Cited by 505Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeural dynamics and brain function

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Impaired Spatial Learning after Saturation of Long-Term Potentiation

Moser, Edvard I., Krobert, Kurt A., Moser, May-Britt, Morris, Richard G. M.·1998·Science

DOI 10.1126/science.281.5385.2038

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Abstract

If information is stored as activity-driven increases in synaptic weights in the hippocampal formation, saturation of hippocampal long-term potentiation (LTP) should impair learning. Here, rats in which one hippocampus had been lesioned were implanted with a multielectrode stimulating array across and into the angular bundle afferent to the other hippocampus. Repeated cross-bundle tetanization caused cumulative potentiation. Residual synaptic plasticity was assessed by tetanizing a naïve test electrode in the center of the bundle. Spatial learning was disrupted in animals with no residual LTP (<10 percent) but not in animals that were capable of further potentiation. Thus, saturation of hippocampal LTP impairs spatial learning.

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Authors: Moser, E. I., Krobert, K. A., Moser, M.-B., & Morris, R. G. M.
Affiliations: University of Oslo (NO)
Corresponding author: Moser, Edvard I.
ORCID: Moser, Edvard I.
Moser, May-Britt
Morris, Richard G. M.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-09-25
Volume: 281
Issue: 5385
Pages: 2038-2042
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.281.5385.2038
OpenAlex: W2095510381
Cited by: 505
References: 31
Citations by year: 2026: 7 · 2025: 11 · 2024: 16 · 2023: 16 · 2022: 14 · 2021: 12 · 2020: 19 · 2019: 13 · 2018: 18 · 2017: 18 · 2016: 16 · 2015: 18 · 2014: 27 · 2013: 19 · 2012: 25
FWCI: 10.83
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: long-term potentiation, spatial learning, hippocampus, hippocampal lesions, synaptic plasticity, hippocampal formation
MeSH terms: Animals, Electric Stimulation, Electrodes, Implanted, Evoked Potentials, Hippocampus, Male, Synapses, Tetany, Long-Term Potentiation, Maze Learning, Dentate Gyrus, Perforant Pathway, Excitatory Postsynaptic Potentials, Rats

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Impaired Spatial Learning after Saturation of Long-Term Potentiation

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