Cited by 818Angiogenesis and VEGF in CancerLymphatic System and DiseasesVascular Tumors and Angiosarcomas

The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.

Increased Vascularization in Mice Overexpressing Angiopoietin-1

Suri, Chitra, McClain, Joyce, Thurston, Gavin, McDonald, Donald M., Zhou, Hao, Oldmixon, Eben H., Sato, Thomas N., Yancopoulos, George D.·1998·Science

DOI 10.1126/science.282.5388.468

Open this paper in CoChat — free account

Abstract

The angiopoietins and members of the vascular endothelial growth factor (VEGF) family are the only growth factors thought to be largely specific for vascular endothelial cells. Targeted gene inactivation studies in mice have shown that VEGF is necessary for the early stages of vascular development and that angiopoietin-1 is required for the later stages of vascular remodeling. Here it is shown that transgenic overexpression of angiopoietin-1 in the skin of mice produces larger, more numerous, and more highly branched vessels. These results raise the possibility that angiopoietins can be used, alone or in combination with VEGF, to promote therapeutic angiogenesis.

Integrity signals

Registry

Crossref · 10.1126/science.282.5388.468

Cites

25 of 25 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Mechanisms of angiogenesis
Risau, W. (1997) · Nature · doi:10.1038/386671a0 · Cited by 5,727
Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
Shalaby, F., Rossant, J., Yamaguchi, T. P., Gertsenstein, M., Wu, X.-F., Breitman, M. L., & Schuh, A. C. (1995) · Nature · doi:10.1038/376062a0 · Cited by 3,931
Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis
Maisonpierre, P. C., Suri, C., Jones, P. F., Bartunkova, S., Wiegand, S. J., Radziejewski, C., Compton, D., McClain, J., Aldrich, T. H., Papadopoulos, N., et al. (1997) · Science · doi:10.1126/science.277.5322.55 · Cited by 3,570
Self-citation
Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis
Suri, C., Jones, P. F., Patan, S., Bartunkova, S., Maisonpierre, P. C., Davis, S. H., Sato, T. N., & Yancopoulos, G. D. (1996) · Cell · doi:10.1016/s0092-8674(00)81813-9 · Cited by 2,872
Self-citation
Stereological Methods. Practical methods for biological morphometry
Weibel, E. R. (1979) · Academic Press eBooks · Cited by 1,994
Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning
Davis, S., Aldrich, T. H., Jones, P. F., Acheson, A., Compton, D. L., Jain, V., Ryan, T. E., Bruno, J., Radziejewski, C., Maisonpierre, P. C., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81812-7 · Cited by 1,989
Self-citation
Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation
Sato, T. N., Tozawa, Y., Deutsch, U., Wolburg‐Buchholz, K., Fujiwara, Y., Gendron‐Maguire, M., Gridley, T., Wolburg, H., Risau, W., & Qin, Y. (1995) · Nature · doi:10.1038/376070a0 · Cited by 1,821
Self-citation
Hyperplasia of Lymphatic Vessels in VEGF-C Transgenic Mice
Jeltsch, M., Kaipainen, A., Joukov, V., Meng, X., Lakso, M., Rauvala, H., Swartz, M. A., Fukumura, D., Jain, R. K., & Alitalo, K. K. (1997) · Science · doi:10.1126/science.276.5317.1423 · Cited by 1,279
A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF
Benjamin, L. E., Hemo, I., & Keshet, E. (1998) · Development · doi:10.1242/dev.125.9.1591 · Cited by 1,273
Dominant-negative and targeted null mutations in the endothelial receptor tyrosine kinase, tek, reveal a critical role in vasculogenesis of the embryo.
Dumont, D. J., Gradwohl, G., Fong, G. H., Puri, M. C., Gertsenstein, M., Auerbach, A., & Breitman, M. L. (1994) · Genes & Development · doi:10.1101/gad.8.16.1897 · Cited by 985

Flagged first, then by citations

Show all 25 references

Research works printed but not linked: 5

Carmeliet P., et al., ibid. 380, 435 (1996).
Okamoto N., et al., Am. J. Pathol. 151, 281 (1997).
Nagy J. A., et al., Cancer Res. 55, 360 (1995).
Thurston G., Baluk P., Hirata A., McDonald D., Am. J. Physiol. 271, H2547 (1996).
Oldmixon E., Brismar H., Lai J., Ekstein B., Rogers R. A., FASEB J. 8, A691 (1994).

