Cyclooxygenase knockout mice

Langenbach, Robert; Loftin, Charles; Lee, Christopher; Tiano, Howard

doi:10.1016/s0006-2952(99)00158-6

Cited by 230Inflammatory mediators and NSAID effectsEicosanoids and Hypertension PharmacologyPeroxisome Proliferator-Activated Receptors

Cyclooxygenase knockout mice

Langenbach, Robert, Loftin, Charles, Lee, Christopher, Tiano, Howard·1999·Biochemical Pharmacology

DOI 10.1016/s0006-2952(99)00158-6

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Abstract

The development of cyclooxygenase (COX) deficient mice has allowed investigation into the individual physiological roles of the COX-1 and COX-2 isoforms. In the following article, the phenotypes of the two Ptgs (genes coding for COX-1 and COX-2) knockouts are summarized, and recent studies to investigate the effects of COX deficiency on cancer susceptibility, inflammatory response, gastric ulceration, and female reproductive processes are discussed. Also, the development and potential uses of mice deficient in both COX isoforms and mice containing only a single copy of one isoform are discussed. Additionally, when the data permit, the effects of genetic ablation of COX activity are compared with those of pharmacological inhibition of COX activity by nonsteroidal anti-inflammatory drugs. The data suggest that prostaglandins derived via the individual COX isoforms have separate as well as common functions. However, for the maintenance of normal physiology, it appears that deficiency of COX-2 has more profound effects than deficiency of COX-1.

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The prolonged gestation interval observed in the ERKdko females was reminiscent of phenotype described for the cyclooxygenase 1 (PGHS1/COX1) knockout animal.
“First, the prolonged gestation interval observed in the ERKdko females was reminiscent of phenotype described for the cyclooxygenase 1 (PGHS1/COX1) knockout animal34–39.”
From Conditional loss of ERK1 and ERK2 results in abnormal placentation and delayed parturition in the mouse (2019) · cites this paper as [37]

Inhibition of Prostaglandin Synthesis as a Mechanism of Action for Aspirin-like Drugs
VANE, J. R. (1971) · Nature New Biology · doi:10.1038/newbio231232a0 · Cited by 8,605 · see citing works
Cancer chemopreventive activity of resveratrol, a natural product derived from grapes
Jang, M., Cai, L., Udeani, G. O., Slowing, K. V., Thomas, C. F., Beecher, C. W. W., Fong, H. H. S., Farnsworth, N. R., Kinghorn, A. D., Mehta, R. G., et al. (1997) · Science · doi:10.1126/science.275.5297.218 · Cited by 4,935 · see citing works
Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas
Eberhart, C. E., Coffey, R. J., Aramandla, R., Giardiello, F. M., Ferrenbach, S., & DuBois, R. N. (1994) · Gastroenterology · doi:10.1016/0016-5085(94)90246-1 · Cited by 2,512 · see citing works
Suppression of Intestinal Polyposis in ApcΔ716 Knockout Mice by Inhibition of Cyclooxygenase 2 (COX-2)
Oshima, M., Dinchuk, J. E., Kargman, S., Oshima, H., Hancock, B. C., Kwong, E. C., Trzăskos, J. M., Evans, J. F., & Taketo, M. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81988-1 · Cited by 2,363 · see citing works
Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2
Tsujii, M., & DuBois, R. N. (1995) · Cell · doi:10.1016/0092-8674(95)90127-2 · Cited by 2,292 · see citing works
Cyclooxygenase regulates angiogenesis induced by colon cancer cells
Tsujii, M., Kawano, S., Tsuji, S., Sawaoka, H., Hori, M., & DuBois, R. N. (1998) · Cell · doi:10.1016/s0092-8674(00)81433-6 · Cited by 2,272 · see citing works
Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
Kliewer, S. A., Sundseth, S. S., Jones, S. A., Brown, P. J., Wisely, G. B., Koble, C. S., Devchand, P., Wahli, W., Willson, T. M., Lenhard, J. M., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4318 · Cited by 2,164 · see citing works
Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2
Smith, W. L., Garavito, R. M., & DeWitt, D. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33157 · Cited by 1,973 · see citing works
TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
Kujubu, D. A., Fletcher, B. S., Varnum, B. C., Lim, R. W., & Herschman, H. R. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98774-0 · Cited by 1,786 · see citing works
Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.
Xie, W. L., Chipman, J. G., Robertson, D. L., Erikson, R. L., & Simmons, D. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2692 · Cited by 1,707 · see citing works
Aspirin Use and Reduced Risk of Fatal Colon Cancer
Thun, M. J., Namboodiri, M. M., & Heath, C. W. (1991) · New England Journal of Medicine · doi:10.1056/nejm199112053252301 · Cited by 1,682 · see citing works
A Dominant Mutation That Predisposes to Multiple Intestinal Neoplasia in the Mouse
Moser, A. R., Pitot, H. C., & Dove, W. F. (1990) · Science · doi:10.1126/science.2296722 · Cited by 1,591 · see citing works
Multiple Female Reproductive Failures in Cyclooxygenase 2–Deficient Mice
Lim, H. J., Paria, B. C., Das, S., Dinchuk, J. E., Langenbach, R. I., Trzăskos, J. M., & Dey, S. K. (1997) · Cell · doi:10.1016/s0092-8674(00)80402-x · Cited by 1,426 · see citing works
Self-citation
Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs.
Meade, E. A., Smith, W. L., & DeWitt, D. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)53294-4 · Cited by 1,262 · see citing works
Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids
Yamagata, K., Andreasson, K. I., Kaufmann, W. E., Barnes, C. A., & Worley, P. F. (1993) · Neuron · doi:10.1016/0896-6273(93)90192-t · Cited by 1,224 · see citing works
Prostaglandin synthase 2
Herschman, H. R. (1996) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00194-8 · Cited by 1,200 · see citing works
Expression of cyclooxygenase-1 and -2 in human colorectal cancer.
Sano, H., Kawahito, Y., Wilder, R. L., Hashiramoto, A., Mukai, S., Asai, K., Kimura, S., Kato, H., Kondo, M., & Hla, T. (1995) · PubMed · Cited by 1,126 · see citing works
Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
Langenbach, R. J., Morham, S. G., Tiano, H. F., Loftin, C. D., Ghanayem, B. I., Chulada, P. C., Mahler, J. F., Lee, C. A., Goulding, E. H., Kluckman, K. D., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90126-4 · Cited by 1,120 · see citing works
Self-citation
Peroxisome Proliferator-activated Receptors α and γ Are Activated by Indomethacin and Other Non-steroidal Anti-inflammatory Drugs
Lehmann, J. M., Lenhard, J. M., Oliver, B. B., Ringold, G. M., & Kliewer, S. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3406 · Cited by 1,110 · see citing works
Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
Morham, S. G., Langenbach, R. J., Loftin, C. D., Tiano, H. F., Vouloumanos, N., Jennette, J. C., Mahler, J. F., Kluckman, K. D., Ledford, A., Lee, C. A., et al. (1995) · Cell · doi:10.1016/0092-8674(95)90125-6 · Cited by 1,080 · see citing works
Self-citation
Cytoprotection by prostaglandins
Robert, A. (1979) · Gastroenterology · doi:10.1016/0016-5085(79)90235-x · Cited by 1,074 · see citing works
Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation.
