The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Targets for Dioxin: Genes for Plasminogen Activator Inhibitor-2 and Interleukin-1β
Abstract
Dioxin (2,3,7,8-tetrachlorodibenzo- p -dioxin, TCDD), a widespread environmental contaminant, may elicit its effects by altering gene expression in susceptible cells. Five TCDD-responsive complementary DNA clones were isolated from a human keratinocyte cell line. One of these clones encodes plasminogen activator inhibitor-2, a factor that influences growth and differentiation by regulating proteolysis of the extracellular matrix. Another encodes the cytokine interleukin-1β. Thus, TCDD alters the expression of growth regulatory genes and has effects similar to those of other tumor-promoting agents that affect both inflammation and differentiation.
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Metadata
- Authors
- Sutter, T. R., Guzman, K., Dold, K. M., & Greenlee, W. F.
- Venue
- Science
- Published
- 1991-10-18
- Volume
- 254
- Issue
- 5030
- Pages
- 415-418
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993713336
- Cited by
- 337
- References
- 43
- FWCI
- 14.17
- Type
- journal article
- Language
- en
- Open access
- closed
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