Sorted by citations

Angiogenesis in health and disease
Carmeliet, P. (2003) · Nature Medicine · doi:10.1038/nm0603-653 · Cited by 4,379
Mechanisms of angiogenesis and arteriogenesis
Carmeliet, P. (2000) · Nature Medicine · doi:10.1038/74651 · Cited by 4,235
Vascular-specific growth factors and blood vessel formation
Yancopoulos, G. D., Davis, S., Gale, N. W., Rudge, J. S., Wiegand, S. J., & Holash, J. (2000) · Nature · doi:10.1038/35025215 · Cited by 3,699
Self-citation
Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF
Holash, J. A., Maisonpierre, P. C., Compton, D. L., Boland, P., Alexander, C., Zagzag, D., Yancopoulos, G. D., & Wiegand, S. J. (1999) · Science · doi:10.1126/science.284.5422.1994 · Cited by 2,222
Self-citation
Endothelial/Pericyte Interactions
Armulik, A., Abramsson, A., & Betsholtz, C. (2005) · Circulation Research · doi:10.1161/01.res.0000182903.16652.d7 · Cited by 2,048
Adipose tissue remodeling and obesity
Sun, K., Kusminski, C. M., & Scherer, P. E. (2011) · Journal of Clinical Investigation · doi:10.1172/jci45887 · Cited by 1,941
Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system
Augustin, H. G., Koh, G. Y., Thurston, G., & Alitalo, K. K. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2639 · Cited by 1,512
Self-citation
Leakage-Resistant Blood Vessels in Mice Transgenically Overexpressing Angiopoietin-1
Thurston, G., Suri, C., Smith, K., McClain, J., Sato, T. T., Yancopoulos, G. D., & McDonald, D. M. (1999) · Science · doi:10.1126/science.286.5449.2511 · Cited by 1,350
Self-citation
Angiopoietin-1 protects the adult vasculature against plasma leakage
Thurston, G., Rudge, J. S., Ioffe, E., Zhou, H., Ross, L. H., Croll, S. D., Glazer, N. L., Holash, J. A., McDonald, D. M., & Yancopoulos, G. D. (2000) · Nature Medicine · doi:10.1038/74725 · Cited by 1,314
Self-citation
Molecular mechanisms of blood vessel growth
Conway, E. (2001) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00281-9 · Cited by 1,030
Clinical applications of angiogenic growth factors and their inhibitors
Ferrara, N., & Alitalo, K. (1999) · Nature Medicine · doi:10.1038/70928 · Cited by 1,004
Age-related macular degeneration: etiology, pathogenesis, and therapeutic strategies
Ambati, J., Ambati, B. K., Yoo, S. H., Ianchulev, S., & Adamis, A. P. (2003) · Survey of Ophthalmology · doi:10.1016/s0039-6257(03)00030-4 · Cited by 959
Mechanisms of normal and tumor-derived angiogenesis
Papetti, M., & Herman, I. M. (2002) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00389.2001 · Cited by 809
Growth factors acting via endothelial cell-specific receptor tyrosine kinases: VEGFs, Angiopoietins, and ephrins in vascular developmentPreprint
Gale, N. W., & Yancopoulos, G. D. (1999) · Genes & Development · doi:10.1101/gad.13.9.1055 · Cited by 794
Self-citation
Angiogenesis in wound repair: Angiogenic growth factors and the extracellular matrix
Li, J., Zhang, Y., & Kirsner, R. S. (2003) · Microscopy Research and Technique · doi:10.1002/jemt.10249 · Cited by 740
New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
Holash, J. A., Wiegand, S. J., & Yancopoulos, G. D. (1999) · Oncogene · doi:10.1038/sj.onc.1203035 · Cited by 752
Self-citation
Coordinated Interaction of Neurogenesis and Angiogenesis in the Adult Songbird Brain
Louissaint, A., Rao, S., Leventhal, C., & Goldman, S. A. (2002) · Neuron · doi:10.1016/s0896-6273(02)00722-5 · Cited by 735
The brain tumor microenvironment
Charles, N. A., Holland, E. C., Gilbertson, R., Glass, R., & Kettenmann, H. (2011) · Glia · doi:10.1002/glia.21136 · Cited by 718
The brain tumor microenvironment