Vane, J. R., Mitchell, J. A., Appleton, I., Tomlinson, A., Bishop‐Bailey, D., Croxtall, J. D., & Willoughby, D. A. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.6.2046 · Cited by 1,035 · see citing works
Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
Dinchuk, J. E., Car, B. D., Focht, R. J., Johnston, J. J., JAFFEE, B. D., Covington, M. B., Contel, N. R., Eng, V. M., Collins, R. J., Czerniak, P. M., et al. (1995) · Nature · doi:10.1038/378406a0 · Cited by 967 · see citing works
Aspirin use and risk of fatal cancer.
Thun, M. J., Namboodiri, M. M., Calle, E. E., Flanders, W. D., & Heath, C. W. (1993) · PubMed · Cited by 870 · see citing works
Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction.
Harris, R. C., McKanna, J. A., Akai, Y., Jacobson, H. R., DuBois, R. N., & Breyer, M. D. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117620 · Cited by 856 · see citing works
Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer.
Kargman, S., O’Neill, G. P., Vickers, P. J., Evans, J. F., Mancini, J. A., & Jothy, S. (1995) · PubMed · Cited by 831 · see citing works
NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
Futaki, N., Takahashi, S., Yokoyama, M., Arai, I., Higuchi, S., & Otomo, S. (1994) · Prostaglandins · doi:10.1016/0090-6980(94)90074-4 · Cited by 821 · see citing works
Pharmacological analysis of cyclooxygenase-1 in inflammation
Smith, C., Zhang, Y., Koboldt, C. M., Muhammad, J., Zweifel, B. S., Shaffer, A. F., Talley, J. J., Masferrer, J. L., Seibert, K., & Isakson, P. C. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.22.13313 · Cited by 802 · see citing works
The Function and Mechanism of Promoters of Carcinogenesis
Boutwell, R. K., & Sivak, A. J. (1973) · Critical Reviews in Toxicology · doi:10.3109/10408447309025704 · Cited by 750 · see citing works
Mechanism of Action of Nonsteroidal Anti-inflammatory Drugs
Vane, J. R., & Botting, R. M. (1998) · The American Journal of Medicine · doi:10.1016/s0002-9343(97)00203-9 · Cited by 723 · see citing works
Prostaglandin Endoperoxide H Synthases-1 and -2
Smith, W. L., & DeWitt, D. L. (1996) · Advances in immunology · doi:10.1016/s0065-2776(08)60430-7 · Cited by 711 · see citing works
Towards a better aspirin
Vane, J. R. (1994) · Nature · doi:10.1038/367215a0 · Cited by 698 · see citing works
Aspirin and the potential role of prostaglandins in colon cancer.
Marnett, L. J. (1992) · PubMed · Cited by 685 · see citing works
Induction of cyclooxygenase 2 in gastric mucosal lesions and its inhibition by the specific antagonist delays healing in mice
Mizuno, H., Sakamoto, C., Matsuda, K., Wada, K., Uchida, T., Noguchi, H., Akamatsu, T. M., & Kasuga, M. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9024292 · Cited by 637 · see citing works
Failure of Parturition in Mice Lacking the Prostaglandin F Receptor
Sugimoto, Y., Yamasaki, A., Segi, E., Tsuboi, K., Aze, Y., Nishimura, T., Oida, H., Yoshida, N., Tanaka, T., Katsuyama, M., et al. (1997) · Science · doi:10.1126/science.277.5326.681 · Cited by 608 · see citing works
Rapid Colorectal Adenoma Formation Initiated by Conditional Targeting of the Apc Gene
Shibata, H., Toyama, K., Shioya, H., Ito, M., Hirota, M., Hasegawa, S., Matsumoto, H., Takano, H., Akiyama, T., Toyoshima, K., et al. (1997) · Science · doi:10.1126/science.278.5335.120 · Cited by 605 · see citing works
Effects of nonsteroidal anti-inflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway
Hanif, R., Pittas, A., Feng, Y., Koutsos, M. I., Qiao, L., Staiano‐Coico, L., Shiff, S. I., & Rigas, B. (1996) · Biochemical Pharmacology · doi:10.1016/0006-2952(96)00181-5 · Cited by 604 · see citing works
Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.
DeWitt, D. L., & Smith, W. L. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.5.1412 · Cited by 598 · see citing works
Different Intracellular Locations for Prostaglandin Endoperoxide H Synthase-1 and −2
Morita, I., Schindler, M., Regier, M. K., Otto, J. C., Hori, T., DeWitt, D. L., & Smith, W. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.18.10902 · Cited by 572 · see citing works
Nonsteroidal anti-inflammatory drugs and gastroenteropathy: The second hundred years
Jl, W. (1997) · Gastroenterology · doi:10.1053/gast.1997.v112.pm9041264 · Cited by 568 · see citing works
Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment
Funk, C. D., Funk, L. B., Kennedy, M. E., Pong, A. S., & FitzGerald, G. A. (1991) · The FASEB Journal · doi:10.1096/fasebj.5.9.1907252 · Cited by 568 · see citing works
Loss of Apc heterozygosity and abnormal tissue building in nascent intestinal polyps in mice carrying a truncated Apc gene.
Oshima, M., Oshima, H., Kitagawa, K., Kobayashi, M., Itakura, C., & Taketo, M. M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4482 · Cited by 558 · see citing works
A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein.
O’Banion, M. K., Sadowski, H. B., Winn, V. D., & Young, D. A. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)54491-4 · Cited by 557 · see citing works
Cyclooxygenase-2 overexpression and tumor formation are blocked by sulindac in a murine model of familial adenomatous polyposis.
Boolbol, S. K., Dannenberg, A. J., Chadburn, A., Martucci, C., Guo, X., Ramonetti, J. T., Abreu-Goris, M., Newmark, H. L., Lipkin, M. L., DeCosse, J. J., et al. (1996) · PubMed · Cited by 545 · see citing works
The mechanism of action of nonsteroidal antiinflammatory drugs.
Brandt, K. D. (1991) · PubMed · Cited by 518 · see citing works
A Hypothesis: Nonsteroidal Anti-Inflammatory Drugs Reduce the Incidence of Large-Bowel Cancer
Rosenberg, L. A., Palmer, J. R., Zauber, A. G., Warshauer, M. E., Stolley, P. D., & Shapiro, S. (1991) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/83.5.355 · Cited by 500 · see citing works
Differential activation of adipogenesis by multiple PPAR isoforms.Preprint
Brun, R. P., Tontonoz, P., FORMAN, B. M., Ellis, R., Chen, J., Evans, R. M., & Spiegelman, B. M. (1996) · Genes & Development · doi:10.1101/gad.10.8.974 · Cited by 474 · see citing works
The mechanisms of action of nonsteroidal antiinflammatory drugs
Abramson, S. B., & Weissmann, G. (1989) · Arthritis & Rheumatism · doi:10.1002/anr.1780320102 · Cited by 469 · see citing works
Conditional gene targeting.
Rajewsky, K., Gu, H., Kühn, R., Betz, U. A. K., Müller, W., Roes, J., & Schwenk, F. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118828 · Cited by 461 · see citing works
Prostaglandin endoperoxide synthase: why two isoforms?
Williams, C. S., & DuBois, R. N. (1996) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1996.270.3.g393 · Cited by 459 · see citing works
Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).
Merlie, J. P., Fagan, D., Mudd, J. L., & Needleman, P. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68959-8 · Cited by 429 · see citing works
Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors
Dubois, R. N., Radhika, A., Reddy, B., & Entingh, A. J. (1996) · Gastroenterology · doi:10.1053/gast.1996.v110.pm8613017 · Cited by 425 · see citing works
Chemoprevention of colon carcinogenesis by sulindac, a nonsteroidal anti-inflammatory agent.
