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Cited by 2,355

The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.

Identification of FAP Locus Genes from Chromosome 5q21

Kinzler, Kenneth W., Nilbert, Mef C., Su, Li-Kuo, Vogelstein, Bert, Bryan, Tracy M., Levy, Daniel B., Smith, Kelly J., Preisinger, Antonette C., Hedge, Philip, McKechnie, Douglas, Finniear, Rachel, Markham, Alex, Groffen, John, Boguski, Mark S., Altschul, Stephen F., Horii, Akira, Ando, Hiroshi, Miyoshi, Yasuo, Miki, Yoshio, Nishisho, Isamu, Nakamura, Yusuke·1991·Science
DOI 10.1126/science.1651562
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Abstract

Recent studies suggest that one or more genes on chromosome 5q21 are important for the development of colorectal cancers, particularly those associated with familial adenomatous polyposis (FAP). To facilitate the identification of genes from this locus, a portion of the region that is tightly linked to FAP was cloned. Six contiguous stretches of sequence (contigs) containing approximately 5.5 Mb of DNA were isolated. Subclones from these contigs were used to identify and position six genes, all of which were expressed in normal colonic mucosa. Two of these genes (APC and MCC) are likely to contribute to colorectal tumorigenesis. The MCC gene had previously been identified by virtue of its mutation in human colorectal tumors. The APC gene was identified in a contig initiated from the MCC gene and was found to encode an unusually large protein. These two closely spaced genes encode proteins predicted to contain coiled-coil regions. Both genes were also expressed in a wide variety of tissues. Further studies of MCC and APC and their potential interaction should prove useful for understanding colorectal neoplasia.

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Metadata

Authors
Kinzler, K. W., Nilbert, M. C., Su, L.-K., Vogelstein, B., Bryan, T. M., Levy, D. B., Smith, K. J., Preisinger, A. C., Hedge, P., McKechnie, D., Finniear, R., Markham, A., Groffen, J., Boguski, M. S., Altschul, S. F., Horii, A., Ando, H., Miyoshi, Y., Miki, Y., Nishisho, I., & Nakamura, Y.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1991-08-09
Volume
253
Issue
5020
Pages
661-665
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.1651562
OpenAlex
W2059813946
Cited by
2,355
References
3
FWCI
118.56
Type
journal article
Language
en
Open access
closed

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