Charles, N. A., Holland, E. C., Gilbertson, R. J., Glaß, R., & Kettenmann, H. (2011) · Glia · doi:10.1002/glia.21264 · Cited by 729
Angiopoietin-2 displays VEGF-dependent modulation of capillary structure and endothelial cell survival in vivo
Lobov, I. B., Brooks, P. C., & Lang, R. A. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.172161899 · Cited by 676
Angiopoietin-1 Regulates Endothelial Cell Survival Through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway
Kim, I., Kim, H. G., So, J.-N., Kim, J. H., Kwak, H. J., & Koh, G. Y. (2000) · Circulation Research · doi:10.1161/01.res.86.1.24 · Cited by 649
Therapeutic targeting of the angiopoietin–TIE pathway
Saharinen, P., Eklund, L., & Alitalo, K. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.278 · Cited by 620
Million-fold Preconcentration of Proteins and Peptides by Nanofluidic Filter
Wang, Y., Stevens, A. L., & Han, J. (2005) · Analytical Chemistry · doi:10.1021/ac050321z · Cited by 618
The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
Pola, R., Ling, L. E., Silver, M., Corbley, M. J., Kearney, M., Pepinsky, R. B., Shapiro, R. I., Taylor, F. R., Baker, D. P., Asahara, T., et al. (2001) · Nature Medicine · doi:10.1038/89083 · Cited by 610
Angiopoietins: a link between angiogenesis and inflammation
Fiedler, U., & Augustin, H. G. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.10.004 · Cited by 606
Normal Cutaneous Wound Healing: Clinical Correlation with Cellular and Molecular Events
Baum, C. L., & Arpey, C. J. (2006) · Dermatologic Surgery · doi:10.1111/j.1524-4725.2005.31612 · Cited by 608
Expression and Function of Laminins in the Embryonic and Mature Vasculature
Hallmann, R., Horn, N., Selg, M., Wendler, O., Pausch, F., & Sorokin, L. M. (2005) · Physiological Reviews · doi:10.1152/physrev.00014.2004 · Cited by 597
Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis
Ozawa, C. R., Banfi, A., Glazer, N. L., Thurston, G., Springer, M. L., Kraft, P. E., McDonald, D. M., & Blau, H. M. (2004) · Journal of Clinical Investigation · doi:10.1172/jci18420 · Cited by 517
Self-citation
VEGF Receptor Signaling in Tumor Angiogenesis
McMahon, G. (2000) · The Oncologist · doi:10.1634/theoncologist.5-suppl_1-3 · Cited by 521
Structure and Function of VEGF/VEGF-receptor System Involved in Angiogenesis.
Shibuya, M. (2001) · Cell Structure and Function · doi:10.1247/csf.26.25 · Cited by 509
A Role for Hematopoietic Stem Cells in Promoting Angiogenesis
Takakura, N., Watanabe, T., Suenobu, S., Yamada, Y., Noda, T., Ito, Y., Satake, M., & Suda, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00025-8 · Cited by 501
Signaling and Functions of Angiopoietin-1 in Vascular Protection
Brindle, N. P. J., Saharinen, P., & Alitalo, K. K. (2006) · Circulation Research · doi:10.1161/01.res.0000218275.54089.12 · Cited by 485
Current understanding of molecular and cellular mechanisms in fibroplasia and angiogenesis during acute wound healing
Greaves, N. S., Ashcroft, K. J., Baguneid, M. S., & Bayat, A. (2013) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2013.07.008 · Cited by 493
Angiogenesis and vasculogenesis in pregnancy
Zygmunt, M., Herr, F., Münstedt, K., Lang, U., & Liang, O. D. (2003) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/s0301-2115(03)00168-4 · Cited by 473
Angiopoietins 3 and 4: Diverging gene counterparts in mice and humans
Valenzuela, D. M., Griffiths, J. A., Rojas, J., Aldrich, T. H., Jones, P. F., Zhou, H., McClain, J., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.5.1904 · Cited by 477
Self-citation
The transcription factor EPAS-1/hypoxia-inducible factor 2α plays an important role in vascular remodeling