Rao, C. V., Rivenson, A., Simi, B., Zang, E. A., Kelloff, G. V., Steele, V. E., & Reddy, B. S. (1995) · PubMed · Cited by 402 · see citing works
Molecular mechanisms of diverse actions of prostanoid receptors
Negishi, M., Sugimoto, Y., & Ichikawa, A. (1995) · Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism · doi:10.1016/0005-2760(95)00146-4 · Cited by 391 · see citing works
Cyclooxygenase-2: Regulation and relevance in inflammation
Mitchell, J. A., Larkin, S. W., & Williams, T. J. (1995) · Biochemical Pharmacology · doi:10.1016/0006-2952(95)00212-x · Cited by 375 · see citing works
Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug: independence from COX-2 protein expression.
Elder, D. J. E., Halton, D. E., Hague, A., & Paraskeva, C. (1997) · PubMed · Cited by 366 · see citing works
The prostaglandin receptor EP4 triggers remodelling of the cardiovascular system at birth
Nguyen, M., Camenisch, T. D., Snouwaert, J. N., Hicks, E., Coffman, T. M., Anderson, P. A. W., Malouf, N. N., & Koller, B. H. (1997) · Nature · doi:10.1038/36342 · Cited by 361 · see citing works
Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels.
Piazza, G. A., Alberts, D. S., Hixson, L. J., Paranka, N. S., Li, H., Finn, T., Bogert, C. L., Guillen, J. M., Brendel, K., Gross, P. H., et al. (1997) · PubMed · Cited by 361 · see citing works
Anovulation in Cyclooxygenase-2-Deficient Mice Is Restored by Prostaglandin E2 and Interleukin-1β*
Davis, B. J., Lennard, D. E., Lee, C. A., Tiano, H. F., Morham, S. G., Wetsel, W. C., & Langenbach, R. J. (1999) · Endocrinology · doi:10.1210/endo.140.6.6715 · Cited by 352 · see citing works
Self-citation
Apoptosis primarily accounts for the growth-inhibitory properties of sulindac metabolites and involves a mechanism that is independent of cyclooxygenase inhibition, cell cycle arrest, and p53 induction.
Piazza, G. A., Rahm, A. K., Finn, T. S., Fryer, B., Li, H., Stoumen, A. L., Pamukcu, R., & Ahnen, D. J. (1997) · PubMed · Cited by 351 · see citing works
Inhibitory effect of aspirin on azoxymethane-induced colon carcinogenesis in F344 rats
Reddy, B. S., Rao, C. V., Rivenson, A., & Kelloff, G. V. (1993) · Carcinogenesis · doi:10.1093/carcin/14.8.1493 · Cited by 344 · see citing works
Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity
Wallace, J. L., Bak, A., McKnight, W., Asfaha, S., Sharkey, K. A., & MacNaughton, W. K. (1998) · Gastroenterology · doi:10.1016/s0016-5085(98)70370-1 · Cited by 336 · see citing works
Patent Ductus Arteriosus and Neonatal Death in Prostaglandin Receptor EP4-Deficient Mice
Segi‐Nishida, E., Sugimoto, Y., Yamasaki, A., Aze, Y., Oida, H., Nishimura, T., Murata, T., Matsuoka, T., Ushikubi, F., Hirose, M., et al. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8461 · Cited by 311 · see citing works
Induction of cyclo‐oxygenase‐2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone
Mitchell, J. A., Belvisi, M. G., Akarasereenont, P., Robbins, R., Kwon, O. J., Croxtall, J. J., Barnes, P. J., & Vane, J. R. (1994) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1994.tb17093.x · Cited by 308 · see citing works
Mitogen‐inducible prostaglandin G/H synthase: A new target for nonsteroidal antiinflammatory drugs
Xie, W., Robertson, D. L., & Simmons, D. L. (1992) · Drug Development Research · doi:10.1002/ddr.430250402 · Cited by 306 · see citing works
Renal Toxicity of the Nonsteroidal Anti-Inflammatory Drugs
Murray, M. D., & Brater, D. C. (1993) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.33.040193.002251 · Cited by 295 · see citing works
Inhibition by prostaglandin synthesis inhibitors of the induction of epidermal ornithine decarboxylase activity, the accumulation of prostaglandins, and tumor promotion caused by 12-O-tetradecanoylphorbol-13-acetate.
Verma, A. K., Ashendel, C. L., & Boutwell, R. K. (1980) · PubMed · Cited by 271 · see citing works
Aspirin-like Molecules that Covalently Inactivate Cyclooxygenase-2
Kalgutkar, A. S. S., Crews, B. C., Rowlinson, S. W., Garner, C., Seibert, K., & Marnett, L. J. (1998) · Science · doi:10.1126/science.280.5367.1268 · Cited by 257 · see citing works
Hormonal regulation of messenger ribonucleic acid encoding a novel isoform of prostaglandin endoperoxide H synthase in rat preovulatory follicles. Induction in vivo and in vitro.
Sirois, J., Simmons, D. L., & Richards, J. S. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49951-1 · Cited by 256 · see citing works
Opposing actions of prostaglandins and oxytocin determine the onset of murine labor
Gross, G. A., Imamura, T., Luedke, C., Vogt, S. K., Olson, L. M., Nelson, D. M., Sadovsky, Y., & Muglia, L. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.20.11875 · Cited by 238 · see citing works
Nonsteroidal antiinflammatory drugs and the gastrointestinal tract the double-edged sword
Lichtenstein, D. R., Syngal, S., & Wolfe, M. M. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380103 · Cited by 220 · see citing works
Distinct isoforms (COX‐1 and COX‐2) of cyclooxygenase: possible physiological and therapeutic implications
Pairet, M., & Engelhardt, G. (1996) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1996.tb00144.x · Cited by 218 · see citing works
The Pharmacology of the Ductus Arteriosus
Smith, G. C. S. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01348-6 · Cited by 212 · see citing works
Self-Promotion? Intimate Connections Between APC and Prostaglandin H Synthase-2
Prescott, S. M., & White, R. L. (1996) · Cell · doi:10.1016/s0092-8674(00)81983-2 · Cited by 198 · see citing works
Effect of advancing gestational age on the frequency of fetal ductal constriction in association with maternal indomethacin use
Moise, K. J. (1993) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(11)90763-7 · Cited by 194 · see citing works
Sulindac causes rapid regression of preexisting tumors in Min/+ mice independent of prostaglandin biosynthesis.
Chiu, C. H., McEntee, M. F., & Whelan, J. (1997) · PubMed · Cited by 174 · see citing works
Prostaglandin Synthase-1 and Prostaglandin Synthase-2 Are Coupled to Distinct Phospholipases for the Generation of Prostaglandin D2 in Activated Mast Cells
Reddy, S. T., & Herschman, H. R. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.6.3231 · Cited by 171 · see citing works
CYCLOOXYGENASE-2 INHIBITORS
Masferrer, J. L., Isakson, P. C., & Seibert, K. (1996) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70252-1 · Cited by 165 · see citing works
Selective inhibition of NS-398 on prostanoid production in inflamed tissue in rat carrageenan-air-pouch inflammation
Futaki, N., Arai, I., Hamasaka, Y., Takahashi, S., Higuchi, S., & Otomo, S. (1993) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.1993.tb07103.x · Cited by 154 · see citing works
Studies of neoplasia in the Min mouse1C57BL/6J Min/+ mice are available worldwide from The Jackson Laboratory, Bar Harbor, ME 04609, USA.1
Shoemaker, A. R., Gould, K. A., Luongo, C., Moser, A. R., & Dove, W. F. (1997) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(96)00041-8 · Cited by 151 · see citing works
Differential expression of prostaglandin h synthase isozymes during multistage carcinogenesis in mouse epidermis
Müller‐Decker, K., Scholz, K., Marks, F., & Fürstenberger, G. (1995) · Molecular Carcinogenesis · doi:10.1002/mc.2940120106 · Cited by 147 · see citing works
Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin.
