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Regulation of an Early Developmental Checkpoint in the B Cell Pathway by Igβ

Gong, Shiaoching, Nussenzweig, Michel C.·1996·Science
DOI 10.1126/science.272.5260.411
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Abstract

Many of the cell fate decisions in precursor B cells and more mature B cells are controlled by membrane immunoglobulin (Ig) M heavy chain (mμ) and the Igα-Igβ signal transducers. The role of Igβ in regulating early B cell development was examined in mice that lack Igβ (Igβ −/− ). These mice had a complete block in B cell development at the immature CD43 + B220 + stage. Immunoglobulin heavy chain diversity (D H ) and joining (J H ) segments rearranged, but variable (V H ) to DJ H recombination and immunoglobulin messenger RNA expression were compromised. These experiments define an unexpected, early requirement for Igβ to produce B cells that can complete VDJ H recombination.

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Research works printed but not linked: 47

  1. ALT F.W., ORDERED REARRANGEMENT OF IMMUNOGLOBULIN HEAVY-CHAIN VARIABLE REGION SEGMENTS, EMBO JOURNAL 3, 1209 (1984). · DOI · Paper page
  2. 10.1126/science.3317825 · DOI
  3. CHEN C, THE SITE AND STAGE OF ANTI-DNA B-CELL DELETION, NATURE 373, 252 (1995). · DOI
  4. COSTA T.E., FUNCTIONAL RECONSTITUTION OF AN IMMUNOGLOBULIN ANTIGEN RECEPTOR IN T-CELLS, JOURNAL OF EXPERIMENTAL MEDICINE 175, 1669 (1992). · DOI
  5. COSTA TEF, CHROMOSOMAL POSITION OF REARRANGING GENE SEGMENTS INFLUENCES ALLELIC EXCLUSION IN TRANSGENIC MICE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 89, 2205 (1992). · DOI
  6. EHLICH A, IMMUNOGLOBULIN HEAVY AND LIGHT CHAIN GENES REARRANGE INDEPENDENTLY AT EARLY STAGES OF B-CELL DEVELOPMENT, CELL 72, 695 (1993). · DOI
  7. EHLICH A, ANALYSIS OF THE B-CELL PROGENITOR COMPARTMENT AT THE LEVEL OF SINGLE CELLS, CURRENT BIOLOGY 4, 573 (1994). · DOI
  8. FERRIER P, SEPARATE ELEMENTS CONTROL DJ AND VDJ REARRANGEMENT IN A TRANSGENIC RECOMBINATION SUBSTRATE, EMBO JOURNAL 9, 117 (1990). · DOI
  9. GOLD M.R., BIOCHEMISTRY OF B-LYMPHOCYTE ACTIVATION, ADVANCES IN IMMUNOLOGY, VOL 55 55, 221 (1994). · DOI
  10. GRAWUNDER U, REARRANGEMENT AND EXPRESSION OF KAPPA LIGHT-CHAIN GENES CAN OCCUR WITHOUT MU HEAVY-CHAIN EXPRESSION DURING DIFFERENTIATION OF PRE-B CELLS, INTERNATIONAL IMMUNOLOGY 5, 1609 (1993). · DOI
  11. HARDY R.R., RESOLUTION AND CHARACTERIZATION OF PRO-B AND PRE-PRO-B CELL STAGES IN NORMAL MOUSE BONE-MARROW, JOURNAL OF EXPERIMENTAL MEDICINE 173, 1213 (1991). · DOI
  12. HARTLEY S.B., ELIMINATION FROM PERIPHERAL LYMPHOID-TISSUES OF SELF-REACTIVE LYMPHOCYTES-B RECOGNIZING MEMBRANE-BOUND ANTIGENS, NATURE 353, 765 (1991). · DOI