Peng, J., Zhang, L., Drysdale, L., & Fong, G.-H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.140087397 · Cited by 460
Zebrafishnma is involved in TGF? family signaling
Tsang, M., Kim, R., de Caestecker, M. P., Kudoh, T., Roberts, A. B., & Dawid, I. B. (2000) · genesis · doi:10.1002/1526-968x(200010)28:2 · Cited by 64
Self-citation
Tumor Development and Angiogenesis in Adult Brain Tumor: Glioblastoma
Ahir, B. K., Engelhard, H. H., & Lakka, S. S. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01892-8 · Cited by 454
Vasculogenesis and Angiogenesis
Patan, S. (2004) · Cancer treatment and research · doi:10.1007/978-1-4419-8871-3_1 · Cited by 447
Tie receptors: new modulators of angiogenic and lymphangiogenic responses
Jones, N., Iljin, K., Dumont, D., & Alitalo, K. K. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35067005 · Cited by 419
Angiopoietin-1 Prevents VEGF-Induced Endothelial Permeability by Sequestering Src through mDia
Gavard, J., Patel, V., & Gutkind, J. S. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.10.019 · Cited by 409
The role of the Angiopoietins in vascular morphogenesis
Thomas, M., & Augustin, H. G. (2009) · Angiogenesis · doi:10.1007/s10456-009-9147-3 · Cited by 418
Normal Cutaneous Wound Healing
Baum, C. L., & Arpey, C. J. (2005) · Dermatologic Surgery · doi:10.1097/00042728-200506000-00011 · Cited by 403
Angiogenesis in the atherosclerotic plaque
Camaré, C., Pucelle, M., Nègre-Salvayre, A., & Salvayre, R. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.007 · Cited by 401
Correlation of VEGF and Angiopoietin Expression with Disruption of Blood–Brain Barrier and Angiogenesis after Focal Cerebral Ischemia
Zhang, Z. G., Li, Z., Tsang, W., Hamid Soltanian-zadeh, A., Morris, D. C., Zhang, R., Goussev, A. V., Powers, C., Yeich, T., & Chopp, M. (2002) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200204000-00002 · Cited by 399
Understanding the biology of angiogenesis: Review of the most important molecular mechanisms
Otrock, Z. K., Mahfouz, R. A., Makarem, J. A., & Shamseddine, A. I. (2007) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2007.04.001 · Cited by 408
Mechanisms of angiogenesis
Karamysheva, A. F. (2008) · Biochemistry (Moscow) · doi:10.1134/s0006297908070031 · Cited by 407
Angiogenesis and Remodeling of Airway Vasculature in Chronic Inflammation
McDonald, D. M. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.supplement_2.2106065 · Cited by 386
Self-citation
Vasculogenesis and Angiogenesis as Mechanisms of Vascular Network Formation, Growth and Remodeling
Patan, S. (2000) · Journal of Neuro-Oncology · doi:10.1023/a:1006493130855 · Cited by 397
VEGF: an update on biological and therapeutic aspects
Ferrara, N. (2000) · Current Opinion in Biotechnology · doi:10.1016/s0958-1669(00)00153-1 · Cited by 377
Transgenic delivery of VEGF to mouse skin leads to an inflammatory condition resembling human psoriasis
Xia, Y.-P., Li, B., Hylton, D., Detmar, M., Yancopoulos, G. D., & Rudge, J. S. (2003) · Blood · doi:10.1182/blood-2002-12-3793 · Cited by 367
Self-citation
Blood vessel maturation in a 3‐dimensional spheroidal coculture model: direct contact with smooth muscle cells regulates endothelial cell quiescence and abrogates VEGF responsiveness
Korff, T., Kimmina, S., Martiny‐Baron, G., & Augustin, H. G. (2001) · The FASEB Journal · doi:10.1096/fj.00-0139com · Cited by 367
Aspects of Human Fetoplacental Vasculogenesis and Angiogenesis. I. Molecular Regulation
Jones, D. S., Kaufmann, P., & Mayhew, T. M. (2003) · Placenta · doi:10.1016/j.placenta.2003.10.004 · Cited by 372
Sweeping of Analyte Zones in Electrokinetic Chromatography
Quirino, J. P., & Terabe, S. (1999) · Analytical Chemistry · doi:10.1021/ac9810866 · Cited by 349
