Cited by 505Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

Impaired Spatial Learning after Saturation of Long-Term Potentiation

Moser, Edvard I., Krobert, Kurt A., Moser, May-Britt, Morris, Richard G. M.·1998·Science

DOI 10.1126/science.281.5385.2038

Open this paper in CoChat — free account

Abstract

If information is stored as activity-driven increases in synaptic weights in the hippocampal formation, saturation of hippocampal long-term potentiation (LTP) should impair learning. Here, rats in which one hippocampus had been lesioned were implanted with a multielectrode stimulating array across and into the angular bundle afferent to the other hippocampus. Repeated cross-bundle tetanization caused cumulative potentiation. Residual synaptic plasticity was assessed by tetanizing a naïve test electrode in the center of the bundle. Spatial learning was disrupted in animals with no residual LTP (<10 percent) but not in animals that were capable of further potentiation. Thus, saturation of hippocampal LTP impairs spatial learning.

Integrity signals

Registry

Crossref · 10.1126/science.281.5385.2038

Cites

31 of 31 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Developments of a water-maze procedure for studying spatial learning in the rat
Morris, R. (1984) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(84)90007-4 · Cited by 7,180
Self-citation
Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
Morris, R. G. M., Anderson, E., Lynch, G. S., & Baudry, M. (1986) · Nature · doi:10.1038/319774a0 · Cited by 3,640
Self-citation
Simple memory: a theory for archicortex
Marr, D. (1971) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1971.0078 · Cited by 2,771
Activity-dependent scaling of quantal amplitude in neocortical neurons
Turrigiano, G. G., Leslie, K. R., Desai, N. S., Rutherford, L. C., & Nelson, S. B. (1998) · Nature · doi:10.1038/36103 · Cited by 2,226
The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory.
Tsien, J. Z., Huerta, P. T., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81827-9 · Cited by 1,782
Synaptic tagging and long-term potentiation
Frey, U., & Morris, R. G. M. (1997) · Nature · doi:10.1038/385533a0 · Cited by 1,736
Self-citation
Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant Mice
Silva, A. J., Paylor, R. E., Wehner, J. M., & Tonegawa, S. (1992) · Science · doi:10.1126/science.1321493 · Cited by 1,366
Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice
Liao, D., Hessler, N. A., & Malinow, R. (1995) · Nature · doi:10.1038/375400a0 · Cited by 1,365
Hippocampal synaptic enhancement and information storage within a distributed memory system
McNaughton, B. L., & Morris, R. G. M. (1987) · Trends in Neurosciences · doi:10.1016/0166-2236(87)90011-7 · Cited by 1,304
Self-citation

Flagged first, then by citations

Show all 31 references

Research works printed but not linked: 3

Morris R. G. M., Hagan J. J., Rawlins J. N. P., Q. J. Exp. Psychol. 38B, 365 (1986);
Errington M. L., Bliss T. V. P., Morris R. J., Laroche S., Davis S., ibid. 387, 666 (1997).
Marr D., Proc. R. Soc. London Ser. B 262, 23 (1971);

