Cited by 2,337Pancreatic and Hepatic Oncology ResearchGenetic factors in colorectal cancerCancer-related Molecular Pathways

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DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

Hahn, Stephan A., Schutte, Mieke, Shamsul Hoque, A. T. M., Moskaluk, Christopher A., da Costa, Luis T., Rozenblum, Ester, Weinstein, Craig L., Fischer, Aryeh, Yeo, Charles J., Hruban, Ralph H., Kern, Scott E.·1996·Science

DOI 10.1126/science.271.5247.350

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Abstract

About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tumors had homozygous deletions at 18q21.1, a site that excludes DCC (a candidate suppressor gene for colorectal cancer) and includes DPC4 , a gene similar in sequence to a Drosophila melanogaster gene ( Mad ) implicated in a transforming growth factor-β (TGF-β)-like signaling pathway. Potentially inactivating mutations in DPC4 were identified in six of 27 pancreatic carcinomas that did not have homozygous deletions at 18q21.1. These results identify DPC4 as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers.

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Authors: Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., & Kern, S. E.
Affiliations: Johns Hopkins University (US)
S. A. Hahn, M. Schutte, A. T. M. S. Hoque, C. A. Moskaluk, E. Rozenblum, C. L. Weinstein, A. Fischer, R. H. Hruban, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
L. T. da Costa, Graduate Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Corresponding author: Kern, Scott E.
ORCID: Hahn, Stephan A.
Moskaluk, Christopher A.
Fischer, Aryeh
Yeo, Charles J.
Hruban, Ralph H.
Kern, Scott E.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-01-19
Volume: 271
Issue: 5247
Pages: 350-353
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.271.5247.350
OpenAlex: W2100522747
Cited by: 2,337
References: 25
Citations by year: 2026: 20 · 2025: 21 · 2024: 29 · 2023: 26 · 2022: 31 · 2021: 41 · 2020: 33 · 2019: 44 · 2018: 41 · 2017: 46 · 2016: 55 · 2015: 59 · 2014: 71 · 2013: 64 · 2012: 67
FWCI: 70.80
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P50CA062924, CA 62924)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: SMAD4, tumor suppressor, pancreatic cancer, homozygous deletion, loss of heterozygosity, TGF-beta signaling, loss-of-function mutations, candidate gene identification
MeSH terms: Alleles, Amino Acid Sequence, Animals, Base Sequence, Cell Division, Chromosome Mapping, Chromosomes, Human, Pair 18, DNA-Binding Proteins, Genetic Markers, Humans, Molecular Sequence Data, Mutation, Neoplasm Transplantation, Pancreatic Neoplasms, Proteins, Transplantation, Heterologous, Tumor Cells, Cultured, Signal Transduction, Trans-Activators, Gene Expression, Genes, Tumor Suppressor, Transforming Growth Factor beta, Gene Deletion, Mice, Smad4 Protein

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DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

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