The DOI matches its Crossref record; 37 of the 39 references it cites were found in a registry or an index.
Phenotypic Analysis of Antigen-Specific T Lymphocytes
Abstract
Identification and characterization of antigen-specific T lymphocytes during the course of an immune response is tedious and indirect. To address this problem, the peptide-major histocompatability complex (MHC) ligand for a given population of T cells was multimerized to make soluble peptide-MHC tetramers. Tetramers of human lymphocyte antigen A2 that were complexed with two different human immunodeficiency virus (HIV)-derived peptides or with a peptide derived from influenza A matrix protein bound to peptide-specific cytotoxic T cells in vitro and to T cells from the blood of HIV-infected individuals. In general, tetramer binding correlated well with cytotoxicity assays. This approach should be useful in the analysis of T cells specific for infectious agents, tumors, and autoantigens.
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“Studies can estimate the extent of CMV “obsession” by identifying antigen-specific cells using peptide-MHC class-I or class-II multimers (Altman et al. 1996; Davis et al. 2011).”
From Is immunosenescence influenced by our lifetime “dose” of exercise? (2016) · cites this paper as Altman et al. 1996
Citations
Cites
Handbook of Experimental Immunology.
Denman, A. (1968) · Annals of Internal Medicine · doi:10.7326/0003-4819-68-6-1376_1 · Cited by 2,414
HANDBOOK OF EXPERIMENTAL IMMUNOLOGY
Holborow, E. J. (1968) · Journal of Clinical Pathology · doi:10.1136/jcp.21.4.534-c · Cited by 678
Garboczi, D. N., Hung, D. T., & Wiley, D. C. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.8.3429 · Cited by 671
Schatz, P. J. (1993) · Nature Biotechnology · doi:10.1038/nbt1093-1138 · Cited by 585
Antigen-Specific Development of Primary and Memory T Cells in Vivo
McHeyzer‐Williams, M. G., & Davis, M. M. (1995) · Science · doi:10.1126/science.7535476 · Cited by 439
Self-citationKo, H. S., Fu, S. M., WINCHESTER, R. J., Yu, D. T. Y., & Kunkel, H. G. (1979) · The Journal of Experimental Medicine · doi:10.1084/jem.150.2.246 · Cited by 439
Nixon, D. F., Townsend, A., Elvin, J. G., Rizza, C. R., Gallwey, J., & McMichael, A. J. (1988) · Nature · doi:10.1038/336484a0 · Cited by 431
Self-citationMatsui, K., Boniface, J. J., Steffner, P., Reay, P. A., & Davis, M. M. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.26.12862 · Cited by 425
Self-citationCarmichael, A. J., Jin, X., Sissons, P., & Borysiewicz, L. K. (1993) · The Journal of Experimental Medicine · doi:10.1084/jem.177.2.249 · Cited by 418
Unusually high frequencies of HIV-specific cytotoxic T lymphocytes in humans.
Hoffenbach, A., Langlade‐Demoyen, P., Dadaglio, G., VILMER, E., Michel, F., Mayaud, C. M., Autran, B., & Plata, F. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.142.2.452 · Cited by 304
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2 of the 39 references couldn’t be matched to a known paper.
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- Hayakawa K., Ishii R., Yamasaki K., Kishimoto T., Hardy R. R., ibid. 84, 1379 (1987);
- Schatz P. J., Biotechnology 11, 1138 (1993).
- Johnson R. P., et al., ibid. 147, 1512 (1991).
- Koup R. A., et al., ibid. 174, 1593 (1991).
- Tripp R. A., Hou S., Doherty P. C., ibid. 154, 5870 (1995);
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Items 1,001–1,007 of 1,007
Multimer monitoring of CMV-specific T cells in research and in clinical applications
Borchers, S., Ogonek, J., Varanasi, P. R., Tischer, S., Bremm, M., Eiz-Vesper, B., Koehl, U., & Weissinger, E. M. (2014) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2013.11.007 · Cited by 18
Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages
Shahoei, S. H., Kim, Y.-C., Cler, S. J., Ma, L., Anakk, S., Kemper, J. K., & Nelson, E. R. (2019) · Endocrinology · doi:10.1210/en.2019-00025 · Cited by 16
“Fluorophore-conjugated tetramers displaying the OVA peptide were obtained from the National Institutes of Health Tetramer Core Facility at Emory University (41).”
MethodTsuchihashi (2000) · doi:10.1002/1521-4141(200006)30:6
Rodriguez-Palmero, M. (1999) · doi:10.1002/(sici)1521-4141(199912)29:12
(2002) · PubMed · Cited by 193
Daws (2001) · doi:10.1002/1521-4141(200103)31:3
Hoerr, I. (2000) · doi:10.1002/1521-4141(200001)30:1
Metadata
- Authors
- Altman, J. D., Moss, P. A. H., Goulder, P. J. R., Barouch, D. H., McHeyzer-Williams, M. G., Bell, J. I., McMichael, A. J., & Davis, M. M.
- Affiliations
- Stanford Medicine (US)
- John Radcliffe Hospital (GB)
- J. D. Altman and M. G. McHeyzer-Williams, Department of Microbiology and Immunology, Stanford University School of Medicine, Stanford, CA 94305-5428, USA.
- Howard Hughes Medical Institute (US)
- Corresponding author
- Davis, Mark M.
- ORCID
- Venue
- Science
- Published
- 1996-10-04
- Volume
- 274
- Issue
- 5284
- Pages
- 94-96
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2067069532
- Cited by
- 3,544
- References
- 39
- Citations by year
- 2026: 44 · 2025: 41 · 2024: 45 · 2023: 59 · 2022: 43 · 2021: 68 · 2020: 59 · 2019: 71 · 2018: 70 · 2017: 42 · 2016: 62 · 2015: 73 · 2014: 69 · 2013: 101 · 2012: 93
- FWCI
- 35.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wellcome Trust
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › vaccines and immunoinformatics approaches
- Keywords
- antigen-specific T cells, peptide-MHC tetramers, HLA-A2, cytotoxic T lymphocytes, cytotoxicity assay, T cell phenotyping, HIV infection, tumor-specific T cells, autoantigen-specific T cells
- MeSH terms
- Amino Acid Sequence, Epitopes, Antigens, Viral, Base Sequence, Cell Line, Coloring Agents, Flow Cytometry, HIV Seropositivity, Humans, Molecular Sequence Data, Peptide Fragments, Phenotype, RNA-Directed DNA Polymerase, T-Lymphocytes, Cytotoxic, Viral Matrix Proteins, Gene Products, gag, HLA-A2 Antigen, CD8-Positive T-Lymphocytes
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