Bozza, P. T., Payne, J. L., Morham, S. G., Langenbach, R. J., Smithies, O., & Weller, P. F. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.20.11091 · Cited by 125 · see citing works
Self-citation
Differentiation of Monocytoid THP-1 Cells with Phorbol Ester Induces Expression of Prostaglandin Endoperoxide Synthase-1 (COX-1)
Smith, C. J., Morrow, J. D., Roberts, L. J., & Marnett, L. J. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.1483 · Cited by 124 · see citing works
Eicosanoids and multistage carcinogenesis in NMRI mouse skin: role of prostaglandins E and F in conversion (first stage of tumor promotion) and promotion (second stage of tumor promotion)
Fürstenberger, G., Gross, M., & Marks, F. (1989) · Carcinogenesis · doi:10.1093/carcin/10.1.91 · Cited by 116 · see citing works
Prostacyclin synthesis in ovine pulmonary artery is developmentally regulated by changes in cyclooxygenase-1 gene expression.
Brannon, T. S., North, A. J., Wells, L. B., & Shaul, P. W. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117220 · Cited by 111 · see citing works
Effects of Transforming Growth Factor β and Interleukin-1β on Expression of Cyclooxygenase 1 and 2 and Phospholipase A2 mRNA in Lung Fibroblasts and Endothelial Cells in Culture
Jackson, B. A., Goldstein, R. H., Roy, R., Cozzani, M., Taylor, L., & POLGAR, P. R. (1993) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1993.2642 · Cited by 110 · see citing works
Nonsteroidal antiinflammatory drugs and the gastrointestinal tract.
Hirschowitz, B. I. (1994) · PubMed · Cited by 102 · see citing works
Do NSAIDs exert their colon cancer chemoprevention activities through the inhibition of mucosal prostaglandin synthetase?
Alberts, D. S., Hixson, L. J., Ahnen, D. J., Bogert, C. L., Einspahr, J. G., Paranka, N. S., Brendel, K., Gross, P. H., Pamukcu, R., & Burt, R. W. (1995) · Journal of Cellular Biochemistry · doi:10.1002/jcb.240590804 · Cited by 100 · see citing works
R-flurbiprofen chemoprevention and treatment of intestinal adenomas in the APC(Min)/+ mouse model: implications for prophylaxis and treatment of colon cancer.
Wechter, W. J., Kantoci, D., Murray, E. D., Quiggle, D. D., Leipold, D. D., Gibson, K. M., & McCracken, J. D. (1997) · PubMed · Cited by 98 · see citing works
Tumorigenic Transformation of Immortalized ECV Endothelial Cells by Cyclooxygenase-1 Overexpression
Narko, K., Ristimaki, A. P., MacPhee, M. J., Smith, E., Haudenschild, C. C., & Hla, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.34.21455 · Cited by 97 · see citing works
Multiple Controls in Inflammation
Cirino, G. (1998) · Biochemical Pharmacology · doi:10.1016/s0006-2952(97)00215-3 · Cited by 95 · see citing works
Temporal and spatial immunolocalization of cytokines in murine chronic granulomatous tissue. Implications for their role in tissue development and repair processes.
Appleton, I., Tomlinson, A., Colville‐Nash, P., & Willoughby, D. A. (1993) · PubMed · Cited by 87 · see citing works
Induction of growth inhibition of 293 cells by downregulation of the cyclin E and cyclin-dependent kinase 4 proteins due to overexpression of TIS21
Lim, I. K., Lee, M. S., Ryu, M. S., Park, T. J., Fujiki, H., Eguchi, H., & Paik, W. K. (1998) · Molecular Carcinogenesis · doi:10.1002/(sici)1098-2744(199809)23:1 · Cited by 74 · see citing works
Prostaglandin-endoperoxide synthase
Schomburg, D., & Stephan, D. (1994) · Springer eBooks · doi:10.1007/978-3-642-57942-4_153 · Cited by 68 · see citing works
Role of Prostaglandins in Gastroduodenal Mucosal Protection
Wilson, D. E. (1991) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199112001-00011 · Cited by 66 · see citing works
Selective Induction of Prostaglandin G/H Synthase I by Stem Cell Factor and Dexamethasone in Mast Cells
Samet, J. M., Fasano, M. B., Fonteh, A. N., & Chilton, F. H. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.14.8044 · Cited by 59 · see citing works
NON-STEROIDAL ANTI-INFLAMMATORY DRUGS: HOW DO THEY DAMAGE THE GUT?
Levi, S., & Shaw-Smith, C. J. (1994) · Lara D. Veeken · doi:10.1093/rheumatology/33.7.605 · Cited by 55 · see citing works
Constitutive expression of prostaglandin endoperoxide G/H synthetase (PGHS)-2 but not PGHS-1 in hum an tracheal epithelial cells in vitro
Walenga, R. W., KESTER, M. A., Coroneos, E., Butcher, S., Dwivedi, R., & Statt, C. (1996) · Prostaglandins · doi:10.1016/s0090-6980(96)00101-3 · Cited by 51 · see citing works
Mechanisms of NSAID-Induced Gastroenteropathy
Price, A. H., & Fletcher, M. (1990) · Drugs · doi:10.2165/00003495-199000405-00003 · Cited by 51 · see citing works
Renal Toxicity of Non-Steroidal Anti-Inflammatory Drugs
Black, H. E. (1986) · Toxicologic Pathology · doi:10.1177/019262338601400110 · Cited by 51 · see citing works
Editorial: Sounding the Alarm—Does Induction of Prostaglandin Endoperoxide Synthase-2 Control the Mammalian Ovulatory Clock?1
Richards, J. S. (1997) · Endocrinology · doi:10.1210/endo.138.10.5515 · Cited by 50 · see citing works
Renal Effects of Over‐the‐Counter Analgesics
Whelton, A. (1995) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1995.tb04088.x · Cited by 47 · see citing works
Biosynthesis and Role of the Endothelium‐Derived Vasodilator, Nitric Oxide, in the Gastric Mucosa
Whittle, B. J. R., Boughton-Smith, N. K., & Moncada, S. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb39755.x · Cited by 45 · see citing works
Bleeding disorder due to platelet prostaglandin H synthase‐1 (PGHS‐1) deficiency
Matijevic‐Aleksic, N., McPhedran, P., & Wu, K. K. (1996) · British Journal of Haematology · doi:10.1046/j.1365-2141.1996.279813.x · Cited by 33 · see citing works
Characteristic Morphology of the Constricted Fetal Ductus Arteriosus following Maternal Administration of Indomethacin
Momma, K., Konish, T., & Hagiwara, H. (1985) · Pediatric Research · doi:10.1203/00006450-198505000-00017 · Cited by 32 · see citing works
Pharmacology of interleukin-1-induced neutrophil migration
Perretti, M., Appleton, I., Parente, L., & Flower, R. J. (1993) · Inflammation Research · doi:10.1007/bf01991139 · Cited by 28 · see citing works
Prostaglandins and reproduction—what do knockouts really tell us?
