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Increased Vascularization in Mice Overexpressing Angiopoietin-1
Abstract
The angiopoietins and members of the vascular endothelial growth factor (VEGF) family are the only growth factors thought to be largely specific for vascular endothelial cells. Targeted gene inactivation studies in mice have shown that VEGF is necessary for the early stages of vascular development and that angiopoietin-1 is required for the later stages of vascular remodeling. Here it is shown that transgenic overexpression of angiopoietin-1 in the skin of mice produces larger, more numerous, and more highly branched vessels. These results raise the possibility that angiopoietins can be used, alone or in combination with VEGF, to promote therapeutic angiogenesis.
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“Ang-2, on the other hand, is an antagonist for the Tie-2 receptor and is exclu-sively expressed in sites of vascular remodeling (83,84,88)”
From Adipose tissue remodeling and obesity (2011) · cites this paper as [88]
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Cites
Risau, W. (1997) · Nature · doi:10.1038/386671a0 · Cited by 5,727
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570
Self-citationRequisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,872
Self-citationStereological Methods. Practical methods for biological morphometry
Weibel, E. R. (1979) · Academic Press eBooks · Cited by 1,994
Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning
Davis, S., Aldrich, T. H., Jones, P. F., Acheson, A., Compton, D. L., Jain, V., Ryan, T. E., Bruno, J., Radziejewski, C., Maisonpierre, P. C., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81812-7 · Cited by 1,989
Self-citationDistinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg‐Buchholz, K., Fujiwara, Y., Gendron‐Maguire, M., Gridley, T., Wolburg, H., Risau, W., & Qin, Y. (1995) · Nature · doi:10.1038/376070a0 · Cited by 1,821
Self-citationHyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice
Jeltsch, M., Kaipainen, A., Joukov, V., Meng, X., Lakso, M., Rauvala, H., Swartz, M. A., Fukumura, D., Jain, R. K., & Alitalo, K. K. (1997) · Science · doi:10.1126/science.276.5317.1423 · Cited by 1,279
Benjamin, L. E., Hemo, I., & Keshet, E. (1998) · Development · doi:10.1242/dev.125.9.1591 · Cited by 1,273
Dumont, D. J., Gradwohl, G., Fong, G. H., Puri, M. C., Gertsenstein, M., Auerbach, A., & Breitman, M. L. (1994) · Genes & Development · doi:10.1101/gad.8.16.1897 · Cited by 985
Cellular markers that distinguish the phases of hemangioma during infancy and childhood.
Takahashi, K., Mulliken, J. B., Kozakewich, H. P., Rogers, R. A., Folkman, J., & Ezekowitz, R. A. B. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117241 · Cited by 644
Detmar, M. J., Brown, L. F., Schön, M. P., Elicker, B. M., Velasco, P., Richard, L., Fukumura, D., Monsky, W. L., Claffey, K. P., & Jain, R. K. (1998) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.1998.00262.x · Cited by 550
Endothelial receptor tyrosine kinases involved in angiogenesis.
Mustonen, T., & Alitalo, K. K. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.4.895 · Cited by 524
Angiopoietin-1 induces sprouting angiogenesis in vitro
Koblizek, T. I., Weiss, C., Yancopoulos, G. D., Deutsch, U., & Risau, W. (1998) · Current Biology · doi:10.1016/s0960-9822(98)70205-2 · Cited by 459
Self-citationCationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice.