  13. HERMANSON G.G., B29 - A MEMBER OF THE IMMUNOGLOBULIN GENE SUPERFAMILY EXCLUSIVELY EXPRESSED ON B-LINEAGE CELLS, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 85, 6890 (1988). · DOI
  14. HOMBACH J, MOLECULAR-COMPONENTS OF THE B-CELL ANTIGEN RECEPTOR COMPLEX OF THE IGM CLASS, NATURE 343, 760 (1990). · DOI
  15. KARASUYAMA H, THE EXPRESSION OF V-PRE-B/LAMBDA-5 SURROGATE LIGHT-CHAIN IN EARLY BONE-MARROW PRECURSOR B-CELLS OF NORMAL AND B-CELL-DEFICIENT MUTANT MICE, CELL 77, 133 (1994). · DOI
  16. KARASUYAMA H, A COMPLEX OF GLYCOPROTEINS IS ASSOCIATED WITH V(PREB)/LAMBDA(5) SURROGATE LIGHT-CHAIN ON THE SURFACE OF MU HEAVY CHAIN-NEGATIVE EARLY PRECURSOR B-CELL LINES, JOURNAL OF EXPERIMENTAL MEDICINE 178, 469 (1993). · DOI
  17. KITAMURA D, TARGETED DISRUPTION OF MU-CHAIN MEMBRANE EXON CAUSES LOSS OF HEAVY-CHAIN ALLELIC EXCLUSION, NATURE 356, 154 (1992). · DOI · Paper page
  18. KUDO A, ORGANIZATION OF THE MURINE IG-RELATED LAMBDA-5 GENE TRANSCRIBED SELECTIVELY IN LYMPHOCYTES-PRE-B, EMBO JOURNAL 6, 103 (1987). · DOI
  19. LENNON G.G., C-MU-CONTAINING TRANSCRIPTS INITIATE HETEROGENEOUSLY WITHIN THE IGH ENHANCER REGION AND CONTAIN A NOVEL 5′-NONTRANSLATABLE EXON, NATURE 318, 475 (1985). · DOI
  20. LIN H.H., FAILURE OF B-CELL DIFFERENTIATION IN MISE LACKING THE TRANSCRIPTION FACTOR EBF, NATURE 376, 263 (1995). · DOI · Paper page
  21. LOFFERT D, EARLY B-CELL DEVELOPMENT IN THE MOUSE - INSIGHTS FROM MUTATIONS INTRODUCED BY GENE TARGETING, IMMUNOLOGICAL REVIEWS 137, 135 (1994). · DOI
  22. MANZ J, FEEDBACK INHIBITION OF IMMUNOGLOBULIN GENE REARRANGEMENT BY MEMBRANE-MU, BUT NOT BY SECRETED-MU HEAVY-CHAINS, JOURNAL OF EXPERIMENTAL MEDICINE 168, 1363 (1988). · DOI
  23. MELTON D.A., EFFICIENT INVITRO SYNTHESIS OF BIOLOGICALLY-ACTIVE RNA AND RNA HYBRIDIZATION PROBES FROM PLASMIDS CONTAINING A BACTERIOPHAGE-SP6 PROMOTER, NUCLEIC ACIDS RESEARCH 12, 7035 (1984). · DOI · Paper page
  24. MOMBAERTS P, RAG-1-DEFICIENT MICE HAVE NO MATURE LYMPHOCYTES-B AND LYMPHOCYTES-T, CELL 68, 869 (1992). · DOI
  25. NEMAZEE D.A., CLONAL DELETION OF LYMPHOCYTE-B IN A TRANSGENIC MOUSE BEARING ANTI-MHC CLASS-I ANTIBODY GENES, NATURE 337, 562 (1989). · DOI
  26. 10.1126/science.3107126 · DOI
  27. OKADA A, DIFFERENTIAL ACTIVATION OF TRANSCRIPTION VERSUS RECOMBINATION OF TRANSGENIC T-CELL RECEPTOR-BETA VARIABLE REGION GENE SEGMENTS IN B-LINEAGE AND T-LINEAGE CELLS, JOURNAL OF EXPERIMENTAL MEDICINE 180, 261 (1994). · DOI
  28. OKAMOTO M, A TRANSGENIC MODEL OF AUTOIMMUNE HEMOLYTIC-ANEMIA, JOURNAL OF EXPERIMENTAL MEDICINE 175, 71 (1992). · DOI
  29. PAPAVASILIOU F, THE CYTOPLASMIC DOMAINS OF IMMUNOGLOBULIN (IG)-ALPHA AND IG-BETA CAN INDEPENDENTLY INDUCE THE PRECURSOR B-CELL TRANSITION AND ALLELIC EXCLUSION, JOURNAL OF EXPERIMENTAL MEDICINE 182, 1389 (1995). · DOI
