Cited by 2,337Pancreatic and Hepatic Oncology ResearchGenetic factors in colorectal cancerCancer-related Molecular Pathways

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DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

Hahn, Stephan A., Schutte, Mieke, Shamsul Hoque, A. T. M., Moskaluk, Christopher A., da Costa, Luis T., Rozenblum, Ester, Weinstein, Craig L., Fischer, Aryeh, Yeo, Charles J., Hruban, Ralph H., Kern, Scott E.·1996·Science

DOI 10.1126/science.271.5247.350

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Abstract

About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tumors had homozygous deletions at 18q21.1, a site that excludes DCC (a candidate suppressor gene for colorectal cancer) and includes DPC4 , a gene similar in sequence to a Drosophila melanogaster gene ( Mad ) implicated in a transforming growth factor-β (TGF-β)-like signaling pathway. Potentially inactivating mutations in DPC4 were identified in six of 27 pancreatic carcinomas that did not have homozygous deletions at 18q21.1. These results identify DPC4 as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers.

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A cell cycle regulator potentially involved in genesis of many tumor types
Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., Johnson, B. E., & Skolnick, M. H. (1994) · Science · doi:10.1126/science.8153634 · Cited by 2,751
Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability
Markowitz, S. D., Wang, J., Myeroff, L. L., Parsons, R. E., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., et al. (1995) · Science · doi:10.1126/science.7761852 · Cited by 2,267
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
Almoguera, C., Shibata, D. K., Forrester, K., Wj, M., Arnheim, N., & Perucho, M. (1988) · Cell · doi:10.1016/0092-8674(88)90571-5 · Cited by 2,122
pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest
Hannon, G. J., & Beach, D. (1994) · Nature · doi:10.1038/371257a0 · Cited by 1,950
Tumor Suppressor Genes
Weinberg, R. A. (1991) · Science · doi:10.1126/science.1659741 · Cited by 1,765
Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers
Fearon, E. R., Cho, K. R., Nigro, J. M., Kern, S. E., Simons, J. W., Ruppert, J. M., Hamilton, S. R., Preisinger, A. C., Thomas, G., Kinzler, K. W., et al. (1990) · Science · doi:10.1126/science.2294591 · Cited by 1,760
Self-citation
The Molecular Genetics of Cancer
Bishop, J. M. (1987) · Science · doi:10.1126/science.3541204 · Cited by 1,674
Hereditary cancer, oncogenes, and antioncogenes.
Knudson, A. G. (1985) · PubMed · Cited by 1,218
Thermal asymmetric interlaced PCR: automatable amplification and sequencing of insert end fragments from P1 and YAC clones for chromosome walking
Liu, Y., & Whittier, R. F. (1995) · Genomics · doi:10.1016/0888-7543(95)80010-j · Cited by 1,141
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
Caldas, C., Hahn, S. A., da Costa, L. T., Redston, M. S., Schutte, M. E. M., Seymour, A. B., Weinstein, C. L., Hruban, R. H., Yeo, C. J., & Kern, S. E. (1994) · Nature Genetics · doi:10.1038/ng0994-27 · Cited by 1,132
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Zhang, J., Zhang, X., Xie, F., Zhang, Z., van Dam, H., Zhang, L., & Zhou, F. (2014) · Protein & Cell · doi:10.1007/s13238-014-0058-8 · Cited by 114
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Ma, Z., & TURK, J. W. (2001) · Progress in nucleic acid research and molecular biology · doi:10.1016/s0079-6603(01)67023-5 · Cited by 106
Ever since Knudson
Devilee, P., Cleton-Jansen, A., & Cornelisse, C. J. (2001) · Trends in Genetics · doi:10.1016/s0168-9525(01)02416-7 · Cited by 106
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Miller, B. J., Wang, D., Krahe, R., & Wright, F. A. (2003) · The American Journal of Human Genetics · doi:10.1086/378522 · Cited by 106
