The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Abnormal Hippocampal Spatial Representations in αCaMKII T286A and CREB αΔ− Mice
Abstract
Hippocampal "place cells" fire selectively when an animal is in a specific location. The fine-tuning and stability of place cell firing was compared in two types of mutant mice with different long-term potentiation (LTP) and place learning impairments. Place cells from both mutants showed decreased spatial selectivity. Place cell stability was also deficient in both mutants and, consistent with the severities in their LTP and spatial learning deficits, was more affected in mice with a point mutation [threonine (T) at position 286 mutated to alanine (A)] in the alpha calmodulin kinase II (alphaCaMKIIT286A) than in mice deficient for the alpha and Delta isoforms of adenosine 3'5'-monophosphate-responsive element binding proteins (CREBalphaDelta-). Thus, LTP appears to be important for the fine tuning and stabilization of place cells, and these place cell properties may be necessary for spatial learning.
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“Furthermore, studies in knockin mice containing the T286A mutation of CaMKII show the importance of CaMKII in spatial selectivity (421, 422).”
From Synaptic memory and CaMKII (2023) · cites this paper as [422]
Citations
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Metadata
- Authors
- Cho, Y. H., Giese, K. P., Tanila, H., Silva, A. J., & Eichenbaum, H.
- Affiliations
- Boston University (US)
- Corresponding author
- Eichenbaum, Howard
- Venue
- Science
- Published
- 1998-02-06
- Volume
- 279
- Issue
- 5352
- Pages
- 867-869
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1992949123
- Cited by
- 189
- References
- 16
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 2 · 2022: 3 · 2021: 3 · 2019: 1 · 2018: 9 · 2017: 6 · 2016: 3 · 2015: 7 · 2014: 4 · 2013: 3 · 2012: 7
- FWCI
- 10.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (King's College London) (submittedVersion)
- Funders
- National Institute on Aging (AG 13622)
- National Institute of Mental Health (MH51570, R01MH051570)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- place cells, hippocampus, CaMKIIα, long-term potentiation, spatial learning, spatial selectivity, mouse mutants, synaptic plasticity
- MeSH terms
- Animals, Cues, Hippocampus, Learning, Mice, Inbred C57BL, Mice, Mutant Strains, Orientation, Space Perception, Point Mutation, Cyclic AMP Response Element-Binding Protein, Long-Term Potentiation, Calcium-Calmodulin-Dependent Protein Kinases, Pyramidal Cells, Maze Learning, Mice, Calcium-Calmodulin-Dependent Protein Kinase Type 2
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