Cited by 2,337Pancreatic and Hepatic Oncology ResearchGenetic factors in colorectal cancerCancer-related Molecular Pathways

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DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

Hahn, Stephan A., Schutte, Mieke, Shamsul Hoque, A. T. M., Moskaluk, Christopher A., da Costa, Luis T., Rozenblum, Ester, Weinstein, Craig L., Fischer, Aryeh, Yeo, Charles J., Hruban, Ralph H., Kern, Scott E.·1996·Science

DOI 10.1126/science.271.5247.350

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Abstract

About 90 percent of human pancreatic carcinomas show allelic loss at chromosome 18q. To identify candidate tumor suppressor genes on 18q, a panel of pancreatic carcinomas were analyzed for convergent sites of homozygous deletion. Twenty-five of 84 tumors had homozygous deletions at 18q21.1, a site that excludes DCC (a candidate suppressor gene for colorectal cancer) and includes DPC4 , a gene similar in sequence to a Drosophila melanogaster gene ( Mad ) implicated in a transforming growth factor-β (TGF-β)-like signaling pathway. Potentially inactivating mutations in DPC4 were identified in six of 27 pancreatic carcinomas that did not have homozygous deletions at 18q21.1. These results identify DPC4 as a candidate tumor suppressor gene whose inactivation may play a role in pancreatic and possibly other human cancers.

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A cell cycle regulator potentially involved in genesis of many tumor types
Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., Johnson, B. E., & Skolnick, M. H. (1994) · Science · doi:10.1126/science.8153634 · Cited by 2,751
Inactivation of the Type II TGF-β Receptor in Colon Cancer Cells with Microsatellite Instability
Markowitz, S. D., Wang, J., Myeroff, L. L., Parsons, R. E., Sun, L., Lutterbaugh, J., Fan, R. S., Zborowska, E., Kinzler, K. W., Vogelstein, B., et al. (1995) · Science · doi:10.1126/science.7761852 · Cited by 2,267
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
Almoguera, C., Shibata, D. K., Forrester, K., Wj, M., Arnheim, N., & Perucho, M. (1988) · Cell · doi:10.1016/0092-8674(88)90571-5 · Cited by 2,122
pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest
Hannon, G. J., & Beach, D. (1994) · Nature · doi:10.1038/371257a0 · Cited by 1,950
Tumor Suppressor Genes
Weinberg, R. A. (1991) · Science · doi:10.1126/science.1659741 · Cited by 1,765
Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers
Fearon, E. R., Cho, K. R., Nigro, J. M., Kern, S. E., Simons, J. W., Ruppert, J. M., Hamilton, S. R., Preisinger, A. C., Thomas, G., Kinzler, K. W., et al. (1990) · Science · doi:10.1126/science.2294591 · Cited by 1,760
Self-citation
The Molecular Genetics of Cancer
Bishop, J. M. (1987) · Science · doi:10.1126/science.3541204 · Cited by 1,674
Hereditary cancer, oncogenes, and antioncogenes.