Tie receptors and their angiopoietin ligands are context-dependent regulators of vascular remodeling
Eklund, L., & Olsen, B. R. (2005) · Experimental Cell Research · doi:10.1016/j.yexcr.2005.09.002 · Cited by 342
Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF)
Visconti, R. P., Richardson, C. D., & Sato, T. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122109599 · Cited by 339
Self-citation
In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse
Schechner, J. S., Nath, A. K., Lian, Z., Kluger, M. S., Hughes, C. C. W., Sierra-Honigmann, M. R., Lorber, M. I., Tellides, G., Kashgarian, M. J., Bothwell, A. L. M., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.150242297 · Cited by 333
Angiopoietin-2 at high concentration can enhance endothelial cell survival through the phosphatidylinositol 3′-kinase/Akt signal transduction pathway
Kim, I., Kim, J., Moon, S.-O., Kwak, H. J., Kim, N., & Koh, G. Y. (2000) · Oncogene · doi:10.1038/sj.onc.1203800 · Cited by 306
Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke
Zacharek, A., Chen, J., Li, A., Cui, X., Li, Y., Roberts, C., Feng, Y., Gao, Q., & Chopp, M. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600475 · Cited by 297
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1αPreprint
Elson, D. A., Thurston, G., Huang, E. L., Ginzinger, D. G., McDonald, D. M., Johnson, R. S., & Arbeit, J. M. (2001) · Genes & Development · doi:10.1101/gad.914801 · Cited by 297
Self-citation
Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis
Thurston, G. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0749-6 · Cited by 297
Self-citation
Vascular Apoptosis and Involution in Gliomas Precede Neovascularization: A Novel Concept for Glioma Growth and Angiogenesis
Zagzag, D., Amirnovin, R., GRECO, M. A., Yee, H. T., Holash, J. A., Wiegand, S. J., Zabski, S. M., Yancopoulos, G. D., & Grumet, M. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780088 · Cited by 298
Self-citation
Axl as a potential therapeutic target in cancer: role of Axl in tumor growth, metastasis and angiogenesis
Li, Y., Ye, X., Tan, C., Hongo, J. A., Zha, J., Liu, J., Kallop, D. Y., Ludlam, M. J. C., & Pei, L. (2009) · Oncogene · doi:10.1038/onc.2009.212 · Cited by 294
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells
Uemura, A., Ogawa, M., Hirashima, M., Fujiwara, T., Koyama, S., Takagi, H., Honda, Y., Wiegand, S. J., Yancopoulos, G. D., & Nishikawa, S.-I. (2002) · Journal of Clinical Investigation · doi:10.1172/jci15621 · Cited by 282
Self-citation
Cellular and molecular pathways of renal repair after acute kidney injury
Kumar, S. (2018) · Kidney International · doi:10.1016/j.kint.2017.07.030 · Cited by 271
When bad things happen to good fish: the loss of hemoglobin and myoglobin expression in Antarctic icefishes
Sidell, B. D., & O’Brien, K. M. (2006) · Journal of Experimental Biology · doi:10.1242/jeb.02091 · Cited by 269
The Complex Role of Angiopoietin-2 in the Angiopoietin-Tie Signaling PathwayPreprint
Thurston, G., & Daly, C. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006650 · Cited by 267
Self-citation
Active Hair Growth (Anagen) is Associated with Angiogenesis
Mecklenburg, L., Tobin, D. J., Müller‐Röver, S., Handjiski, B., Wendt, G., Peters, E. M. J., Pohl, S., Moll, I., & Paus, R. (2000) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2000.00954.x · Cited by 265
Spatial and temporal role of the apelin/APJ system in the caliber size regulation of blood vessels during angiogenesis
Kidoya, H., Ueno, M., Yamada, Y., Mochizuki, N., Nakata, M., Yano, T., Fujii, R., & Takakura, N. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601982 · Cited by 270