Sorted by citations

Items 201–300 of 504

In Vivo and in Vitro Exposure to PCB 153 Reduces Long-Term Potentiation
Hussain, R. J., Győri, J., DeCaprio, A. P., & Carpenter, D. O. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108827 · Cited by 43
Synaptic Plasticity in the Amygdala
Chapman, P., Ramsay, M., Krężel, W., & Knevett, S. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07076.x · Cited by 51
The water maze paradigm in experimental studies of chronic cognitive disorders: Theory, protocols, analysis, and inference
Kapadia, M., Xu, J., & Šakić, B. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.016 · Cited by 44
What does LTP tell us about the roles of CaMKII and PKMζ in memory?
Sacktor, T. C., & Fenton, A. A. (2018) · Molecular Brain · doi:10.1186/s13041-018-0420-5 · Cited by 43
Dorsal hippocampal kindling selectively impairs spatial learning/short‐term memory
Hannesson, D. K., Mohapel, P., & Corcoran, M. E. (2001) · Hippocampus · doi:10.1002/hipo.1042 · Cited by 42
Chronic ethanol and withdrawal effects on kainate receptor–mediated excitatory neurotransmission in the rat basolateral amygdala
Läck, A. K., Christian, D., Diaz, M. R., & McCool, B. A. (2009) · Alcohol · doi:10.1016/j.alcohol.2008.11.002 · Cited by 42
Differential regulation of synaptic plasticity of the hippocampal and the hypothalamic inputs to the anterior thalamus
Tsanov, M., Vann, S. D., Erichsen, J. T., Wright, N. F., Aggleton, J. P., & O’Mara, S. M. (2009) · Hippocampus · doi:10.1002/hipo.20749 · Cited by 42
Learning twice is different from learning once and from learning more
Cammarota, M., Bevilaqua, L. R., Köhler, C. A., Medina, J. H., & Izquierdo, I. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.01.022 · Cited by 43
Augmenting saturated LTP by broadly spaced episodes of theta-burst stimulation in hippocampal area CA1 of adult rats and mice
Cao, G., & Harris, K. M. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00297.2014 · Cited by 41
The effect of non-competitive NMDA receptor antagonist MK-801 on neuronal activity in rodent prefrontal cortex: an animal model for cognitive symptoms of schizophrenia
Blot, K., Bai, J., & Otani, S. (2013) · Journal of Physiology-Paris · doi:10.1016/j.jphysparis.2013.04.003 · Cited by 41
Hippocampal Sleep Features: Relations to Human Memory Function
Ferrara, M., Moroni, F., Gennaro, L. D., & Nobili, L. (2012) · Frontiers in Neurology · doi:10.3389/fneur.2012.00057 · Cited by 43
Subacute ibuprofen treatment rescues the synaptic and cognitive deficits in advanced-aged mice
Rogers, J. T., Liu, C., Zhao, N., Wang, J., Putzke, T., Yang, L., Shinohara, M., Fryer, J. D., Kanekiyo, T., & Bu, G. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.02.001 · Cited by 39
Altered Cognitive Flexibility and Synaptic Plasticity in the Rat Prefrontal Cortex after Exposure to Low (≤15 cGy) Doses of 28Si Radiation
Britten, R. A., Duncan, V. D., Fesshaye, A. S., Rudobeck, E., Nelson, G. A., & Vlkolinský, R. (2020) · Radiation Research · doi:10.1667/rr15458.1 · Cited by 43
Frequency of network synchronization in the hippocampus marks learning
Ponomarenko, A. A., Li, J., Korotkova, T. M., Huston, J. P., & Haas, H. L. (2008) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2008.06232.x · Cited by 40
Plasticity of the Hippocampal Place Cell Representation
Jeffery, K. J., & Hayman, R. M. A. (2004) · Reviews in the Neurosciences · doi:10.1515/revneuro.2004.15.5.309 · Cited by 43
Effect of head-only sub-chronic and chronic exposure to 900-MHz GSM electromagnetic fields on spatial memory in rats
Ammari, M., Jacquet, A. D. R., Lecomte, A., Sakly, M., Abdelmelek, H., & de Sèze, R. (2008) · Brain Injury · doi:10.1080/02699050802530599 · Cited by 40