Knudson, A. G. (1985) · PubMed · Cited by 1,218
Thermal asymmetric interlaced PCR: automatable amplification and sequencing of insert end fragments from P1 and YAC clones for chromosome walking
Liu, Y., & Whittier, R. F. (1995) · Genomics · doi:10.1016/0888-7543(95)80010-j · Cited by 1,141
Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
Caldas, C., Hahn, S. A., da Costa, L. T., Redston, M. S., Schutte, M. E. M., Seymour, A. B., Weinstein, C. L., Hruban, R. H., Yeo, C. J., & Kern, S. E. (1994) · Nature Genetics · doi:10.1038/ng0994-27 · Cited by 1,132
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Wolff, R. A., Crane, C. H., Li, D., Evans, D. B., Maitra, A., & Tsai, S. (2017) · Wiley eBooks · doi:10.1002/9781119000822.hfcm094 · Cited by 64
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Langeveld, D., van Hattem, W. A., de Leng, W. W. J., Morsink, F. H. M., ten Kate, F. J. W., Giardiello, F. M., Offerhaus, G. J. A., & Brosens, L. A. A. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-0168 · Cited by 63
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Müller, N., Reinacher‐Schick, A., Baldus, S. E., van Hengel, J., Berx, G., Baar, A., Roy, F. M. V., Schmiegel, W., & Schwarte‐Waldhoff, I. (2002) · Oncogene · doi:10.1038/sj.onc.1205766 · Cited by 65
A role for cadherins in cellular signaling and differentiation
Knudsen, K. A., Frankowski, C., Johnson, K. R., & Wheelock, M. J. (1998) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1998)72:30/31+ · Cited by 88
SMADS AS INTRACELLULAR MEDIATORS OF AIRWAY INFLAMMATION
Groneberg, D. A., Witt, H., Adcock, I. M., Hansen, G., & Springer, J. (2004) · Experimental Lung Research · doi:10.1080/01902140490276320 · Cited by 61
Loss of Smad4 correlates with loss of the invasion suppressor E‐cadherin in advanced colorectal carcinomas
Reinacher-Schick, A., Baldus, S. E., Romdhana, B., Landsberg, S., Zapatka, M., Mönig, S., Hölscher, A. H., Dienes, H. P., Schmiegel, W., & Schwarte‐Waldhoff, I. (2004) · The Journal of Pathology · doi:10.1002/path.1516 · Cited by 63
Thioredoxin Is Downstream of Smad7 in a Pathway That Promotes Growth and Suppresses Cisplatin-Induced Apoptosis in Pancreatic Cancer
Arnold, N. B., Ketterer, K., Kleeff, J. H., Friess, H., Büchler, M. W., & Korc, M. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2999 · Cited by 64
K-Ras Mutations and Benign Pancreatic Disease
Löhr, M. J., Maisonneuve, P., & Lowenfels, A. B. (2000) · International Journal of Gastrointestinal Cancer · doi:10.1385/ijgc:27:2:093 · Cited by 63
Expression of thrombospondin-1 in human pancreatic adenocarcinomas: Role in matrix metalloproteinase-9 production
Qian, X., Rothman, V. L., Nicosia, R. F., & Tuszynski, G. P. (2001) · Pathology & Oncology Research · doi:10.1007/bf03032381 · Cited by 63
Identification of two common regions of allelic loss in chromosome arm 12q in human pancreatic cancer.
Kimura, M., Furukawa, T., Abe, T., Yatsuoka, T., Youssef, E. M., Yokoyama, T., Ouyang, H. W., Ohnishi, Y., Sunamura, M., Kobari, M., et al. (1998) · PubMed · Cited by 63
Challenges of drug resistance in the management of pancreatic cancer
Sheikh, R. M., Walsh, N., CLYNES, M. M., O'Connor, R. A., & McDermott, R. (2010) · Expert Review of Anticancer Therapy · doi:10.1586/era.10.148 · Cited by 61
Restoration of receptor-type protein tyrosine phosphatase function inhibits human pancreatic carcinoma cell growth in vitro and in vivo
Trapasso, F. (2004) · Carcinogenesis · doi:10.1093/carcin/bgh224 · Cited by 62
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Ellenrieder, V. (2008) · PubMed · Cited by 61
