Cited by 520Multiple Sclerosis Research StudiesImmunotherapy and Immune ResponsesT-cell and B-cell Immunology

A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis

Krienke, Christina, Kolb, Laura, Diken, Elif, Streuber, Michael, Kirchhoff, Sarah, Bukur, Thomas, Akilli-Öztürk, Özlem, Kranz, Lena M. +9 more·2021·Science

Abstract

Precision therapy for immune tolerance: Autoimmune diseases, such as multiple sclerosis (MS), result from a breach of immunological self-tolerance and tissue damage by autoreactive T lymphocytes. Current treatments can cause systemic immune suppression and side effects such as increased risk of infections. Krienke et al. designed a messenger RNA vaccine strategy that lacks adjuvant activity and delivers MS autoantigens into lymphoid dendritic cells. This approach expands a distinct type of antigen-specific effector regulatory T cell that suppresses autoreactivity against targeted autoantigens and promotes bystander suppression of autoreactive T cells against other myelin-specific autoantigens. In mouse models of MS, the vaccine delayed the onset and reduced the severity of established disease without showing overt symptoms of general immune suppression. Science , this issue p. 145

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Crossref · 10.1126/science.aay3638

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53 of 53 references verified0 citation errors · 0 not checkable

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  • Organ selectivity can be achieved by adjusting the proportions of lipid components.

    “Organ selectivity can also be achieved by adjusting the proportions of lipid components, for example, to design spleen-targeted mRNA vaccines26,27 or lung-targeted genome editing delivery systems114,134.”

    From Lipid nanoparticles for mRNA delivery (2021) · cites this paper as [27]

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Authors
Krienke, C., Kolb, L., Diken, E., Streuber, M., Kirchhoff, S., Bukur, T., Akilli-Öztürk, Ö., Kranz, L. M., Berger, H., Petschenka, J., Diken, M., Kreiter, S., Yogev, N., Waisman, A., Karikó, K., Türeci, Ö., & Sahin, U.
Affiliations
  • Johannes Gutenberg University Mainz (DE)
  • University Medical Center of the Johannes Gutenberg University Mainz (DE)
  • TRON – Translational Oncology at the University Medical Center of the Johannes Gutenberg University gGmbH, Freiligrathstr. 12, Mainz 55131, Germany.
  • BioNTech (Germany) (DE)
  • Boehringer Ingelheim (Germany) (DE)
Corresponding author
  • Kolb, Laura
  • Diken, Elif
Venue
Science
Published
2021-01-08
Volume
371
Issue
6525
Pages
145-153
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W3120567430
Cited by
520
References
53
Citations by year
2026: 89 · 2025: 89 · 2024: 98 · 2023: 87 · 2022: 84 · 2021: 72
FWCI
56.69
Type
journal article
Language
en
Open access
closed
Locations
  • Science (publishedVersion)
  • PubMed (publishedVersion)
  • Kölner Universitäts PublikationsServer (Universität zu Köln) (publishedVersion)
Funders
  • Deutsche Forschungsgemeinschaft DFG (SFB/CRC-TR 128)
  • Immunology Research Center (FZI) Mainz (FZI-TRP 2014-12)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords
mRNA vaccines, experimental autoimmune encephalomyelitis, multiple sclerosis, regulatory T cells, dendritic cells, myelin autoantigens, bystander suppression, immune tolerance, adjuvant-free vaccine, autoreactive T cells
MeSH terms
mRNA Vaccines, Animals, Antigen-Presenting Cells, Autoantigens, Encephalomyelitis, Autoimmune, Experimental, Immunosuppression Therapy, Inflammation, Mice, Inbred C57BL, Multiple Sclerosis, Pseudouridine, RNA, Messenger, Vaccines, Synthetic, Bystander Effect, T-Lymphocytes, Regulatory, Mice

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