Stimulation of the right entorhinal white matter enhances visual memory encoding in humans
Mankin, E. A., Aghajan, Z. M., Schuette, P. J., Tran, M. E., Tchemodanov, N., Titiz, A. S., Kalender, G., Eliashiv, D. S., Stern, J. M., Weiss, S. A., et al. (2020) · Brain stimulation · doi:10.1016/j.brs.2020.11.015 · Cited by 40
Context‐dependent behavioural and neuronal sensitization in striatum to MDMA (ecstasy) administration in rats
Ball, K. T., Budreau, D., & Rebec, G. V. (2006) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2006.04885.x · Cited by 40
Cocaine self-administration improves performance in a highly demanding water maze task
Olmo, N. D., Higuera‐Matas, A., Miguéns, M., Garcı́a-Lecumberri, C., & Ambrosio, E. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0873-1 · Cited by 39
Short-term memory of TiO 2 -based electrochemical capacitors: empirical analysis with adoption of a sliding threshold
Lim, H., Kim, I., Kim, J.-S., Hwang, C. S., & Jeong, D. S. (2013) · Nanotechnology · doi:10.1088/0957-4484/24/38/384005 · Cited by 40
Low-dose proton radiation effects in a transgenic mouse model of Alzheimer’s disease – Implications for space travel
Rudobeck, E., Bellone, J. A., Szűcs, A. L., Bonnick, K., Mehrotra, S., Badaut, J., Nelson, G. A., Hartman, R. E., & Vlkolinský, R. (2017) · PLoS ONE · doi:10.1371/journal.pone.0186168 · Cited by 42
Behavioural and physiological characterization of inbred mouse strains: prospects for elucidating the molecular mechanisms of mammalian learning and memory
Nguyen, P., & Gerlai, R. T. (2002) · Genes Brain & Behavior · doi:10.1034/j.1601-183x.2002.10202.x · Cited by 40
Factors influencing the processing and function of the amyloid β precursor protein—a potential therapeutic target in Alzheimer's disease?
Coughlan, C. M. (2000) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(00)00036-x · Cited by 39
Selective Modification of Short-Term Hippocampal Synaptic Plasticity and Impaired Memory Extinction in Mice with a Congenitally Reduced Hippocampal Commissure
Schimanski, L. A., Wahłsten, D., & Nguyen, P. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-18-08277.2002 · Cited by 38
Hydroxysafflor yellow A improves learning and memory in a rat model of vascular dementia by increasing VEGF and NR1 in the hippocampus
Zhang, N., Xing, M., Wang, Y., Liang, H., Yang, Z. R., Shi, F., & Cheng, Y. (2013) · Neuroscience Bulletin · doi:10.1007/s12264-013-1375-2 · Cited by 38
Hippocampal Synaptic Plasticity and Water Maze Learning in Cocaine Self‐Administered Rats
Olmo, N. D., Higuera‐Matas, A., Miguéns, M., Garcı́a-Lecumberri, C., Borcel, É., Solís, J. M., & Ambrosio, E. (2006) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1369.043 · Cited by 38
Impaired hippocampal LTP in inbred mouse strains can be rescued by β‐adrenergic receptor activation
Schimanski, L. A., Ali, D. W., Baker, G. B., & Nguyen, P. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05376.x · Cited by 37
HSP70 Facilitates Memory Consolidation of Fear Conditioning through MAPK Pathway in the Hippocampus
Porto, R. R., Dutra, F. D., Crestani, A. P., Holsinger, R. M. D., Quillfeldt, J. A., de Bittencourt, P. I. H., & Alvares, L. D. O. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.028 · Cited by 37
Long-Term Potentiation and Depression as Putative Mechanisms for Memory Formation
Escobar, M. L., & Derrick, B. E. (2007) · Frontiers in neuroscience · doi:10.1201/9781420008418.ch2 · Cited by 37
Expression of immediate-early genes in the inferior colliculus and auditory cortex in salicylate-induced tinnitus in rat
Hu, S., Mei, L., Chen, J. Y., Huang, Z., & Wu, H. (2014) · European Journal of Histochemistry · doi:10.4081/ejh.2014.2294 · Cited by 39
