The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
What if Minkowski Had Been Ageusic? An Alternative Angle on Diabetes
Abstract
Despite decades of intensive investigation, the basic pathophysiological mechanisms responsible for the metabolic derangements associated with diabetes mellitus have remained elusive. Explored here is the possibility that traditional concepts in this area might have carried the wrong emphasis. It is suggested that the phenomena of insulin resistance and hyperglycemia might be more readily understood if viewed in the context of underlying abnormalities of lipid metabolism.
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In the citing paper
“Although it is clear that insulin resistance plays a major role in the pathogenesis of T2DM”
From Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men (2006) · cites this paper as [12]
In the citing paper
“and that insulin resistance is strongly associated with increases in hepatic (HTG) and ∕ or intramyocellular lipid content”
From Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men (2006) · cites this paper as [12]
Citations
Cites
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Metadata
- Authors
- McGarry, J. D.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- McGarry, J. Denis
- ORCID
- McGarry, J. Denis
- Venue
- Science
- Published
- 1992-10-30
- Volume
- 258
- Issue
- 5083
- Pages
- 766-770
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2036344921
- Cited by
- 657
- References
- 24
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 8 · 2023: 9 · 2022: 10 · 2021: 10 · 2020: 16 · 2019: 10 · 2018: 12 · 2017: 18 · 2016: 16 · 2015: 20 · 2014: 16 · 2013: 21 · 2012: 25
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk011313-25)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 18573, DK11313)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- diabetes mellitus, insulin resistance, hyperglycemia, lipid metabolism, metabolic disorders, diabetes pathophysiology
- MeSH terms
- Acetoacetates, Adipose Tissue, Blood Glucose, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Fatty Acids, Nonesterified, Glucose Tolerance Test, Humans, Hydroxybutyrates, Insulin, Insulin Resistance, Islets of Langerhans, Ketone Bodies, Lipoproteins, VLDL, Liver, Triglycerides, 3-Hydroxybutyric Acid, Lipid Metabolism
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