Thurston, G., McLean, J. W., Rizen, M., Bałuk, P., Haskell, A., Murphy, T. J., Hanahan, D., & McDonald, D. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci965 · Cited by 417
Self-citationVassar, R. J., Rosenberg, M. J., Ross, S. R., Tyner, A. L., & Fuchs, E. V. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.5.1563 · Cited by 368
Okamoto, N., Tobe, T., Hackett, S. F., Ozaki, H., Vinores, M. A., Rochelle, W. L., Zack, D. J., & Campochiaro, P. A. (1998) · Retina · doi:10.1097/00006982-199805000-00034 · Cited by 366
Drake, C. J., & Little, C. D. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.7657 · Cited by 332
Nagy, J. A., Masse, E., Herzberg, K. T., Meyers, M., Yeo, K. T., Yeo, T.-K., Sioussat, T. M., & Dvorak, H. F. (1995) · PubMed · Cited by 281
Extracellular FGF-1 acts as a lens differentiation factor in transgenic mice
Robinson, M. L., Overbeek, P. A., Verran, D. J., Grizzle, W. E., Stockard, C. R., Friesel, R. E., Maciag, T., & Thompson, J. A. (1995) · Development · doi:10.1242/dev.121.2.505 · Cited by 224
Rosenstein, J. M., Mani, N., Silverman, W. F., & Krum, J. M. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.7086 · Cited by 214
Viac, J., Palacio, S., Schmitt, D., & Claudy, A. (1997) · Archives of Dermatological Research · doi:10.1007/s004030050172 · Cited by 92
Zeng, Y., Rosborough, R. C., Li, Y., Gupta, A. R., & Bennett, J. (1998) · Developmental Dynamics · doi:10.1002/(sici)1097-0177(199803)211:3 · Cited by 44
Lengths and topology of alveolar septal borders
Oldmixon, E. H., Butler, J. P., & Hoppin, F. G. (1989) · Journal of Applied Physiology · doi:10.1152/jappl.1989.67.5.1930 · Cited by 31
Self-citationAngiogenic Factors in Diabetic Ocular Disease: Mechanisms of Today, Therapies for Tomorrow
Robinson, G. S., & Aiello, L. P. (1998) · International Ophthalmology Clinics · doi:10.1097/00004397-199803820-00007 · Cited by 24
Flagged first, then by citations
Research works printed but not linked: 5
- Carmeliet P., et al., ibid. 380, 435 (1996).
- Okamoto N., et al., Am. J. Pathol. 151, 281 (1997).
- Nagy J. A., et al., Cancer Res. 55, 360 (1995).
- Thurston G., Baluk P., Hirata A., McDonald D., Am. J. Physiol. 271, H2547 (1996).
- Oldmixon E., Brismar H., Lai J., Ekstein B., Rogers R. A., FASEB J. 8, A691 (1994).
Cited by
Sorted by citations
Angiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,379
Mechanisms of angiogenesis and arteriogenesis
Carmeliet, P. (2000) · Nature Medicine · doi:10.1038/74651 · Cited by 4,235
Vascular-specific growth factors and blood vessel formation
Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., & Holash, J. (2000) · Nature · doi:10.1038/35025215 · Cited by 3,699
Self-citationVessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF
Holash, J. A., Maisonpierre, P. C., Compton, D. L., Boland, P., Alexander, C., Zagzag, D., Yancopoulos, G. D., & Wiegand, S. J. (1999) · Science · doi:10.1126/science.284.5422.1994 · Cited by 2,222
Self-citationEndothelial/Pericyte Interactions
Armulik, A., Abramsson, A., & Betsholtz, C. (2005) · Circulation Research · doi:10.1161/01.res.0000182903.16652.d7 · Cited by 2,048
Metadata
- Authors
- Suri, C., McClain, J., Thurston, G., McDonald, D. M., Zhou, H., Oldmixon, E. H., Sato, T. N., & Yancopoulos, G. D.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Yancopoulos, George D.
- Venue
- Science
- Published
- 1998-10-16
- Volume
- 282
- Issue
- 5388
- Pages
- 468-471
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2051487747
- Cited by
- 818
- References
- 25
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 16 · 2019: 13 · 2018: 14 · 2017: 17 · 2016: 14 · 2015: 26 · 2014: 24 · 2013: 21 · 2012: 40
- FWCI
- 15.61
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R01HL059157, HL 24136, HL 59157, P01HL024136)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
- Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
- Keywords
- angiopoietin-1, transgenic overexpression, vascularization, skin vasculature, vascular branching, vascular remodeling, vascular endothelial growth factor, therapeutic angiogenesis, endothelial cells
- MeSH terms
- Animals, Capillaries, Endothelium, Vascular, Lymphokines, Membrane Glycoproteins, Mice, Transgenic, Skin, Venules, Keratinocytes, Gene Expression, Endothelial Growth Factors, Neovascularization, Physiologic, Transgenes, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Angiopoietin-1, Mice
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