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Kim, D., & Lassar, A. B. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.23.8704-8717.2003 · Cited by 106
Intraductal papillary mucinous tumor of the pancreas
Farrell, J. J., & Brugge, W. R. (2002) · Gastrointestinal Endoscopy · doi:10.1067/mge.2002.123641 · Cited by 105
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Wu, L., Wu, Y., Gathings, B., Wan, M., Li, X., Grizzle, W. E., Liu, Z., Lu, C., Mao, Z., & Cao, X. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m212332200 · Cited by 107
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Kleeff, J. H., Maruyama, H., Frieß, H., Büchler, M. W., Falb, D., & Korc, M. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0171 · Cited by 105
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Reduced Expression of Histone Methyltransferases KMT2C and KMT2D Correlates with Improved Outcome in Pancreatic Ductal Adenocarcinoma
Dawkins, J. B. N., Wang, J., Maniati, E., Heward, J. A., Koniali, L., Kocher, H. M., Martin, S. A., Chelala, C., Balkwill, F. R., Fitzgibbon, J., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-0481 · Cited by 104
TGF-β-induced stromal CYR61 promotes resistance to gemcitabine in pancreatic ductal adenocarcinoma through downregulation of the nucleoside transporters hENT1 and hCNT3
Hesler, R., Huang, J. J., Starr, M. D., Treboschi, V. M., Bernanke, A., Nixon, A. B., McCall, S. J., White, R. R., & Blobe, G. C. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw093 · Cited by 105
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Chalaux, E., López‐Rovira, T., Rosa, J. L., Bartrons, R., & Ventura, F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.1.537 · Cited by 104
The t(3;21) Fusion Product, AML1/Evi-1, Interacts With Smad3 and Blocks Transforming Growth Factor-β–Mediated Growth Inhibition of Myeloid Cells
Kurokawa, M., Mitani, K., Imai, Y., Ogawa, S., Yazaki, Y., & Hirai, H. (1998) · Blood · doi:10.1182/blood.v92.11.4003 · Cited by 106
Defects in TGFβ signaling overcome senescence of mouse keratinocytes expressing v-rasHa
Tremain, R., Marko, M. G., Vijayachandra, K., Ueno, H., Böttinger, E. P., & Glick, A. B. (2000) · Oncogene · doi:10.1038/sj.onc.1203471 · Cited by 107
Transforming growth factor-β and breast cancer: Transforming growth factor-β/SMAD signaling defects and cancer
Kretzschmar, M. (2000) · Breast Cancer Research · doi:10.1186/bcr42 · Cited by 103
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Lebrun, J. J., Takabe, K., Chen, Y., & Vale, W. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.1.0218 · Cited by 103
TGFβ signaling in head and neck squamous cell carcinoma
White, R. A., Malkoski, S. P., & Wang, X. (2010) · Oncogene · doi:10.1038/onc.2010.306 · Cited by 104
Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines
Campbell, J., Ryan, C. J., Brough, R., Bajrami, I., Pemberton, H. N., Chong, I. Y.-S., Costa-Cabral, S., Frankum, J. R., Gulati, A., Holme, H., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.023 · Cited by 104
Pancreatic cancer: Current research and future directions
Falasca, M., Kim, M., & Casari, I. (2016) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2016.01.001 · Cited by 101
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Martin, C. L., Reshmi, S. C., Ried, T., Gottberg, W., Wilson, J. W., Reddy, J. K., Khanna, P., Johnson, J. T., Myers, E. N., & Gollin, S. M. (2007) · Oral Oncology · doi:10.1016/j.oraloncology.2007.05.003 · Cited by 101
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Cox, C., Bignell, G. R., Greenman, C., Stabenau, A., Warren, W., Stephens, P., Davies, H. R., Watt, S., Teague, J. W., Edkins, S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408593102 · Cited by 100
Expression of novel markers of pancreatic ductal adenocarcinoma in pancreatic nonductal neoplasms: additional evidence of different genetic pathways
