The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking mGluR2
Abstract
Subtype 2 of the metabotropic glutamate receptor (mGluR2) is expressed in the presynaptic elements of hippocampal mossy fiber-CA3 synapses. Knockout mice deficient in mGluR2 showed no histological changes and no alterations in basal synaptic transmission, paired-pulse facilitation, or tetanus-induced long-term potentiation (LTP) at the mossy fiber-CA3 synapses. Long-term depression (LTD) induced by low-frequency stimulation, however, was almost fully abolished. The mutant mice performed normally in water maze learning tasks. Thus, the presynaptic mGluR2 is essential for inducing LTD at the mossy fiber-CA3 synapses, but this hippocampal LTD does not seem to be required for spatial learning.
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Cites
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Self-citationMediation of Hippocampal Mossy Fiber Long-Term Potentiation by Cyclic AMP
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Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease
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Metadata
- Authors
- Yokoi, M., Kobayashi, K., Manabe, T., Takahashi, T., Sakaguchi, I., Katsuura, G., Shigemoto, R., Ohishi, H., Nomura, S., Nakamura, K., Nakao, K., Katsuki, M., & Nakanishi, S.
- Venue
- Science
- Published
- 1996-08-02
- Volume
- 273
- Issue
- 5275
- Pages
- 645-647
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2146112646
- Cited by
- 339
- References
- 23
- FWCI
- 9.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yokoi, M., Kobayashi, K., Manabe, T., Takahashi, T., Sakaguchi, I., Katsuura, G., Shigemoto, R., Ohishi, H., Nomura, S., Nakamura, K., Nakao, K., Katsuki, M., & Nakanishi, S. (1996). Impairment of Hippocampal Mossy Fiber LTD in Mice Lacking mGluR2. Science. https://doi.org/10.1126/science.273.5275.645
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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