Modulation of synaptic transmission and long-term potentiation: effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus
Abstract
1. Whole-cell patch-clamp recordings of excitatory postsynaptic currents (EPSCs) were made from guinea pig hippocampal CA1 pyramidal cells. The sensitivity of paired pulse facilitation (PPF) and EPSC variance to changes in synaptic transmission was investigated and the results were compared with the changes in these parameters evoked by long-term potentiation (LTP). 2. Presynaptic manipulations, such as activation of presynaptic gamma-aminobutyric acid-B receptors by baclofen, blockade of presynaptic adenosine receptors by theophylline, blockade of presynaptic potassium channels by cesium, and increasing the Ca(2+)-Mg2+ ratio in the external recording solution, each reliably changed PPF in a fashion reciprocal to the change in the EPSC amplitude. However, recruitment of additional synaptic release sites by increasing stimulus strength and antagonism of non-N-methyl-D-aspartate (NMDA) glutamate receptors by 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) failed to alter PPF. 3. Presynaptic manipulations including increased stimulus strength gave the predicted changes in the value of mean 2/variance (M2/sigma 2). Moreover, postsynaptic manipulations that altered EPSC amplitude, including blockade of non-NMDA receptors by CNQX, or changing the holding potential of the postsynaptic cell, gave little change in M2/sigma 2, as would be predicted for manipulations resulting in a uniform postsynaptic change. 4. LTP caused no change in PPF, whereas the presynaptic manipulations, which caus…
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Paired-pulse ratios and short-term facilitation or depression of synaptic responses during short, high-frequency bursts are greatly influenced by baseline release probability yet were unaffected by the generation of LTP.
“These ubiquitous forms of short-term synaptic plasticity are greatly influenced by the baseline release probability yet were unaffected by the generation of LTP (McNaughton 1982;Manabe et al. 1993; but see Schulz et al. 1995).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Manabe et al. 1993
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- Authors
- Manabe, T., Wyllie, D. J., Perkel, D. J., & Nicoll, R. A.
- Affiliations
- University of California, San Francisco (US)
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1993-10-01
- Volume
- 70
- Issue
- 4
- Pages
- 1451-1459
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2102268999
- Cited by
- 666
- References
- 0
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 11 · 2023: 10 · 2022: 6 · 2021: 12 · 2020: 12 · 2019: 16 · 2018: 20 · 2017: 17 · 2016: 19 · 2015: 26 · 2014: 26 · 2013: 24 · 2012: 26
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- synaptic transmission, long-term potentiation, paired-pulse facilitation, CA1 pyramidal neurons, hippocampus, presynaptic modulation, baclofen, GABAB receptors, adenosine receptors, theophylline, cesium, NMDA receptor antagonism, CNQX
- MeSH terms
- Animals, Calcium, Electric Stimulation, Guinea Pigs, Hippocampus, Magnesium, Male, Synaptic Transmission, Quinoxalines, Synapses, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Receptors, GABA-B, 6-Cyano-7-nitroquinoxaline-2,3-dione, In Vitro Techniques
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