Cao, D., Maitra, A., Saavedra, J.-A., Klimstra, D. S., Adsay, V. N., & Hruban, R. H. (2005) · Modern Pathology · doi:10.1038/modpathol.3800363 · Cited by 98
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Novel MLLCBP fusion transcript in therapy‐related chronic myelomonocytic leukemia with a t(11;16) (q23;p13) chromosome translocation
Satake, N., Ishida, Y., Otoh, Y., Hinohara, S., Kobayashi, H., Sakashita, A., Maseki, N., & Kaneko, Y. (1997) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199709)20:1 · Cited by 91
Genome-wide screening for complete genetic loss in prostate cancer by comparative hybridization onto cDNA microarrays
Clark, J., Edwards, S. E., Feber, A., Flohr, P., John, M. M., Giddings, I., Crossland, S., Stratton, M. R., Wooster, R., Campbell, C., et al. (2003) · Oncogene · doi:10.1038/sj.onc.1206247 · Cited by 100
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Hong, S., Oh, H., Valera, V., Stull, J., Ngo, D.-T., Baba, M., Merino, M. J., Linehan, W. M., & Schmidt, L. S. (2010) · Molecular Cancer · doi:10.1186/1476-4598-9-160 · Cited by 99
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Wechman, S. L., Emdad, L., Sarkar, D., Das, S. K., & Fisher, P. B. (2020) · Advances in cancer research · doi:10.1016/bs.acr.2020.06.001 · Cited by 101
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Salek, C. (2007) · World Journal of Gastroenterology · doi:10.3748/wjg.v13.i27.3714 · Cited by 99
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Liao, Q., Guo, J., Kleeff, J. H., Zimmermann, A., Büchler, M. W., Korc, M., & Frieß, H. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00398-6 · Cited by 99
RAS/ERK modulates TGF -regulated PTEN expression in human pancreatic adenocarcinoma cells
Chow, J. Y. C., Quach, K. T., Cabrera, B. L., Cabral, J. A., Beck, S. E., & Carethers, J. M. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm159 · Cited by 100
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Alevizopoulos, A., & Mermod, N. (1997) · BioEssays · doi:10.1002/bies.950190709 · Cited by 99
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Ahn, S.-M., Cha, J.-Y., Kim, J., Kim, D., Trang, H. T. H., Kim, Y.-M., Yh, C., Park, D., & Hong, S. (2011) · Oncogene · doi:10.1038/onc.2011.484 · Cited by 98
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Self-citation
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Xia, X., Wu, W., Huang, C., Cen, G., Jiang, T., Cao, J., Huang, K., & Qiu, Z. (2014) · Tumor Biology · doi:10.1007/s13277-014-2883-z · Cited by 98
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Self-citation
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Takebayashi, S., Ogawa, T., Jung, K. Y., Muallem, A., Mineta, H., Fisher, S. G., Grenman, R. A., & Carey, T. E. (2000) · PubMed · Cited by 97
APM‐1, a novel human gene, identified by aberrant co‐transcription with papillomavirus oncogenes in a cervical carcinoma cell line, encodes a BTB/POZ‐zinc finger protein with growth inhibitory activity
Reuter, S., Bartelmann, M., Vogt, M., Geisen, C., Napierski, I., Kahn, T., Delius, H., Lichter, P., Weitz, S., Korn, B., et al. (1998) · The EMBO Journal · doi:10.1093/emboj/17.1.215 · Cited by 97
Squamous cell carcinoma and mammary abscess formation through squamous metaplasia inSmad4/Dpc4conditional knockout mice
Li, W.-M., Qiao, W., Chen, L., Xu, X., Yang, X. Y., Li, D., Li, C., Brodie, S. G., Meguid, M. M., Hennighausen, L. G., et al. (2003) · Development · doi:10.1242/dev.00820 · Cited by 99
Fins, limbs, and tails: outgrowths and axial patterning in vertebrate evolution
Coates, M. I., & Cohn, M. J. (1998) · BioEssays · doi:10.1002/(sici)1521-1878(199805)20:5 · Cited by 107
Localization of putative tumor suppressor loci by genome-wide allelotyping in human pancreatic endocrine tumors.