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T he R ole of TGF-β in E pithelial M alignancy and its R elevance to the P athogenesis of O ral C ancer (P art II)
Prime, S. S., Davies, M., Pring, M., & Paterson, I. C. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500603 · Cited by 63
Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients
Koyama, M., Ito, M., Nagai, H., Emi, M., & Moriyama, Y. (1999) · Mutation Research/Mutation Research Genomics · doi:10.1016/s1383-5726(99)00003-5 · Cited by 62
Expression of the Deleted in Colorectal Cancer Gene Is Related to Prognosis in DNA Diploid and Low Proliferative Colorectal Adenocarcinoma
Sun, X., Rütten, S., Zhang, H., & Nordenskjöld, B. A. (1999) · Journal of Clinical Oncology · doi:10.1200/jco.1999.17.6.1745 · Cited by 62
Development and progression of colorectal neoplasia
Manne, U., Shanmugam, C., Katkoori, V. R., Bumpers, H. L., & Grizzle, W. E. (2011) · Cancer Biomarkers · doi:10.3233/cbm-2011-0160 · Cited by 68
Heritability of cervical tumours
Magnusson, P. K. E., Lichtenstein, P., & Gyllensten, U. B. (2000) · International Journal of Cancer · doi:10.1002/1097-0215(20001201)88:5 · Cited by 179
Homozygous Deletion Scanning in Hepatobiliary Tumor Cell Lines Reveals Alternative Pathways for Liver Carcinogenesis
Pineau, P., Marchio, A., Nagamori, S., Seki, S., Tiollais, P., & Dejean, A. (2003) · Hepatology · doi:10.1053/jhep.2003.50138 · Cited by 61
Expression of Smad4 and Smad7 in human thyroid follicular carcinoma cell lines
Cerutti, J. M., Ebina, K. N., Matsuo, S. E., Martins, L., Maciel, R. M. B., & Kimura, E. T. (2003) · Journal of Endocrinological Investigation · doi:10.1007/bf03345213 · Cited by 61
p53 expression and risk factors for cutaneous melanoma: A case-control study
Whiteman, D. C., Parsons, P. G., & Green, A. C. (1998) · International Journal of Cancer · doi:10.1002/(sici)1097-0215(19980911)77:6 · Cited by 154
A single missense mutant of Smad3 inhibits activation of both Smad2 and Smad3, and has a dominant negative effect on TGF‐β signals
Goto, D., Yagi, K., Inoue, H., Iwamoto, I., Kawabata, M., Miyazono, K., & Kato, M. (1998) · FEBS Letters · doi:10.1016/s0014-5793(98)00658-9 · Cited by 61
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Brian, T. Z. (2000) · Frontiers in bioscience · doi:10.2741/zafonte · Cited by 61
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Ahmed, M. M., Alcock, R. A., Damodaran, C., Dey, S., Das, A., Venkatasubbarao, K., Mohiuddin, M., Sun, L., Strodel, W. E., & Freeman, J. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m110168200 · Cited by 60
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Muro‐Cacho, C., Rosario-Ortiz, K., Livingston, S. K., & Muñoz-Antonia, T. (2001) · PubMed · Cited by 60
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Simeone, D. M., Zhang, L., Graziano, K. D., Nicke, B., Pham, T. M., Schaefer, C., & Logsdon, C. D. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.281.1.c311 · Cited by 59
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Strom, A., Bonal, C., Ashery‐Padan, R., Hashimoto, N., Campos, M. L., Trumpp, A., Noda, T., Kido, Y., Real, F. X., Thorel, F., et al. (2007) · Development · doi:10.1242/dev.02875 · Cited by 59
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Kornmann, M., Ishiwata, T., Kleeff, J. H., Beger, H. G., & Korc, M. (2000) · Annals of Surgery · doi:10.1097/00000658-200003000-00010 · Cited by 59
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Yatsuoka, T., Sunamura, M., Furukawa, T., Fukushige, S., Yokoyama, T., Inoue, H., Shibuya, K., Takeda, K., Matsuno, S., & Horii, A. (2000) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2000.02171.x · Cited by 59