Hippocampal CA1 kindling but not long-term potentiation disrupts spatial memory performancePreprint
Leung, L.-W. S., & Bixia Shen, A. (2006) · Learning & Memory · doi:10.1101/lm.66106 · Cited by 36
Growth hormone modulates hippocampal excitatory synaptic transmission and plasticity in old rats
Molina, D. P., Ariwodola, O. J., Linville, C., Sonntag, W. E., Weiner, J. L., Brunso-Bechtold, J. K., & Adams, M. M. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.014 · Cited by 35
Expression of long‐term potentiation in aged rats involves perforated synapses but dendritic spine branching results from high‐frequency stimulation alone
Dhanrajan, T. M., Lynch, M. A., Kelly, A. M., Popov, V. I., Rusakov, D. A., & Stewart, M. G. (2004) · Hippocampus · doi:10.1002/hipo.10172 · Cited by 34
Adolescent Alcohol Exposure Alters GABA A Receptor Subunit Expression in Adult Hippocampus
Centanni, S. W., Teppen, T. L., Risher, M., Fleming, R. L., Moss, J. L., Acheson, S. K., Mulholland, P. J., Pandey, S. C., Chandler, L. J., & Swartzwelder, H. S. (2014) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12562 · Cited by 34
A Comparison of the Roles of Protein Kinase C in Long-Term Potentiation in Rat Hippocampal Areas CA1 and CA3
Hussain, R. J., & Carpenter, D. O. (2005) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-005-4045-8 · Cited by 34
Learning associated increase in heat shock cognate 70 mRNA and protein expression
Pizarro, J. M., Haro, L. S., & Barea-Rodrı́guez, E. J. (2003) · Neurobiology of Learning and Memory · doi:10.1016/s1074-7427(02)00008-4 · Cited by 34
The 5‐hydroxytryptamine4receptor enables differentiation of informational content and encoding in the hippocampus
Twarkowski, H., Hagena, H., & Manahan‐Vaughan, D. (2016) · Hippocampus · doi:10.1002/hipo.22569 · Cited by 33
The memory gene KIBRA is a bidirectional regulator of synaptic and structural plasticity in the adult brain
Heitz, F. D., Farinelli, M., Mohanna, S., Kahn, M. C., Duning, K., Frey, M. C., Pavenstädt, H. J., & Mansuy, I. M. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.07.028 · Cited by 30
Neurobiological Mechanisms of Autism Spectrum Disorder and Epilepsy, Insights from Animal Models
Sierra-Arregui, T., Llorente, J., Mínguez, P., Tønnesen, J., & Peñagarikano, O. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.02.043 · Cited by 34
Ginsenoside Rg1 restores the impairment of learning induced by chronic morphine administration in rats
Qi, D., Zhu, Y., Wen, L., Liu, Q., & Qiao, H. (2008) · Journal of Psychopharmacology · doi:10.1177/0269881107082950 · Cited by 32
The Synaptomic Theory of Behavior and Brain DiseasePreprint
Grant, S. G. N. (2018) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2018.83.037887 · Cited by 32
Strain-Dependent Variations in Spatial Learning and in Hippocampal Synaptic Plasticity in the Dentate Gyrus Of Freely Behaving Rats
Manahan‐Vaughan, D., & Schwegler, H. (2011) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2011.00007 · Cited by 31
P2Y1 receptor inhibition rescues impaired synaptic plasticity and astroglial Ca2+-dependent activity in the epileptic hippocampus
Martorell, A., Wellmann, M., Guiffa, F., Fuenzalida, M., & Bonansco, C. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.105132 · Cited by 32
The role of AMPAR lateral diffusion in memory
Choquet, D., & Opazo, P. (2022) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2022.01.009 · Cited by 31
Early deprivation reduced anxiety and enhanced memory in adult male rats
Zhang, X., Wang, B., Jin, J., An, S., Zeng, Q., Duan, Y., Yang, L., Ma, J., & Cao, X. (2014) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2014.08.005 · Cited by 31
