Cited by 128Neuroscience and Neuropharmacology ResearchCellular transport and secretionNeural dynamics and brain function

Superpriming of synaptic vesicles as a common basis for intersynapse variability and modulation of synaptic strength

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Taschenberger, Holger, Woehler, Andrew, Neher, Erwin·2016·Proceedings of the National Academy of Sciences

Abstract

Significance: Short-term plasticity (STP) of synaptic connections underlies many basic signal processing capabilities of the brain, such as gain control, temporal filtering, and adaptation. Glutamatergic synapses, the predominant excitatory synapses in the brain, display large variability both in basal synaptic strength and in STP. We show that a small fraction of release-ready vesicles are released with much higher probability than other vesicles. The number of these “superprimed” vesicles is variable among synapses, but increases strongly after application of phorbol ester, an analogue of the second messenger diacylglycerol, and after inducing posttetanic potentiation. Thus, modulatory transmitter systems, acting through the phospholipase-C–diacylglycerol pathway, will be able to upregulate superprimed vesicles and thereby boost synaptic strength at the onset of burst-like activity.

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Authors
Taschenberger, H., Woehler, A., & Neher, E.
Affiliations
Nanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103 (DE)
Corresponding author
Neher, Erwin
Venue
Proceedings of the National Academy of Sciences
Published
2016-07-18
Volume
113
Issue
31
Pages
E4548-57
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2477973977
Cited by
128
References
67
Citations by year
2026: 10 · 2025: 12 · 2024: 13 · 2023: 18 · 2022: 10 · 2021: 12 · 2020: 8 · 2019: 15 · 2018: 13 · 2017: 16 · 2016: 1
FWCI
8.44
Type
journal article
Language
en
Open access
Locations
  • Proceedings of the National Academy of Sciences (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
Funders
  • Deutsche Forschungsgemeinschaft (CNMPB)
  • European Commission Directorate-General for Research and Innovation (FP7-HEALTH-F2-2009-241498)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
synaptic vesicles, short-term plasticity, post-tetanic potentiation, short-term depression, synaptic facilitation, phospholipase C, diacylglycerol, phorbol ester, glutamatergic synapses
MeSH terms
Algorithms, Animals, Animals, Newborn, Cells, Cultured, Electric Stimulation, Female, Male, Models, Neurological, Synaptic Transmission, Neuronal Plasticity, Synapses, Synaptic Vesicles, Signal Transduction, Rats, Wistar, Glutamic Acid, Excitatory Postsynaptic Potentials

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