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Self-citation
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Scherer, A., & Graff, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005727200 · Cited by 59
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Self-citation
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Self-citation
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MH1 domain of Smad is a degraded homing endonuclease
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Expression of Smad1 and Smad2 during embryogenesis suggests a role in organ development
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Azar, R., Alard, A., Susini, C., Bousquet, C., & Pyronnet, S. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.291 · Cited by 56
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Wang, P., Chen, Z., Meng, Z.-Q., Fan, J., Luo, J.-M., Wang, L., Lin, J.-H., Zhou, Z.-H., Chen, H. H., Wang, K., et al. (2009) · Carcinogenesis · doi:10.1093/carcin/bgp154 · Cited by 56
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Ijichi, H., Ikenoue, T., Kato, N., Mitsuno, Y., Togo, G., Kato, J., Kanai, F., Shiratori, Y., & Omata, M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5988 · Cited by 56
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Geriatric assessment in oncology
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cDNA expression array reveals heterogeneous gene expression profiles in three glioblastoma cell lines
Rhee, C. H., Hess, K. R., Jabbur, J. R., Ruiz, M., Yang, Y., Chen, S., Chenchik, A. A., Fuller, G. N., & Zhang, W. (1999) · Oncogene · doi:10.1038/sj.onc.1202623 · Cited by 56
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Sheng, H., Shao, J., O'Mahony, C. A., Lamps, L. W., Albo, D., Isakson, P. C., Berger, D. H., DuBois, R. N., & Beauchamp, R. D. (1999) · Oncogene · doi:10.1038/sj.onc.1202397 · Cited by 56
RNA-Seq Accurately Identifies Cancer Biomarker Signatures to Distinguish Tissue of Origin
Wei, I. H., Shi, Y., Jiang, H., Kumar‐Sinha, C., & Chinnaiyan, A. M. (2014) · Neoplasia · doi:10.1016/j.neo.2014.09.007 · Cited by 55
Differential Gene Expression of TGFβ Inducible Early Gene (TIEG), Smad7, Smad2 and Bard1 in Normal and Malignant Breast Tissue
Reinholz, M. M., An, M., Johnsen, S. A., Subramaniam, M., Suman, V. J., Ingle, J. N., Roche, P. C., & Spelsberg, T. C. (2004) · Breast Cancer Research and Treatment · doi:10.1023/b:brea.0000032926.74216.7d · Cited by 56
Myhre and LAPS syndromes: clinical and molecular review of 32 patients
Michot, C., Goff, C. L., Mahaut, C., Afenjar, A., Brooks, A. S., Campeau, P. M., Destrèe, A., Rocco, M. D., Donnai, D., Hennekam, R. C. M., et al. (2014) · European Journal of Human Genetics · doi:10.1038/ejhg.2013.288 · Cited by 55
SCFβ-TrCP1 Controls Smad4 Protein Stability in Pancreatic Cancer Cells
Wan, M., Huang, J., Jhala, N. C., Tytler, E. M., Yang, L. F., Vickers, S. M., Tang, Y., Lu, C., Wang, N., & Cao, X. (2005) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)62356-5 · Cited by 54
Morphogenesis of pancreatic cancer: role of pancreatic intraepithelial neoplasia (PanINs)
Koorstra, J.-B. M., Feldmann, G., Habbe, N., & Maitra, A. (2008) · Langenbeck s Archives of Surgery · doi:10.1007/s00423-008-0282-x · Cited by 54
Distinguishing adrenal cortical carcinomas and adenomas: a study of clinicopathological features and biomarkers
Wang, C., Sun, Y., Wu, H., Zhao, D., & Chen, J. (2013) · Histopathology · doi:10.1111/his.12283 · Cited by 55
Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals.
Miyabayashi, K., Ijichi, H., Mohri, D., Tada, M., Yamamoto, K., Asaoka, Y., Ikenoue, T., Tateishi, K., Nakai, Y., Isayama, H., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-1453 · Cited by 57
Pathway- and Expression Level-Dependent Effects of Oncogenic N-Ras: p27Kip1 Mislocalization by the Ral-GEF Pathway and Erk-Mediated Interference with Smad Signaling
Kfir, S., Ehrlich, M., Goldshmid-Shagal, A., Liu, X., Kloog, Y., & Henis, Y. I. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.18.8239-8250.2005 · Cited by 54
Loss of DPC4 expression and its correlation with clinicopathological parameters in pancreatic carcinoma
Hua, Z. (2003) · World Journal of Gastroenterology · doi:10.3748/wjg.v9.i12.2764 · Cited by 55
Direct genetic testing for Smad4 mutations in patients at risk for juvenile polyposis
Howe, J. R., Ringold, J. C., Hughes, J. H., & Summers, R. W. (1999) · Surgery · doi:10.1016/s0039-6060(99)70150-9 · Cited by 55
Glypican-1 antisense transfection modulates TGF-β-dependent signaling in Colo-357 pancreatic cancer cells
Li, J., Kleeff, J. H., Kayed, H., Felix, K., Penzel, R., Büchler, M. W., Korc, M., & Frieß, H. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.06.063 · Cited by 54
Long-term effects of the Holocaust: empirical evidence for resilience in the first, second, and third generation.
Sigal, J. J. (1998) · PubMed · Cited by 55
Isolation of a Pancreas-Specific Gene Located on Human Chromosome 14q31: Expression Analysis in Human Pancreatic Ductal Carcinomas
Biunno, I., Appierto, V., Cattaneo, M., Leone, B. E., Balzano, G., Socci, C., Saccone, S., Letizia, A., Valle, G. D., & Sgaramella, V. (1997) · Genomics · doi:10.1006/geno.1997.5018 · Cited by 55
Smad2 Overexpression Enhances Smad4 Gene Expression and Suppresses CBFA1 Gene Expression in Osteoblastic Osteosarcoma ROS17/2.8 Cells and Primary Rat Calvaria Cells
Li, J., Tsuji, K., Komori, T., Miyazono, K., Wrana, J. L., Ito, Y., Nifuji, A., & Noda, M. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.47.31009 · Cited by 55
Smad4 Transcriptional Pathways and Angiogenesis
Schwarte‐Waldhoff, I., & Schmiegel, W. (2002) · International Journal of Gastrointestinal Cancer · doi:10.1385/ijgc:31:1-3:47 · Cited by 54
Genetic alterations in hepatocellular carcinoma and intrahepatic cholangiocarcinoma
Koo, S. H., Ihm, C. H., Kwon, K. C., Park, J. W., Kim, J., & Kong, G. (2001) · Cancer Genetics and Cytogenetics · doi:10.1016/s0165-4608(01)00460-5 · Cited by 54
Frequent Inactivation of a Putative Tumor Suppressor, Angiopoietin-Like Protein 2, in Ovarian Cancer
Kikuchi, R., Tsuda, H., Kozaki, K., Kanai, Y., Kasamatsu, T., Sengoku, K., Hirohashi, S., Inazawa, J., & Imoto, I. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0062 · Cited by 54
Reliable Detection of Somatic Mutations in Fine Needle Aspirates of Pancreatic Cancer With Next-generation Sequencing
Valero, V., Saunders, T., He, J. P., Weiss, M. J., Cameron, J. L., Dholakia, A. S., Wild, A. T., Shin, E. J., Khashab, M. A., Lennon, A. M., et al. (2015) · Annals of Surgery · doi:10.1097/sla.0000000000001156 · Cited by 55
Self-citation
MiR-34a-3p alters proliferation and apoptosis of meningioma cells in vitro and is directly targeting SMAD4, FRAT1 and BCL2
Werner, T. V., Hart, M., Nickels, R. M., Kim, Y.-J., Menger, M. D., Bohle, R. M., Keller, A., Ludwig, N., & Meese, E. U. (2017) · Aging · doi:10.18632/aging.101201 · Cited by 54
Enhanced VEGF production and decreased immunogenicity induced by TGF-β 1 promote liver metastasis of pancreatic cancer
