10.1016/0306-9877(86)90012-5 · Cited by 2
Intracranial Self-Stimulation and the Curve-Shift Paradigm: A Putative Model to Study the Brain
Fakhoury, M., & Rompré, P. (2020) · doi:10.1007/978-1-0716-1146-3_1 · Cited by 2

Authors: Bishop, M. P., Elder, S. T., & Heath, R. G.
Affiliations: Tulane University (US)
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1963-04-26
Volume: 140
Issue: 3565
Pages: 394-396
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.140.3565.394
OpenAlex: W2012590570
Cited by: 142
References: 0
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 7 · 2019: 3 · 2018: 5 · 2017: 3 · 2016: 4 · 2015: 8 · 2014: 8 · 2013: 6 · 2012: 5
FWCI: 1.95
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Neurology › Neurological disorders and treatments
Keywords: intracranial self-stimulation, electrical brain stimulation, reinforcement, positive reinforcement, negative reinforcement, subcortical structures, neuropsychiatric patients, human brain
MeSH terms: Brain, Electric Stimulation, Electrophysiology, Reinforcement, Psychology, Self Stimulation

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Intracranial Self-Stimulation in Man

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