Chung, D. C., Brown, S. B., Graeme‐Cook, F., Tillotson, L. G., Warshaw, A. L., Jensen, R. T., & Arnold, A. (1998) · PubMed · Cited by 97
Histone deacetylase class-I inhibition promotes epithelial gene expression in pancreatic cancer cells in a BRD4- and MYC-dependent manner
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Minakuchi, M., Kakazu, N., Gorrín-Rivas, M. J., Abe, T., Copeland, T. D., Ueda, K., & Adachi, Y. (2001) · European Journal of Biochemistry · doi:10.1046/j.1432-1327.2001.02000.x · Cited by 96
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Liu, Y., & Huang, N. (1998) · Plant Molecular Biology Reporter · doi:10.1023/a:1007420918645 · Cited by 96
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Ehata, S., Hanyu, A., Hayashi, M., Aburatani, H., Kato, Y., Fujime, Μ., Saitoh, M., Miyazawa, K., Imamura, T., & Miyazono, K. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-1522 · Cited by 96
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Haruki, S., Imoto, I., Kozaki, K., Matsui, T., Kawachi, H., Komatsu, S., Muramatsu, T., Shimada, Y., Kawano, T., & Inazawa, J. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq053 · Cited by 96
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Pasche, B., Luo, Y., Rao, P. H., Nimer, S. D., Dmitrovsky, E., Caron, P., Luzzatto, L., Offit, K., Cordón-Cardó, C., Renault, B., et al. (1998) · PubMed · Cited by 96
Identification of Two Smad4 Proteins in Xenopus
Masuyama, N., Hanafusa, H., Kusakabe, M., Shibuyà, H., & Nishida, E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.17.12163 · Cited by 96
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Clifford, S. C., Walsh, S., Hewson, K., Green, E., Brinke, A., Green, P. M., Gianelli, F., Eng, C., & Maher, E. R. (1999) · Genes Chromosomes and Cancer · doi:10.1002/(sici)1098-2264(199909)26:1 · Cited by 22
Self-citation
Molecular mechanisms of pancreatic carcinogenesis
Furukawa, T., Sunamura, M., & Horii, A. (2005) · Cancer Science · doi:10.1111/j.1349-7006.2005.00134.x · Cited by 95
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Kornmann, M., Ishiwata, T., Itakura, J., Tangvoranuntakul, P., Beger, H. G., & Korc, M. (1998) · Oncology · doi:10.1159/000011879 · Cited by 95
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Zhong, Y., Wang, Z., Fu, B., Pan, F., Yachida, S., Dhara, M., Albesiano, E., Li, L., Naito, Y., Vilardell, F., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022129 · Cited by 97
TGF-β-induced nuclear localization of Smad2 and Smad3 in Smad4 null cancer cell lines
Fink, S. P., Mikkola, D. L., Willson, J. K. V., & Markowitz, S. D. (2003) · Oncogene · doi:10.1038/sj.onc.1206128 · Cited by 95
Smad3 regulates senescence and malignant conversion in a mouse multistage skin carcinogenesis model.
Vijayachandra, K., Lee, J., & Glick, A. B. (2003) · PubMed · Cited by 95
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Piek, E., & Roberts, A. B. (2001) · Advances in cancer research · doi:10.1016/s0065-230x(01)83001-3 · Cited by 94
Molecular biology of pancreatic cancer; oncogenes, tumour suppressor genes, growth factors, and their receptors from a clinical perspective
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Boulay, J., Mild, G., Lowy, A., Reuter, J., Lagrange, M., Terracciano, L., Laffer, U. T., Herrmann, R., & Rochlitz, C. F. (2003) · International Journal of Cancer · doi:10.1002/ijc.10908 · Cited by 94
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Self-citation
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Nakanishi, Y., Zen, Y., Kondo, S., Itoh, T., Itatsu, K., & Nakanuma, Y. (2008) · Human Pathology · doi:10.1016/j.humpath.2007.11.018 · Cited by 94
Loss of Smad4 Function in Pancreatic Tumors
Maurice, D., Pierreux, C. E., Howell, M. T., Wilentz, R. E., Owen, M. J., & Hill, C. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m105895200 · Cited by 94
