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Cited by 55Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchIon channel regulation and function

Calcium and activity-dependent signaling in the developing cerebral cortex

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Arjun McKinney, Arpana, Petrova, Ralitsa, Panagiotakos, Georgia·2022·Development
DOI 10.1242/dev.198853PMC PMC9578689
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Abstract

Calcium influx can be stimulated by various intra- and extracellular signals to set coordinated gene expression programs into motion. As such, the precise regulation of intracellular calcium represents a nexus between environmental cues and intrinsic genetic programs. Mounting genetic evidence points to a role for the deregulation of intracellular calcium signaling in neuropsychiatric disorders of developmental origin. These findings have prompted renewed enthusiasm for understanding the roles of calcium during normal and dysfunctional prenatal development. In this Review, we describe the fundamental mechanisms through which calcium is spatiotemporally regulated and directs early neurodevelopmental events. We also discuss unanswered questions about intracellular calcium regulation during the emergence of neurodevelopmental disease, and provide evidence that disruption of cell-specific calcium homeostasis and/or redeployment of developmental calcium signaling mechanisms may contribute to adult neurological disorders. We propose that understanding the normal developmental events that build the nervous system will rely on gaining insights into cell type-specific calcium signaling mechanisms. Such an understanding will enable therapeutic strategies targeting calcium-dependent mechanisms to mitigate disease.

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  • CYFIP1 regulation of calcium channel subunits compromises intracellular calcium levels, resulting in delayed axonal development.

    “These findings support our model in which CYFIP1 regulation of calcium channel subunits compromise intracellular calcium levels, resulting in delayed axonal development10,84,85 (Fig. 7).”

    From CYFIP1 governs the development of cortical axons by modulating calcium availability (2025) · cites this paper as [85]

    The review’s “Mechanisms regulating intracellular calcium signaling” section explains that calcium-channel subunits regulate calcium entry. Its “Differentiation” section links intracellular calcium signaling to axonal pathfinding and neuronal activity to callosal axon outgrowth. It does not identify CYFIP1 as a regulator of those subunits or establish the proposed chain from CYFIP1 to altered calcium levels and delayed axonal development; the citing sentence labels that chain as the authors’ model. Page numbers were not available in our copy. (LLM, conf=0.82)

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Authors
Arjun McKinney, A., Petrova, R., & Panagiotakos, G.
Affiliations
  • University of California 1 Graduate Program in Developmental and Stem Cell Biology , , San Francisco, CA 94143 , USA
  • University of California, San Francisco (US)
Corresponding author
Panagiotakos, Georgia
ORCID
Venue
Development
Publisher
The Company of Biologists
Published
2022-09-01
Volume
149
Issue
17
ISSN
  • 0950-1991 (ISSN-L)
  • 1477-9129
DOI
10.1242/dev.198853
PMC
PMC9578689
OpenAlex
W4295654268
Cited by
55
References
40
Citations by year
2026: 17 · 2025: 16 · 2024: 8 · 2023: 14
FWCI
1.49
Type
journal article
Language
en
Open access
Licence
Locations
  • Development (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
  • University of California, San Francisco
  • Sandler Foundation
  • National Institutes of Health (R01 MH125004, R56/R01 MH127075)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Keywords
intracellular calcium signaling, calcium homeostasis, cortical development, brain development, activity-dependent signaling, neuropsychiatric disorders, prenatal development
MeSH terms
Calcium, Cerebral Cortex, Humans, Nervous System Diseases, Calcium Signaling

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