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Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx
Abstract
The Fas death receptor can activate the Jun NH 2 -terminal kinase (JNK) pathway through the receptor-associated protein Daxx. Daxx was found to activate the JNK kinase kinase ASK1, and overexpression of a kinase-deficient ASK1 mutant inhibited Fas- and Daxx-induced apoptosis and JNK activation. Fas activation induced Daxx to interact with ASK1, which consequently relieved an inhibitory intramolecular interaction between the amino- and carboxyl-termini of ASK1, activating its kinase activity. The Daxx-ASK1 connection completes a signaling pathway from a cell surface death receptor to kinase cascades that modulate nuclear transcription factors.
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Cites
Lethal effect of the anti-Fas antibody in mice
Ogasawara, J., Watanabe-Fukunaga, R., Adachi, M., Matsuzawa, A., Kasugai, T., Kitamura, Y., Itoh, N., Suda, T., & Nagata, S. (1993) · Nature · doi:10.1038/364806a0 · Cited by 1,881
Takayama, S., Sato, T., Krajewski, S., Kochel, K., Irie, S., Milian, J. A., & Reed, J. C. (1995) · Cell · doi:10.1016/0092-8674(95)90410-7 · Cited by 857
Cited by
Reactive oxygen species, cellular redox systems, and apoptosis
Circu, M. L., & Aw, T. Y. (2010) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2009.12.022 · Cited by 3,340
JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction
Solinas, G., & Karin, M. (2010) · The FASEB Journal · doi:10.1096/fj.09-151340 · Cited by 347
The ASK1-MAP Kinase Cascades in Mammalian Stress Response
Matsukawa, J. (2004) · Journal of Biochemistry · doi:10.1093/jb/mvh134 · Cited by 343
Fas ligand/Fas system in the brain: regulator of immune and apoptotic responses
Choi, C., & Benveniste, E. N. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2003.08.007 · Cited by 270
Epigenomics: Genome-Wide Study of Methylation Phenomena
(2002) · Current Issues in Molecular Biology · doi:10.21775/cimb.004.111 · Cited by 150
Metadata
- Authors
- Chang, H. Y., Nishitoh, H., Yang, X., Ichijo, H., & Baltimore, D.
- Venue
- Science
- Published
- 1998-09-18
- Volume
- 281
- Issue
- 5384
- Pages
- 1860-1863
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2012357103
- Cited by
- 593
- References
- 2
- FWCI
- 13.06
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx. https://app.cochat.ai/papers/10.1126/science.281.5384.1860
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- Chang, H. Y., Nishitoh, H., Yang, X., Ichijo, H., & Baltimore, D. (1998). Activation of Apoptosis Signal-Regulating Kinase 1 (ASK1) by the Adapter Protein Daxx. Science. https://doi.org/10.1126/science.281.5384.1860
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