Behavioral changes with brief exposures to weak magnetic fields patterned to stimulate long-term potentiation
Mach, Q. H., & Persinger, M. A. (2009) · Brain Research · doi:10.1016/j.brainres.2009.01.002 · Cited by 33
Temporal phases of long-term potentiation (LTP): myth or fact?
Abbas, A.-K., Villers, A., & Ris, L. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2014-0072 · Cited by 31
GABAA receptor activation is involved in noncontingent shock inhibition of instrumental conditioning in spinal rats.
Ferguson, A. R., Washburn, S. N., Crown, E. D., & Grau, J. W. (2003) · Behavioral Neuroscience · doi:10.1037/0735-7044.117.4.799 · Cited by 31
Brief novelty exposure facilitates dentate gyrus LTP in aged rats
Sierra‐Mercado, D., Dieguez, D., & Barea-Rodríguez, E. J. (2008) · Hippocampus · doi:10.1002/hipo.20447 · Cited by 33
Chronic Caffeine Treatment Prevents Stress-Induced LTP Impairment: the Critical Role of Phosphorylated CaMKII and BDNF
Alzoubi, K., Srivareerat, M., Aleisa, A., & Alkadhi, K. (2012) · Journal of Molecular Neuroscience · doi:10.1007/s12031-012-9836-z · Cited by 33
Cell-type-specific optogenetic stimulation of the locus coeruleus induces slow-onset potentiation and enhances everyday memory in rats
Tse, D., Privitera, L., Norton, A. C., Gobbo, F., Spooner, P. A., Takeuchi, T., Martin, S. J., & Morris, R. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2307275120 · Cited by 31
Self-citation
Spatial memory formation requires netrin-1 expression by neurons in the adult mammalian brain
Wong, E. W., Glasgow, S. D., Trigiani, L. J., Chitsaz, D., Rymar, V., Sadikot, A., Ruthazer, E. S., Hamel, E., & Kennedy, T. E. (2019) · Learning & Memory · doi:10.1101/lm.049072.118 · Cited by 30
Serotonergic neuromodulation of synaptic plasticity
Higa, G. S. V., Viana, F. J. C., Francis-Oliveira, J., Cruvinel, E., Franchin, T. S., Marcourakis, T., Ulrich, H., & De Pasquale, R. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110036 · Cited by 29
KIBRA anchoring the action of PKMζ maintains the persistence of memory
Tsokas, P., Hsieh, C., Flores‐Obando, R. E., Bernabo, M., Tcherepanov, A., Hernandez, A. I., Thomas, C., Bergold, P. J., Cottrell, J. E., Kremerskothen, J., et al. (2024) · Science Advances · doi:10.1126/sciadv.adl0030 · Cited by 29
A saturation hypothesis to explain both enhanced and impaired learning with enhanced plasticity
Nguyen-Vu, T. B., Zhao, G., Lahiri, S., Kimpo, R. R., Lee, H., Ganguli, S., Shatz, C. J., & Raymond, J. L. (2017) · eLife · doi:10.7554/elife.20147 · Cited by 26
L-3-n-butylphthalide protects against vascular dementia via activation of the Akt kinase pathway.
Huai, Y., Dong, Y., Xu, J., Meng, N., Song, C., Li, W., & Lv, P. (2013) · PubMed Central · doi:10.3969/j.issn.1673-5374.2013.19.001 · Cited by 29
Effects of chronic cocaine administration on spatial learning and hippocampal spine density in two genetically different strains of rats
Fole, A., González‐Martín, C., Huarte, C., Alguacil, L. F., Ambrosio, E., & Olmo, N. D. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.02.012 · Cited by 27
Emergence of NMDAR‐independent long‐term potentiation at hippocampal CA1 synapses following early adolescent exposure to chronic intermittent ethanol: Role for sigma‐receptors
Sabeti, J., & Gruol, D. L. (2007) · Hippocampus · doi:10.1002/hipo.20379 · Cited by 29
The generative grammar of the brain: a critique of internally generated representations
Dragoi, G. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-023-00763-0 · Cited by 28
Altered neuronal excitability underlies impaired hippocampal function in an animal model of psychosis
