Cited by 652Protein Kinase Regulation and GTPase SignalingMelanoma and MAPK PathwaysProtein Tyrosine Phosphatases

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A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

Whitmarsh, Alan J., Cavanagh, Julie, Tournier, Cathy, Yasuda, Jun, Davis, Roger J.·1998·Science

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Abstract

The c-Jun NH 2 -terminal kinase (JNK) group of mitogen-activated protein (MAP) kinases is activated by the exposure of cells to multiple forms of stress. A putative scaffold protein was identified that interacts with multiple components of the JNK signaling pathway, including the mixed-lineage group of MAP kinase kinase kinases (MLK), the MAP kinase kinase MKK7, and the MAP kinase JNK. This scaffold protein selectively enhanced JNK activation by the MLK signaling pathway. These data establish that a mammalian scaffold protein can mediate activation of a MAP kinase signaling pathway.

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Authors: Whitmarsh, A. J., Cavanagh, J., Tournier, C., Yasuda, J., & Davis, R. J.
Affiliations: Howard Hughes Medical Institute (US)
Corresponding author: Davis, Roger J.
ORCID: Whitmarsh, Alan J.
Cavanagh, Julie
Tournier, Cathy
Yasuda, Jun
Davis, Roger J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-09-11
Volume: 281
Issue: 5383
Pages: 1671-1674
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.281.5383.1671
OpenAlex: W1967218150
Cited by: 652
References: 25
Citations by year: 2026: 1 · 2025: 5 · 2024: 4 · 2023: 5 · 2022: 8 · 2021: 3 · 2020: 4 · 2019: 8 · 2018: 7 · 2017: 11 · 2016: 8 · 2015: 7 · 2014: 10 · 2013: 17 · 2012: 10
FWCI: 25.47
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Research Explorer (The University of Manchester) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
Keywords: scaffold proteins, c-Jun NH2-terminal kinase, JNK activation, MAPK signaling, mixed lineage kinase, MKK7, MAP kinase kinase kinase, stress signaling, protein-protein interaction
MeSH terms: Mitogen-Activated Protein Kinase Kinase Kinase 11, Animals, Carrier Proteins, Cell Line, Chlorocebus aethiops, Enzyme Activation, Interleukin-1, Molecular Sequence Data, Protein Kinases, Recombinant Fusion Proteins, Signal Transduction, Protein Serine-Threonine Kinases, Calcium-Calmodulin-Dependent Protein Kinases, COS Cells, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase Kinases, MAP Kinase Kinase Kinases, JNK Mitogen-Activated Protein Kinases, MAP Kinase Kinase 7

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A Mammalian Scaffold Complex That Selectively Mediates MAP Kinase Activation

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