The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Increased Vascularization in Mice Overexpressing Angiopoietin-1
Abstract
The angiopoietins and members of the vascular endothelial growth factor (VEGF) family are the only growth factors thought to be largely specific for vascular endothelial cells. Targeted gene inactivation studies in mice have shown that VEGF is necessary for the early stages of vascular development and that angiopoietin-1 is required for the later stages of vascular remodeling. Here it is shown that transgenic overexpression of angiopoietin-1 in the skin of mice produces larger, more numerous, and more highly branched vessels. These results raise the possibility that angiopoietins can be used, alone or in combination with VEGF, to promote therapeutic angiogenesis.
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“Ang-2, on the other hand, is an antagonist for the Tie-2 receptor and is exclu-sively expressed in sites of vascular remodeling (83,84,88)”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [88]
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Cites
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Self-citationRequisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
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El-Sayed, S. M., Mohamed, M. R., Naguib, M. M., Aglan, H. A., & Ahmed, H. H. (2025) · Inflammopharmacology · doi:10.1007/s10787-025-02078-1 · Cited by 1
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Din, F. A. E. (2015) · theses.fr (ABES) · doi:10.70675/2bea4075z05b5z47d5zbbd3z3f6caf32edd8
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Blervaque, L. (2020) · theses.fr (ABES) · doi:10.70675/e92c2e66zd08fz46b1z9f7fz040fdb91964d
Torres-Reverón, A., Ortiz, J. M. V., Cruz, M. L., Rivera‐Arce, L. A., Finch-Cruz, C., Fernandez, N. S. M., Flores, I., & Appleyard, C. B. (2026) · Disease and Therapeutics · doi:10.1016/j.dist.2026.100014
BindingDB Entry 50003575: Computational analysis of PKA-balanol interactions.
BindingDB (2020) · UC San Diego · doi:10.7270/q28d0007
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Engineering Novel Angiopoietin Receptor Ligands
Moss, A. (2011) · Figshare
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Oncogenes, Anti-Oncogenes, and Genetic Regulators of Vascular Development
Lane, T. F., & Collado-Hidalgo, A. (2001) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-0213-4_5
Hematopoietic Stem Cells and Angiogenesis
Takakura, N. (2003) · Developments in cardiovascular medicine · doi:10.1007/978-1-4419-9264-2_35
Metadata
- Authors
- Suri, C., McClain, J., Thurston, G., McDonald, D. M., Zhou, H., Oldmixon, E. H., Sato, T. N., & Yancopoulos, G. D.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Yancopoulos, George D.
- Venue
- Science
- Published
- 1998-10-16
- Volume
- 282
- Issue
- 5388
- Pages
- 468-471
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2051487747
- Cited by
- 818
- References
- 25
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 16 · 2019: 13 · 2018: 14 · 2017: 17 · 2016: 14 · 2015: 26 · 2014: 24 · 2013: 21 · 2012: 40
- FWCI
- 15.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL059157, HL 24136, HL 59157, P01HL024136)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
- Keywords
- angiopoietin-1, transgenic overexpression, vascularization, skin vasculature, vascular branching, vascular remodeling, vascular endothelial growth factor, therapeutic angiogenesis, endothelial cells
- MeSH terms
- Animals, Capillaries, Endothelium, Vascular, Lymphokines, Membrane Glycoproteins, Mice, Transgenic, Skin, Venules, Keratinocytes, Gene Expression, Endothelial Growth Factors, Neovascularization, Physiologic, Transgenes, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Angiopoietin-1, Mice
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