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Cited by 4,935Sirtuins and Resveratrol in MedicinePhytochemicals and Antioxidant ActivitiesGenomics, phytochemicals, and oxidative stress

The DOI matches its Crossref record; 32 of the 33 references it cites were found in a registry or an index.

Cancer Chemopreventive Activity of Resveratrol, a Natural Product Derived from Grapes

Jang, Meishiang, Cai, Lining, Udeani, George O., Slowing, Karla V., Thomas, Cathy F., Beecher, Christopher W. W., Fong, Harry H. S., Farnsworth, Norman R., Kinghorn, A. Douglas, Mehta, Rajendra G., Moon, Richard C., Pezzuto, John M.·1997·Science
DOI 10.1126/science.275.5297.218
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Abstract

Resveratrol, a phytoalexin found in grapes and other food products, was purified and shown to have cancer chemopreventive activity in assays representing three major stages of carcinogenesis. Resveratrol was found to act as an antioxidant and antimutagen and to induce phase II drug-metabolizing enzymes (anti-initiation activity); it mediated anti-inflammatory effects and inhibited cyclooxygenase and hydroperoxidase functions (antipromotion activity); and it induced human promyelocytic leukemia cell differentiation (antiprogression activity). In addition, it inhibited the development of preneoplastic lesions in carcinogen-treated mouse mammary glands in culture and inhibited tumorigenesis in a mouse skin cancer model. These data suggest that resveratrol, a common constituent of the human diet, merits investigation as a potential cancer chemopreventive agent in humans.

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Crossref · 10.1126/science.275.5297.218

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Citations

Cites

Research works printed but not linked: 11

  1. Sporn M. B., Newton D. L., Fed. Proc. 38, 2528 (1979).
  2. Kudo T., Narisawa T., Abo S., Gann 71 260 (1980);
  3. Zenser T. V., et al., J. Pharmacol. Exp. Ther. 227 545 (1983);
  4. Wattenberg L. W., Cancer Res. 53, 5890 (1993).
  5. Sharma S., Stutzman J. D., Kelloff G. J., Steele V. E., Cancer Res. 54 5848 (1994);
  6. Shamon L. A., et al., Anticancer Res. 14 1775 (1995).
  7. Suh N., Luyengi L., Fong H. H. S., Kinghorn A. D., Pezzuto J. M., Anticancer Res. 15, 233 (1995).
  8. Moon R. C., Mehta R. G., in Chemistry and Biology of Retinoids, , Dawson M. I., Okamura W. H., Eds. (CRC Press, Boca Raton, FL, 1990), pp. 501-518.
  9. Dercks W., Creasy L. L., Physiol. Mol. Plant Pathol. 34, 289 (1989).
  10. Siemann E. H. and , Creasy L. L., ibid. 43, 49 (1992);
  11. Goldberg D. M., et al., ibid. 46, 159 (1995).

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Metadata

Authors
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., Moon, R. C., & Pezzuto, J. M.
Affiliations
  • University of Illinois Chicago (US)
  • Universidad Complutense de Madrid (ES)
  • M. Jang, L. Cai, C. W. W. Beecher, H. H. S. Fong, N. R. Farnsworth, A. D. Kinghorn, J. M. Pezzuto, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
Corresponding author
  • Cai, Lining
  • Pezzuto, John M.
ORCID
Venue
Science
Publisher
American Association for the Advancement of Science (AAAS)
Published
1997-01-10
Volume
275
Issue
5297
Pages
218-220
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
DOI
10.1126/science.275.5297.218
OpenAlex
W2151089147
Cited by
4,935
References
33
Citations by year
2026: 45 · 2025: 75 · 2024: 105 · 2023: 95 · 2022: 148 · 2021: 166 · 2020: 179 · 2019: 168 · 2018: 181 · 2017: 202 · 2016: 179 · 2015: 222 · 2014: 225 · 2013: 264 · 2012: 252
FWCI
96.50
Type
journal article
Language
en
Open access
closed
Locations
Science (publishedVersion)
Funders
National Cancer Institute (P01CA048112)
Topics
  • Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
  • Health Sciences › Medicine › Biochemistry (medical) › Phytochemicals and Antioxidant Activities
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
Keywords
resveratrol, chemoprevention, phytoalexins, grapes, antioxidant activity, antimutagenic activity, phase II enzymes, anti-inflammatory activity, cyclooxygenase inhibition, mammary carcinogenesis, precancerous lesions

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