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Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes
Abstract
Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.
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“The scientific interest in resveratrol dates back to 1997 when studies on animal models demonstrated its anticancer properties [7].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [7]
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“Resveratrol has antioxidant, anti-inflammatory and anticarcinogenic properties [34,128,129].”
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“(12), the first animal study of the chemopreventive effects of resveratrol was reported in a two-stage mouse skin carcinogenesis model.”
BackgroundIMPROVING THE NUTRIENT COMPOSITION OF PLANTS TO ENHANCE HUMAN NUTRITION AND HEALTH
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“These include flavonoids, flavones, phytosterols, phenols and polyphenols, phytoestrogens, glucosinolates, and indoles, to name but a few (11, 27, 33, 37, 69, 82, 152).”
BackgroundWang, H., Khor, T. O., Shu, L., Su, Z., Fuentes, F., Lee, J. H., & Kong, A. T. (2012) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/187152012803833026 · Cited by 547
“Jang et al reported cancer chemopreventive activity of resveratrol [164].”
Resveratrol Acts as a Mixed Agonist/Antagonist for Estrogen Receptors α and β*
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“It is further supported by the results of our recent study of the relation between beer, wine, and spirits and cancer of the upper digestive tract (41), although these cancers are rare.”
ResultResveratrol and cancer: focus on in vivo evidence
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“After Jang et al .”
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“Since its identification in 1939, resveratrol’s pleiotropic activities have been reported in a number of studies.(3,257) However, most of these discussions are based on preclinical work.”
BackgroundResveratrol: from grapevines to mammalian biology
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“Results indicated that the presence of RSV prevented the activation of NF- B triggered by exposure of these cell types to TNF, PMA, H2O2, LPS, okadaic acid, and ceramide (15).”
BackgroundInfluentialTsai, S., Lin‐Shiau, S., & Lin, J. (1999) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0702357 · Cited by 511
Biological Effects of Resveratrol
Bhat, K., Kosmeder, J. W., & Pezzuto, J. M. (2001) · Antioxidants and Redox Signaling · doi:10.1089/152308601317203567 · Cited by 510
“Resveratrol has been shown to in-BHAT hibit the activity of the COX-1 enzyme derived from sheep seminal vesicles (68, 112).”
InfluentialSelf-citationXia, C., Meng, Q., Liu, L.-Z., Rojanasakul, Y., Wang, X., & Jiang, B. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-0783 · Cited by 520
Resveratrol for cancer therapy: Challenges and future perspectives
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Resveratrol: a review of plant sources, synthesis, stability, modification and food application
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Waterhouse, A. L. (2002) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2002.tb02903.x · Cited by 494
Resveratrol as an anticancer nutrient: molecular basis, open questions and promises
Signorelli, P., & Ghidoni, R. (2005) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2005.01.017 · Cited by 497
“Resveratrol noncompetitively inhibited both the COX and hydroperoxidase activities of COX1 in vitro [13,89].”
BackgroundMethodInfluentialStivala, L. A., Savio, M., Carafoli, F., Perucca, P., Bianchi, L. C., Maga, G., Forti, L., PAGNONI, U. M., Albini, A., Prosperi, E., et al. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101846200 · Cited by 496
Cancer Prevention With Natural Compounds
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Self-citationImproving industrial yeast strains: exploiting natural and artificial diversity
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“Resveratrol is a compound that, apart from its antifungal characteristics, has been proposed to reduce the risk of cancer and coronary heart disease (Jang et al., 1997; Becker et al., 2003).”
BackgroundMarier, J., Vachon, P., Gritsas, A., Zhang, J., Moreau, J., & Ducharme, M. P. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.033340 · Cited by 480
“Finally, trans-resveratrol was shown to have cancer chemoprotective properties and to induce apoptosis in leukemia and human breast carcinoma (Jang et al., 1997; Mgbonyebi et al., 1998; Lu and Serrero, 1999).”
BackgroundTargeting NOX, iNOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals
Murakami, A., & Ohigashi, H. (2007) · International Journal of Cancer · doi:10.1002/ijc.23161 · Cited by 478
“Resveratrol is a well-known compound that regulates both COX-1 and COX-2.”
BackgroundThe molecular targets of resveratrol
Kulkarni, S. S., & Cantó, C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.005 · Cited by 477
Cyclooxygenase-2 and carcinogenesis
Prescott, S. M., & Fitzpatrick, F. A. (2000) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(00)00006-8 · Cited by 483
Functional foods: their role in disease prevention and health promotion
Hasler, C. M. (1998) · Food technology · Cited by 473
The Mediterranean diets: what is so special about the diet of Greece? The scientific evidence
Simopoulos, A. P. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.11.3065s · Cited by 473
Metadata
- Authors
- Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., & Pezzuto, J. M.
- Affiliations
- University of Illinois Chicago (US)
- Universidad Complutense de Madrid (ES)
- M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
- Corresponding author
- Cai, Lining
- Pezzuto, John M.
- Venue
- Science
- Published
- 1997-01-10
- Volume
- 275
- Issue
- 5297
- Pages
- 218-220
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2151089147
- Cited by
- 4,935
- References
- 33
- Citations by year
- 2026: 45 · 2025: 75 · 2024: 105 · 2023: 95 · 2022: 148 · 2021: 166 · 2020: 179 · 2019: 168 · 2018: 181 · 2017: 202 · 2016: 179 · 2015: 222 · 2014: 225 · 2013: 264 · 2012: 252
- FWCI
- 96.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- Funders
- National Cancer Institute (P01CA048112)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- resveratrol, chemoprevention, phytoalexins, grapes, antioxidant activity, antimutagenic activity, phase II enzymes, anti-inflammatory activity, cyclooxygenase inhibition, mammary carcinogenesis, precancerous lesions
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