Challis, J. R. G. (1997) · Nature Medicine · doi:10.1038/nm1297-1326 · Cited by 26 · see citing works
Disruption of Cyclooxygenase Genes in Mice
Mahler, J. F., Davis, B. J., Morham, S. G., & Langenbach, R. I. (1996) · Toxicologic Pathology · doi:10.1177/019262339602400607 · Cited by 14 · see citing works
Self-citation
Prostaglandin-Endoperoxide Synthase
Choi, S. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_103086 · Cited by 8 · see citing works
Importance of gastric acid in gastric ulcer formation in rabbits with antibody-induced prostaglandin deficiency
Lee, M., Aldred, K., Lee, E. W., Prince, M. D., & Feldman, M. L. (1992) · Gastroenterology · doi:10.1016/0016-5085(92)91166-2 · Cited by 4 · see citing works

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Prostaglandins and Inflammation
Ricciotti, E., & FitzGerald, G. A. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.110.207449 · Cited by 3,852 · see citing works
Cyclooxygenases: Structural, cellular, and molecular biology
Smith, W. L., DeWitt, D. L., & Garavito, R. M. (2000) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.69.1.145 · Cited by 2,925 · see citing works
Cyclooxygenase Isozymes: The Biology of Prostaglandin Synthesis and Inhibition
Simmons, D. L., Botting, R. M., & Hla, T. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.3.3 · Cited by 1,692 · see citing works
Nonsteroidal Anti-inflammatory Drugs as Anticancer Agents: Mechanistic, Pharmacologic, and Clinical Issues
Thun, M. J., Henley, S. J., & Patrono, C. (2002) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/94.4.252 · Cited by 1,430 · see citing works
Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis
North, T. E., Goessling, W., Walkley, C. R., Lengerke, C., Kopani, K. R., Lord, A. M., Weber, G. J., Bowman, T. V., Jang, I. H., Großer, T., et al. (2007) · Nature · doi:10.1038/nature05883 · Cited by 1,095 · see citing works
Cyclooxygenases: structural and functional insights
Rouzer, C. A., & Marnett, L. J. (2008) · Journal of Lipid Research · doi:10.1194/jlr.r800042-jlr200 · Cited by 690 · see citing works
Synopsis of arachidonic acid metabolism: A review
Hanna, V. S., & HAFEZ, E. A. A. (2018) · Journal of Advanced Research · doi:10.1016/j.jare.2018.03.005 · Cited by 595 · see citing works
Cyclooxygenase-2—10 Years Later
Hinz, B., & Brune, K. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.300.2.367 · Cited by 517 · see citing works
Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice.
Chulada, P. C., Thompson, M. B., Mahler, J. F., Doyle, C. M., Gaul, B. W., Lee, C., Tiano, H. F., Morham, S. G., Smithies, O., & Langenbach, R. J. (2000) · PubMed · Cited by 496 · see citing works
Self-citation
Signalling networks regulating cyclooxygenase-2
Tsatsanis, C., Androulidaki, A., Venihaki, M., & Margioris, A. N. (2006) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2006.03.021 · Cited by 493 · see citing works
Cyclooxygenases, lipoxygenases, and epoxygenases in CNS: Their role and involvement in neurological disorders
Phillis, J. W., Horrocks, L. A., & Farooqui, A. A. (2006) · Brain Research Reviews · doi:10.1016/j.brainresrev.2006.02.002 · Cited by 456 · see citing works
Knockouts model the 100 best-selling drugs—will they model the next 100?
Zambrowicz, B., & Sands, A. (2002) · Nature Reviews Drug Discovery · doi:10.1038/nrd987 · Cited by 393 · see citing works
Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway
Murakami, M., & Kudo, I. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00037-7 · Cited by 371 · see citing works
The COX-2 pathway is essential during early stages of skeletal muscle regeneration
Bondesen, B. A., Mills, S. T., Kegley, K. M., & Pavlath, G. K. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00088.2004 · Cited by 300 · see citing works
Biochemistry of Cyclooxygenase (COX)-2 Inhibitors and Molecular Pathology of COX-2 in Neoplasia
Fosslien, E. (2000) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360091174286 · Cited by 296 · see citing works
Cyclooxygenase in normal human tissues – is COX‐1 really a constitutive isoform, and COX‐2 an inducible isoform?
Zidar, N., Odar, K., Glavač, D., Jerše, M., Zupanc, T., & Štajer, D. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00430.x · Cited by 255 · see citing works
Cyclooxygenase inhibitors: From pharmacology to clinical read-outs
Patrignani, P., & Patrono, C. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.09.016 · Cited by 240 · see citing works
NSAIDs and Chemoprevention
Rao, C. V., & Reddy, B. S. (2004) · Current Cancer Drug Targets · doi:10.2174/1568009043481632 · Cited by 226 · see citing works
Raging the War Against Inflammation With Natural Products
Attiq, A., Jalil, J., Husain, K., & Ahmad, W. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00976 · Cited by 212 · see citing works
In vitro effects of cyclooxygenase inhibitors in whole blood of horses, dogs, and cats
Brideau, C., van Staden, C., & Chan, C. (2001) · American Journal of Veterinary Research · doi:10.2460/ajvr.2001.62.1755 · Cited by 210 · see citing works
Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin
Neufang, G., Fürstenberger, G., Heidt, M., Marks, F., & Müller‐Decker, K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.121574098 · Cited by 204 · see citing works
CCAAT/enhancer binding protein-β is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling
Zhu, S., Yoon, K., Sterneck, E., Johnson, P. F., & Smart, R. C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.012437299 · Cited by 197 · see citing works
Allergic lung responses are increased in prostaglandin H synthase–deficient mice
Gavett, S. H., Madison, S. L., Chulada, P. C., Scarborough, P. E., Qu, W., Boyle, J. E., Tiano, H. F., Lee, C. A., Langenbach, R. J., Roggli, V. L., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6890 · Cited by 196 · see citing works
Self-citation
Distribution and function of prostanoid receptors: studies from knockout mice
Sugimoto, Y., Narumiya, S., & Ichikawa, A. (2000) · Progress in Lipid Research · doi:10.1016/s0163-7827(00)00008-4 · Cited by 192 · see citing works
p38/NF‐kB‐dependent expression of COX‐2 during differentiation and inflammatory response of chondrocytes
Ulivi, V., Giannoni, P., Gentili, C., Cancedda, R., & Descalzi, F. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21717 · Cited by 188 · see citing works
Vomitoxin-Induced Cyclooxygenase-2 Gene Expression in Macrophages Mediated by Activation of ERK and p38 but Not JNK Mitogen-Activated Protein Kinases
Moon, Y. (2002) · Toxicological Sciences · doi:10.1093/toxsci/69.2.373 · Cited by 161 · see citing works
NSAID–Gut Microbiota Interactions
Maseda, D., & Ricciotti, E. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01153 · Cited by 166 · see citing works
Genetic deletion or pharmacological inhibition of cyclooxygenase‐1 attenuate lipopolysaccharide‐ induced inflammatory response and brain injury
Choi, S., Langenbach, R. I., & Bosetti, F. (2007) · The FASEB Journal · doi:10.1096/fj.07-9411com · Cited by 158 · see citing works
Self-citation
Cyclooxygenase-2 in oncogenesis
Rizzo, M. T. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.12.026 · Cited by 153 · see citing works
Highly Unsaturated (n-3) Fatty Acids, but Not α-Linolenic, Conjugated Linoleic or γ-Linolenic Acids, Reduce Tumorigenesis in Apc Mice
