Cited by 2,729Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

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Long-Term Potentiation--A Decade of Progress?

Malenka, Robert C., Nicoll, and Roger A.·1999·Science

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Abstract

Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.

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Authors: Malenka, R. C., & Nicoll, A. R. A.
Affiliations: Stanford Medicine (US)
Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, CA 94143, USA.and
ORCID: Malenka, Robert C.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1999-09-17
Volume: 285
Issue: 5435
Pages: 1870-1874
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.285.5435.1870
OpenAlex: W2110724392
Cited by: 2,729
References: 127
Citations by year: 2026: 25 · 2025: 33 · 2024: 52 · 2023: 66 · 2022: 53 · 2021: 55 · 2020: 54 · 2019: 59 · 2018: 62 · 2017: 74 · 2016: 80 · 2015: 91 · 2014: 103 · 2013: 103 · 2012: 122
FWCI: 12.00
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords: long-term potentiation, synaptic plasticity, hippocampus, synaptic transmission, learning and memory, molecular mechanisms
MeSH terms: Animals, Hippocampus, Humans, Models, Neurological, Synaptic Transmission, Protein Kinases, Synapses, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Pyramidal Cells, Receptors, AMPA, Calcium Signaling

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Long-Term Potentiation--A Decade of Progress?

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