Grüter, T., Wiescholleck, V., Dubovyk, V., Aliane, V., & Manahan‐Vaughan, D. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00117 · Cited by 32
Post-training reversible inactivation of the rat’s basolateral amygdala interferes with hippocampus-dependent place avoidance memory in a time-dependent manner
Vafaei, A. A., Ježek, K., Bureš, J., Fenton, A. A., & Rashidy‐Pour, A. (2007) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2007.02.004 · Cited by 28
Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampusPreprint
Chen, P. E., Errington, M. L., Kneussel, M., Chen, G., Annala, A. J., Rudhard, Y., Rast, G. F., Specht, C. G., Tigaret, C. M., Nassar, M. A., et al. (2009) · Learning & Memory · doi:10.1101/lm.1316909 · Cited by 28
Self-citation
Intracellular calcium stores mediate metaplasticity at hippocampal dendritic spines
Mahajan, G., & Nadkarni, S. (2019) · The Journal of Physiology · doi:10.1113/jp277726 · Cited by 25
Molecular and cellular mechanisms of cognitive function: implications for psychiatric disorders
Silva, A. J., Elgersma, Y., & Costa, R. M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00294-2 · Cited by 26
Sleep and Synaptic Homeostasis
Vyazovskiy, V. V., & Faraguna, U. (2014) · Current topics in behavioral neurosciences · doi:10.1007/7854_2014_301 · Cited by 35
The nature and mechanisms of plasticity
Rioult-Pedotti, M.-S., & Donoghue, J. P. (2003) · Cambridge University Press eBooks · doi:10.1017/cbo9780511544903.002 · Cited by 26
NMDA receptor activity in learning spatial procedural strategies
Federico, F., Leggio, M. G., Neri, P. E., Mandolesi, L., & Petrosini, L. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.06.005 · Cited by 25
Cortistatin overexpression in transgenic mice produces deficits in synaptic plasticity and learning
Tallent, M. K., Fabre, V., Qiu, C., Calbet, M., Lamp, T., Baratta, M. V., Suzuki, C., Levy, C. L., Siggins, G. R., Henriksen, S. J., et al. (2005) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.08.010 · Cited by 25
A Healthy Gut for a Healthy Brain: Preclinical, Clinical and Regulatory Aspects
Petrella, C., Vecchioli, S. F., Cisale, G. Y., Strimpakos, G., Borg, J.-J., Ceccanti, M., Fiore, M., Monteleone, G., & Nisticò, R. (2020) · Current Neuropharmacology · doi:10.2174/1570159x18666200730111528 · Cited by 24
Effects of pentylenetetrazol-induced brief convulsive seizures on spatial memory and fear memory
Mao, R., Tian, M., Yang, Y., Zhou, Q., Xu, L., & Cao, J. (2009) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2009.05.015 · Cited by 24
About similar characteristics of visual perceptual learning and LTP
Aberg, K. C., & Herzog, M. H. (2012) · Vision Research · doi:10.1016/j.visres.2011.12.013 · Cited by 27
Small ubiquitin‐like modifier 2 (SUMO2) is critical for memory processes in mice
Yu, S., Galeffi, F., Rodriguiz, R. M., Wang, Z., Shen, Y., Lyu, J., Li, R., Bernstock, J. D., Johnson, K. R., Liu, S., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202000850rr · Cited by 23
Cross‐generational trans fat intake modifies BDNF m RNA in the hippocampus: Impact on memory loss in a mania animal model
Trevizol, F., Dias, V. T., Roversi, K., Barcelos, R. C. S., Kuhn, F. T., Roversi, K., Pase, C. S., Golombieski, R. M., Veit, J. C., Piccolo, J., et al. (2014) · Hippocampus · doi:10.1002/hipo.22391 · Cited by 23
Administration of the TrkB receptor agonist 7,8-dihydroxyflavone prevents traumatic stress-induced spatial memory deficits and changes in synaptic plasticity
García, A. S., Knafo, S., Pereda-Pérez, I., Esteban, J. A., Venero, C., & Armario, A. (2016) · Hippocampus · doi:10.1002/hipo.22599 · Cited by 23
The Paradoxical Effect of Deep Brain Stimulation on Memory