Petrik, M. B. H., Johnson, B. T., Whelan, J. N., McEntee, M. F., & Obukowicz, M. G. (2000) · Journal of Nutrition · doi:10.1093/jn/130.10.2434 · Cited by 146 · see citing works
Multiple NSAID-Induced Hits Injure the Small Intestine: Underlying Mechanisms and Novel Strategies
Boelsterli, U. A., Redinbo, M. R., & Saitta, K. S. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs310 · Cited by 143 · see citing works
Drosophila Pxt: a cyclooxygenase-like facilitator of follicle maturation
Tootle, T. L., & Spradling, A. C. (2008) · Development · doi:10.1242/dev.017590 · Cited by 142 · see citing works
Cyclooxygenase enzymes and prostaglandins in pathology of the endometrium
Sales, K. J., & Jabbour, H. N. (2003) · Reproduction · doi:10.1530/rep.0.1260559 · Cited by 177 · see citing works
Cyclooxygenase-2 and inflammation in atherosclerosis
Linton, M. F. (2004) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2003.12.003 · Cited by 133 · see citing works
Targeting COX-2 expression by natural compounds: A promising alternative strategy to synthetic COX-2 inhibitors for cancer chemoprevention and therapy
Cerella, C., Sobolewski, C., Dicato, M., & Diederich, M. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.050 · Cited by 129 · see citing works
Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation
Weinberg, J. B. (2000) · Immunologic Research · doi:10.1385/ir:22:2-3:319 · Cited by 121 · see citing works
Bioactive lysolipids in cancer and angiogenesis
Hisano, Y., & Hla, T. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.07.006 · Cited by 120 · see citing works
Prostaglandins and bone metabolism
Choudhary, S., & Pilbeam, C. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814841-9.00051-8 · Cited by 116 · see citing works
Dual Effect of Platelet Lysate on Human Articular Cartilage: A Maintenance of Chondrogenic Potential and a Transient Proinflammatory Activity Followed by an Inflammation Resolution
Pereira, R. C., Scaranari, M., Benelli, R., Strada, P., Reis, R. L., Cancedda, R., & Gentili, C. (2013) · Tissue Engineering Part A · doi:10.1089/ten.tea.2012.0225 · Cited by 116 · see citing works
Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function
Wang, D., Patel, V. V., Ricciotti, E., Zhou, R., Levin, M. D., Gao, E., Zhou, Y., Ferrari, V. A., Lu, M. M., Xu, J., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0805806106 · Cited by 116 · see citing works
Prostanoids and inflammatory pain
Chen, L., Yang, G., & Großer, T. (2012) · Prostaglandins & Other Lipid Mediators · doi:10.1016/j.prostaglandins.2012.08.006 · Cited by 114 · see citing works
Susceptibility of Cyclooxygenase-2-Deficient Mice to Pulmonary Fibrogenesis
Bonner, J. C., Rice, A. B., Ingram, J. L., Moomaw, C. R., Nyska, A., Bradbury, A., Sessoms, A. R., Chulada, P. C., Morgan, D. L., Zeldin, D. C., et al. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64202-2 · Cited by 113 · see citing works
Self-citation
MPP + ‐induced COX‐2 activation and subsequent dopaminergic neurodegeneration
Wang, T., Pei, Z., Zhang, W., Liu, B., Langenbach, R. I., Lee, C., Wilson, B. C., Reece, J. M., Miller, D. S., & Hong, J. (2005) · The FASEB Journal · doi:10.1096/fj.04-2457fje · Cited by 113 · see citing works
Self-citation
Healthy animals and animal models of human disease(s) in safety assessment of human pharmaceuticals, including therapeutic antibodies
Dixit, R., & Boelsterli, U. A. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.02.018 · Cited by 112 · see citing works
Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2
Loftin, C. D., Tiano, H. F., & Langenbach, R. J. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00028-x · Cited by 111 · see citing works
Self-citation
Prostaglandin synthases: Molecular characterization and involvement in prostaglandin biosynthesis
Seo, M., & Oh, D. (2017) · Progress in Lipid Research · doi:10.1016/j.plipres.2017.04.003 · Cited by 110 · see citing works
Cyclooxygenase and prostaglandin synthases in atherosclerosis: Recent insights and future perspectives
Cipollone, F., Cicolini, G., & Bucci, M. (2008) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2008.01.002 · Cited by 105 · see citing works
The “Aspirin” of the New Millennium: Cyclooxygenase-2 Inhibitors
Buttar, N. S., & Wang, K. K. (2000) · Mayo Clinic Proceedings · doi:10.4065/75.10.1027 · Cited by 105 · see citing works
Stretch-induced myoblast proliferation is dependent on the COX2 pathway
Otis, J. S., Burkholder, T. J., & Pavlath, G. K. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.08.009 · Cited by 102 · see citing works
The effects of aspirin on gastric mucosal integrity, surface hydrophobicity, and prostaglandin metabolism in cyclooxygenase knockout mice
Darling, R. L., Romero, J. J., Dial, E. J., Akunda, J. K., Langenbach, R. J., & Lichtenberger, L. M. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.04.003 · Cited by 101 · see citing works
Self-citation
Prostaglandin receptors are mediators of vascular function in endometrial pathologies
Jabbour, H. N., Sales, K. J., Smith, O. P. M., Battersby, S., & Boddy, S. C. (2006) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2006.03.025 · Cited by 97 · see citing works
Effects of eccentric treadmill exercise on inflammatory gene expression in human skeletal muscle
Buford, T. W., Cooke, M. B., Shelmadine, B., Hudson, G. M., Redd, L., & Willoughby, D. S. (2009) · Applied Physiology Nutrition and Metabolism · doi:10.1139/h09-067 · Cited by 88 · see citing works
Identification of CYP4F8 in Human Seminal Vesicles as a Prominent 19-Hydroxylase of Prostaglandin Endoperoxides
Bylund, J., Hidestrand, M., Ingelman‐Sundberg, M., & Oliw, E. H. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001712200 · Cited by 88 · see citing works
Cyclooxygenase enzymes and prostaglandins in reproductive tract physiology and pathology
Sales, K. J., & Jabbour, H. N. (2003) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s1098-8823(03)00050-9 · Cited by 85 · see citing works
Prostaglandins and Inflammation: The Cyclooxygenase Controversy
Morteau, O. (2001) · Springer eBooks · doi:10.1007/978-94-015-9702-9_6 · Cited by 85 · see citing works
Cyclooxygenase-2 Inhibits UVB-Induced Apoptosis in Mouse Skin by Activating the Prostaglandin E2 Receptors, EP2 and EP4
Chun, K., Akunda, J. K., & Langenbach, R. J. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3617 · Cited by 84 · see citing works
Self-citation
Role of cyclic AMP responsive element in the UVB induction of cyclooxygenase-2 transcription in human keratinocytes
Tang, Q., Chen, W., Gonzales, M. S., Finch, J. S., Inoue, H., & Bowden, G. T. (2001) · Oncogene · doi:10.1038/sj.onc.1204667 · Cited by 83 · see citing works
Roles of Akt and glycogen synthase kinase 3beta in the ultraviolet B induction of cyclooxygenase-2 transcription in human keratinocytes.
Tang, Q., Gonzales, M., Inoue, H., & Bowden, G. T. (2001) · PubMed · Cited by 84 · see citing works
PGE2-induced hypertrophy of cardiac myocytes involves EP4 receptor-dependent activation of p42/44 MAPK and EGFR transactivation
Méndez, M., & LaPointe, M. C. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00838.2004 · Cited by 80 · see citing works
PGE2 vs PGF2α in human parturition
Li, W.-J., Lu, J.-W., Zhang, C.-Y., Wang, W., Ying, H., Myatt, L., & Sun, K. (2020) · Placenta · doi:10.1016/j.placenta.2020.12.012 · Cited by 80 · see citing works
Cyclooxygenase-2 gene expression and regulation in human retinal pigment epithelial cells.