Direct Cell Adhesion to the Angiopoietins Mediated by Integrins
Carlson, T. R., Feng, Y., Maisonpierre, P. C., Mrksich, M., & Morla, A. O. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100282200 · Cited by 265
Angiopoietin-1 Induces Endothelial Cell Sprouting Through the Activation of Focal Adhesion Kinase and Plasmin Secretion
Kim, I., Kim, H. G., Moon, S.-O., Chae, S., So, J.-N., Koh, K. N., Ahn, B. C., & Koh, G. Y. (2000) · Circulation Research · doi:10.1161/01.res.86.9.952 · Cited by 254
COMP-Ang1: A designed angiopoietin-1 variant with nonleaky angiogenic activity
Cho, C., Kammerer, R. A., Lee, H. J., Steinmetz, M. O., Ryu, Y. S., Lee, S. H., Yasunaga, K., Kim, K.-T., Kim, I., Choi, H.-H., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0307574101 · Cited by 253
Microfluidic Models of Vascular Functions
Wong, K. H. K., Chan, J. M., Kamm, R. D., & Tien, J. (2012) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071811-150052 · Cited by 254
Opposing actions of angiopoietin-2 on Tie2 signaling and FOXO1 activation
Kim, M., Allen, B. M., Korhonen, E. A., Nitschké, M., Yang, H. W., Bałuk, P., Saharinen, P., Alitalo, K. K., Daly, C., Thurston, G., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84871 · Cited by 248
Self-citation
Angiopoietin‐1 is an apoptosis survival factor for endothelial cells
Kwak, H. J., So, J.-N., Lee, S. J., Kim, I., & Koh, G. Y. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00378-6 · Cited by 238
Molecular angiogenesis
Klagsbrun, M., & Moses, M. A. (1999) · Chemistry & Biology · doi:10.1016/s1074-5521(99)80081-7 · Cited by 242
Therapeutic Benefits by Human Mesenchymal Stem Cells (hMSCs) and Ang-1 Gene-Modified hMSCs after Cerebral Ischemia
Onda, T., Honmou, O., Harada, K., Houkin, K., Hamada, H., & Kocsis, J. D. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600527 · Cited by 237
Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system
Takeda, K., Cowan, A., & Fong, G.-H. (2007) · Circulation · doi:10.1161/circulationaha.107.701516 · Cited by 236
Angiopoietin-1 promotes lymphatic sprouting and hyperplasia
Tammela, T., Saaristo, A. M., Lohela, M. K., Morisada, T., Tornberg, J., Norrmén, C., Oike, Y., Pajusola, K., Thurston, G., Suda, T., et al. (2005) · Blood · doi:10.1182/blood-2004-08-3327 · Cited by 236
Self-citation
Angiopoietins have distinct modular domains essential for receptor binding, dimerization and superclustering
Davis, S., Papadopoulos, N., Aldrich, T. H., Maisonpierre, P. C., Huang, T., Kovac, L., Xu, A., Leidich, R., Radziejewska, E., Rafique, A., et al. (2003) · Nature Structural Biology · doi:10.1038/nsb880 · Cited by 234
Self-citation
Recombinant angiopoietin-1 restores higher-order architecture of growing blood vessels in mice in the absence of mural cells
Uemura, A., Ogawa, M., Hirashima, M., Fujiwara, T., Koyama, S., Takagi, H., Honda, Y., Wiegand, S. J., Yancopoulos, G. D., & Nishikawa, S. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215621 · Cited by 226
Self-citation
Molecular genetics of vascular malformations
Vikkula, M., Boon, L. M., & Mulliken, J. B. (2001) · Matrix Biology · doi:10.1016/s0945-053x(01)00150-0 · Cited by 225
Coadministration of Angiopoietin-1 and Vascular Endothelial Growth Factor Enhances Collateral Vascularization
Chae, J. K., Kim, I., Lim, S. T., Chung, M. J., Kim, W. H., Kim, H. G., Ko, J. K., & Koh, G. Y. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.12.2573 · Cited by 225
In Situ Expression of Angiopoietins in Astrocytomas Identifies Angiopoietin-2 as an Early Marker of Tumor Angiogenesis
Zagzag, D., Hooper, A. T., Friedlander, D. R., Chan, W., Holash, J. A., Wiegand, S. J., Yancopoulos, G. D., & Grumet, M. (1999) · Experimental Neurology · doi:10.1006/exnr.1999.7162 · Cited by 222
Self-citation
A Universal Concept for Stacking Neutral Analytes in Micellar Capillary Electrophoresis
Palmer, J., Munro, N. J., & Landers, J. P. (1999) · Analytical Chemistry · doi:10.1021/ac981302a · Cited by 216
Manipulating angiogenesis in medicine
Carmeliet, P. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2003.01297.x · Cited by 215
The effects of angiopoietin-1 and -2 on tumor growth and angiogenesis in human colon cancer.
Ahmad, S. A., Liu, W., Jung, Y. D., Fan, F., Wilson, M., Reinmuth, N., Shaheen, R. M., Bucana, C. D., & Ellis, L. M. (2001) · PubMed · Cited by 208
Angiopoietin–Tie signalling in the cardiovascular and lymphatic systems
Eklund, L., Kangas, J., & Saharinen, P. (2016) · Clinical Science · doi:10.1042/cs20160129 · Cited by 210
The role of erythropoietin in regulating angiogenesis
Kertesz, N. L., Wu, J., Chen, T. H.-P., Sucov, H. M., & Wu, H. (2004) · Developmental Biology · doi:10.1016/j.ydbio.2004.08.025 · Cited by 205
Angiopoietin‐2 expression in breast cancer correlates with lymph node invasion and short survival
Sfiligoi, C., de Luca, A., Cascone, I., Sorbello, V., Fuso, L., Ponzone, R., Biglia, N., Audero, E., Arisio, R., Bussolino, F., et al. (2003) · International Journal of Cancer · doi:10.1002/ijc.10851 · Cited by 203
Expression of angiogenic factors during distraction osteogenesis
Pacicca, D. M., Patel, N., Lee, C., Palomares, K. T. S., Lehmann, W., Carvalho, R. S., Gerstenfeld, L. C., & Einhorn, T. A. (2003) · Bone · doi:10.1016/j.bone.2003.06.002 · Cited by 202
VEGF Induces Tie2 Shedding via a Phosphoinositide 3-Kinase/Akt–Dependent Pathway to Modulate Tie2 Signaling
Findley, C. M., Cudmore, M., Ahmed, A., & Kontos, C. D. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.150482 · Cited by 201
Velocity-Difference Induced Focusing of Nucleotides in Capillary Electrophoresis with a Dynamic pH Junction
Britz‐McKibbin, P., Bebault, G. M., & Chen, D. D. Y. (2000) · Analytical Chemistry · doi:10.1021/ac991104z · Cited by 201
Protective Role of Angiopoietin-1 in Endotoxic Shock
Witzenbichler, B., Westermann, D., Knueppel, S., Schultheiss, H., & Tschöpe, C. (2004) · Circulation · doi:10.1161/01.cir.0000151287.08202.8e · Cited by 199
Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice
Carlson, T. R., Yan, Y., Wu, X., Lam, M. T. Y., Tang, G. L., Beverly, L. J., Messina, L. M., Capobianco, A. J., Werb, Z., & Wang, R. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504391102 · Cited by 198
Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4.
Ito, Y., Oike, Y., Yasunaga, K., Hamada, K., Miyata, K., Matsumoto, S.-I., Sugano, S., Tanihara, H., Masuho, Y., & Suda, T. (2003) · PubMed · Cited by 196
Angiogenic factors as potential drug target: Efficacy and limitations of anti-angiogenic therapy
Gacche, R. N., & Meshram, R. J. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.05.002 · Cited by 203
Redundant roles ofSox17andSox18in postnatal angiogenesis in mice
Matsui, T., Kanai‐Azuma, M., Hara, K., Matoba, S., Hiramatsu, R., Kawakami, H., Kurohmaru, M., Koopman, P. A., & Kanai, Y. (2006) · Journal of Cell Science · doi:10.1242/jcs.03081 · Cited by 197
Hypoxia and Hypoxia Signaling in Tissue Repair and Fibrosis
Lokmic‐Tomkins, Z., Musyoka, J. N., Hewitson, T. D., & Darby, I. A. (2012) · International review of cytology · doi:10.1016/b978-0-12-394307-1.00003-5 · Cited by 198
Signaling Pathways in Vascular Development
Rossant, J., & Howard, L. T. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.012502.105825 · Cited by 195

Authors: Suri, C., McClain, J., Thurston, G., McDonald, D. M., Zhou, H., Oldmixon, E. H., Sato, T. N., & Yancopoulos, G. D.
Affiliations: University of California, San Francisco (US)
Corresponding author: Yancopoulos, George D.
ORCID: Thurston, Gavin
McDonald, Donald M.
Zhou, Hao
Sato, Thomas N.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1998-10-16
Volume: 282
Issue: 5388
Pages: 468-471
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.282.5388.468
OpenAlex: W2051487747
Cited by: 818
References: 25
Citations by year: 2026: 1 · 2025: 8 · 2024: 4 · 2023: 8 · 2022: 11 · 2021: 14 · 2020: 16 · 2019: 13 · 2018: 14 · 2017: 17 · 2016: 14 · 2015: 26 · 2014: 24 · 2013: 21 · 2012: 40
FWCI: 15.61
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R01HL059157, HL 24136, HL 59157, P01HL024136)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Health Sciences › Medicine › Oncology › Vascular Tumors and Angiosarcomas
Keywords: angiopoietin-1, transgenic overexpression, vascularization, skin vasculature, vascular branching, vascular remodeling, vascular endothelial growth factor, therapeutic angiogenesis, endothelial cells
MeSH terms: Animals, Capillaries, Endothelium, Vascular, Lymphokines, Membrane Glycoproteins, Mice, Transgenic, Skin, Venules, Keratinocytes, Gene Expression, Endothelial Growth Factors, Neovascularization, Physiologic, Transgenes, Vascular Endothelial Growth Factors, Vascular Endothelial Growth Factor A, Angiopoietin-1, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Increased Vascularization in Mice Overexpressing Angiopoietin-1

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks