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Evidence for a Role of CRM1 in Signal-Mediated Nuclear Protein Export
Abstract
Chromosome maintenance region 1 (CRM1), a protein that shares sequence similarities with the karyopherin β family of proteins involved in nuclear import pathway, was shown to form a complex with the leucine-rich nuclear export signal (NES). This interaction was inhibited by leptomycin B, a drug that prevents the function of the CRM1 protein in yeast. To analyze the role of the CRM1-NES interaction in nuclear export, a transport assay based on semipermeabilized cells was developed. In this system, which reconstituted NES-, cytosol-, and energy-dependent nuclear export, leptomycin B specifically blocked export of NES-containing proteins. Thus, the CRM1 protein could act as a NES receptor involved in nuclear protein export.
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Metadata
- Authors
- Ossareh-Nazari, B., Bachelerie, F., & Dargemont, C.
- Venue
- Science
- Published
- 1997-10-03
- Volume
- 278
- Issue
- 5335
- Pages
- 141-144
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038256325
- Cited by
- 717
- References
- 0
- FWCI
- 21.94
- Type
- journal article
- Language
- en
- Open access
- closed
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