Kai, T. S. Z., Man-Lung, F., Koh, J., Ying-Shing, C., & Lim, L. W. (2020) · Aging and Disease · doi:10.14336/ad.2019.0511 · Cited by 26
Spatial Learning of Mice Lacking a Neuron-Specific Epidermal Growth Factor Family Protein, NELL2
Matsuyama, S., Doe, N., Kurihara, N., Tanizawa, K., Kuroda, S., Iso, H., & Horie, M. (2005) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0050211 · Cited by 23
Small-Dose Pentobarbital Enhances Synaptic Transmission in Rat Hippocampus
Archer, D. P., Samanani, N., & Roth, S. H. (2001) · Anesthesia & Analgesia · doi:10.1097/00000539-200112000-00038 · Cited by 23
Partial unilateral inactivation of the dorsal hippocampus impairs spatial memory in the MWM
Cimadevilla, J. M., Miranda, R., López, L., & Árias, J. L. (2005) · Cognitive Brain Research · doi:10.1016/j.cogbrainres.2005.09.001 · Cited by 23
High frequency stimulation alters motor maps, impairs skilled reaching performance and is accompanied by an upregulation of specific GABA, glutamate and NMDA receptor subunits
Henderson, A. K., Pittman, Q. J., & Teskey, G. C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.04.040 · Cited by 24
Corneal kindled C57BL/6 mice exhibit saturated dentate gyrus long-term potentiation and associated memory deficits in the absence of overt neuron loss
Remigio, G. J., Loewen, J. L., Heuston, S., Helgeson, C., White, H. S., Wilcox, K. S., & West, P. J. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.06.006 · Cited by 23
Learning-induced Glutamate Receptor Phosphorylation Resembles That Induced by Long Term Potentiation
Shukla, K. P., Kim, J., Blundell, J. J., & Powell, C. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702906200 · Cited by 22
Electromagnetic field protects against cognitive and synaptic plasticity impairment induced by electrical kindling in rats
Khajei, S., Mirnajafi‐Zadeh, J., Sheibani, V., Ahmadi‐Zeidabadi, M., Masoumi‐Ardakani, Y., Rajizadeh, M. A., & Esmaeilpour, K. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.03.013 · Cited by 21
Diverse impact of acute and long-term extracellular proteolytic activity on plasticity of neuronal excitability
Wójtowicz, T., Brzdąk, P., & Mozrzymas, J. W. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00313 · Cited by 20
Impaired fear memories are correlated with subregion-specific deficits in hippocampal and amygdalar LTP.
Schimanski, L. A., & Nguyen, P. (2005) · Behavioral Neuroscience · doi:10.1037/0735-7044.119.1.38 · Cited by 21
Mouse models of impaired fear memory exhibit deficits in amygdalar LTP
Schimanski, L. A., & Nguyen, P. (2005) · Hippocampus · doi:10.1002/hipo.20075 · Cited by 21
Selective Increase of Correlated Activity in Arc-Positive Neurons after Chemically Induced Long-Term Potentiation in Cultured Hippocampal Neurons
Jiang, Y., & VanDongen, A. M. J. (2021) · eNeuro · doi:10.1523/eneuro.0540-20.2021 · Cited by 19
Scientific Discoveries: What Is Required for Lasting Impact
Lømo, T. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021115-105257 · Cited by 22
Pomegranate-derived anthocyanin regulates MORs-cAMP/CREB-BDNF pathways in opioid-dependent models and improves cognitive impairments
Ridzwan, N., Jumli, M. N., Baig, A. A., & Rohin, M. A. K. (2020) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2019.12.001 · Cited by 20
Episodic Aspects of a Path Navigated Through Hippocampal Neurobiology
Morris, R. (2024) · Hippocampus · doi:10.1002/hipo.23672 · Cited by 19
Self-citation
Spine Formation Pattern of Adult-Born Neurons Is Differentially Modulated by the Induction Timing and Location of Hippocampal Plasticity
Ohkawa, N., Saitoh, Y., Tokunaga, E., Nihonmatsu, I., Ozawa, F., Murayama, A., Shibata, F., Kitamura, T., & Inokuchi, K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045270 · Cited by 20
