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Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ

Gong, Shiaoching, Nussenzweig, Michel C.·1996·Science
DOI 10.1126/science.272.5260.411
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Abstract

Many of the cell fate decisions in precursor B cells and more mature B cells are controlled by membrane immunoglobulin (Ig) M heavy chain (mμ) and the Igα-Igβ signal transducers. The role of Igβ in regulating early B cell development was examined in mice that lack Igβ (Igβ −/− ). These mice had a complete block in B cell development at the immature CD43 + B220 + stage. Immunoglobulin heavy chain diversity (D H ) and joining (J H ) segments rearranged, but variable (V H ) to DJ H recombination and immunoglobulin messenger RNA expression were compromised. These experiments define an unexpected, early requirement for Igβ to produce B cells that can complete VDJ H recombination.

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Metadata

Authors
Gong, S., & Nussenzweig, M. C.
Affiliations
Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-04-19
Volume
272
Issue
5260
Pages
411-414
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.272.5260.411
Cited by
216
References
0
Language
en

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CoChat. (2026). Citation check: Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ. https://app.cochat.ai/papers/10.1126/science.272.5260.411
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Gong, S., & Nussenzweig, M. C. (1996). Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ. Science. https://doi.org/10.1126/science.272.5260.411