  30. 10.1126/science.7716544 · DOI
  31. PETRIE H.T., T-CELL RECEPTOR GENE RECOMBINATION PATTERNS AND MECHANISMS - CELL-DEATH, RESCUE, AND T-CELL PRODUCTION, JOURNAL OF EXPERIMENTAL MEDICINE 182, 121 (1995). · DOI
  32. PLEIMAN C.M., THE B-CELL ANTIGEN RECEPTOR COMPLEX - STRUCTURE AND SIGNAL-TRANSDUCTION, IMMUNOLOGY TODAY 15, 393 (1994). · DOI
  33. RADIC M.Z., B-LYMPHOCYTES MAY ESCAPE TOLERANCE BY REVISING THEIR ANTIGEN RECEPTORS, JOURNAL OF EXPERIMENTAL MEDICINE 177, 1165 (1993). · DOI
  34. RETH M, B-CELL ANTIGEN RECEPTORS, CURRENT OPINION IN IMMUNOLOGY 6, 3 (1994). · DOI
  35. 10.1038/338383b0 · DOI
  36. ROLINK A, MOLECULAR AND CELLULAR-ORIGINS OF LYMPHOCYTE-B DIVERSITY, CELL 66, 1081 (1991). · DOI
  37. SCHLISSEL M.S., ACTIVATION OF IMMUNOGLOBULIN KAPPA GENE REARRANGEMENT CORRELATES WITH INDUCTION OF GERMLINE KAPPA GENE-TRANSCRIPTION, CELL 58, 1001 (1989). · DOI
  38. SCHLISSEL M.S., VIRUS-TRANSFORMED PRE-B CELLS SHOW ORDERED ACTIVATION BUT NOT INACTIVATION OF IMMUNOGLOBULIN GENE REARRANGEMENT AND TRANSCRIPTION, JOURNAL OF EXPERIMENTAL MEDICINE 173, 711 (1991). · DOI
  39. 10.1016/0092-8674(92)90029-C · DOI
  40. SPANOPOULOU E, FUNCTIONAL IMMUNOGLOBULIN TRANSGENES GUIDE ORDERED B-CELL DIFFERENTIATION IN RAG-1-DEFICIENT MICE, GENES & DEVELOPMENT 8, 1030 (1994). · DOI
  41. SUN X.H., CONSTITUTIVE EXPRESSION OF THE ID1 GENE IMPAIRS MOUSE B-CELL DEVELOPMENT, CELL 79, 893 (1994). · DOI
  42. SWIATEK P.J., PERINATAL LETHALITY AND DEFECTS IN HINDBRAIN DEVELOPMENT IN MICE HOMOZYGOUS FOR A TARGETED MUTATION OF THE ZINC-FINGER GENE KROX20, GENES & DEVELOPMENT 7, 2071 (1993). · DOI
  43. TIEGS S.L., RECEPTOR EDITING IN SELF-REACTIVE BONE-MARROW B-CELLS, JOURNAL OF EXPERIMENTAL MEDICINE 177, 1009 (1993). · DOI
  44. URBANEK P, COMPLETE BLOCK OF EARLY B-CELL DIFFERENTIATION AND ALTERED PATTERNING OF THE POSTERIOR MIDBRAIN IN MICE LACKING PAX5/BSAP, CELL 79, 901 (1994). · DOI · Paper page
  45. VENKITARAMAN A.R., THE B-CELL ANTIGEN RECEPTOR OF THE 5 IMMUNOGLOBULIN CLASSES, NATURE 352, 777 (1991). · DOI
  46. YOUNG F, INFLUENCE OF IMMUNOGLOBULIN HEAVY-CHAIN AND LIGHT-CHAIN EXPRESSION ON B-CELL DIFFERENTIATION, GENES & DEVELOPMENT 8, 1043 (1994). · DOI
  47. ZHUANG Y, THE HELIX-LOOP-HELIX GENE E2A IS REQUIRED FOR B-CELL FORMATION, CELL 79, 875 (1994). · DOI · Paper page

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Metadata

Authors
Gong, S., & Nussenzweig, M. C.
Affiliations
Howard Hughes Medical Institute, Rockefeller University, New York, NY 10021, USA.
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1996-04-19
Volume
272
Issue
5260
Pages
411-414
ISSN
  • 0036-8075
  • 1095-9203
DOI
10.1126/science.272.5260.411
Cited by
216
References
0
Language
en

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