Impact of KRAS mutations and co-mutations on clinical outcomes in pancreatic ductal adenocarcinoma
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Nguyen, H., & Duong, H. (2018) · Oncology Letters · doi:10.3892/ol.2018.8679 · Cited by 244
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Layfield, L. J., Ehya, H., Filie, A. C., Hruban, R. H., Jhala, N. C., Joseph, L. J., Vielh, P. R., & Pitman, M. B. (2014) · Diagnostic Cytopathology · doi:10.1002/dc.23093 · Cited by 93
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Zen, K., Yasui, K., Gen, Y., Dohi, O., Wakabayashi, N., Mitsufuji, S., Itoh, Y., Zen, Y., Nakanuma, Y., Taniwaki, M., et al. (2009) · Oncogene · doi:10.1038/onc.2009.148 · Cited by 93
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Yamada, H., Yanagisawa, K., Tokumaru, S., Taguchi, A., Nimura, Y., Osada, H., Nagino, M., & Takahashi, T. (2008) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20582 · Cited by 93
Missense Mutations of MADH4
Iacobuzio–Donahue, C. A., Song, J., Parmiagiani, G., Yeo, C. J., Hruban, R. H., & Kern, S. E. (2004) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-1121-3 · Cited by 93
Self-citation
Adrenomedullin is induced by hypoxia and enhances pancreatic cancer cell invasion
Keleg, S., Kayed, H., Jiang, X., Penzel, R., Giese, T., Büchler, M. W., Frieß, H., & Kleeff, J. H. (2007) · International Journal of Cancer · doi:10.1002/ijc.22596 · Cited by 93
The Yin and Yang of bone morphogenetic proteins in cancer
Singh, A. K., & Morris, R. J. (2010) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2010.06.003 · Cited by 93
Autocrine stimulatory mechanism by transforming growth factor beta in human hepatocellular carcinoma.
Matsuzaki, K., Date, M., Furukawa, F., Tahashi, Y., Matsushita, M., Sakitani, K., Yamashiki, N., Seki, T., Saito, H., Nishizawa, M., et al. (2000) · PubMed · Cited by 92
Molecular cytogenetic analysis of head and neck squamous cell carcinoma: By comparative genomic hybridization, spectral karyotyping, and expression array analysis
Squire, J. A., Bayani, J., Luk, C. K., Unwin, L., Tokunaga, J., MacMillan, C., Irish, J., Brown, D. H., Gullane, P. J., & Kamel‐Reid, S. (2002) · Head & Neck · doi:10.1002/hed.10122 · Cited by 93
Molecular classification of neoplasms of the pancreas
Hruban, R. H., & Adsay, V. N. (2009) · Human Pathology · doi:10.1016/j.humpath.2009.01.008 · Cited by 94
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Soluble type II transforming growth factor-beta (TGF-beta) receptor inhibits TGF-beta signaling in COLO-357 pancreatic cancer cells in vitro and attenuates tumor formation.
Rowland‐Goldsmith, M., Maruyama, H., Kusama, T., Ralli, S., & Korc, M. (2001) · PubMed · Cited by 93
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Allelotype of gastric adenocarcinoma.
Yustein, A. S., Harper, J., Petroni, G. R., Cummings, O. W., Moskaluk, C. A., & Powell, S. M. (1999) · PubMed · Cited by 93
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Abrogation of Smad3 and Smad2 or of Smad4 Gene Expression Positively Regulates Murine Embryonic Lung Branching Morphogenesis in Culture
Zhao, J., Lee, M., Smith, S. M., & Warburton, D. (1998) · Developmental Biology · doi:10.1006/dbio.1997.8825 · Cited by 93
Sequential Activation of NFAT and c-Myc Transcription Factors Mediates the TGF-β Switch from a Suppressor to a Promoter of Cancer Cell Proliferation
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Molecular biomarkers: their increasing role in the diagnosis, characterization, and therapy guidance in pancreatic cancer
Jimeno, A., & Hidalgo, M. M. (2006) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-06-0005 · Cited by 92
Soluble type II transforming growth factor-beta receptor attenuates expression of metastasis-associated genes and suppresses pancreatic cancer cell metastasis.
