Cited by 818Angiogenesis and VEGF in CancerLymphatic System and DiseasesVascular Tumors and Angiosarcomas

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Increased Vascularization in Mice Overexpressing Angiopoietin-1

Suri, Chitra, McClain, Joyce, Thurston, Gavin, McDonald, Donald M., Zhou, Hao, Oldmixon, Eben H., Sato, Thomas N., Yancopoulos, George D.·1998·Science

DOI 10.1126/science.282.5388.468

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Abstract

The angiopoietins and members of the vascular endothelial growth factor (VEGF) family are the only growth factors thought to be largely specific for vascular endothelial cells. Targeted gene inactivation studies in mice have shown that VEGF is necessary for the early stages of vascular development and that angiopoietin-1 is required for the later stages of vascular remodeling. Here it is shown that transgenic overexpression of angiopoietin-1 in the skin of mice produces larger, more numerous, and more highly branched vessels. These results raise the possibility that angiopoietins can be used, alone or in combination with VEGF, to promote therapeutic angiogenesis.

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Authors: Suri, C., McClain, J., Thurston, G., McDonald, D. M., Zhou, H., Oldmixon, E. H., Sato, T. N., & Yancopoulos, G. D.
Affiliations: University of California, San Francisco (US)
Corresponding author: Yancopoulos, George D.
ORCID: Thurston, Gavin
McDonald, Donald M.
Zhou, Hao
Sato, Thomas N.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-10-16
Volume: 282
Issue: 5388
Pages: 468-471
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.282.5388.468
OpenAlex: W2051487747
Cited by: 818
References: 25
Citations by year: 2026: 1 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 16 · 2019: 13 · 2018: 14 · 2017: 17 · 2016: 14 · 2015: 26 · 2014: 24 · 2013: 21 · 2012: 40
FWCI: 15.61
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL059157, HL 24136, HL 59157, P01HL024136)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
Keywords: angiopoietin-1, transgenic overexpression, vascularization, skin vasculature, vascular branching, vascular remodeling, vascular endothelial growth factor, therapeutic angiogenesis, endothelial cells
MeSH terms: Animals, Capillaries, Endothelium, Vascular, Lymphokines, Membrane Glycoproteins, Mice, Transgenic, Skin, Venules, Keratinocytes, Gene Expression, Endothelial Growth Factors, Neovascularization, Physiologic, Transgenes, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Angiopoietin-1, Mice

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Increased Vascularization in Mice Overexpressing Angiopoietin-1

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