The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.
Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Abstract
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
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“The scientific interest in resveratrol dates back to 1997 when studies on animal models demonstrated its anticancer properties [7].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [7]
Citations
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Therapeutic potential of resveratrol: the in vivo evidence
Baur, J. A., & Sinclair, D. A. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2060 · Cited by 3,958
“2 ) have shown that resveratrol can prevent or slow the progression of a wide variety of illnesses, including cance”
BackgroundSmall molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Howitz, K. T., Bitterman, K. J., Cohen, H. Y., Lamming, D. W., Lavu, S., Wood, J. G., Zipkin, R. E., Chung, P., Kisielewski, A., Zhang, L.-L., et al. (2003) · Nature · doi:10.1038/nature01960 · Cited by 3,796
“The most potent activator was resveratrol (3,5,4′-trihydroxystilbene), a polyphenol found in red wine that is associated with a surprising number of health benefits, most notably the mitigation of age-related diseases, including neurodegeneration, carcinogenesis and atherosclerosi”
BackgroundDietary Intake and Bioavailability of Polyphenols
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“[145] Jang, M.”
Metadata
- Authors
- Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., & Pezzuto, J. M.
- Affiliations
- University of Illinois Chicago (US)
- Universidad Complutense de Madrid (ES)
- M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
- Corresponding author
- Cai, Lining
- Pezzuto, John M.
- Venue
- Science
- Published
- 1997-01-10
- Volume
- 275
- Issue
- 5297
- Pages
- 218-220
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2151089147
- Cited by
- 4,935
- References
- 33
- Citations by year
- 2026: 45 · 2025: 75 · 2024: 105 · 2023: 95 · 2022: 148 · 2021: 166 · 2020: 179 · 2019: 168 · 2018: 181 · 2017: 202 · 2016: 179 · 2015: 222 · 2014: 225 · 2013: 264 · 2012: 252
- FWCI
- 96.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- Funders
- National Cancer Institute (P01CA048112)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- resveratrol, chemoprevention, phytoalexins, grapes, antioxidant activity, antimutagenic activity, phase II enzymes, anti-inflammatory activity, cyclooxygenase inhibition, mammary carcinogenesis, precancerous lesions
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