Multiprotocol-induced plasticity in artificial synapses
Kornijčuk, V., Kavehei, O., Lim, H., Seok, J. Y., Kim, S. K., Kim, I., Lee, W.-S., Choi, B. J., & Jeong, D. S. (2014) · Nanoscale · doi:10.1039/c4nr03405h · Cited by 19
The Vertical Lobe of Cephalopods
Turchetti-Maia, A. L., Shomrat, T., & Hochner, B. (2017) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780190456757.013.29 · Cited by 19
Evaluating visual neuroplasticity with EEG in schizophrenia outpatients
Wynn, J. K., Roach, B. J., McCleery, A., Marder, S. R., Mathalon, D. H., & Green, M. F. (2019) · Schizophrenia Research · doi:10.1016/j.schres.2019.08.015 · Cited by 19
Changes in Ca2+/calmodulin-dependent protein kinase II activity and its relation to performance in passive avoidance response and long-term potentiation formation in mice prenatally exposed to diethylstilbestrol
Kaitsuka, T., Fukunaga, K., Soeda, F., Shirasaki, T., Miyamoto, E., & Takahama, K. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2006.10.051 · Cited by 19
Development of long‐lasting potentiation effects in the dentate gyrus during pentylenetetrazol kindling
Rüthrich, H., Grecksch, G., & Krug, M. (2001) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(01)00008-9 · Cited by 19
Simultaneous training on two hippocampus-dependent tasks facilitates acquisition of trace eyeblink conditioningPreprint
Kuo, A. G., Lee, G., & Disterhoft, J. F. (2006) · Learning & Memory · doi:10.1101/lm.98406 · Cited by 19
Object location learning in mice requires hippocampal somatostatin interneuron activity and is facilitated by mTORC1-mediated long-term potentiation of their excitatory synapses
Honoré, È., & Lacaille, J. (2022) · Molecular Brain · doi:10.1186/s13041-022-00988-7 · Cited by 18
Exposure to intermittent nociceptive stimulation under pentobarbital anesthesia disrupts spinal cord function in rats
Washburn, S. N., Patton, B. C., Ferguson, A. R., Hudson, K. L., & Grau, J. W. (2007) · Psychopharmacology · doi:10.1007/s00213-007-0707-1 · Cited by 18
NMDA receptor activity in learning spatial procedural strategies
Leggio, M. G., Federico, F., Neri, P. E., Graziano, A., Mandolesi, L., & Petrosini, L. (2006) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.06.006 · Cited by 18
The effects of pool shape manipulations on rat spatial memory acquired in the Morris water maze
Bye, C. M., Hong, N. S., Moore, K., Deibel, S. H., & McDonald, R. J. (2018) · Learning & Behavior · doi:10.3758/s13420-018-0319-0 · Cited by 18

Authors: Moser, E. I., Krobert, K. A., Moser, M.-B., & Morris, R. G. M.
Affiliations: University of Oslo (NO)
Corresponding author: Moser, Edvard I.
ORCID: Moser, Edvard I.
Moser, May-Britt
Morris, Richard G. M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-09-25
Volume: 281
Issue: 5385
Pages: 2038-2042
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.281.5385.2038
OpenAlex: W2095510381
Cited by: 505
References: 31
Citations by year: 2026: 7 · 2025: 11 · 2024: 16 · 2023: 16 · 2022: 14 · 2021: 12 · 2020: 19 · 2019: 13 · 2018: 18 · 2017: 18 · 2016: 16 · 2015: 18 · 2014: 27 · 2013: 19 · 2012: 25
FWCI: 10.83
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: long-term potentiation, spatial learning, hippocampus, hippocampal lesions, synaptic plasticity, hippocampal formation
MeSH terms: Animals, Electric Stimulation, Electrodes, Implanted, Evoked Potentials, Hippocampus, Male, Synapses, Tetany, Long-Term Potentiation, Maze Learning, Dentate Gyrus, Perforant Pathway, Excitatory Postsynaptic Potentials, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Impaired Spatial Learning after Saturation of Long-Term Potentiation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks