The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Open accessAbstract
Inactivation of the adenomatous polyposis coli ( APC ) tumor suppressor gene initiates colorectal neoplasia. One of the biochemical activities associated with the APC protein is down-regulation of transcriptional activation mediated by β-catenin and T cell transcription factor 4 (Tcf-4). The protein products of mutant APC genes present in colorectal tumors were found to be defective in this activity. Furthermore, colorectal tumors with intact APC genes were found to contain activating mutations of β-catenin that altered functionally significant phosphorylation sites. These results indicate that regulation of β-catenin is critical to APC's tumor suppressive effect and that this regulation can be circumvented by mutations in either APC or β-catenin.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919
Self-citationFunctional interaction of β-catenin with the transcription factor LEF-1
Behrens, J., von Kries, J. P., Kühl, M., Bruhn, L., Wedlich, D., Grosschedl, R., & Birchmeier, W. (1996) · Nature · doi:10.1038/382638a0 · Cited by 2,912
Cited by
Items 101–123 of 123
A Novel β-Catenin-binding Protein Inhibits β-Catenin-dependent Tcf Activation and Axis Formation
Sakamoto, I., Kishida, S., Fukui, A., Kishida, M., Yamamoto, H., Hino, S.-I., Michiue, T., Takada, S., Asashima, M., & Kikuchi, A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m004089200 · Cited by 106
McKim, J. M. (2014) · Critical Reviews in Toxicology · doi:10.3109/10408444.2013.861797 · Cited by 108
Chromatin-specific regulation of LEF-1–β-catenin transcription activation and inhibition in vitro
Tutter, A. V., Fryer, C. J., & Jones, K. A. (2001) · Genes & Development · doi:10.1101/gad.946501 · Cited by 107
Ip, W., Shao, W., Chiang, Y.-T. A., & Jin, T. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00249.2012 · Cited by 77
Datta, K., Suman, S., Kallakury, B. V. S., & Fornace, A. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059295 · Cited by 75
Natarajan, L., Witwer, N. E., & Eisenmann, D. M. (2001) · Genetics · doi:10.1093/genetics/159.1.159 · Cited by 75
Khan, Z., Vijayakumar, S., de la Torre, T. V., Rotolo, S., & Bafico, A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00773-07 · Cited by 73
Koelman, E. M. R., Yeste-Vázquez, A., & Grossmann, T. N. (2022) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2022.116920 · Cited by 63
HPV16 E6 augments Wnt signaling in an E6AP-dependent manner
Lichtig, H., Gilboa, D. A., Jackman, A., Gonen, P., Levav-Cohen, Y., Haupt, Y., & Sherman, L. (2010) · Virology · doi:10.1016/j.virol.2009.10.011 · Cited by 61
van Leeuwen, I. M. M., Byrne, H. M., Jensen, O. E., & King, J. R. (2007) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2007.01.019 · Cited by 59
Benham-Pyle, B. W., Sim, J. Y., Hart, K. C., Pruitt, B. L., & Nelson, W. J. (2016) · eLife · doi:10.7554/elife.19799 · Cited by 46
Wnt-independent role of β-catenin in thyroid cell proliferation and differentiation
Sastre-Perona, A., & Santisteban, P. (2014) · Molecular Endocrinology · doi:10.1210/me.2013-1377 · Cited by 43
ZHAO, D. H., HONG, J. J., GUO, S. Y., YANG, R. L., YUAN, J., WEN, C. J., ZHOU, K. Y., & LI, C. J. (2004) · Cell Research · doi:10.1038/sj.cr.7290205 · Cited by 39
Bläker, H., Scholten, M., Sutter, C., Otto, H. F., & Penzel, R. (2003) · American Journal of Clinical Pathology · doi:10.1309/4e4wg3aygjncd11p · Cited by 35
Farooqi, A. A., Rakhmetova, V. S., Kapanova, G., Tashenova, G., Tulebayeva, A., Akhenbekova, A., Ibekenov, O., Turgambayeva, A., & Xu, B. (2023) · Molecules · doi:10.3390/molecules28052231 · Cited by 25
Monoclonal Antibodies to Kaiso: A Novel Transcription Factor and p120 ctn -Binding Protein
Daniel, J. M., Ireton, R. C., & Reynolds, A. B. (2001) · Hybridoma · doi:10.1089/027245701750293484 · Cited by 20
Lee, H. N., Jeon, G. S., Kim, D. W., Cho, I.-H., & Cho, S. S. (2010) · Neurochemical Research · doi:10.1007/s11064-009-0036-3 · Cited by 19
Selective Wnt/β-catenin Small-molecule Inhibitor CWP232228 Impairs Tumor Growth of Colon Cancer
KIM, J. Y., PARK, G., KRISHNAN, M., HA, E., & CHUN, K.-S. (2019) · Anticancer Research · doi:10.21873/anticanres.13514 · Cited by 18
USP10 drives cancer stemness and enables super-competitor signalling in colorectal cancer
Reissland, M., Hartmann, O., Tauch, S., Bugter, J. M., Prieto-Garcia, C., Schulte, C., Loebbert, S., Solvie, D., Bitman-Lotan, E., Narain, A., et al. (2024) · Oncogene · doi:10.1038/s41388-024-03141-x · Cited by 16
Costa, Â. M. S., Pereira-Castro, I., Ricardo, E., Spencer, F., Fisher, S., & Costa, L. T. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0067694 · Cited by 13
Gαz Inhibits Serum Response Factor-Dependent Transcription by Inhibiting Rho Signaling
Dutt, P., Jaffe, A. B., Merdek, K. D., Hall, A., & Toksoz, D. (2004) · Molecular Pharmacology · doi:10.1124/mol.104.002949 · Cited by 13
WNT/β-catenin pathway activation in hepatocellular carcinoma: a clinical perspective
Chua, M.-S., Ma, L., Wei, W., & So, S. (2014) · Gastrointestinal Cancer: Targets and Therapy · doi:10.2147/gictt.s44256 · Cited by 12
USP10 drives cancer stemness and enables super-competitor signalling in Colorectal Cancer
(2023) · doi:10.21203/rs.3.rs-3742742/v1
Metadata
- Authors
- Morin, P. J., Sparks, A. B., Korinek, V., Barker, N., Clevers, H., Vogelstein, B., & Kinzler, K. W.
- Venue
- Science
- Published
- 1997-03-21
- Volume
- 275
- Issue
- 5307
- Pages
- 1787-1790
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1967137553
- Cited by
- 3,942
- References
- 2
- FWCI
- 64.12
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