Rowland‐Goldsmith, M., Maruyama, H., Matsuda, K., Idezawa, T., Ralli, M., Ralli, S., & Korc, M. (2002) · PubMed · Cited by 92
Xenopus Smad4β Is the Co-Smad Component of Developmentally Regulated Transcription Factor Complexes Responsible for Induction of Early Mesodermal Genes
Howell, M. T., Itoh, F., Pierreux, C. E., Valgeirsdóttir, S., Itoh, S., ten Dijke, P., & Hill, C. S. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9430 · Cited by 92
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Wood, L. D., Yurgelun, M. B., & Goggins, M. G. (2019) · Gastroenterology · doi:10.1053/j.gastro.2018.12.039 · Cited by 91
Precursor Lesions of Pancreatic Cancer
Yonezawa, S., Higashi, M., Yamada, N., & Goto, M. (2008) · Gut and Liver · doi:10.5009/gnl.2008.2.3.137 · Cited by 91
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Ozolek, J. A., & Hunt, J. L. (2006) · The American Journal of Surgical Pathology · doi:10.1097/01.pas.0000213344.55605.77 · Cited by 91
TGFβ/Smad signaling system and its pathologic correlates
Cohen, M. M. (2002) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.10750 · Cited by 91
Smad4 and transforming growth factor beta1 expression in patients with squamous cell carcinoma of the esophagus.
Natsugoe, S., Xiangming, C., Matsumoto, M., Okumura, H., Nakashima, S., Sakita, H., Ishigami, S., Baba, M., Takao, S., & Aikou, T. (2002) · PubMed · Cited by 91
Orthotopic xenografts of human pancreatic carcinomas acquire genetic aberrations during dissemination in nude mice.
Reyes, G., Villanueva, A., García, C., Sancho, F. J., Piulats, J. M., Lluı́s, F., & Capellá, G. (1996) · PubMed · Cited by 90
Mothers against dpp participates in a DPP/TGF-β responsive serine-threonine kinase signal transduction cascade
Newfeld, S. J., Mehra, A., Singer, M. A., Wrana, J. L., Attisano, L., & Gelbart, W. M. (1997) · Development · doi:10.1242/dev.124.16.3167 · Cited by 91
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Okadome, T., Oeda, E., Saitoh, M., Ichijo, H., Moses, H. L., Miyazono, K., & Kawabata, M. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.36.21687 · Cited by 90

Authors: Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., & Kern, S. E.
Affiliations: Johns Hopkins University (US)
S. A. Hahn, M. Schutte, A. T. M. S. Hoque, C. A. Moskaluk, E. Rozenblum, C. L. Weinstein, A. Fischer, R. H. Hruban, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
L. T. da Costa, Graduate Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Corresponding author: Kern, Scott E.
ORCID: Hahn, Stephan A.
Moskaluk, Christopher A.
Fischer, Aryeh
Yeo, Charles J.
Hruban, Ralph H.
Kern, Scott E.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-01-19
Volume: 271
Issue: 5247
Pages: 350-353
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.271.5247.350
OpenAlex: W2100522747
Cited by: 2,337
References: 25
Citations by year: 2026: 20 · 2025: 21 · 2024: 29 · 2023: 26 · 2022: 31 · 2021: 41 · 2020: 33 · 2019: 44 · 2018: 41 · 2017: 46 · 2016: 55 · 2015: 59 · 2014: 71 · 2013: 64 · 2012: 67
FWCI: 70.80
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P50CA062924, CA 62924)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: SMAD4, tumor suppressor, pancreatic cancer, homozygous deletion, loss of heterozygosity, TGF-beta signaling, loss-of-function mutations, candidate gene identification
MeSH terms: Alleles, Amino Acid Sequence, Animals, Base Sequence, Cell Division, Chromosome Mapping, Chromosomes, Human, Pair 18, DNA-Binding Proteins, Genetic Markers, Humans, Molecular Sequence Data, Mutation, Neoplasm Transplantation, Pancreatic Neoplasms, Proteins, Transplantation, Heterologous, Tumor Cells, Cultured, Signal Transduction, Trans-Activators, Gene Expression, Genes, Tumor Suppressor, Transforming Growth Factor beta, Gene Deletion, Mice, Smad4 Protein

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DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

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