Chin, M. S., Nagineni, C. N., Hooper, L. C., Detrick, B., & Hooks, J. J. (2001) · PubMed · Cited by 80 · see citing works
Effects of MF-tricyclic, a selective cyclooxygenase-2 inhibitor, on atherosclerosis progression and susceptibility to cytomegalovirus replication in apolipoprotein-E knockout mice
Rott, D., Zhu, J., Burnett, M. S., Zhou, Y., Zalles-Ganley, A., Ogunmakinwa, J., & Epstein, S. E. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00304-8 · Cited by 79 · see citing works
Pretreatment with melatonin exerts anti‐inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model
Pei, Z., & Cheung, R. T. F. (2004) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2004.00138.x · Cited by 79 · see citing works
Pharmacologic Inhibition of COX-1 and COX-2 in Influenza A Viral Infection in Mice
Carey, M. A., Bradbury, J. A., Rebolloso, Y. D., Graves, J. P., Zeldin, D. C., & Germolec, D. R. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011610 · Cited by 77 · see citing works
Anti-Inflammatory and Anticancer Properties of Birch Bark-Derived Betulin: Recent Developments
Tuli, H. S., Sak, K., Gupta, D., Kaur, G., Aggarwal, D., Parashar, N. C., Choudhary, R., Yerer, M. B., Kaur, J., Kumar, M., et al. (2021) · Plants · doi:10.3390/plants10122663 · Cited by 76 · see citing works
Role of cyclooxygenases COX-1 and COX-2 in modulating adipogenesis in 3T3-L1 cells
Yan, H., Kermouni, A., Abdel-Hafez, M., & Lau, D. C. W. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200357-jlr200 · Cited by 76 · see citing works
Expression of Messenger RNA for Prostaglandin E Receptor Subtypes EP4/EP2 and Cyclooxygenase Isozymes in Mouse Periovulatory Follicles and Oviducts During Superovulation1
Segi‐Nishida, E., Haraguchi, K., Sugimoto, Y., Tsuji, M., Tsunekawa, H., Tamba, S., Tsuboi, K., Tanaka, S., & Ichikawa, A. (2003) · Biology of Reproduction · doi:10.1095/biolreprod.102.003590 · Cited by 76 · see citing works
Genetic and Genomic Approaches to Identify and Study the Targets of Bioactive Small Molecules
Zheng, X., Chan, T., & Zhou, H. H. (2004) · Chemistry & Biology · doi:10.1016/j.chembiol.2003.08.011 · Cited by 72 · see citing works
The role of nitric oxide in prostaglandin biology; update
Kim, S. F. (2011) · Nitric Oxide · doi:10.1016/j.niox.2011.07.002 · Cited by 72 · see citing works
COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing
Xie, C. L., Ming, X., Wang, Q., Schwarz, E. M., Guldberg, R. E., O’Keefe, R. J., & Zhang, X. (2008) · Bone · doi:10.1016/j.bone.2008.08.109 · Cited by 70 · see citing works
Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro
Zhang, D., Hu, X., Li, Q., Wilson, B. C., Lee, C., Flood, P. M., Langenbach, R. J., & Hong, J. (2009) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2009.04.015 · Cited by 69 · see citing works
Self-citation
Obesity is induced in mice heterozygous for cyclooxygenase-2
Fain, J. N., Ballou, L. R., & Bahouth, S. W. (2001) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(01)00136-8 · Cited by 69 · see citing works
Combination of a Poxvirus-Based Vaccine with a Cyclooxygenase-2 Inhibitor (Celecoxib) Elicits Antitumor Immunity and Long-Term Survival in CEA.Tg/MIN Mice
Zeytin, H. E., Patel, A. C., Rogers, C. J., Canter, D. J., Hursting, S. D., Schlom, J., & Greiner, J. W. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3878 · Cited by 67 · see citing works
Evaluation of Dendrimer Safety and Efficacy through Cell Line Studies
Kesharwani, P., Gajbhiye, V., Tekade, R. K., & Jain, N. K. (2011) · Current Drug Targets · doi:10.2174/138945011796818135 · Cited by 66 · see citing works
Distinct Roles for Cyclooxygenases 1 and 2 in Interleukin-1-Induced Behavioral Changes
Swiergiel, A. H., & Dunn, A. J. (2002) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.036640 · Cited by 66 · see citing works
Sperm and oocyte communication mechanisms controlling C. elegans fertility
Han, S. M., Cottee, P. A., & Miller, M. A. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22202 · Cited by 63 · see citing works
COX-2-deficient mice are less prone to MPTP-neurotoxicity than wild-type mice
Feng, Z., Li, D., Fung, P. C. W., Pei, Z., Ramsden, D. B., & Ho, S. (2003) · Neuroreport · doi:10.1097/00001756-200310270-00009 · Cited by 65 · see citing works
Endoplasmic reticulum stress (ER-stress) by 2-deoxy-D-glucose (2DG) reduces cyclooxygenase-2 (COX-2) expression and N-glycosylation and induces a loss of COX-2 activity via a Src kinase-dependent pathway in rabbit articular chondrocytes
Yu, S., & Kim, S. J. (2010) · Experimental & Molecular Medicine · doi:10.3858/emm.2010.42.11.079 · Cited by 62 · see citing works
Progesterone: a pivotal hormone at menstruation
Maybin, J. A., & Critchley, H. (2011) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.05953.x · Cited by 63 · see citing works
Potential Role of Aspirin in the Prevention of Aneurysmal Subarachnoid Hemorrhage
Starke, R. M., Chalouhi, N., Ding, D., & Hasan, D. M. (2015) · Cerebrovascular Diseases · doi:10.1159/000381137 · Cited by 59 · see citing works
General Method for the 11C‐Labeling of 2‐Arylpropionic Acids and Their Esters: Construction of a PET Tracer Library for a Study of Biological Events Involved in COXs Expression
Takashima‐Hirano, M., Shukuri, M., Takashima, T., Goto, M., Wada, Y., Watanabe, Y., Onoe, H., Doi, H., & Suzuki, M. (2010) · Chemistry - A European Journal · doi:10.1002/chem.200903044 · Cited by 58 · see citing works
Androgen Control of Cyclooxygenase Expression in the Rat Epididymis1
Cheuk, B. L. Y., Leung, P. S., Lo, A. C. T., & Wong, P. Y. D. (2000) · Biology of Reproduction · doi:10.1093/biolreprod/63.3.775 · Cited by 56 · see citing works
The Immunophysiology of Male Reproduction
Hedger, M. P. (2014) · Elsevier eBooks · doi:10.1016/b978-0-12-397175-3.00019-3 · Cited by 56 · see citing works
Protein Kinase C-α Coordinately Regulates Cytosolic Phospholipase A2Activity and the Expression of Cyclooxygenase-2 through Different Mechanisms in Mouse Keratinocytes
Wang, H. Q., Kim, M. P., Tiano, H. F., Langenbach, R. I., & Smart, R. C. (2001) · Molecular Pharmacology · doi:10.1124/mol.59.4.860 · Cited by 55 · see citing works
Self-citation
The tissue-specific, compensatory expression of cyclooxygenase-1 and -2 in transgenic mice
Zhang, J., Goorha, S., Raghow, R., & Ballou, L. R. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(01)00177-0 · Cited by 54 · see citing works
Effects of Selective and Nonselective Nonsteroidal Anti-inflammatory Drugs on Antibiotic Efficacy of Experimental Group A Streptococcal Myonecrosis