Teraoka, H., Sawada, T., Nishihara, T., Yashiro, M., Ohira, M., Ishikawa, T., Nishino, H., & Hirakawa, K. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.1941 · Cited by 54
The expression of S100A8 in pancreatic cancer‐associated monocytes is associated with the Smad4 status of pancreatic cancer cells
Sheikh, A. A., Vimalachandran, D., Thompson, C. C., Jenkins, R. E., Nedjadi, T., Shekouh, A., Campbell, F., Dodson, A. R., Prime, W., Crnogorac‐Jurcevic, T., et al. (2007) · PROTEOMICS · doi:10.1002/pmic.200700072 · Cited by 54
Orthotopic Models of Human Pancreatic Cancer
Capellá, G., Farré, L., Villanueva, A., Reyes, G., GARCÍ, C., Tarafa, G., & Lluı́s, F. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09514.x · Cited by 54
Characterization of theMADH2/Smad2Gene, a HumanMadHomolog Responsible for the Transforming Growth Factor-β and Activin Signal Transduction Pathway
Takenoshita, S., Mogi, A., Nagashima, M., Ke, Y., Yagi, K., Hanyu, A., Nagamachi, Y., Miyazono, K., & Hagiwara, K. (1998) · Genomics · doi:10.1006/geno.1997.5149 · Cited by 54
Cancer genomics
Weber, B. L. (2002) · Cancer Cell · doi:10.1016/s1535-6108(02)00026-0 · Cited by 54
Reduced transforming growth factor-β receptor II expression in hepatocellular carcinoma correlates with intrahepatic metastasis
Mamiya, T., Yamazaki, K., Masugi, Y., Mori, T., Effendi, K., Du, W., Hibi, T., Tanabe, M., Ueda, M., Takayama, T., et al. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.105 · Cited by 54

Authors: Hahn, S. A., Schutte, M., Shamsul Hoque, A. T. M., Moskaluk, C. A., da Costa, L. T., Rozenblum, E., Weinstein, C. L., Fischer, A., Yeo, C. J., Hruban, R. H., & Kern, S. E.
Affiliations: Johns Hopkins University (US)
S. A. Hahn, M. Schutte, A. T. M. S. Hoque, C. A. Moskaluk, E. Rozenblum, C. L. Weinstein, A. Fischer, R. H. Hruban, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
L. T. da Costa, Graduate Program in Human Genetics and Molecular Biology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Corresponding author: Kern, Scott E.
ORCID: Hahn, Stephan A.
Moskaluk, Christopher A.
Fischer, Aryeh
Yeo, Charles J.
Hruban, Ralph H.
Kern, Scott E.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1996-01-19
Volume: 271
Issue: 5247
Pages: 350-353
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.271.5247.350
OpenAlex: W2100522747
Cited by: 2,337
References: 25
Citations by year: 2026: 20 · 2025: 21 · 2024: 29 · 2023: 26 · 2022: 31 · 2021: 41 · 2020: 33 · 2019: 44 · 2018: 41 · 2017: 46 · 2016: 55 · 2015: 59 · 2014: 71 · 2013: 64 · 2012: 67
FWCI: 70.80
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (P50CA062924, CA 62924)
Topics: Health Sciences › Medicine › Oncology › Pancreatic and Hepatic Oncology Research
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Keywords: SMAD4, tumor suppressor, pancreatic cancer, homozygous deletion, loss of heterozygosity, TGF-beta signaling, loss-of-function mutations, candidate gene identification
MeSH terms: Alleles, Amino Acid Sequence, Animals, Base Sequence, Cell Division, Chromosome Mapping, Chromosomes, Human, Pair 18, DNA-Binding Proteins, Genetic Markers, Humans, Molecular Sequence Data, Mutation, Neoplasm Transplantation, Pancreatic Neoplasms, Proteins, Transplantation, Heterologous, Tumor Cells, Cultured, Signal Transduction, Trans-Activators, Gene Expression, Genes, Tumor Suppressor, Transforming Growth Factor beta, Gene Deletion, Mice, Smad4 Protein

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DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

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