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Long-Term Potentiation--A Decade of Progress?
Abstract
Long-term potentiation of synaptic transmission in the hippocampus is the leading experimental model for the synaptic changes that may underlie learning and memory. This review presents a current understanding of the molecular mechanisms of this long-lasting increase in synaptic strength and describes a simple model that unifies much of the data that previously were viewed as contradictory.
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“Moreover, each biological synapse contains a plurality of presynaptic release sites53 and postsynaptic ion channels54.”
From Neuromorphic computing with multi-memristive synapses (2018) · cites this paper as [54]
In the citing paper
“The involvement of progressively larger numbers of memristive devices during potentiation is analogous to the development of new ion channels in a potentiated synapse53,54.”
From Neuromorphic computing with multi-memristive synapses (2018) · cites this paper as [54]
In the citing paper
“Importantly, this manipulation occludes further LTP, suggesting a shared mechanism between the ways of increasing synaptic strength (Malenka and Nicoll 1999;Lisman et al. 2002).”
From NMDA receptor-dependent long-term potentiation and long-term depression (LTP/LTD). (2012) · cites this paper as Malenka and Nicoll 1999
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Metadata
- Authors
- Malenka, R. C., & Nicoll, A. R. A.
- Affiliations
- Stanford Medicine (US)
- Departments of Cellular and Molecular Pharmacology and Physiology, University of California, San Francisco, CA 94143, USA.and
- ORCID
- Malenka, Robert C.
- Venue
- Science
- Published
- 1999-09-17
- Volume
- 285
- Issue
- 5435
- Pages
- 1870-1874
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2110724392
- Cited by
- 2,729
- References
- 127
- Citations by year
- 2026: 25 · 2025: 33 · 2024: 52 · 2023: 66 · 2022: 53 · 2021: 55 · 2020: 54 · 2019: 59 · 2018: 62 · 2017: 74 · 2016: 80 · 2015: 91 · 2014: 103 · 2013: 103 · 2012: 122
- FWCI
- 12.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, synaptic plasticity, hippocampus, synaptic transmission, learning and memory, molecular mechanisms
- MeSH terms
- Animals, Hippocampus, Humans, Models, Neurological, Synaptic Transmission, Protein Kinases, Synapses, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Pyramidal Cells, Receptors, AMPA, Calcium Signaling
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