Hamilton, S. M., Bayer, C. R., Stevens, D. L., & Bryant, A. E. (2013) · The Journal of Infectious Diseases · doi:10.1093/infdis/jit594 · Cited by 51 · see citing works
Embryonic prostaglandin H synthase‐2 (PHS‐2) expression and benzo[ α ]pyrene teratogenicity in PHS‐2 knockout mice 1
Parman, T., & Wells, P. G. (2002) · The FASEB Journal · doi:10.1096/fj.01-0140com · Cited by 52 · see citing works
Reduced sulfur mustard-induced skin toxicity in cyclooxygenase-2 knockout and celecoxib-treated mice
Wormser, U., Langenbach, R. J., Peddada, S. D., Sintov, A. C., Brodsky, B., & Nyska, A. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.03.013 · Cited by 49 · see citing works
Self-citation
Formation of the Epididymal Fluid Microenvironment
Wong, P. Y. D., Gong, X. D., Leung, G., & Cheuk, B. L. Y. (2002) · Springer eBooks · doi:10.1007/978-1-4615-0679-9_7 · Cited by 49 · see citing works
The fall and rise of in vivo pharmacology
Alabaster, V. A. (2002) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01882-4 · Cited by 49 · see citing works
Structural and functional differences between cyclooxygenases: Fatty acid oxygenases with a critical role in cell signaling
Rouzer, C. A., & Marnett, L. J. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.07.198 · Cited by 48 · see citing works
Trophic Effects of the Cyclooxygenase-2 Product Prostaglandin E 2 in Cardiac Myocytes
Méndez, M., & LaPointe, M. C. (2002) · Hypertension · doi:10.1161/hy02t2.102808 · Cited by 47 · see citing works
Aberrant over-expression of COX-1 intersects multiple pro-tumorigenic pathways in high-grade serous ovarian cancer
Wilson, A. J., Fadare, O., Beeghly-Fadiel, A. C., Son, D., Liu, Q., Zhao, S., Saskowski, J. L., Uddin, M. J., Daniel, C. K., Crews, B. C., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.3860 · Cited by 45 · see citing works
Eicosanoids as endogenous regulators of leptin release and lipolysis by mouse adipose tissue in primary culture
Fain, J. N., Leffler, C. W., & Bahouth, S. W. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32003-4 · Cited by 46 · see citing works
Regulation of COX-2 Mediates Acid-Induced Bone Calcium Efflux in Vitro
Krieger, N. S., Frick, K. K., Strutz, K. L., Michalenka, A., & Bushinsky, D. A. (2007) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.070316 · Cited by 45 · see citing works
Prostaglandin-endoperoxide synthase 2 (cyclooxygenase-2), a complex target for colorectal cancer prevention and therapy
Benelli, R., Venè, R., & Ferrari, N. (2018) · Translational research · doi:10.1016/j.trsl.2018.01.003 · Cited by 45 · see citing works
Mechanotransduction in Bone Does Not Require a Functional Cyclooxygenase-2 (COX-2) Gene
Alam, I., Warden, S. J., Robling, A. G., & Turner, C. H. (2005) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.041124 · Cited by 45 · see citing works
Anti-inflammatory Effect of D-Allose in Cerebral Ischemia/Reperfusion Injury in Rats
Gao, D., KAWAI, N., Nakamura, T., Feng, L., Fei, Z., & Tamiya, T. (2013) · Neurologia medico-chirurgica · doi:10.2176/nmc.53.365 · Cited by 44 · see citing works
The roles of injury and nonsteroidal anti-inflammatory drugs in the development and outcomes of severe group A streptococcal soft tissue infections
Bryant, A. E., Bayer, C. R., Aldape, M. J., & Stevens, D. L. (2015) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0000000000000160 · Cited by 44 · see citing works
Selectivity of cyclooxygenase isoform activity and prostanoid production in normal and diseased Han:SPRD-cyrat kidneys
Warford‐Woolgar, L., Peng, C. Y.-C., Shuhyta, J. N., Wakefield, A. P., Sankaran, D., Ogborn, M. R., & Aukema, H. M. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00332.2005 · Cited by 44 · see citing works

Phenotypes of the COX-deficient mice indicate physiological and pathophysiological roles for COX-1 and COX-2
Loftin, C. D., Tiano, H. F., & Langenbach, R. J. (2002) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(02)00028-x · Cited by 111 · see citing works
Self-citation
Cyclooxygenase‐deficient Mice: A Summary of Their Characteristics and Susceptibilities to Inflammation and Carcinogenesis
LANGENBACH, R., LOFTIN, C. D., LEE, C., & TIANO, H. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb08723.x · Cited by 170 · see citing works
Self-citation
Comparative Analysis of Pharmacologic and/or Genetic Disruption of Cyclooxygenase-1 and Cyclooxygenase-2 Function in Female Reproduction in Mice
Reese, J., Zhao, X., Ma, W., Brown, N., Maziasz, T. J., & Dey, S. K. (2001) · Endocrinology · doi:10.1210/en.142.7.3198 · Cited by 104 · see citing works
Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II
Dinchuk, J. E., Car, B. D., Focht, R. J., Johnston, J. J., JAFFEE, B. D., Covington, M. B., Contel, N. R., Eng, V. M., Collins, R. J., Czerniak, P. M., et al. (1995) · Nature · doi:10.1038/378406a0 · Cited by 967 · see citing works
Disruption of the mouse cyclooxygenase 1 gene. Characteristics of the mutant and areas of future study.
Langenbach, R. J., Morham, S. G., Tiano, H. F., Loftin, C. D., Bi, G., Chulada, P. C., Mahler, J. F., Davis, B. J., & Ca, L. (1997) · PubMed · Cited by 26 · see citing works
Self-citation

Authors: Langenbach, R., Loftin, C., Lee, C., & Tiano, H.
Affiliations: National Institutes of Health (US)
National Institute of Environmental Health Sciences (US)
Corresponding author: Langenbach, Robert
ORCID: Lee, Christopher
Venue: Biochemical Pharmacology
Publisher: Elsevier BV
Published: 1999-10
Volume: 58
Issue: 8
Pages: 1237-1246
ISSN: 0006-2952 (ISSN-L)
DOI: 10.1016/s0006-2952(99)00158-6
OpenAlex: W113612665
Cited by: 230
References: 115
Citations by year: 2026: 2 · 2025: 3 · 2024: 2 · 2023: 3 · 2022: 2 · 2021: 5 · 2020: 6 · 2019: 6 · 2018: 8 · 2017: 7 · 2016: 2 · 2015: 13 · 2014: 5 · 2013: 7 · 2012: 9
FWCI: 12.40
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochemical Pharmacology (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Pharmacology › Inflammatory mediators and NSAID effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
Keywords: cyclooxygenase, cyclooxygenase-1, cyclooxygenase-2, prostaglandins, cancer susceptibility, inflammation, gastric ulcer, nonsteroidal anti-inflammatory drugs, cyclooxygenase inhibition, gene ablation
MeSH terms: Animals, Cell Transformation, Neoplastic, Female, Humans, Inflammation, Isoenzymes, Membrane Proteins, Phenotype, Prostaglandin-Endoperoxide Synthases, Reproduction, Stomach Ulcer, Mice, Knockout, Mice, Cyclooxygenase 1, Cyclooxygenase 2

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